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CCL13 Gene

protein-coding   GIFtS: 62
GCID: GC17P032684

Chemokine (C-C Motif) Ligand 13

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 13)
(Previous symbol: SCYA13)
  See CCL13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 131 2     MCP-42 3
SCYA131 2 3 5     NCC-12 3
NCC12 3 5     CKb102
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 131 2     SCYL12
Monocyte Chemoattractant Protein 42 3     C-C Motif Chemokine 132
Monocyte Chemotactic Protein 42 3     New CC Chemokine 12
Small-Inducible Cytokine A132 3     MCP43
CK-beta-102 3     

External Ids:    HGNC: 106111   Entrez Gene: 63572   Ensembl: ENSG000001813747   OMIM: 6013915   UniProtKB: Q996163   

Export aliases for CCL13 gene to outside databases

Previous GC identifers: GC17P032453 GC17P034723 GC17P032829 GC17P029707 GC17P028869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL13 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in
accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the
arterial wall during artherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL13 Gene:
CCL13 (chemokine (C-C motif) ligand 13) is a protein-coding gene. Diseases associated with CCL13 include far eastern spotted fever, and spotted fever. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
exposed to exogenous pathogens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL13 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   Meis-1b   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL13 promoter sequence
   Search Chromatin IP Primers for CCL13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032684:  view genomic region     (about GC identifiers)

Start:
32,683,471 bp from pter      End:
32,685,629 bp from pter
Size:
2,159 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616 (See protein sequence)
Recommended Name: C-C motif chemokine 13 precursor  
Size: 98 amino acids; 10986 Da
Mass spectrometry: Mass=9314; Mass_error=30; Method=MALDI; Range=17-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8760; Mass_error=30; Method=MALDI; Range=22-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8575; Mass_error=30; Method=MALDI; Range=24-98; Source=PubMed:8642349;
Miscellaneous: This protein can bind heparin
1 PDB 3D structure from and Proteopedia for CCL13:
2RA4 (3D)    
Secondary accessions: O95689 Q6ICQ6

Explore the universe of human proteins at neXtProt for CCL13: NX_Q99616

Explore proteomics data for CCL13 at MOPED

Post-translational modifications: 

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal
    peptide cleavage. The medium chain is about 30-fold less active than the long chain1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCL13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005399.1  
    ENSEMBL proteins: 
     ENSP00000225844   ENSP00000463667  

    CCL13 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCL13
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCL13
    GenScript Purified and Recombinant Proteins for CCL13
    Novus Biologicals CCL13 Proteins
    Novus Biologicals CCL13 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CCL13
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CCL13 

    CCL13 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL13 (CCL13/MCP-4)
    OriGene Antibodies for CCL13
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    Novus Biologicals CCL13 Antibodies
    Abcam antibodies for CCL13
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CCL13
    LSBio Antibodies in human, mouse, rat for CCL13

    CCL13 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CCL13 (CCL13/MCP-4)         (see all)
    GenScript Custom Assay Services for CCL13
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CCL13 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99616

    ProtoNet protein and cluster: Q99616

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL13           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL13_HUMAN, Q99616
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
    Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
    allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
    during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
    exposed to exogenous pathogens
    Induction: By IL1/interleukin-1 and TNF

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9195948
    GO:0008009chemokine activity IDA10072545
         
    Find genes that share ontologies with CCL13           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL13:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL13

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CCL13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL13
    Predesigned siRNA for gene silencing in human, mouse, rat CCL13

    Gene Editing
    Products:
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    Sino Biological Human cDNA Clone for CCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL13 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL13_HUMAN, Q99616: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL13           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL13 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL13           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL13
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL13 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL13
        Immune response CCR3 signaling in eosinophils



    3 Kegg Pathways  (Kegg details for CCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CCL13 (Q996162, 3 ENSP000002258444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH3P319422, 3MINT-63662 I2D: score=4 
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    ACKR4Q9NPB93, ENSP000002498874I2D: score=2 STRING: ENSP00000249887
    CCR5P516813, ENSP000002923034I2D: score=2 STRING: ENSP00000292303
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS9195948
    GO:0006935chemotaxis TAS9195948
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007010cytoskeleton organization IDA10072545

    Find genes that share ontologies with CCL13           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL13

    7 Novoseek inferred chemical compound relationships for CCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.5 86 10570327 (4), 10725746 (4), 9276730 (4), 10553092 (3) (see all 49)
    tarc 76.1 6 10419874 (1), 19236470 (1), 9430724 (1), 15644118 (1) (see all 5)
    histamine 31.9 2 8955214 (1), 9276730 (1)
    calcium 26.6 17 10069890 (2), 8955214 (1), 9365122 (1), 10072545 (1) (see all 11)
    dexamethasone 0.655 1 11597922 (1)
    oxygen 0 3 9367876 (1), 9551887 (1), 11286614 (1)
    steroid 0 3 15523430 (2)



    Find genes that share compounds with CCL13           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL13 gene: 
    NM_005408.2  

    Unigene Cluster for CCL13:

    Chemokine (C-C motif) ligand 13
    Hs.414629  [show with all ESTs]
    Unigene Representative Sequence: NM_005408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225844(uc002hic.3) ENST00000577681
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCL13
    Predesigned siRNA for gene silencing in human, mouse, rat CCL13
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    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
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    Primer
    Products:
        
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL13
      QuantiTect SYBR Green Assays in human, mouse, rat CCL13
      QuantiFast Probe-based Assays in human, mouse, rat CCL13

    Additional mRNA sequence: 

    AJ001634.1 BC008621.1 BT007385.1 CR450337.1 U46767.1 U59808.1 X98306.1 Z77650.1 
    Z77651.1 

    1 DOTS entry:

    DT.110724 

    Selected AceView cDNA sequences (see all 28):

    AA403048 CK902425 CR450337 U59808 BU071409 BX119227 NM_005408 BC008621 
    AJ001634 AW015321 AA760939 BF339001 Z77650 BG620880 Z77651 U46767 
    AA426245 BM991948 AW204819 BT007385 AA404346 AI459919 BU071645 T64262 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL13    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for CCL13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGATGCT
    CCL13 Expression
    About this image

    CCL13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCL13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414629

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph
    node. Low levels seen in the pulmonary artery smooth muscle cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCL13
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL13
    QuantiTect SYBR Green Assays in human, mouse, rat CCL13
    QuantiFast Probe-based Assays in human, mouse, rat CCL13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL13 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl21 chemokine (C-C motif) ligand 2 70.7(n)
    56.04(a)
      20296  NM_011333.3  NP_035463.1 


    ENSEMBL Gene Tree for CCL13 (if available)
    TreeFam Gene Tree for CCL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL13 gene
    CCL112  CCL72  CCL82  CCL22  CCL242  
    Selected SIMAP similar genes for CCL13 using alignment to 3 protein entries:     CCL13_HUMAN (see all proteins) (see all similar genes):
    CCL2    CCL11    CCL7    MCP-3    CCL8    XCL1
    XCL2    CCL3L1    CCL3L3    CCL3    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL18    CCL14    CCL5    CCL1

    Find genes that share paralogs with CCL13           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL13 (see all 127)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178604541,2
    F--32681505(+) GGAGAC/TAACAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143110701,2
    F--32681562(+) AGAAGC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1494938441,2
    --32681582(+) ACCCAA/GTCAGA 1 -- us2k10--------
    rs1148537051,2
    F--32681621(+) TAACCC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1885869581,2
    --32681693(+) AGCTTA/GTAATA 1 -- us2k10--------
    rs1929586551,2
    --32681782(+) CTTTTG/TATATT 1 -- us2k10--------
    rs728270141,2
    C,F--32681871(+) CCCAGA/GGAATG 1 -- us2k13Minor allele frequency- G:0.07WA NA EA 358
    rs1459717661,2
    --32681888(+) GGGAAG/TATTTT 1 -- us2k10--------
    rs1398399891,2
    --32681890(+) GAAGAC/TTTTCA 1 -- us2k10--------
    rs1848696971,2
    C--32681915(+) TTCTTC/TAATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL13 (32683471 - 32685629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL13:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CCL13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL13
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601391    OMIM disorders: --

    4 diseases for CCL13:    
    About MalaCards
    far eastern spotted fever    spotted fever    bullous pemphigoid    allergic rhinitis

    4 diseases from the University of Copenhagen DISEASES database for CCL13:
    Asthma     Atopic dermatitis     Eosinophilia     Far Eastern spotted fever

    Find genes that share disorders with CCL13           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCL13 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 54.5 21 11400154 (2), 8955214 (1), 10808183 (1), 11391951 (1) (see all 15)
    asthma 48.5 34 15046375 (8), 10934112 (4), 10069883 (3), 12805085 (1) (see all 5)
    eosinophilia 41.1 2 10415058 (1), 10491000 (1)
    nasal polyps 38.4 6 15523430 (2), 17851891 (2), 10415058 (1)
    allergic reaction 35.5 2 10934112 (1), 10491000 (1)
    necrosis 30.8 8 10934112 (1), 9060459 (1), 20139115 (1), 19643942 (1) (see all 7)
    allergy 29.5 3 9800627 (1), 10875484 (1), 10640766 (1)
    allergic rhinitis 23.5 2 10359883 (1), 17982926 (1)
    asthma allergic 18.4 2 10934112 (1)
    dermatitis atopic 4.84 1 10808183 (1)

    Genetic Association Database (GAD): CCL13
    Human Genome Epidemiology (HuGE) Navigator: CCL13 (13 documents)

    Export disorders for CCL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCL13 gene, integrated from 10 sources (see all 141) (see top 10):
    (articles sorted by number of sources associating them with CCL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PubMed id 8642349)1, 2, 9 Uguccioni M.... Baggiolini M. (J. Exp. Med. 1996)
    2. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PubMed id 9195948)1, 2, 9 Berkhout T.A.... Macphee C. (J. Biol. Chem. 1997)
    3. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PubMed id 9060459)1, 2, 9 Godiska R....Gray P.W. (J. Leukoc. Biol. 1997)
    4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PubMed id 8955214)1, 2, 9 Garcia-Zepeda E.A.... Luster A.D. (J. Immunol. 1996)
    5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PubMed id 10049733)1, 2, 9 Hein H....Bartels J. (Biochem. Biophys. Res. Commun. 1999)
    6. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (Genes Immun. 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    11. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    12. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    13. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    14. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    15. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    16. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)1, 3 Naruse K....Miura R. (Genomics 1996)
    17. Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. (PubMed id 12805085)1, 9 Kalayci O....Lilly C.M. (Am. J. Respir. Cell Mol. Biol. 2003)
    18. Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. (PubMed id 19565514)1, 9 Hintzen C....Hermanns H.M. (Arthritis Rheum. 2009)
    19. Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. (PubMed id 11400154)1, 9 Chakravorty S.J....Savage C.O. (J. Pathol. 2001)
    20. IL-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells. (PubMed id 11597922)1, 9 Nakamura H....Lilly C.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2001)
    21. Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation. (PubMed id 20139115)1, 9 Breland U.M....Aukrust P. (Cardiovasc. Res. 2010)
    22. Expression of MCP-4 by TLR ligand-stimulated nasal polyp fibroblasts. (PubMed id 17851891)1, 9 Nonaka M....Yagi T. (Acta Otolaryngol. 2007)
    23. Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. (PubMed id 16855189)1, 9 Hashimoto I....Makino H. (Obesity (Silver Spring) 2006)
    24. Structure of human monocyte chemoattractant protein 4 (MCP- 4/CCL13). (PubMed id 18323622)2, 9 Barinka C.... Lubkowski J. (Acta Crystallogr. D 2008)
    25. A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis. (PubMed id 17824960)1, 9 Iwamoto T....Momohara S. (FEBS J. 2007)
    26. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. (PubMed id 12149192)1, 9 McQuibban G.A....Overall C.M. (Blood 2002)
    27. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. (PubMed id 10072545)1, 9 Sabroe I....Williams T.J. (J. Immunol. 1999)
    28. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. (PubMed id 10734104)1, 9 Schweickart V.L.... Gray P.W. (J. Biol. Chem. 2000)
    29. Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cells. (PubMed id 17541284)1, 9 Odaka M....Adachi M. (Int. Arch. Allergy Immunol. 2007)
    30. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. (PubMed id 11342433)1, 9 Majka M....Ratajczak M.Z. (Blood 2001)
    31. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. (PubMed id 10477718)1, 9 Blanpain C....Parmentier M. (Blood 1999)
    32. Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis. (PubMed id 23375121)1 Pradeep A.R....Priyanka N. (Cytokine 2013)
    33. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    34. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. (PubMed id 22393877)1 Yamaguchi A....Takasaki Y. (Immunopharmacol Immunotoxicol 2012)
    35. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    36. Chemokine expression by small sputum macrophages in COPD. (PubMed id 21327296)1 Frankenberger M....Ziegler-Heitbrock L. (Mol. Med. 2011)
    37. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    38. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    39. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)
    40. Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays. (PubMed id 18219197)1 Komatsuda A....Sawada K. (Am. J. Nephrol. 2008)
    41. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. (PubMed id 18660381)1 Dean R.A....Overall C.M. (Blood 2008)
    42. Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications. (PubMed id 17181634)1 Plager D.A....Pittelkow M.R. (Exp. Dermatol. 2007)
    43. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    44. Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. (PubMed id 12731055)1 Culley F.J....Pease J.E. (Eur. J. Immunol. 2003)
    45. Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells. (PubMed id 12915769)1 Meyer-Hoffert U....Teran L.M. (Int. Arch. Allergy Immunol. 2003)
    46. Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall. (PubMed id 14560935)1 Kaul D....Singh D. (Indian Heart J 2003)
    47. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    48. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. (PubMed id 9558100)1 Rubbert A....Weissman D. (J. Immunol. 1998)
    49. Cloning and characterization of a novel promiscuous human beta- chemokine receptor D6. (PubMed id 9405404)1 Nibbs R.J.B.... Graham G.J. (J. Biol. Chem. 1997)
    50. (PubMed id )2 
    51. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. (PubMed id 15046375)9 Kalayci O....Lilly C.M. (J Asthma 2004)
    52. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. (PubMed id 10934112)9 Lamkhioued B....Luster A.D. (Am. J. Respir. Crit. Care Med. 2000)
    53. Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. (PubMed id 9551887)9 Petering H....Elsner J. (J. Immunol. 1998)
    54. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. (PubMed id 9062350)9 Stellato C....Schleimer R.P. (J. Clin. Invest. 1997)
    55. The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. (PubMed id 9367876)9 Tenscher K....Norgauer J. (Biochem. Biophys. Res. Commun. 1997)
    56. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. (PubMed id 10808183)9 Taha R.A....Hamid Q.A. (J. Allergy Clin. Immunol. 2000)
    57. Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. (PubMed id 10069883)9 Taha R.A....Hamid Q.A. (J. Allergy Clin. Immunol. 1999)
    58. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. (PubMed id 9276730)9 Uguccioni M....Dahinden C.A. (J. Clin. Invest. 1997)
    59. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. (PubMed id 11502664)9 Taha R.A....Olivenstein R. (Chest 2001)
    60. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. (PubMed id 10553092)9 Stellato C....Schleimer R.P. (J. Immunol. 1999)
    61. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). (PubMed id 10491000)9 Ying S....Kay A.B. (J. Immunol. 1999)
    62. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis. (PubMed id 16303818)9 Iwamoto T....Momohara S. (Rheumatology (Oxford) 2006)
    63. The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. (PubMed id 15739168)9 Sabroe I....Pease J.E. (Eur. J. Immunol. 2005)
    64. Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. (PubMed id 15523430)9 Woodworth B.A....Schlosser R.J. (Otolaryngol Head Neck Surg 2004)
    65. Migration of eosinophils across endothelial cell monolayers: interactions among IL-5, endothelial-activating cytokines, and C-C chemokines. (PubMed id 10725746)9 Shahabuddin S....Schleimer R.P. (J. Immunol. 2000)
    66. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. (PubMed id 10570327)9 Ying S....Kay A.B. (J. Immunol. 1999)
    67. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. (PubMed id 9800627)9 Wright E.D....Hamid Q. (J Otolaryngol 1998)
    68. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. (PubMed id 16782408)9 Gounni Abdelilah S....Lamkhioued B. (Clin. Immunol. 2006)
    69. Pharmacological characterization of the chemokine receptor, CCR5. (PubMed id 11861332)9 Mueller A....Strange P.G. (Br. J. Pharmacol. 2002)
    70. Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids. (PubMed id 10359883)9 Christodoulopoulos P....Hamid Q. (J. Allergy Clin. Immunol. 1999)
    71. Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat. (PubMed id 10516663)9 Kudlacz E.M....Cheng J.B. (Br. J. Pharmacol. 1999)
    72. CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells. (PubMed id 9790730)9 Ruffing N....Wu L. (Cell. Immunol. 1998)
    73. Detection of mRNA for eotaxin-2 and eotaxin-3 in human dermal fibroblasts and their distinct activation profile on human eosinophils. (PubMed id 11286614)9 Dulkys Y....Elsner J. (J. Invest. Dermatol. 2001)
    74. Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling. (PubMed id 11120855)9 Heinemann A....Sabroe I. (J. Immunol. 2000)
    75. Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells. (PubMed id 10733106)9 Umland S.P....Billah M.M. (J. Leukoc. Biol. 2000)
    76. Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner. (PubMed id 10069890)9 Bochner B.S....Godiska R. (J. Allergy Clin. Immunol. 1999)
    77. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. (PubMed id 10415058)9 Jahnsen F.L....Johansen F.E. (J. Immunol. 1999)
    78. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. (PubMed id 9365122)9 White J.R....Sarau H.M. (J. Leukoc. Biol. 1997)
    79. Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. (PubMed id 19236470)9 Kuhle J....Czaplinski A. (Eur. J. Neurol. 2009)
    80. Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. (PubMed id 17698927)9 Ardigo D....Quertermous T. (Physiol. Genomics 2007)
    81. [Experiment of genes expression of chemokines and their receptors in allergic rhinitis with gene chip]. (PubMed id 15844573)9 Yu S....Shen X. (Lin Chuang Er Bi Yan Hou Ke Za Zhi 2005)
    82. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa. (PubMed id 15696082)9 Fukakusa M....Chakir J. (J. Allergy Clin. Immunol. 2005)
    83. Untreated chronic rhinosinusitis: a comparison of symptoms and mediator profiles. (PubMed id 15091235)9 Kuehnemund M....Mann W.J. (Laryngoscope 2004)
    84. Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. (PubMed id 12450563)9 Wan Y....Umland S.P. (Eur. J. Pharmacol. 2002)
    85. Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3. (PubMed id 12421570)9 Iino T....Bacon K.B. (Cytokine 2002)
    86. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. (PubMed id 11467997)9 Papadopoulos N.G....Johnston S.L. (Clin. Exp. Allergy 2001)
    87. Antichemokine immunotherapy for allergic diseases. (PubMed id 11964742)9 Luster A.D. (Curr Opin Allergy Clin Immunol 2001)
    88. Chemokines induce eosinophil degranulation through CCR-3. (PubMed id 10984371)9 Fujisawa T....Hirai K. (J. Allergy Clin. Immunol. 2000)
    89. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. (PubMed id 10969084)9 White J.R....Sarau H.M. (J. Biol. Chem. 2000)
    90. The limited infectability by R5 HIV of CD34(+) cells from thymus, cord, and peripheral blood and bone marrow is explained by their ability to produce beta-chemokines. (PubMed id 11146155)9 Majka M....Ratajczak M.Z. (Exp. Hematol. 2000)
    91. Are chemokines essential or secondary participants in allergic responses? (PubMed id 10875484)9 Gangur V. and Oppenheim J.J. (amp 2000)
    92. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. (PubMed id 10101011)9 Teran L.M....SchrAPder J.M. (Am. J. Respir. Cell Mol. Biol. 1999)
    93. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PubMed id 10373330)9 Guo R.F.... Shi M.M. (Genomics 1999)
    94. IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. (PubMed id 9551956)9 Mochizuki M....SchrAPder J.M. (J. Immunol. 1998)
    95. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)9 Imai T.... Gray P.W. (J. Biol. Chem. 1998)
    96. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. (PubMed id 9257866)9 Sozzani S....Mantovani A. (J. Immunol. 1997)
    97. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. (PubMed id 9005985)9 Heath H....Mackay C.R. (J. Clin. Invest. 1997)
    98. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)9 Loetscher M.... Moser B. (J. Exp. Med. 1996)
    99. Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study. (PubMed id 19643942)9 Eagan T.M....Bakke P.S. (Eur. Respir. J. 2010)
    100. Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 (CCL26) and other CCR3 ligands in alveolar type II cells. (PubMed id 19038554)9 Taka E....Heiman A.S. (Cytokine 2008)
    101. Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients. (PubMed id 18662305)9 Iwamoto T....Momohara S. (FEBS J. 2008)
    102. Molecular targets of rheumatoid arthritis. (PubMed id 18473901)9 Okamoto H....Kamatani N. (amp 2008)
    103. Macrophage inflammatory protein-3alpha influences growth of K562 leukemia cells in co-culture with anticancer drug-pretreated HS-5 stromal cells. (PubMed id 18538911)9 Lee Y.C....Chu S.T. (Toxicology 2008)
    104. Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor. (PubMed id 18282300)9 Wang M....Ghannoum M.A. (BMC Microbiol. 2008)
    105. Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes. (PubMed id 18286574)9 Catusse J....Gompels U.A. (Eur. J. Immunol. 2008)
    106. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. (PubMed id 17982926)9 Zhang R.X....Liu G.J. (amp 2007)
    107. Defensin and chemokine expression patterns in the palatine tonsil: a model of their local interaction. (PubMed id 16362266)9 Meyer J.E....Maune S. (Eur Arch Otorhinolaryngol 2006)
    108. Chemokine expression in human erythroid leukemia cell line AS-E2: macrophage inflammatory protein-3alpha/CCL20 is induced by inflammatory cytokines. (PubMed id 16413387)9 Inoue Y....Tomonaga M. (Exp. Hematol. 2006)
    109. Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays. (PubMed id 16844680)9 Ellmark P....Borrebaeck C.A. (amp 2006)
    110. New chemokine targets for asthma therapy. (PubMed id 15683617)9 Garcia G....Humbert M. (Curr Allergy Asthma Rep 2005)
    111. CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. (PubMed id 15765748)9 Yamamoto H....Sakamoto Y. (amp 2005)
    112. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. (PubMed id 15644118)9 Gratchev A....Goerdt S. (Scand. J. Immunol. 2005)
    113. Chemokines and atherosclerosis. (PubMed id 15119830)9 Sheikine Y. and Hansson G.K. (Ann. Med. 2004)
    114. Cytokine-regulated accumulation of eosinophils in inflammatory disease. (PubMed id 15230810)9 Lampinen M....Venge P. (Allergy 2004)
    115. Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma. (PubMed id 12952266)9 Rojas-Ramos E....TerA!n L.M. (Eur. Respir. J. 2003)
    116. Role of the chemokine eotaxin in the pathogenesis of equine sweet itch. (PubMed id 12503787)9 Benarafa C....Cunningham F.M. (Vet. Rec. 2002)
    117. Analysis of eosinophils and myeloid progenitor responses to modified forms of MPIF-2. (PubMed id 11237428)9 Grzegorzewski K.J....Salcedo T.W. (Cytokine 2001)
    118. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. (PubMed id 11295656)9 Miotto D....Hamid Q. (J. Allergy Clin. Immunol. 2001)
    119. Chemokines, chemokine receptors and allergy. (PubMed id 11340325)9 Kaplan A.P. (Int. Arch. Allergy Immunol. 2001)
    120. Expression of the chemokine receptor CCR3 on human mast cells. (PubMed id 11306952)9 de Paulis A....Romagnani P. (Int. Arch. Allergy Immunol. 2001)
    121. Characterization of the CC chemokine receptor 3 on human keratinocytes. (PubMed id 11286622)9 Petering H....Elsner J. (J. Invest. Dermatol. 2001)
    122. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. (PubMed id 11110785)9 Loetscher P....Clark-Lewis I. (J. Biol. Chem. 2001)
    123. [Eosinophils and related chemokines]. (PubMed id 11391951)9 Kayaba H. and Chihara J. (Rinsho Byori 2001)
    124. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. (PubMed id 10854442)9 Sabroe I....Pease J.E. (J. Biol. Chem. 2000)
    125. C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. (PubMed id 10640766)9 Nibbs R.J....Graham G.J. (J. Immunol. 2000)
    126. CCR3 blockade as a new therapy for asthma. (PubMed id 11060659)9 Bertrand C.P. and Ponath P.D. (Expert Opin Investig Drugs 2000)
    127. CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. (PubMed id 10737895)9 Votta B.J....Gowen M. (J. Cell. Physiol. 2000)
    128. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. (PubMed id 10574939)9 Blanpain C....Parmentier M. (J. Biol. Chem. 1999)
    129. The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils. (PubMed id 9885232)9 Petering H....Elsner J. (Blood 1999)
    130. Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines. (PubMed id 10449163)9 Dieu-Nosjean M.C....Caux C. (J. Leukoc. Biol. 1999)
    131. Development of a sensitive enzyme-linked immunosorbent assay for eotaxin and measurement of its levels in human blood. (PubMed id 10410981)9 Morita A....Hirai K. (J. Immunol. Methods 1999)
    132. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. (PubMed id 10415065)9 Shinkai A....Nishi T. (J. Immunol. 1999)
    133. Serial analysis of gene expression in human monocyte-derived dendritic cells. (PubMed id 10419874)9 Hashimoto S....Matsushima K. (Blood 1999)
    134. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. (PubMed id 9660793)9 Weng Y....DeMartino J.A. (J. Biol. Chem. 1998)
    135. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. (PubMed id 9182688)9 Forssmann U....Baggiolini M. (J. Exp. Med. 1997)
    136. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PubMed id 9104803)9 Patel V.P.... Garotta G. (J. Exp. Med. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6357 HGNC: 10611 AceView: CCL13 Ensembl:ENSG00000181374 euGenes: HUgn6357
    ECgene: CCL13 Kegg: 6357 H-InvDB: CCL13

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL13 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL13 gene:
    Search GeneIP for patents involving CCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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