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Aliases for CCL13 Gene

Aliases for CCL13 Gene

  • C-C Motif Chemokine Ligand 13 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13 2 3
  • Monocyte Chemoattractant Protein 4 3 4
  • Chemokine (C-C Motif) Ligand 13 2 3
  • Monocyte Chemotactic Protein 4 3 4
  • Small-Inducible Cytokine A13 3 4
  • CK-Beta-10 3 4
  • SCYA13 3 4
  • MCP-4 3 4
  • NCC-1 3 4
  • NCC1 3 4
  • C-C Motif Chemokine 13 3
  • New CC Chemokine 1 3
  • CKb10 3
  • SCYL1 3
  • MCP4 4

External Ids for CCL13 Gene

Previous HGNC Symbols for CCL13 Gene

  • SCYA13

Previous GeneCards Identifiers for CCL13 Gene

  • GC17P032453
  • GC17P034723
  • GC17P032829
  • GC17P029707
  • GC17P032684
  • GC17P028869

Summaries for CCL13 Gene

Entrez Gene Summary for CCL13 Gene

  • This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL13 Gene

CCL13 (C-C Motif Chemokine Ligand 13) is a Protein Coding gene. Diseases associated with CCL13 include Allergic Hypersensitivity Disease. Among its related pathways are Peptide ligand-binding receptors and PEDF Induced Signaling. GO annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL13 Gene

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL13 Gene

Genomics for CCL13 Gene

Regulatory Elements for CCL13 Gene

Enhancers for CCL13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G034960 1.1 ENCODE 12.1 +605.2 605214 2.2 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 LIG3 ENSG00000270871 TLK2P1 ZNF830 CCL13 LINC02001 C17orf50 GC17P034979
GH17G033468 0.5 ENCODE 4.6 -886.6 -886553 2.0 FOSL1 JUND ZFP64 FOS CCL13 GC17M033432 AA06
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL13 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL13 Gene

Chromosome:
17
Start:
34,356,452 bp from pter
End:
34,358,610 bp from pter
Size:
2,159 bases
Orientation:
Plus strand

Genomic View for CCL13 Gene

Genes around CCL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL13 Gene

Proteins for CCL13 Gene

  • Protein details for CCL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99616-CCL13_HUMAN
    Recommended name:
    C-C motif chemokine 13
    Protein Accession:
    Q99616
    Secondary Accessions:
    • O95689
    • Q6ICQ6

    Protein attributes for CCL13 Gene

    Size:
    98 amino acids
    Molecular mass:
    10986 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This protein can bind heparin.

    Three dimensional structures from OCA and Proteopedia for CCL13 Gene

neXtProt entry for CCL13 Gene

Post-translational modifications for CCL13 Gene

  • One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCL13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CCL13

Protein Products

  • Abcam proteins for CCL13

Assay Products

  • Abcam assays for CCL13

No data available for DME Specific Peptides for CCL13 Gene

Domains & Families for CCL13 Gene

Gene Families for CCL13 Gene

Protein Domains for CCL13 Gene

Suggested Antigen Peptide Sequences for CCL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q99616

UniProtKB/Swiss-Prot:

CCL13_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL13: view

Function for CCL13 Gene

Molecular function for CCL13 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
UniProtKB/Swiss-Prot Induction:
By IL1/interleukin-1 and TNF.

Gene Ontology (GO) - Molecular Function for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9195948
GO:0005125 cytokine activity IEA --
GO:0008009 chemokine activity IEA,IDA 10072545
GO:0008201 heparin binding IEA --
GO:0031727 CCR2 chemokine receptor binding IEA --
genes like me logo Genes that share ontologies with CCL13: view
genes like me logo Genes that share phenotypes with CCL13: view

Animal Models for CCL13 Gene

MGI Knock Outs for CCL13:

Animal Model Products

CRISPR Products

miRNA for CCL13 Gene

miRTarBase miRNAs that target CCL13

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL13 Gene

Localization for CCL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL13 gene
Compartment Confidence
extracellular 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005615 extracellular space TAS,IBA --
GO:0005623 cell IEA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0030139 endocytic vesicle IEA --
genes like me logo Genes that share ontologies with CCL13: view

Pathways & Interactions for CCL13 Gene

genes like me logo Genes that share pathways with CCL13: view

Gene Ontology (GO) - Biological Process for CCL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001912 positive regulation of leukocyte mediated cytotoxicity IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002523 leukocyte migration involved in inflammatory response IEA --
GO:0002544 chronic inflammatory response IEA --
genes like me logo Genes that share ontologies with CCL13: view

No data available for SIGNOR curated interactions for CCL13 Gene

Drugs & Compounds for CCL13 Gene

(4) Drugs for CCL13 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CCL13 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL13: view

Transcripts for CCL13 Gene

mRNA/cDNA for CCL13 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL13 Gene

Chemokine (C-C motif) ligand 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL13 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3
SP1:
SP2: -

Relevant External Links for CCL13 Gene

GeneLoc Exon Structure for
CCL13
ECgene alternative splicing isoforms for
CCL13

Expression for CCL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL13 Gene

This gene is overexpressed in Nerve - Tibial (x10.9), Colon - Transverse (x5.7), and Lung (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of CCL13 Gene:

CCL13

SOURCE GeneReport for Unigene cluster for CCL13 Gene:

Hs.414629

mRNA Expression by UniProt/SwissProt for CCL13 Gene:

Q99616-CCL13_HUMAN
Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.

Evidence on tissue expression from TISSUES for CCL13 Gene

  • Lung(4.4)
  • Heart(4.3)
  • Skin(4.3)
  • Nervous system(4.1)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with CCL13: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL13 Gene

Orthologs for CCL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL13 34 35
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Ccl2 34 16
  • 70.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccl2 34
  • 68.12 (n)
dog
(Canis familiaris)
Mammalia CCL13 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
Species where no ortholog for CCL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL13 Gene

ENSEMBL:
Gene Tree for CCL13 (if available)
TreeFam:
Gene Tree for CCL13 (if available)

Paralogs for CCL13 Gene

genes like me logo Genes that share paralogs with CCL13: view

Variants for CCL13 Gene

Sequence variations from dbSNP and Humsavar for CCL13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000044301 -- 34,355,853(+) GAAAT(A/C)TGACT upstream-variant-2KB
rs1000171134 -- 34,358,866(+) CCACA(A/C)TCCTG downstream-variant-500B
rs1000544315 -- 34,359,064(+) GGAAG(C/T)ATGGT downstream-variant-500B
rs1001689599 -- 34,354,628(+) GCAGA(G/T)AATAG upstream-variant-2KB
rs1002182252 -- 34,356,528(+) CAACA(C/T)GAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCL13 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL13 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL13 Gene

Human Gene Mutation Database (HGMD)
CCL13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL13 Gene

Disorders for CCL13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCL13 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic hypersensitivity disease
  • allergic disease
- elite association - COSMIC cancer census association via MalaCards
Search CCL13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL13

Genetic Association Database (GAD)
CCL13
Human Genome Epidemiology (HuGE) Navigator
CCL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL13
genes like me logo Genes that share disorders with CCL13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL13 Gene

Publications for CCL13 Gene

  1. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PMID: 10049733) Hein H. … Bartels J. (Biochem. Biophys. Res. Commun. 1999) 3 4 22 64
  2. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PMID: 9060459) Godiska R. … Gray P.W. (J. Leukoc. Biol. 1997) 3 4 22 64
  3. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PMID: 9195948) Berkhout T.A. … Macphee C. (J. Biol. Chem. 1997) 3 4 22 64
  4. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PMID: 8642349) Uguccioni M. … Baggiolini M. (J. Exp. Med. 1996) 3 4 22 64
  5. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PMID: 8955214) Garcia-Zepeda E.A. … Luster A.D. (J. Immunol. 1996) 3 4 22 64

Products for CCL13 Gene

Sources for CCL13 Gene

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