CCL13 Gene

Aliases
for CCL13 gene

Previous GC identifers: GC17P032453 GC17P034723 GC17P032829 GC17P029707 GC17P028869

Summaries
for CCL13 gene

Genomic Views
for CCL13 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010799.15  

SwitchGear Promoter luciferase reporter plasmid: CCL13 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL13

CCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032684:  view genomic region     (about GC identifiers)

Proteins
for CCL13 gene

1 PDB 3D structure from and Proteopedia for CCL13:

2RA4 (3D)    

Explore the universe of human proteins at neXtProt for CCL13: NX_Q99616

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CCL13 (CCL13/MCP-4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CCL13 OriGene Custom Protein Services for CCL13
	GenScript Purified and Recombinant Proteins for CCL13
	Novus Biologicals CCL13 Proteins Novus Biologicals CCL13 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CCL13
	Uscn Proteins for CCL13

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CCL13 (CCL13/MCP-4)
	Browse OriGene Antibodies OriGene Custom Antibody Services for CCL13
	GenScript Superior Antibodies for CCL13
	Novus Biologicals CCL13 Antibodies
	Search for Antibodies for CCL13 at Abcam
	Uscn Antibodies for CCL13
	ThermoFisher Antibodies for CCL13

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CCL13 (CCL13/MCP-4)
	GenScript Custom Assay Services for CCL13
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCL13

Protein Domains /
Families
for CCL13 gene

ProtoNet protein and cluster: Q99616

Function
for CCL13 gene

miRNA Products:		miRTarBase miRNAs that target CCL13: hsa-let-7b (MIRT001596)
		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL13
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL13:
		hsa-miR-544
		SwitchGear 3'UTR luciferase reporter plasmid: CCL13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCL13 OriGene shRNA RFP: CCL13 OriGene siRNA: CCL13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCL13

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CCL13

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCL13 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
		Sino Biological Human cDNA Clone for CCL13
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CCL13
		Search LifeMap BioReagents cell lines for CCL13

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for CCL13 gene

	Super-pathway	contained gene-specific pathways
1	PEDF Induced Signaling	8/12 pathways (see all 12) PEDF Induced Signaling 1.00 STAT3 Pathway 0.47 MIF Mediated Glucocorticoid Regulation 0.73 Endothelin-1 Signaling Pathway 0.44 MIF Regulation of Innate Immune Cells 0.71 NFAT Signaling and Lymphocyte Interactions 0.37 IL-6 Pathway 0.61 PGC1Alpha Pathway 0.33
2	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JNK Pathway 0.50 MAPK Family Pathway 0.60 Regulation of eIF4 and p70S6K 0.43 JAK-STAT Pathway 0.57 SOCS Pathway 0.29
3	Akt Signaling	Akt Signaling 1.00 Tec Kinases Signaling 0.55 p38 Signaling 0.60
4	Rho Family GTPases	Rho Family GTPases 1.00 Molecular Mechanisms of Cancer 0.51 ERK Signaling 0.61
5	Immune response _CCR3 signaling in eosinophils	Immune response _CCR3 signaling in eosinophils 1.00 Immune response CCR3 signaling in eosinophils 1.00

1 EMD Millipore Pathway for CCL13

Immune response CCR3 signaling in eosinophils

5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL13

	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C
	NFAT Signaling and Lymphocyte Interactions
	JNK Pathway

1 GeneGo (Thomson Reuters) Pathway for CCL13

Immune response CCR3 signaling in eosinophils

2         Kegg Pathways  (Kegg details for CCL13)

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for CCL13 gene

Transcripts
for CCL13 gene

Expression
for CCL13 gene

CCL13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGGATGCT

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCL13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCL13
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

Orthologs
for CCL13 gene

Paralogs
for CCL13 gene

Paralogs for CCL13 gene

CCL15²  CCL16²  CCL2²  CCL14²  CCL24²  CCL4L1²  CCL11²  CCL7²  

CCL4L2²  CCL3L1²  CCL5²  CCL23²  CCL3L3²  CCL4²  CCL8²  CCL26²  

CCL3²  CCL18²  

18/28 SIMAP similar genes for CCL13 using alignment to 3 protein entries:     CCL13_HUMAN (see all proteins) (see all similar genes):

CCL2    CCL11    CCL7    MCP-3    CCL8    XCL1

XCL2    CCL3L1    CCL3L3    CCL3    CCL4    CCL4L2

LOC728835    CCL4L1    CCL18    CCL14    CCL5    CCL1

CCL13 for paralogs           About GeneDecksing

Genomic Variants
for CCL13 gene

10/96 NCBI SNPs in CCL13 are shown (see all 96)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1178604541,2		--	32681505(+)	GGAGAC/TAACAG	1	--	us2k1		1		NA	120
rs1143110701,2	F,	--	32681562(+)	AGAAGC/TTCCCT	1	--	us2k1		1		WA	118
rs1494938441,2		--	32681582(+)	ACCCAA/GTCAGA	1	--	us2k1		0	--	--	--	--
rs1148537051,2		--	32681621(+)	TAACCC/TACCAA	1	--	us2k1		1		WA	118
rs1885869581,2		--	32681693(+)	AGCTTA/GTAATA	1	--	us2k1		0	--	--	--	--
rs1929586551,2		--	32681782(+)	CTTTTG/TATATT	1	--	us2k1		0	--	--	--	--
rs728270141,2	C,F,	--	32681871(+)	CCCAGA/GGAATG	1	--	us2k1		3		WA NA EA	358
rs1459717661,2		--	32681888(+)	GGGAAG/TATTTT	1	--	us2k1		0	--	--	--	--
rs1398399891,2		--	32681890(+)	GAAGAC/TTTTCA	1	--	us2k1		0	--	--	--	--
rs1848696971,2		--	32681915(+)	TTCTTC/TAATAG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCL13 (32683471 - 32685629 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCL13
     1 CNV: 49841
Human Gene Mutation Database (HGMD): CCL13

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCL13

DNA2.0 Custom Variant and Variant Library Synthesis for CCL13

Disorders / Diseases
for CCL13 gene

20/32 diseases for CCL13

10/14 Novoseek disease relationships for CCL13 gene (see all 14)    About this table

Publications
for CCL13 gene

PubMed articles for CCL13 gene, integrated from 9 sources (see all 139) (see top 10): (articles sorted by number of sources associating them with CCL13)

Utopia: connect your pdf to the dynamic world of online information

1. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PubMed id 8642349)^{1, 2, 9} Uguccioni M.... Baggiolini M. (1996)
2. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PubMed id 9195948)^{1, 2, 9} Berkhout T.A.... Macphee C. (1997)
3. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PubMed id 9060459)^{1, 2, 9} Godiska R....Gray P.W. (1997)
4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PubMed id 8955214)^{1, 2, 9} Garcia-Zepeda E.A.... Luster A.D. (1996)
5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PubMed id 10049733)^{1, 2, 9} Hein H....Bartels J. (1999)
6. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)^{1, 2} Zody M.C.... Nusbaum C. (2006)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. (PubMed id 8661057)^{1, 3} Naruse K....Miura R. (1996)
9. Monocyte chemoattractant protein-4 core promoter genetic variants: influence on YY-1 affinity and plasma levels. (PubMed id 12805085)^{1, 9} Kalayci O....Lilly C.M. (2003)
10. Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. (PubMed id 19565514)^{1, 9} Hintzen C....Hermanns H.M. (2009)
11. Potential role for monocyte chemotactic protein-4 (MCP-4) in monocyte/macrophage recruitment in acute renal inflammation. (PubMed id 11400154)^{1, 9} Chakravorty S.J....Savage C.O. (2001)
12. IL-4 differentially regulates eotaxin and MCP-4 in lu ng epithelium and circulating mononuclear cells. (PubMed id 11597922)^{1, 9} Nakamura H....Lilly C.M. (2001)
13. Raised MCP-4 levels in symptomatic carotid atheroscle rosis: an inflammatory link between platelet and monocyte activation. (PubMed id 20139115)^{1, 9} Breland U.M....Aukrust P. (2010)
14. Expression of MCP-4 by TLR ligand-stimulated nasal polyp fibroblasts. (PubMed id 17851891)^{1, 9} Nonaka M....Yagi T. (2007)
15. Elevated serum monocyte chemoattractant protein-4 and chronic inflammation in overweight subjects. (PubMed id 16855189)^{1, 9} Hashimoto I....Makino H. (2006)
16. Structure of human monocyte chemoattractant protein 4 (MCP- 4/CCL13). (PubMed id 18323622)^{2, 9} Barinka C.... Lubkowski J. (2008)
17. A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis. (PubMed id 17824960)^{1, 9} Iwamoto T....Momohara S. (2007)
18. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. (PubMed id 12149192)^{1, 9} McQuibban G.A....Overall C.M. (2002)
19. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways. (PubMed id 10072545)^{1, 9} Sabroe I....Williams T.J. (1999)
20. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. (PubMed id 10734104)^{1, 9} Schweickart V.L.... Gray P.W. (2000)
21. Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cells. (PubMed id 17541284)^{1, 9} Odaka M....Adachi M. (2007)
22. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. (PubMed id 11342433)^{1, 9} Majka M....Ratajczak M.Z. (2001)
23. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. (PubMed id 10477718)^{1, 9} Blanpain C....Parmentier M. (1999)
24. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (2012)
25. Estrogen inhibits apoptosis and promotes CC motif chem okine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. (PubMed id 22393877)¹ Yamaguchi A....Takasaki Y. (2012)
26. Chemokine expression by small sputum macrophages in C OPD. (PubMed id 21327296)¹ Frankenberger M....Ziegler-Heitbrock L. (2011)
27. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
28. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)¹ Rajaraman P....Inskip P.D. (2010)
29. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)¹ Han S....Kang D. (2010)
30. Genetic variants of CC chemokine genes in experimenta l autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)¹ Ockinger J....Olsson T. (2010)
31. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)¹ Johnatty S.E.... . (2010)
32. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
33. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)¹ Segat L....Crovella S. (2010)
34. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)¹ Schuurhof A....Janssen R. (2010)
35. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)¹ Rajaraman P....Chanock S.J. (2009)
36. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)¹ Siezen C.L....Janssen R. (2009)
37. Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays. (PubMed id 18219197)¹ Komatsuda A....Sawada K. (2008)
38. Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx. (PubMed id 18660381)¹ Dean R.A....Overall C.M. (2008)
39. Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications. (PubMed id 17181634)¹ Plager D.A....Pittelkow M.R. (2007)
40. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)¹ Janssen R....Hoebee B. (2007)
41. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
42. Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. (PubMed id 12731055)¹ Culley F.J....Pease J.E. (2003)
43. Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells. (PubMed id 12915769)¹ Meyer-Hoffert U....Teran L.M. (2003)
44. Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall. (PubMed id 14560935)¹ Kaul D....Singh D. (2003)
45. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
46. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
47. Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry. (PubMed id 9558100)¹ Rubbert A....Weissman D. (1998)
48. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. (PubMed id 9405404)¹ Nibbs R.J....Graham G.J. (1997)
49. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. (PubMed id 15046375)⁹ Kalayci O....Lilly C.M. (2004)
50. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. (PubMed id 10934112)⁹ Lamkhioued B....Luster A.D. (2000)
51. Detection of MCP-4 in dermal fibroblasts and its activation of the respiratory burst in human eosinophils. (PubMed id 9551887)⁹ Petering H....Elsner J. (1998)
52. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. (PubMed id 9062350)⁹ Stellato C....Schleimer R.P. (1997)
53. The monocyte chemotactic protein-4 induces oxygen radical production, actin reorganization, and CD11b up-regulation via a pertussis toxin-sensitive G-protein in human eosinophils. (PubMed id 9367876)⁹ Tenscher K....Norgauer J. (1997)
54. Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. (PubMed id 10808183)⁹ Taha R.A....Hamid Q.A. (2000)
55. Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. (PubMed id 10069883)⁹ Taha R.A....Hamid Q.A. (1999)
56. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. (PubMed id 9276730)⁹ Uguccioni M....Dahinden C.A. (1997)
57. Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. (PubMed id 11502664)⁹ Taha R.A....Olivenstein R. (2001)
58. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. (PubMed id 10553092)⁹ Stellato C....Schleimer R.P. (1999)
59. C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). (PubMed id 10491000)⁹ Ying S....Kay A.B. (1999)
60. Monocyte chemoattractant protein-4 (MCP-4)/CCL13 is highly expressed in cartilage from patients with rheumatoid arthritis. (PubMed id 16303818)⁹ Iwamoto T....Momohara S. (2006)
61. The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner. (PubMed id 15739168)⁹ Sabroe I....Pease J.E. (2005)
62. Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. (PubMed id 15523430)⁹ Woodworth B.A....Schlosser R.J. (2004)
63. Migration of eosinophils across endothelial cell monolayers: interactions among IL-5, endothelial-activating cytokines, and C-C chemokines. (PubMed id 10725746)⁹ Shahabuddin S....Schleimer R.P. (2000)
64. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. (PubMed id 10570327)⁹ Ying S....Kay A.B. (1999)
65. Monocyte chemotactic protein expression in allergy and non-allergy-associated chronic sinusitis. (PubMed id 9800627)⁹ Wright E.D....Hamid Q. (1998)
66. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. (PubMed id 16782408)⁹ Gounni Abdelilah S....Lamkhioued B. (2006)
67. Pharmacological characterization of the chemokine receptor, CCR5. (PubMed id 11861332)⁹ Mueller A....Strange P.G. (2002)
68. Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids. (PubMed id 10359883)⁹ Christodoulopoulos P....Hamid Q. (1999)
69. Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat. (PubMed id 10516663)⁹ Kudlacz E.M....Cheng J.B. (1999)
70. CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells. (PubMed id 9790730)⁹ Ruffing N....Wu L. (1998)
71. Detection of mRNA for eotaxin-2 and eotaxin-3 in human dermal fibroblasts and their distinct activation profile on human eosinophils. (PubMed id 11286614)⁹ Dulkys Y....Elsner J. (2001)
72. Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling. (PubMed id 11120855)⁹ Heinemann A....Sabroe I. (2000)
73. Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells. (PubMed id 10733106)⁹ Umland S.P....Billah M.M. (2000)
74. Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner. (PubMed id 10069890)⁹ Bochner B.S....Godiska R. (1999)
75. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. (PubMed id 10415058)⁹ Jahnsen F.L....Johansen F.E. (1999)
76. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. (PubMed id 9365122)⁹ White J.R....Sarau H.M. (1997)
77. Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. (PubMed id 19236470)⁹ Kuhle J....Czaplinski A. (2009)
78. Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. (PubMed id 17698927)⁹ Ardigo D....Quertermous T. (2007)
79. [Experiment of genes expression of chemokines and their receptors in allergic rhinitis with gene chip] (PubMed id 15844573)⁹ Yu S....Shen X. (2005)
80. Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-gamma-inducible protein 10 expression in asthmatic airway mucosa. (PubMed id 15696082)⁹ Fukakusa M....Chakir J. (2005)
81. Untreated chronic rhinosinusitis: a comparison of symptoms and mediator profiles. (PubMed id 15091235)⁹ Kuehnemund M....Mann W.J. (2004)
82. Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. (PubMed id 12450563)⁹ Wan Y....Umland S.P. (2002)
83. Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3. (PubMed id 12421570)⁹ Iino T....Bacon K.B. (2002)
84. Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells. (PubMed id 11467997)⁹ Papadopoulos N.G....Johnston S.L. (2001)
85. Antichemokine immunotherapy for allergic diseases. (PubMed id 11964742)⁹ Luster A.D. (2001)
86. Chemokines induce eosinophil degranulation through CCR-3. (PubMed id 10984371)⁹ Fujisawa T....Hirai K. (2000)
87. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. (PubMed id 10969084)⁹ White J.R....Sarau H.M. (2000)
88. The limited infectability by R5 HIV of CD34(+) cells from thymus, cord, and peripheral blood and bone marrow is explained by their ability to produce beta-chemokines. (PubMed id 11146155)⁹ Majka M....Ratajczak M.Z. (2000)
89. Are chemokines essential or secondary participants in allergic responses? (PubMed id 10875484)⁹ Gangur V. and Oppenheim J.J. (2000)
90. Th1- and Th2-type cytokines regulate the expression and production of eotaxin and RANTES by human lung fibroblasts. (PubMed id 10101011)⁹ Teran L.M....Schroder J.M. (1999)
91. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. (PubMed id 10373330)⁹ Guo R.F.... Shi M.M. (1999)
92. IL-4 induces eotaxin: a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. (PubMed id 9551956)⁹ Mochizuki M....SchrAPder J.M. (1998)
93. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. (PubMed id 9430724)⁹ Imai T.... Gray P.W. (1998)
94. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. (PubMed id 9257866)⁹ Sozzani S....Mantovani A. (1997)
95. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. (PubMed id 9005985)⁹ Heath H....Mackay C.R. (1997)
96. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. (PubMed id 9064356)⁹ Loetscher M.... Moser B. (1996)
97. Systemic inflammatory markers in COPD: results from t he Bergen COPD Cohort Study. (PubMed id 19643942)⁹ Eagan T.M....Bakke P.S. (2010)
98. Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 (CCL26) and other CCR3 ligands in alveolar type II cells. (PubMed id 19038554)⁹ Taka E....Heiman A.S. (2008)
99. Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients. (PubMed id 18662305)⁹ Iwamoto T....Momohara S. (2008)
100. Molecular targets of rheumatoid arthritis. (PubMed id 18473901)⁹ Okamoto H....Kamatani N. (2008)
101. Macrophage inflammatory protein-3alpha influences growth of K562 leukemia cells in co-culture with anticancer drug-pretreated HS-5 stromal cells. (PubMed id 18538911)⁹ Lee Y.C....Chu S.T. (2008)
102. Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor. (PubMed id 18282300)⁹ Wang M....Ghannoum M.A. (2008)
103. Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes. (PubMed id 18286574)⁹ Catusse J....Gompels U.A. (2008)
104. Complementary DNA microarray analysis of chemokines and their receptors in allergic rhinitis. (PubMed id 17982926)⁹ Zhang R.X....Liu G.J. (2007)
105. Defensin and chemokine expression patterns in the palatine tonsil: a model of their local interaction. (PubMed id 16362266)⁹ Meyer J.E....Maune S. (2006)
106. Chemokine expression in human erythroid leukemia cell line AS-E2: macrophage inflammatory protein-3alpha/CCL20 is induced by inflammatory cytokines. (PubMed id 16413387)⁹ Inoue Y....Tomonaga M. (2006)
107. Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays. (PubMed id 16844680)⁹ Ellmark P....Borrebaeck C.A. (2006)
108. New chemokine targets for asthma therapy. (PubMed id 15683617)⁹ Garcia G....Humbert M. (2005)
109. CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. (PubMed id 15765748)⁹ Yamamoto H....Sakamoto Y. (2005)
110. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. (PubMed id 15644118)⁹ Gratchev A....Goerdt S. (2005)
111. Chemokines and atherosclerosis. (PubMed id 15119830)⁹ Sheikine Y. and Hansson G.K. (2004)
112. Cytokine-regulated accumulation of eosinophils in inflammatory disease. (PubMed id 15230810)⁹ Lampinen M....Venge P. (2004)
113. Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma. (PubMed id 12952266)⁹ Rojas-Ramos E....Teran L.M. (2003)
114. Role of the chemokine eotaxin in the pathogenesis of equine sweet itch. (PubMed id 12503787)⁹ Benarafa C....Cunningham F.M. (2002)
115. Analysis of eosinophils and myeloid progenitor responses to modified forms of MPIF-2. (PubMed id 11237428)⁹ Grzegorzewski K.J....Salcedo T.W. (2001)
116. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. (PubMed id 11295656)⁹ Miotto D....Hamid Q. (2001)
117. Chemokines, chemokine receptors and allergy. (PubMed id 11340325)⁹ Kaplan A.P. (2001)
118. Expression of the chemokine receptor CCR3 on human mast cells. (PubMed id 11306952)⁹ de Paulis A....Romagnani P. (2001)
119. Characterization of the CC chemokine receptor 3 on human keratinocytes. (PubMed id 11286622)⁹ Petering H....Elsner J. (2001)
120. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. (PubMed id 11110785)⁹ Loetscher P....Clark-Lewis I. (2001)
121. [Eosinophils and related chemokines] (PubMed id 11391951)⁹ Kayaba H. and Chihara J. (2001)
122. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. (PubMed id 10854442)⁹ Sabroe I....Pease J.E. (2000)
123. C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. (PubMed id 10640766)⁹ Nibbs R.J....Graham G.J. (2000)
124. CCR3 blockade as a new therapy for asthma. (PubMed id 11060659)⁹ Bertrand C.P. and Ponath P.D. (2000)
125. CKbeta-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues. (PubMed id 10737895)⁹ Votta B.J....Gowen M. (2000)
126. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. (PubMed id 10574939)⁹ Blanpain C....Parmentier M. (1999)
127. The biologic role of interleukin-8: functional analysis and expression of CXCR1 and CXCR2 on human eosinophils. (PubMed id 9885232)⁹ Petering H....Elsner J. (1999)
128. Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines. (PubMed id 10449163)⁹ Dieu-Nosjean M.C....Caux C. (1999)
129. Development of a sensitive enzyme-linked immunosorbent assay for eotaxin and measurement of its levels in human blood. (PubMed id 10410981)⁹ Morita A....Hirai K. (1999)
130. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4- stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. (PubMed id 10415065)⁹ Shinkai A....Nishi T. (1999)
131. Serial analysis of gene expression in human monocyte-derived dendritic cells. (PubMed id 10419874)⁹ Hashimoto S....Matsushima K. (1999)
132. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. (PubMed id 9660793)⁹ Weng Y....DeMartino J.A. (1998)
133. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. (PubMed id 9182688)⁹ Forssmann U....Baggiolini M. (1997)
134. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. (PubMed id 9104803)⁹ Patel V.P.... Garotta G. (1997)
135. Animal models of asthma: role of chemokines. (PubMed id 9356998)⁹ Griffiths-Johnson D.A....Williams T.J. (1997)
136. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. (PubMed id 9464841)⁹ Ying S....Kay A.B. (1997)

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