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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL13 Gene

protein-coding   GIFtS: 64
GCID: GC17P032684

Chemokine (C-C Motif) Ligand 13

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 13)
(Previous symbol: SCYA13)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 131 2     MCP-42 3
SCYA131 2 3 5     NCC-12 3
NCC12 3 5     CKb102
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 131 2     SCYL12
Monocyte Chemoattractant Protein 42 3     C-C Motif Chemokine 132
Monocyte Chemotactic Protein 42 3     New CC Chemokine 12
Small-Inducible Cytokine A132 3     MCP43
CK-beta-102 3     

External Ids:    HGNC: 106111   Entrez Gene: 63572   Ensembl: ENSG000001813747   OMIM: 6013915   UniProtKB: Q996163   

Export aliases for CCL13 gene to outside databases

Previous GC identifers: GC17P032453 GC17P034723 GC17P032829 GC17P029707 GC17P028869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL13 Gene:
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a
family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are
proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity
for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in
accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the
arterial wall during artherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCL13 Gene: 
CCL13 (chemokine (C-C motif) ligand 13) is a protein-coding gene. Diseases associated with CCL13 include far eastern spotted fever, and gastric adenocarcinoma, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Chemokine signaling pathway. GO annotations related to this gene include chemokine activity and receptor binding. An important paralog of this gene is CCL11.

UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
exposed to exogenous pathogens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL13 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   Meis-1b   E2F-1   E2F   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032684:  view genomic region     (about GC identifiers)

Start:
32,683,471 bp from pter      End:
32,685,629 bp from pter
Size:
2,159 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616 (See protein sequence)
Recommended Name: C-C motif chemokine 13 precursor  
Size: 98 amino acids; 10986 Da
Subcellular location: Secreted
Mass spectrometry: Mass=9314; Mass_error=30; Method=MALDI; Range=17-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8760; Mass_error=30; Method=MALDI; Range=22-98; Source=PubMed:8642349;
Mass spectrometry: Mass=8575; Mass_error=30; Method=MALDI; Range=24-98; Source=PubMed:8642349;
Miscellaneous: This protein can bind heparin
1 PDB 3D structure from and Proteopedia for CCL13:
2RA4 (3D)    
Secondary accessions: O95689 Q6ICQ6

Explore the universe of human proteins at neXtProt for CCL13: NX_Q99616

Explore proteomics data for CCL13 at MOPED 

Post-translational modifications:

  • UniProtKB: One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal
    peptide cleavage. The medium chain is about 30-fold less active than the long chain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99616

  • CCL13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL13 Protein Expression
    REFSEQ proteins: NP_005399.1  
    ENSEMBL proteins: 
     ENSP00000225844   ENSP00000463667  

    Human Recombinant Protein Products for CCL13: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL13
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCL13
    GenScript Purified and Recombinant Proteins for CCL13
    Novus Biologicals CCL13 Proteins
    Novus Biologicals CCL13 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL13
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    CCL13 for ontologies           About GeneDecksing



    CCL13 Antibody Products: 
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    ThermoFisher Antibodies for CCL13
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    Assay Products for CCL13: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99616

    ProtoNet protein and cluster: Q99616

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL13_HUMAN, Q99616
    Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils.
    Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of
    allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall
    during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically
    exposed to exogenous pathogens
    Induction: By IL1/interleukin-1 and TNF

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS9195948
    GO:0008009chemokine activity IDA10072545
         
    CCL13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL13:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL13 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL13:
    hsa-let-7b (MIRT001596)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL13
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CCL13

    Clone
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    OriGene clones in human, mouse for CCL13 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    Sino Biological Human cDNA Clone for CCL13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13
    Sirion Biotech Customized lentivirus for stable overexpression of CCL13 
                         Customized lentivirus expression plasmids for stable overexpression of CCL13 

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    GenScript Custom overexpressing Cell Line Services for CCL13
    Search LifeMap BioReagents cell lines for CCL13
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL13 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCL13
        Immune response CCR3 signaling in eosinophils

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL13 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    1 GeneGo (Thomson Reuters) Pathway for CCL13
        Immune response CCR3 signaling in eosinophils



    3         Kegg Pathways  (Kegg details for CCL13):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    NF-kappa B signaling pathway


    CCL13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for CCL13 (Q996162, 3 ENSP000002258444) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HNRNPH3P319422, 3MINT-63662 I2D: score=4 
    ACKR2O005903, ENSP000002731454I2D: score=3 STRING: ENSP00000273145
    ACKR4Q9NPB93, ENSP000002498874I2D: score=2 STRING: ENSP00000249887
    CCR5P516813, ENSP000002923034I2D: score=2 STRING: ENSP00000292303
    CCR3P516773, ENSP000003500034I2D: score=1 STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS9195948
    GO:0006935chemotaxis TAS9195948
    GO:0006954inflammatory response IEA--
    GO:0006955immune response IEA--
    GO:0007010cytoskeleton organization IDA10072545

    CCL13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL13

    7 Novoseek inferred chemical compound relationships for CCL13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 90.5 86 10570327 (4), 10725746 (4), 9276730 (4), 10553092 (3) (see all 49)
    tarc 76.1 6 10419874 (1), 19236470 (1), 9430724 (1), 15644118 (1) (see all 5)
    histamine 31.9 2 8955214 (1), 9276730 (1)
    calcium 26.6 17 10069890 (2), 8955214 (1), 9365122 (1), 10072545 (1) (see all 11)
    dexamethasone 0.655 1 11597922 (1)
    oxygen 0 3 9367876 (1), 9551887 (1), 11286614 (1)
    steroid 0 3 15523430 (2)

    Search CenterWatch for drugs/clinical trials and news about CCL13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL13 gene: 
    NM_005408.2  

    Unigene Cluster for CCL13:

    Chemokine (C-C motif) ligand 13
    Hs.414629  [show with all ESTs]
    Unigene Representative Sequence: NM_005408
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225844(uc002hic.3) ENST00000577681

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL13:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCCL13 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    OriGene clones in human, mouse for CCL13 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: CCL13 (NM_005408)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL13
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13

    Additional mRNA sequence: 

    AJ001634.1 BC008621.1 BT007385.1 CR450337.1 U46767.1 U59808.1 X98306.1 Z77650.1 
    Z77651.1 

    1 DOTS entry:

    DT.110724 

    24/28 AceView cDNA sequences (see all 28):

    CK902425 U59808 BC008621 AA403048 BU071409 BX119227 NM_005408 CR450337 
    AW204819 BF339001 Z77651 AI459919 BT007385 BM991948 AA404346 AJ001634 
    AA426245 BG620880 Z77650 U46767 AA760939 AW015321 BU071645 AI925360 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CCL13    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for CCL13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGATGCT
    CCL13 Expression
    About this image


    See CCL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL13

    SOURCE GeneReport for Unigene cluster: Hs.414629

    UniProtKB/Swiss-Prot: CCL13_HUMAN, Q99616
    Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph
    node. Low levels seen in the pulmonary artery smooth muscle cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL13 (see all 17): 
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Th17 Response in human mouse rat
              Endothelial Cell Biology in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL13
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL13 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl21 chemokine (C-C motif) ligand 2 70.7(n)
    56.04(a)
      20296  NM_011333.3  NP_035463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.36
    si:dkeyp-59a8.26
    (see all 5)
    si:dkeyp-59a8.2
    (see all 5)
    31(a)
    30(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38310380-38311158)
    20(38304232-38305101)


    ENSEMBL Gene Tree for CCL13 (if available)
    TreeFam Gene Tree for CCL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL13 gene
    CCL112  CCL72  CCL22  CCL82  CCL242  
    18/28 SIMAP similar genes for CCL13 using alignment to 3 protein entries:     CCL13_HUMAN (see all proteins) (see all similar genes):
    CCL2    CCL11    CCL7    MCP-3    CCL8    XCL1
    XCL2    CCL3L1    CCL3L3    CCL3    CCL4    CCL4L2
    LOC728835    CCL4L1    CCL18    CCL14    CCL5    CCL1

    CCL13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 SNPs in CCL13 are shown (see all 127)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1178604541,2
    F--32681505(+) GGAGAC/TAACAG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1143110701,2
    F--32681562(+) AGAAGC/TTCCCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1494938441,2
    --32681582(+) ACCCAA/GTCAGA 1 -- us2k10--------
    rs1148537051,2
    F--32681621(+) TAACCC/TACCAA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1885869581,2
    --32681693(+) AGCTTA/GTAATA 1 -- us2k10--------
    rs1929586551,2
    --32681782(+) CTTTTG/TATATT 1 -- us2k10--------
    rs728270141,2
    C,F--32681871(+) CCCAGA/GGAATG 1 -- us2k13Minor allele frequency- G:0.07WA NA EA 358
    rs1459717661,2
    --32681888(+) GGGAAG/TATTTT 1 -- us2k10--------
    rs1398399891,2
    --32681890(+) GAAGAC/TTTTCA 1 -- us2k10--------
    rs1848696971,2
    C--32681915(+) TTCTTC/TAATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCL13 (32683471 - 32685629 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CCL13
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL13
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601391    OMIM disorders: --

    20/32 diseases for CCL13 (see all 32):    About MalaCards
    far eastern spotted fever    gastric adenocarcinoma    human immunodeficiency virus infectious disease    bullous pemphigoid
    allergic rhinitis    spotted fever    pertussis    eosinophilia
    rhinitis    tonsillitis    atopic dermatitis    atopy
    bronchiolitis    nephrotic syndrome    dermatitis    sinusitis
    encephalomyelitis    asthma    meningioma    lateral sclerosis

    4 diseases from the University of Copenhagen DISEASES database for CCL13:
    Asthma     Atopic dermatitis     Eosinophilia     Far Eastern spotted fever

    CCL13 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/14 Novoseek inferred disease relationships for CCL13 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 54.5 21 11400154 (2), 8955214 (1), 10808183 (1), 11391951 (1) (see all 15)
    asthma 48.5 34 15046375 (8), 10934112 (4), 10069883 (3), 12805085 (1) (see all 5)
    eosinophilia 41.1 2 10415058 (1), 10491000 (1)
    nasal polyps 38.4 6 15523430 (2), 17851891 (2), 10415058 (1)
    allergic reaction 35.5 2 10934112 (1), 10491000 (1)
    necrosis 30.8 8 10934112 (1), 9060459 (1), 20139115 (1), 19643942 (1) (see all 7)
    allergy 29.5 3 9800627 (1), 10875484 (1), 10640766 (1)
    allergic rhinitis 23.5 2 10359883 (1), 17982926 (1)
    asthma allergic 18.4 2 10934112 (1)
    dermatitis atopic 4.84 1 10808183 (1)

    Genetic Association Database (GAD): CCL13
    Human Genome Epidemiology (HuGE) Navigator: CCL13 (13 documents)

    Export disorders for CCL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL13 gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with CCL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. (PubMed id 8642349)1, 2, 9 Uguccioni M.... Baggiolini M. (1996)
    2. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. (PubMed id 9195948)1, 2, 9 Berkhout T.A.... Macphee C. (1997)
    3. Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2. (PubMed id 9060459)1, 2, 9 Godiska R....Gray P.W. (1997)
    4. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. (PubMed id 8955214)1, 2, 9 Garcia-Zepeda E.A.... Luster A.D. (1996)
    5. Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts: a comparison to other eosinophilic beta-chemokines. (PubMed id 10049733)1, 2, 9 Hein H....Bartels J. (1999)
    6. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Genetic variants of CC chemokine genes in experimenta l autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    10. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6357 HGNC: 10611 AceView: CCL13 Ensembl:ENSG00000181374 euGenes: HUgn6357
    ECgene: CCL13 Kegg: 6357 H-InvDB: CCL13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL13 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL13

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL13 gene:
    Search GeneIP for patents involving CCL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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