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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCL11 Gene

protein-coding   GIFtS: 67
GCID: GC17P032612

Chemokine (C-C Motif) Ligand 11

(Previous names: small inducible cytokine subfamily A (Cys-Cys), member 11...)
(Previous symbol: SCYA11)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chemokine (C-C Motif) Ligand 111 2     Eosinophil Chemotactic Protein2 3
SCYA111 2 3 5     eotaxin2
Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin)1 2     C-C Motif Chemokine 113
eotaxin-11 2     Small-Inducible Cytokine A113

External Ids:    HGNC: 106101   Entrez Gene: 63562   Ensembl: ENSG000001721567   OMIM: 6011565   UniProtKB: P516713   

Export aliases for CCL11 gene to outside databases

Previous GC identifers: GC17P032382 GC17P034652 GC17P032758 GC17P029636 GC17P028797


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCL11 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This
chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells
or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory
diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. (provided by RefSeq, Jul
2013)

GeneCards Summary for CCL11 Gene: 
CCL11 (chemokine (C-C motif) ligand 11) is a protein-coding gene. Diseases associated with CCL11 include dermatitis, and atopic dermatitis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Immune response TLR signaling pathways. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL13.

UniProtKB/Swiss-Prot: CCL11_HUMAN, P51671
Function: In response to the presence of allergens, this protein directly promotes the accumulation of
eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3

Gene Wiki entry for CCL11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCL11 gene promoter:
         C/EBPbeta   STAT1   Pax-6   RelA   Cdc5   E4BP4   E47   c-Rel   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q21.1-q21.2

CCL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032612:  view genomic region     (about GC identifiers)

Start:
32,612,687 bp from pter      End:
32,615,353 bp from pter
Size:
2,667 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCL11_HUMAN, P51671 (See protein sequence)
Recommended Name: Eotaxin precursor  
Size: 97 amino acids; 10732 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CCL11:
1EOT (3D)        2EOT (3D)    
Secondary accessions: P50877 Q92490 Q92491

Explore the universe of human proteins at neXtProt for CCL11: NX_P51671

Explore proteomics data for CCL11 at MOPED 

Post-translational modifications:

  • UniProtKB: O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51671

  • CCL11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCL11 Protein Expression
    REFSEQ proteins: NP_002977.1  
    ENSEMBL proteins: 
     ENSP00000302234  
    Reactome Protein details: P51671
    Human Recombinant Protein Products for CCL11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CCL11 (CCL11/Eotaxin)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCL11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCL11
    GenScript Purified and Recombinant Proteins for CCL11
    Novus Biologicals CCL11 Proteins
    Novus Biologicals CCL11 Lysates
    Sino Biological Recombinant Protein for CCL11
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CCL11
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    CCL11 for ontologies           About GeneDecksing



    CCL11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CCL11 Antibodies
    Abcam antibodies for CCL11
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for CCL11
    LSBio Antibodies in human, mouse, rat for CCL11 

    Assay Products for CCL11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL11
    R&D Systems Flow Cytometry Kits for CCL11 (CCL11/Eotaxin)         (see all)
    GenScript Custom Assay Services for CCL11
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CCL: Chemokine ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P51671

    ProtoNet protein and cluster: P51671

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL11_HUMAN, P51671
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    CCL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL11_HUMAN, P51671
    Function: In response to the presence of allergens, this protein directly promotes the accumulation of
    eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3
    Induction: By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18275857
    GO:0008009chemokine activity IDA10072545
         
    CCL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCL11:
     Increased cell number in G2M,  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ccl11):
     hematopoietic system  immune system  normal  respiratory system 

    CCL11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccl11tm1Mer for CCL11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCL11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCL11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL11 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL11:
    hsa-miR-1321
    SwitchGear 3'UTR luciferase reporter plasmidCCL11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCL11
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CCL11

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCL11 (see all 7)
    OriGene ORF clones in mouse, rat for CCL11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL11 (NM_002986)
    Sino Biological Human cDNA Clone for CCL11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL11
    Sirion Biotech Customized lentivirus for stable overexpression of CCL11 
                         Customized lentivirus expression plasmids for stable overexpression of CCL11 

    Cell Line
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    Search LifeMap BioReagents cell lines for CCL11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCL11 About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Regulation of Innate Immune Cells0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Chemokine Signaling
    Chemokine Signaling0.33
    Chemokine signaling pathway0.33
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    5Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for CCL11
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Selected targets of GCR-alpha
    Immune response IL-4 signaling pathway
    Immune response CCR3 signaling in eosinophils
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    5/28 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CCL11 (see all 28)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway

    4 GeneGo (Thomson Reuters) Pathways for CCL11
        Immune response IL-4 signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells
    Immune response CCR3 signaling in eosinophils
    Immune response TLR signaling pathways

    3 BioSystems Pathways for CCL11
        TSLP Signaling Pathway
    CXCR3-mediated signaling events
    IL4-mediated signaling events


    5/6        Reactome Pathways for CCL11 (see all 6)
        Peptide ligand-binding receptors
    Chemokine receptors bind chemokines
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding


    3         Kegg Pathways  (Kegg details for CCL11):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway
    Asthma


    CCL11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCL11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CCL11 (P516712, 3 ENSP000003022344) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPI1P601742, 3, ENSP000003799334MINT-63914 I2D: score=4 STRING: ENSP00000379933
    DPP4P274872, 3, ENSP000003537314MINT-8090954 I2D: score=2 STRING: ENSP00000353731
    NUDT3O959892, 3MINT-8264688 I2D: score=2 
    CCR3P516773, ENSP000003500034I2D: score=3 STRING: ENSP00000350003
    ACKR2O005903, ENSP000002731454I2D: score=2 STRING: ENSP00000273145
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19525930
    GO:0002544chronic inflammatory response IEA--
    GO:0002551mast cell chemotaxis IEA--
    GO:0006468protein phosphorylation TAS10706854
    GO:0006874cellular calcium ion homeostasis TAS10415069

    CCL11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCL11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCL11

    10/79 Novoseek inferred chemical compound relationships for CCL11 gene (see all 79)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 94.6 523 18700028 (7), 11090473 (6), 12489019 (6), 8892650 (6) (see all 99)
    tarc 83.9 50 17387476 (5), 15813816 (4), 15144472 (4), 17165591 (4) (see all 28)
    ccl3 81.1 30 17170049 (2), 12794150 (1), 20205697 (1), 12534281 (1) (see all 22)
    5-oxoete 53.1 18 11174193 (7), 16906532 (4), 15153797 (1)
    budesonide 52.6 7 10553092 (3), 11529904 (1), 17988555 (1), 11447387 (1) (see all 5)
    ccl4 48.2 17 17460280 (1), 17369706 (1), 17178797 (1), 19767072 (1) (see all 12)
    pranlukast 47.1 2 15947477 (1), 12682264 (1)
    histamine 44.3 25 11306952 (2), 15298570 (2), 19116009 (2), 18279799 (2) (see all 17)
    unicap 41.2 1 17002703 (1)
    pgd2 41.2 7 16906532 (2), 19169086 (2), 19494504 (1), 17362253 (1)

    Search CenterWatch for drugs/clinical trials and news about CCL11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCL11 gene: 
    NM_002986.2  

    Unigene Cluster for CCL11:

    Chemokine (C-C motif) ligand 11
    Hs.54460  [show with all ESTs]
    Unigene Representative Sequence: NM_002986
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305869(uc002hia.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCL11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CCL11:
    hsa-miR-1321
    SwitchGear 3'UTR luciferase reporter plasmidCCL11 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCL11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL11

    Additional mRNA sequence: 

    BC017850.1 CR457421.1 D49372.1 U46573.1 Z69291.1 Z75668.1 Z75669.1 

    2 DOTS entries:

    DT.311620  DT.100771008 

    24/70 AceView cDNA sequences (see all 70):

    AW294260 X72308 NM_002986 CA306760 BF197516 BC017850 AA127067 W69315 
    CD641158 CD522954 CD520085 BX108913 CD642089 BX109983 AI913629 W69211 
    AI357416 BF594486 BV203341 AI537716 NM_006273 CD520542 X71087 CD520379 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCL11 expression in normal human tissues (normalized intensities)      CCL11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTATCTGG
    CCL11 Expression
    About this image


    CCL11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Mature Cardiac Fibroblasts Myocardium
     
     Adipose (Muscoskeletal System)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Spinal Cord (Nervous System)
             Superior Cervical Ganglion   
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
     
     Smooth Muscle (Muscoskeletal System)

    See CCL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCL11

    SOURCE GeneReport for Unigene cluster: Hs.54460
        SABiosciences Expression via Pathway-Focused PCR Arrays including CCL11 (see all 13): 
              Fibrosis in human mouse rat
              NFKB Signaling Targets in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCL11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCL11 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl111 , 5 chemokine (C-C motif) ligand 111, 5 74.57(n)1
    58.76(a)1
      11 (49.84 cM)5
    202921  NM_011330.31  NP_035460.11 
     820578235 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkeyp-59a8.26
    si:dkeyp-59a8.36
    (see all 5)
    si:dkeyp-59a8.3
    (see all 5)
    31(a)
    30(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    20(38304232-38305101)
    20(38310380-38311158)


    ENSEMBL Gene Tree for CCL11 (if available)
    TreeFam Gene Tree for CCL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCL11 gene
    CCL132  CCL72  CCL22  CCL82  CCL242  
    18/28 SIMAP similar genes for CCL11 using alignment to 2 protein entries:     CCL11_HUMAN (see all proteins) (see all similar genes):
    CCL2    CCL8    CCL7    MCP-3    CCL13    CCL3L1
    CCL3L3    CCL4    CCL4L2    LOC728835    CCL4L1    CX3CL1
    CCL3    CCL26    CCL14    CCL24    XCL1    XCL2

    CCL11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 SNPs in CCL11 are shown (see all 217)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0016374
    ----see VAR_0016372 K R mis40--------
    VAR_0016344
    ----see VAR_0016342 L P mis40--------
    VAR_0016364
    ----see VAR_0016362 R S mis40--------
    rs760280401,2
    C--28800151(+) TTTTTA/TAAAAA 1 -- ut310--------
    rs354895171,2
    C,F--32610887(+) CCTTC-/TTTTTT 1 -- us2k14Minor allele frequency- T:0.38NA CSA 8
    rs2016541511,2
    C--32614836(+) TATAT-/ATTTTT 1 -- ut310--------
    rs10191111,2
    C--32614845(-) ttttaA/Taaaaa 1 -- ut31 trp32Minor allele frequency- T:0.00MN NA 186
    rs10191101,2
    C--32614846(-) tttttA/Taaaaa 1 -- ut31 trp31Minor allele frequency- T:0.00NA 2
    rs354293631,2
    C--32614847(+) TTTTT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs61460401,2
    C--32615559(+) ACCAGAGGTTTA 
     GGTGC
    /-
    AGGTT
    1 -- cds11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for CCL11 (32612687 - 32615353 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): CCL11
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCL11
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601156   
    OMIM disorders: 609423  600807  
    20/136 diseases for CCL11 (see all 136):    About MalaCards
    dermatitis    atopic dermatitis    allergic rhinitis    keratoconjunctivitis
    papillary conjunctivitis    giant papillary conjunctivitis    pediatric ulcerative colitis    cellular leiomyoma
    corneal ulcer    rhinitis    enteropathy-associated t-cell lymphoma    common cold
    gastroenteritis    eosinophilic disorders    folliculitis    eosinophilic gastroenteritis
    eosinophilia    ulcerative colitis    eosinophilic pneumonia    kimura disease

    5 diseases from the University of Copenhagen DISEASES database for CCL11:
    Asthma     Eosinophilia     Eosinophilic esophagitis     Hypersensitivity reaction type I disease
    Atopic dermatitis

    CCL11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/98 Novoseek inferred disease relationships for CCL11 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eosinophilia 84.2 80 10052481 (3), 10782526 (2), 12853519 (2), 14629326 (2) (see all 61)
    asthma 81.1 191 12915771 (6), 15266834 (6), 16461130 (5), 10588612 (5) (see all 99)
    inflammation 78.3 132 11953096 (3), 9698931 (3), 7869037 (2), 16620281 (2) (see all 99)
    nasal polyps 76.5 71 17438850 (6), 15277046 (6), 19522186 (5), 10687940 (4) (see all 25)
    asthma allergic 74.2 16 11401892 (3), 9822268 (2), 10782526 (1), 10934112 (1) (see all 13)
    eosinophilic gastroenteritis 65.9 1 15833687 (1)
    allergic rhinitis 65.1 29 16759010 (4), 9679849 (2), 10998025 (2), 15480318 (2) (see all 18)
    pulmonary eosinophilia 65 1 8784786 (1)
    keratoconjunctivitis vernal 62.7 5 10798661 (1), 11090473 (1), 19333691 (1)
    dermatitis atopic 61.5 26 10417617 (4), 15813816 (2), 14561178 (2), 10319581 (1) (see all 19)

    Genetic Association Database (GAD): CCL11
    Human Genome Epidemiology (HuGE) Navigator: CCL11 (51 documents)

    Export disorders for CCL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCL11 gene, integrated from 9 sources (see all 985):
    (articles sorted by number of sources associating them with CCL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. (PubMed id 9169149)1, 2, 3, 9 Garcia-Zepeda E.A.... Luster A.D. (1997)
    2. Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. (PubMed id 9712872)1, 2, 9 Crump M.P.... Sykes B.D. (1998)
    3. Eotaxin polymorphisms and serum total IgE levels in children with asthma. (PubMed id 16461130)1, 4, 9 Raby B.A....Weiss S.T. (2006)
    4. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts. (PubMed id 9578468)1, 2, 9 Noso N....Schroeder J.-M. (1998)
    5. Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls. (PubMed id 16510147)1, 4, 9 Sheikine Y....Ghaderi M. (2006)
    6. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. (PubMed id 8609214)1, 2, 9 Ponath P.D....Mackay C.R. (1996)
    7. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. (PubMed id 15186951)1, 4, 9 Zee R.Y....Ridker P.M. (2004)
    8. Investigation of the eotaxin gene -426C-->T, -384A-->G and 67G-->a single-nucleotide polymorphisms and atopic dermatitis in Italian children using family-based association methods. (PubMed id 18312459)1, 4, 9 Rigoli L....Pajno G.B. (2008)
    9. An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians. (PubMed id 16872505)1, 4, 9 Bugeja M.J....Stewart G. (2006)
    10. Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician's Health Study. (PubMed id 16184405)1, 4, 9 Rosner S.A....Cook N.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6356 HGNC: 10610 AceView: CCL11andCCL7 Ensembl:ENSG00000172156 euGenes: HUgn6356
    ECgene: CCL11 Kegg: 6356 H-InvDB: CCL11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCL11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCL11 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: CCL11http://www.rndsystems.com/molecule_detail.aspx?m=1367
    Wikipedia http://en.wikipedia.org/wiki/CCL11

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCL11 gene:
    Search GeneIP for patents involving CCL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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