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Aliases for CCL11 Gene

Aliases for CCL11 Gene

  • C-C Motif Chemokine Ligand 11 2 3 5
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin) 2 3
  • Chemokine (C-C Motif) Ligand 11 2 3
  • Eosinophil Chemotactic Protein 3 4
  • Eotaxin-1 2 3
  • SCYA11 3 4
  • Small-Inducible Cytokine A11 4
  • C-C Motif Chemokine 11 4
  • Eotaxin 3

External Ids for CCL11 Gene

Previous HGNC Symbols for CCL11 Gene

  • SCYA11

Previous GeneCards Identifiers for CCL11 Gene

  • GC17P032382
  • GC17P034652
  • GC17P032758
  • GC17P029636
  • GC17P032612
  • GC17P028797

Summaries for CCL11 Gene

Entrez Gene Summary for CCL11 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL11 Gene

CCL11 (C-C Motif Chemokine Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include Asthma and Hiv-1. Among its related pathways are PEDF Induced Signaling and Th2 Differentiation Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL11 Gene

  • In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Gene Wiki entry for CCL11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL11 Gene

Genomics for CCL11 Gene

Regulatory Elements for CCL11 Gene

Enhancers for CCL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G034245 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 -32.8 -32758 14.0 PKNOX1 CBX3 SIN3A GLIS2 GATA2 ZSCAN5C FOS CREM CBFB JUNB CCL7 CCL11 CCL8 CCL1 ASIC2 CCL2 GC17M034278
GH17G034306 1.3 FANTOM5 Ensembl ENCODE 11.4 +21.4 21443 1.5 CTCF REST EBF1 RAD21 RELA JUND NFIC IKZF1 SMC3 FOS CCL7 CCL11 CCL1 ASIC2 CCL8
GH17G034200 0.9 ENCODE 10.6 -85.6 -85552 0.2 ELF3 RB1 TBL1XR1 ARNT ZNF76 KLF17 BRCA1 ZNF2 RAD21 RFX5 CCL1 ASIC2 CCL2 CCL7 CCL8 CCL11 LINC01989 GC17P034213
GH17G034199 0.8 ENCODE 10.6 -85.8 -85812 0.2 GTF2F1 ELF3 CTCF ESRRA ARNT ZNF76 KLF17 ZNF2 RAD21 ZNF324 CCL1 ASIC2 CCL2 CCL7 CCL8 CCL11 LINC01989 GC17P034213
GH17G034299 1.3 FANTOM5 Ensembl ENCODE 0.4 +14.9 14929 2.5 CTCF MXI1 JUN MAX CEBPG RAD21 YY1 POLR2A SMC3 FOS CCL7 CCL8 CCL1 CCL2 CCL11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL11 Gene

Chromosome:
17
Start:
34,285,668 bp from pter
End:
34,288,334 bp from pter
Size:
2,667 bases
Orientation:
Plus strand

Genomic View for CCL11 Gene

Genes around CCL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL11 Gene

Proteins for CCL11 Gene

  • Protein details for CCL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51671-CCL11_HUMAN
    Recommended name:
    Eotaxin
    Protein Accession:
    P51671
    Secondary Accessions:
    • P50877
    • Q92490
    • Q92491

    Protein attributes for CCL11 Gene

    Size:
    97 amino acids
    Molecular mass:
    10732 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL11 Gene

neXtProt entry for CCL11 Gene

Post-translational modifications for CCL11 Gene

  • O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.
  • Glycosylation at posLast=9494
  • Modification sites at PhosphoSitePlus

Other Protein References for CCL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL11 (CCL11/Eotaxin)

No data available for DME Specific Peptides for CCL11 Gene

Domains & Families for CCL11 Gene

Gene Families for CCL11 Gene

Protein Domains for CCL11 Gene

Suggested Antigen Peptide Sequences for CCL11 Gene

Graphical View of Domain Structure for InterPro Entry

P51671

UniProtKB/Swiss-Prot:

CCL11_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL11: view

Function for CCL11 Gene

Molecular function for CCL11 Gene

UniProtKB/Swiss-Prot Function:
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
UniProtKB/Swiss-Prot Induction:
Induced by TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Gene Ontology (GO) - Molecular Function for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 10072545
GO:0031728 CCR3 chemokine receptor binding IDA 11425309
GO:0046983 protein dimerization activity IDA 9712872
genes like me logo Genes that share ontologies with CCL11: view
genes like me logo Genes that share phenotypes with CCL11: view

Animal Models for CCL11 Gene

MGI Knock Outs for CCL11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL11 Gene

Localization for CCL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL11 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0005622 intracellular IEA --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL11: view

Pathways & Interactions for CCL11 Gene

genes like me logo Genes that share pathways with CCL11: view

Gene Ontology (GO) - Biological Process for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002544 chronic inflammatory response IEA --
GO:0002548 monocyte chemotaxis IBA --
GO:0002551 mast cell chemotaxis IEA --
GO:0006468 protein phosphorylation TAS 10706854
genes like me logo Genes that share ontologies with CCL11: view

No data available for SIGNOR curated interactions for CCL11 Gene

Drugs & Compounds for CCL11 Gene

(44) Drugs for CCL11 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CAT-213 Investigational Pharma Target 0

(36) Additional Compounds for CCL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL11: view

Transcripts for CCL11 Gene

mRNA/cDNA for CCL11 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL11 Gene

Chemokine (C-C motif) ligand 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL11 Gene

No ASD Table

Relevant External Links for CCL11 Gene

GeneLoc Exon Structure for
CCL11
ECgene alternative splicing isoforms for
CCL11

Expression for CCL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL11 Gene

This gene is overexpressed in Colon - Sigmoid (x14.9), Stomach (x6.6), Colon - Transverse (x6.4), and Heart - Left Ventricle (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of CCL11 Gene:

CCL11

SOURCE GeneReport for Unigene cluster for CCL11 Gene:

Hs.54460

Evidence on tissue expression from TISSUES for CCL11 Gene

  • Blood(4.6)
  • Lung(4.6)
  • Intestine(4.5)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL11 Gene

Germ Layers:
  • endoderm
Systems:
  • immune
  • respiratory
Organs:
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with CCL11: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCL11 Gene

Orthologs for CCL11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL11 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia CCL11 34 35
  • 79.17 (n)
rat
(Rattus norvegicus)
Mammalia Ccl11 34
  • 75.6 (n)
mouse
(Mus musculus)
Mammalia Ccl11 34 16 35
  • 75.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 18 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
Species where no ortholog for CCL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL11 Gene

ENSEMBL:
Gene Tree for CCL11 (if available)
TreeFam:
Gene Tree for CCL11 (if available)

Paralogs for CCL11 Gene

genes like me logo Genes that share paralogs with CCL11: view

Variants for CCL11 Gene

Sequence variations from dbSNP and Humsavar for CCL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000218287 -- 34,286,524(+) GGGCT(C/T)AGGCT intron-variant
rs1000320152 -- 34,286,827(+) TTTAT(A/G)ATGAC intron-variant
rs1000554042 -- 34,287,931(+) TACCC(C/G)CTGGG utr-variant-3-prime
rs1000806328 -- 34,284,845(+) ATGTA(C/T)AGGTT upstream-variant-2KB
rs1000875319 -- 34,286,190(+) TGGCA(C/G)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL11 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL11 Gene

Residual Variation Intolerance Score: 50.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL11 Gene

Human Gene Mutation Database (HGMD)
CCL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL11 Gene

Disorders for CCL11 Gene

MalaCards: The human disease database

(67) MalaCards diseases for CCL11 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
hiv-1
  • aids, slow progression to
asthma susceptibility, ccl11-related
  • asthma, susceptibility to
eosinophilic gastroenteritis
  • eosinophilic enteropathy
giant papillary conjunctivitis
  • gpc
- elite association - COSMIC cancer census association via MalaCards
Search CCL11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL11

Genetic Association Database (GAD)
CCL11
Human Genome Epidemiology (HuGE) Navigator
CCL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL11
genes like me logo Genes that share disorders with CCL11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL11 Gene

Publications for CCL11 Gene

  1. Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls. (PMID: 16510147) Sheikine Y. … Ghaderi M. (Atherosclerosis 2006) 3 22 46 64
  2. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. (PMID: 15186951) Zee R.Y. … Ridker P.M. (Atherosclerosis 2004) 3 22 46 64
  3. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts. (PMID: 9578468) Noso N. … Schroeder J.-M. (Eur. J. Biochem. 1998) 3 4 22 64
  4. Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. (PMID: 9712872) Crump M.P. … Sykes B.D. (J. Biol. Chem. 1998) 3 4 22 64
  5. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. (PMID: 9169149) Garcia-Zepeda E.A. … Luster A.D. (Genomics 1997) 2 3 4 64

Products for CCL11 Gene

Sources for CCL11 Gene

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