Aliases for CCL11 Gene
External Ids for CCL11 Gene
Previous Symbols for CCL11 Gene
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
GeneCards Summary for CCL11 Gene
CCL11 (Chemokine (C-C Motif) Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include giant papillary conjunctivitis and pediatric ulcerative colitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.
UniProtKB/Swiss-Prot for CCL11 Gene
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3