Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL11 Gene

Aliases for CCL11 Gene

  • Chemokine (C-C Motif) Ligand 11 2 3
  • SCYA11 3 4 6
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin) 2 3
  • Eosinophil Chemotactic Protein 3 4
  • Eotaxin-1 2 3
  • Small-Inducible Cytokine A11 4
  • C-C Motif Chemokine 11 4
  • Eotaxin 3

External Ids for CCL11 Gene

Previous Symbols for CCL11 Gene

  • SCYA11

Summaries for CCL11 Gene

Entrez Gene Summary for CCL11 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL11 Gene

CCL11 (Chemokine (C-C Motif) Ligand 11) is a Protein Coding gene. Diseases associated with CCL11 include giant papillary conjunctivitis and pediatric ulcerative colitis. Among its related pathways are Signaling by GPCR and TGF-Beta Pathway. GO annotations related to this gene include chemokine activity. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL11 Gene

  • In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3

Gene Wiki entry for CCL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL11 Gene

Genomics for CCL11 Gene

Genomic Location for CCL11 Gene

Start:
34,285,668 bp from pter
End:
34,288,334 bp from pter
Size:
2,667 bases
Orientation:
Plus strand

Genomic View for CCL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL11 Gene

Regulatory Elements for CCL11 Gene

Proteins for CCL11 Gene

  • Protein details for CCL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51671-CCL11_HUMAN
    Recommended name:
    Eotaxin
    Protein Accession:
    P51671
    Secondary Accessions:
    • P50877
    • Q92490
    • Q92491

    Protein attributes for CCL11 Gene

    Size:
    97 amino acids
    Molecular mass:
    10732 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCL11 Gene

neXtProt entry for CCL11 Gene

Proteomics data for CCL11 Gene at MOPED

Post-translational modifications for CCL11 Gene

  • O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.
  • Glycosylation at Thr94

Other Protein References for CCL11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCL11 Gene

Domains for CCL11 Gene

Gene Families for CCL11 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • CCL :Chemokine ligands

Protein Domains for CCL11 Gene

UniProtKB/Swiss-Prot:

CCL11_HUMAN
Family:
  • Belongs to the intercrine beta (chemokine CC) family.:
    • P51671
genes like me logo Genes that share domains with CCL11: view

Function for CCL11 Gene

Molecular function for CCL11 Gene

UniProtKB/Swiss-Prot Function: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3
UniProtKB/Swiss-Prot Induction: By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma

Gene Ontology (GO) - Molecular Function for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18275857
GO:0008009 chemokine activity IDA 10072545
genes like me logo Genes that share ontologies with CCL11: view

Phenotypes for CCL11 Gene

genes like me logo Genes that share phenotypes with CCL11: view

Animal Models for CCL11 Gene

MGI Knock Outs for CCL11:

miRNA for CCL11 Gene

miRTarBase miRNAs that target CCL11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCL11 Gene

Localization for CCL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL11 Gene COMPARTMENTS Subcellular localization image for CCL11 gene
Compartment Confidence
extracellular 5
nucleus 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CCL11: view

Pathways for CCL11 Gene

genes like me logo Genes that share pathways with CCL11: view

Gene Ontology (GO) - Biological Process for CCL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19525930
GO:0002544 chronic inflammatory response IEA --
GO:0002551 mast cell chemotaxis IEA --
GO:0006468 protein phosphorylation TAS 10706854
GO:0006874 cellular calcium ion homeostasis TAS 10415069
genes like me logo Genes that share ontologies with CCL11: view

Compounds for CCL11 Gene

(79) Novoseek inferred chemical compound relationships for CCL11 Gene

Compound -log(P) Hits PubMed IDs
rantes 94.6 299
tarc 83.9 47
ccl3 81.1 23
5-oxoete 53.1 12
budesonide 52.6 7
genes like me logo Genes that share compounds with CCL11: view

Transcripts for CCL11 Gene

mRNA/cDNA for CCL11 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL11 Gene

Chemokine (C-C motif) ligand 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL11 Gene

No ASD Table

Relevant External Links for CCL11 Gene

GeneLoc Exon Structure for
CCL11
ECgene alternative splicing isoforms for
CCL11

Expression for CCL11 Gene

mRNA expression in normal human tissues for CCL11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL11 Gene

This gene is overexpressed in Colon - Sigmoid (14.9), Stomach (6.6), Colon - Transverse (6.4), and Heart - Left Ventricle (4.5).

SOURCE GeneReport for Unigene cluster for CCL11 Gene Hs.54460

genes like me logo Genes that share expressions with CCL11: view

Orthologs for CCL11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL11 36
  • 99.66 (n)
  • 100 (a)
CCL11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL11 36
  • 79.17 (n)
  • 65.62 (a)
CCL11 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl11 36
  • 75.31 (n)
  • 60.49 (a)
Ccl11 16
Ccl11 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 18 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
-- 37
  • 43 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 42 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ccl11 36
  • 75.6 (n)
  • 60.82 (a)
Species with no ortholog for CCL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL11 Gene

ENSEMBL:
Gene Tree for CCL11 (if available)
TreeFam:
Gene Tree for CCL11 (if available)

Paralogs for CCL11 Gene

Paralogs for CCL11 Gene

genes like me logo Genes that share paralogs with CCL11: view

Variants for CCL11 Gene

Sequence variations from dbSNP and Humsavar for CCL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1019109 -- 34,288,101(-) TGTAT(C/T)CCTAA utr-variant-3-prime
rs1019110 -- 34,287,827(-) ttttt(A/T)aaaaa utr-variant-3-prime
rs1019111 -- 34,287,826(-) tttta(A/T)aaaaa utr-variant-3-prime
rs1129844 - 34,285,875(+) GGCTC(A/C/G)CTGGG missense, reference
rs3815341 -- 34,287,406(-) CTTGA(C/T)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL11 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Relevant External Links for CCL11 Gene

HapMap Linkage Disequilibrium report
CCL11
Human Gene Mutation Database (HGMD)
CCL11

Disorders for CCL11 Gene

(2) OMIM Diseases for CCL11 Gene (601156)

(98) Novoseek inferred disease relationships for CCL11 Gene

Disease -log(P) Hits PubMed IDs
eosinophilia 84.2 71
asthma 81.1 160
inflammation 78.3 109
nasal polyps 76.5 58
asthma allergic 74.2 16

Relevant External Links for CCL11

Genetic Association Database (GAD)
CCL11
Human Genome Epidemiology (HuGE) Navigator
CCL11
genes like me logo Genes that share disorders with CCL11: view

No data available for UniProtKB/Swiss-Prot for CCL11 Gene

Publications for CCL11 Gene

  1. Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine. (PMID: 9169149) Garcia-Zepeda E.A. … Luster A.D. (Genomics 1997) 2 3 4 23
  2. Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts. (PMID: 9578468) Noso N. … Schroeder J.-M. (Eur. J. Biochem. 1998) 3 4 23
  3. Variant eotaxin: its effects on the asthma phenotype. (PMID: 11742272) Nakamura H. … Lilly C.M. (J. Allergy Clin. Immunol. 2001) 3 23 49
  4. Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. (PMID: 9712872) Crump M.P. … Sykes B.D. (J. Biol. Chem. 1998) 3 4 23
  5. Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils. (PMID: 8609214) Ponath P.D. … Mackay C.R. (J. Clin. Invest. 1996) 3 4 23

Products for CCL11 Gene

Sources for CCL11 Gene

Back to Top

Content