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CCL1 Gene

protein-coding   GIFtS: 59
GCID: GC17M032687

Chemokine (C-C Motif) Ligand 1

(Previous names: small inducible cytokine A1 (I-309, homologous to mouse...)
(Previous symbol: SCYA1)
  See CCL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chemokine (C-C Motif) Ligand 11 2     P5002
SCYA11 2 3 5     SISe2
T Lymphocyte-Secreted Protein I-3091 2 3     TCA32
Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3)1 2     C-C Motif Chemokine 12
Inflammatory Cytokine I-3091 2     Small-Inducible Cytokine A13
I-3092     

External Ids:    HGNC: 106091   Entrez Gene: 63462   Ensembl: ENSG000001087027   OMIM: 1822815   UniProtKB: P223623   

Export aliases for CCL1 gene to outside databases

Previous GC identifers: GC17M032457 GC17M034727 GC17M032536 GC17M032832 GC17M029711 GC17M028873


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCL1 Gene:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily
of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into
four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This
chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for
monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. (provided by RefSeq, Jul
2013)

GeneCards Summary for CCL1 Gene:
CCL1 (chemokine (C-C motif) ligand 1) is a protein-coding gene. Diseases associated with CCL1 include kaposi's sarcoma. GO annotations related to this gene include chemokine activity.

UniProtKB/Swiss-Prot: CCL1_HUMAN, P22362
Function: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCL1 gene promoter:
         Elk-1   AML1a   NCX/Ncx   NF-kappaB   Meis-1b   Nkx6-1   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCL1 promoter sequence
   Search Chromatin IP Primers for CCL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.2

CCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M032687:  view genomic region     (about GC identifiers)

Start:
32,687,347 bp from pter      End:
32,690,252 bp from pter
Size:
2,906 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCL1_HUMAN, P22362 (See protein sequence)
Recommended Name: C-C motif chemokine 1 precursor  
Size: 96 amino acids; 10992 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for CCL1:
1EL0 (3D)    
Secondary accessions: B2R5G9 Q2M309

Explore the universe of human proteins at neXtProt for CCL1: NX_P22362

Post-translational modifications: 

  • Glycosylation2 at Asn52
  • REFSEQ proteins: NP_002972.1  
    ENSEMBL proteins: 
     ENSP00000225842  

    CCL1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCL1
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    GenScript Purified and Recombinant Proteins for CCL1
    Novus Biologicals CCL1 Proteins
    Novus Biologicals CCL1 Lysates
    Sino Biological Recombinant Protein for CCL1
    Sino Biological Cell Lysate for CCL1
    ProSpec Recombinant Protein for CCL1
    Cloud-Clone Corp. Proteins for CCL1

     
    Search eBioscience for Proteins for CCL1 

    CCL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CCL1 (CCL1/I-309/TCA-3)
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    Novus Biologicals CCL1 Antibodies
    Abcam antibodies for CCL1
    Cloud-Clone Corp. Antibodies for CCL1
    ThermoFisher Antibodies for CCL1
    LSBio Antibodies in human, mouse, rat for CCL1

    CCL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCL1
    R&D Systems Flow Cytometry Kits for CCL1 (CCL1/I-309/TCA-3)         (see all)
    GenScript Custom Assay Services for CCL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCL1
    Cloud-Clone Corp. CLIAs for CCL1
    Search eBioscience for ELISAs for CCL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR000827 Chemokine_CC_CS
     IPR001811 Chemokine_IL8-like_dom

    Graphical View of Domain Structure for InterPro Entry P22362

    ProtoNet protein and cluster: P22362

    1 Blocks protein domain: IPB000827 Small chemokine

    UniProtKB/Swiss-Prot: CCL1_HUMAN, P22362
    Similarity: Belongs to the intercrine beta (chemokine CC) family


    Find genes that share domains with CCL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCL1_HUMAN, P22362
    Function: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8
    Induction: By phorbol myristate acetate (PMA)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity ----
    GO:0005515protein binding ----
    GO:0008009chemokine activity IEA--
         
    Find genes that share ontologies with CCL1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CCL1:
     Decreased viability of wild-ty  Increased cell death in breast  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccl1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CCL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ccl1tm1Sman for CCL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCL1:
    hsa-mir-17-5p (MIRT000257)

    Block miRNA regulation of human, mouse, rat CCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL1 (see all 13):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidCCL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCL1
    Predesigned siRNA for gene silencing in human, mouse, rat CCL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCL1

    Clone
    Products:
         
    OriGene clones in human, mouse for CCL1 (see all 5)
    OriGene ORF clones in mouse, rat for CCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL1 (NM_002981)
    Sino Biological Human cDNA Clone for CCL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCL1_HUMAN, P22362: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    chloroplast2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CCL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCL1 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    NFAT Signaling and Lymphocyte Interactions0.57
    MIF Mediated Glucocorticoid Regulation0.94
    PGC1Alpha Pathway0.51
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Chemokine Signaling
    Chemokine signaling pathway0.33
    Chemokine Signaling0.33
    3TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    SOCS Pathway0.40
    4Akt Signaling
    Akt Signaling0.60
    Tec Kinases Signaling0.55
    p38 Signaling0.60
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61


    Find genes that share SuperPaths with CCL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CCL1
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CCL1 (see all 27)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    NFAT Signaling and Lymphocyte Interactions
    JNK Pathway



    2 Kegg Pathways  (Kegg details for CCL1):
        Cytokine-cytokine receptor interaction
    Chemokine signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL1 (see all 6): 
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CCL1 (P223623 ENSP000002258424) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR8P516853, ENSP000003264324I2D: score=2 STRING: ENSP00000326432
    HUWE1Q7Z6Z73, ENSP000002628544I2D: score=1 STRING: ENSP00000262854
    CCR10ENSP000003325044STRING: ENSP00000332504
    CCR2ENSP000002923014STRING: ENSP00000292301
    CCR3ENSP000003500034STRING: ENSP00000350003
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis TAS9417093
    GO:0006935chemotaxis TAS9417093
    GO:0006955immune response IEA--
    GO:0007165signal transduction TAS9417093
    GO:0016032viral process TAS9417093

    Find genes that share ontologies with CCL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCL1

    7 Novoseek inferred chemical compound relationships for CCL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tarc 88.4 19 10760790 (2), 10754297 (2), 12355447 (2), 10540332 (2) (see all 9)
    rantes 85.6 27 11882045 (2), 11590199 (2), 10942204 (1), 11483776 (1) (see all 23)
    ccl3 80.2 13 16905241 (1), 17369706 (1), 12393595 (1), 11145678 (1) (see all 8)
    ccl4 53.2 10 16905241 (1), 17369706 (1), 12393595 (1), 11145678 (1) (see all 6)
    calcium 13.7 21 9469461 (3), 16679317 (2), 9211859 (1), 9207005 (1) (see all 9)
    oligonucleotide 7.19 1 11533168 (1)
    nitric oxide 0 4 17662042 (3)



    Find genes that share compounds with CCL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCL1 gene: 
    NM_002981.2  

    Unigene Cluster for CCL1:

    Chemokine (C-C motif) ligand 1
    Hs.72918  [show with all ESTs]
    Unigene Representative Sequence: DA620119
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225842(uc002hid.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCL1 (see all 13):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-21
    SwitchGear 3'UTR luciferase reporter plasmidCCL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CCL1
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    Clone
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    OriGene ORF clones in mouse, rat for CCL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCL1 (NM_002981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCL1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL1
      QuantiTect SYBR Green Assays in human, mouse, rat CCL1
      QuantiFast Probe-based Assays in human, mouse, rat CCL1

    Additional mRNA sequence: 

    AK312183.1 BC105073.1 BC105075.1 M57502.1 

    1 DOTS entry:

    DT.306225 

    5 AceView cDNA sequences:

    NM_002981 BX093610 M57502 AA931884 AI374101 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTCACCTG
    CCL1 Expression
    About this image


    CCL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stempeucel)
    CCL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.72918
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCL1 (see all 6): 
              Th17 Response in human mouse rat
              Inflammatory Cytokines & Receptors in human mouse rat
              Cytokines & Chemokines in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCL1
    QuantiTect SYBR Green Assays in human, mouse, rat CCL1
    QuantiFast Probe-based Assays in human, mouse, rat CCL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCL1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccl11 , 5 chemokine (C-C motif) ligand 11, 5 62.27(n)1
    42.86(a)1
      11 (49.99 cM)5
    202901  NM_011329.31  NP_035459.11 
     821766575 


    ENSEMBL Gene Tree for CCL1 (if available)
    TreeFam Gene Tree for CCL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CCL1 gene
    Selected SIMAP similar genes for CCL1 using alignment to 1 protein entry:     CCL1_HUMAN(see all similar genes):
    SCYA1    CCL4    CCL4L2    LOC728835    CCL11    CCL2
    CCL4L1    CCL13    CCL3    CCL8    CCL26    CCL18
    CCL3L1    CCL3L3    CCL14    CCL23    CCL5    CCL7

    Find genes that share paralogs with CCL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCL1 (see all 163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728270211,2
    C,F--32686911(+) CCTAGG/AAGGCA 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1811963461,2
    --32686930(+) AGGCTC/GTAATG 1 -- ds50010--------
    rs31366801,2
    C,F,O,H--32686961(+) CTGCAT/ACTCTC 1 -- ds500126Minor allele frequency- A:0.06NA NS EA WA 2948
    rs31366811,2
    C,F,O,H--32687228(+) AAAGCT/GTACAC 1 -- ds500127Minor allele frequency- G:0.46NA NS EA WA 2948
    rs1857983871,2
    --32687253(+) AGTCAC/TTGAGA 1 -- ds50010--------
    rs1147778961,2
    C,F--32687342(+) CCCTGG/TCTCCC 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs31366821,2
    C,F,H--32687442(+) TGCAAC/TAACAT 1 -- ut3123Minor allele frequency- T:0.04NA NS EA WA 2494
    rs1408451471,2
    --32687447(+) CAACAC/TAGCTT 1 -- ut310--------
    rs31366831,2
    C,F--32687511(+) GTGTAG/CGGCTG 1 -- ut31 ese36Minor allele frequency- C:0.05NA WA 302
    rs1447178691,2
    C,F--32687593(+) TTTGAC/TGGGCA 2 P syn11Minor allele frequency- T:0.00NA 4550

    HapMap Linkage Disequilibrium report for CCL1 (32687347 - 32690252 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519297CNV Gain19592680
    nsv517423CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182281    OMIM disorders: --

    1 disease for CCL1:    
    About MalaCards
    kaposi's sarcoma


    Find genes that share disorders with CCL1           About GenesLikeMe

    9 Novoseek inferred disease relationships for CCL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 34.7 3 9211859 (1), 17196668 (1)
    atherosclerotic plaque 32.9 4 11133740 (1), 10942748 (1), 19902068 (1)
    necrosis 23.3 4 11483776 (1), 16735693 (1), 18832998 (1), 10899895 (1)
    kaposi sarcoma 18 2 11133740 (2)
    dermatitis atopic 11.2 2 15814739 (1), 17369706 (1)
    asthma 9.07 1 18279215 (1)
    tumors 0.551 4 11483776 (1), 16735693 (1), 18832998 (1), 10899895 (1)
    pneumonia 0.0379 2 17641040 (2)
    immunodeficiency 0 1 16221874 (1)

    Genetic Association Database (GAD): CCL1
    Human Genome Epidemiology (HuGE) Navigator: CCL1 (19 documents)

    Export disorders for CCL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCL1 gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with CCL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. (PubMed id 2212659)1, 2, 3, 9 Miller M.D....Krangel M.S. (J. Immunol. 1990)
    2. Human CC chemokine I-309, structural consequences of the additional disulfide bond. (PubMed id 10821677)1, 2, 9 Keizer D.W....Sykes B.D. (Biochemistry 2000)
    3. The human cytokine I-309 is a monocyte chemoattractant. (PubMed id 1557400)1, 2, 9 Miller M.D. and Krangel M.S. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    7. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (Genes Immun. 2010)
    8. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    9. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    10. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4 Lee J.Y....Kang D. (Carcinogenesis 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6346 HGNC: 10609 AceView: CCL1 Ensembl:ENSG00000108702 euGenes: HUgn6346
    ECgene: CCL1 Kegg: 6346 H-InvDB: CCL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCL1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/CCL1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCL1 gene:
    Search GeneIP for patents involving CCL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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