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Aliases for CCL1 Gene

Aliases for CCL1 Gene

  • C-C Motif Chemokine Ligand 1 2 3 5
  • T Lymphocyte-Secreted Protein I-309 2 3 4
  • Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3) 2 3
  • Chemokine (C-C Motif) Ligand 1 2 3
  • Inflammatory Cytokine I-309 2 3
  • SCYA1 3 4
  • Small-Inducible Cytokine A1 4
  • C-C Motif Chemokine 1 3
  • I-309 3
  • P500 3
  • SISe 3
  • TCA3 3

External Ids for CCL1 Gene

Previous HGNC Symbols for CCL1 Gene

  • SCYA1

Previous GeneCards Identifiers for CCL1 Gene

  • GC17M032457
  • GC17M034727
  • GC17M032536
  • GC17M032832
  • GC17M029711
  • GC17M032687
  • GC17M028873

Summaries for CCL1 Gene

Entrez Gene Summary for CCL1 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL1 Gene

CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Igg4-Related Sclerosing Cholangitis and Tolosa-Hunt Syndrome. Among its related pathways are Akt Signaling and PEDF Induced Signaling. GO annotations related to this gene include cytokine activity and chemokine activity.

UniProtKB/Swiss-Prot for CCL1 Gene

  • Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.

Additional gene information for CCL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL1 Gene

Genomics for CCL1 Gene

Regulatory Elements for CCL1 Gene

Enhancers for CCL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H034387 1.6 FANTOM5 Ensembl ENCODE dbSUPER 47.9 -24.2 -24224 0 SMARCE1 ATF1 MTA2 ZBTB11 MAFG DPF2 ZNF592 FOSL1 ZNF316 SMARCA4 CCL1 CCL2 CCL7 CCL8 GC17M034364 GC17P034446
GH17H034386 0.8 FANTOM5 dbSUPER 49.3 -23.5 -23501 0 ZNF316 ZKSCAN8 ZBTB11 ATF7 CCL1 CCL2 GC17M034364 GC17P034446
GH17H034399 1.2 FANTOM5 ENCODE dbSUPER 17.8 -36.0 -35988 0 ATF1 L3MBTL2 NR4A1 MAX CEBPG ZNF592 HMBOX1 NR2C2 MGA CCL7 CCL1 CCL8 CCL2 GC17M034364 GC17P034446
GH17H034245 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +110.3 110323 14 PKNOX1 SIN3A GLIS2 FOS RUNX3 CREM REST ELF1 ZNF518A NR2F2 CCL7 CCL11 CCL1 CCL8 ASIC2 CCL2 GC17M034278
GH17H034237 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +122.3 122348 7 SRF DPF2 REST NR2F2 JUND POLR2A ZNF512 IKZF1 FOXP2 RCOR1 CCL7 CCL8 CCL1 ASIC2 CCL2 GC17M034278 GC17P034213
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL1 Gene

Chromosome:
17
Start:
34,360,328 bp from pter
End:
34,363,233 bp from pter
Size:
2,906 bases
Orientation:
Minus strand

Genomic View for CCL1 Gene

Genes around CCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL1 Gene

Proteins for CCL1 Gene

  • Protein details for CCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22362-CCL1_HUMAN
    Recommended name:
    C-C motif chemokine 1
    Protein Accession:
    P22362
    Secondary Accessions:
    • B2R5G9
    • Q2M309

    Protein attributes for CCL1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10992 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL1 Gene

neXtProt entry for CCL1 Gene

Post-translational modifications for CCL1 Gene

Other Protein References for CCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL1 (CCL1/I-309/TCA-3)

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for CCL1
  • Abcam assays for CCL1

No data available for DME Specific Peptides for CCL1 Gene

Domains & Families for CCL1 Gene

Gene Families for CCL1 Gene

Protein Domains for CCL1 Gene

Suggested Antigen Peptide Sequences for CCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22362

UniProtKB/Swiss-Prot:

CCL1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL1: view

Function for CCL1 Gene

Molecular function for CCL1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA).

Phenotypes From GWAS Catalog for CCL1 Gene

Gene Ontology (GO) - Molecular Function for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008009 chemokine activity IDA 1557400
GO:0048020 CCR chemokine receptor binding IBA --
genes like me logo Genes that share ontologies with CCL1: view
genes like me logo Genes that share phenotypes with CCL1: view

Animal Models for CCL1 Gene

MGI Knock Outs for CCL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL1 Gene

Localization for CCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 1557400
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CCL1 Gene

Pathways & Interactions for CCL1 Gene

genes like me logo Genes that share pathways with CCL1: view

SIGNOR curated interactions for CCL1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis TAS 9417093
GO:0006935 chemotaxis TAS 9417093
GO:0006954 inflammatory response IBA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9417093
genes like me logo Genes that share ontologies with CCL1: view

Drugs & Compounds for CCL1 Gene

(4) Drugs for CCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL1: view

Transcripts for CCL1 Gene

mRNA/cDNA for CCL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL1 Gene

Chemokine (C-C motif) ligand 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCL1 Gene

No ASD Table

Relevant External Links for CCL1 Gene

GeneLoc Exon Structure for
CCL1
ECgene alternative splicing isoforms for
CCL1

Expression for CCL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL1 Gene

This gene is overexpressed in Testis (x10.6).

NURSA nuclear receptor signaling pathways regulating expression of CCL1 Gene:

CCL1

SOURCE GeneReport for Unigene cluster for CCL1 Gene:

Hs.72918

Evidence on tissue expression from TISSUES for CCL1 Gene

  • Nervous system(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with CCL1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL1 Gene

Orthologs for CCL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL1 33 34
  • 98.61 (n)
cow
(Bos Taurus)
Mammalia CCL1 33 34
  • 69.23 (n)
dog
(Canis familiaris)
Mammalia CCL1 33 34
  • 69.23 (n)
rat
(Rattus norvegicus)
Mammalia Ccl1 33
  • 64.1 (n)
mouse
(Mus musculus)
Mammalia Ccl1 33 16 34
  • 62.27 (n)
Species where no ortholog for CCL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL1 Gene

ENSEMBL:
Gene Tree for CCL1 (if available)
TreeFam:
Gene Tree for CCL1 (if available)

Paralogs for CCL1 Gene

(19) SIMAP similar genes for CCL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL1: view

No data available for Paralogs for CCL1 Gene

Variants for CCL1 Gene

Sequence variations from dbSNP and Humsavar for CCL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000144556 -- 34,361,237(+) GCCCC(A/G)AGAGG intron-variant
rs1000318014 -- 34,364,681(+) TACTC(A/G)GAATA upstream-variant-2KB
rs1000349152 -- 34,364,344(+) TCACT(C/G)TGTTC upstream-variant-2KB
rs1000626190 -- 34,361,037(+) GACTC(A/G)TGTGT intron-variant
rs1000680953 -- 34,363,076(+) GCCTG(C/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL1 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL1 Gene

Disorders for CCL1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CCL1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
igg4-related sclerosing cholangitis
tolosa-hunt syndrome
  • tolosa hunt syndrome
anterior spinal artery syndrome
  • anterior spinal artery occlusion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CCL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL1

Genetic Association Database (GAD)
CCL1
Human Genome Epidemiology (HuGE) Navigator
CCL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL1
genes like me logo Genes that share disorders with CCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL1 Gene

Publications for CCL1 Gene

  1. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. (PMID: 2212659) Miller MD … Krangel MS (Journal of immunology (Baltimore, Md. : 1950) 1990) 2 3 4 22 60
  2. Human CC chemokine I-309, structural consequences of the additional disulfide bond. (PMID: 10821677) Keizer DW … Sykes BD (Biochemistry 2000) 3 4 22 60
  3. The human cytokine I-309 is a monocyte chemoattractant. (PMID: 1557400) Miller MD … Krangel MS (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 60
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 45 60
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60

Products for CCL1 Gene

Sources for CCL1 Gene

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