Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCL1 Gene

Aliases for CCL1 Gene

  • C-C Motif Chemokine Ligand 1 2 3
  • T Lymphocyte-Secreted Protein I-309 2 3 4
  • Chemokine (C-C Motif) Ligand 1 2 3 5
  • Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3) 2 3
  • Inflammatory Cytokine I-309 2 3
  • SCYA1 3 4
  • Small-Inducible Cytokine A1 4
  • I-309 3
  • P500 3
  • SISe 3
  • TCA3 3

External Ids for CCL1 Gene

Previous HGNC Symbols for CCL1 Gene

  • SCYA1

Previous GeneCards Identifiers for CCL1 Gene

  • GC17M032457
  • GC17M034727
  • GC17M032536
  • GC17M032832
  • GC17M029711
  • GC17M032687
  • GC17M028873

Summaries for CCL1 Gene

Entrez Gene Summary for CCL1 Gene

  • This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

GeneCards Summary for CCL1 Gene

CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include igg4-related sclerosing cholangitis and kaposi sarcoma. Among its related pathways are Signaling by GPCR and ERK Signaling. GO annotations related to this gene include cytokine activity and chemokine activity.

UniProtKB/Swiss-Prot for CCL1 Gene

  • Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL1 Gene

Genomics for CCL1 Gene

Regulatory Elements for CCL1 Gene

Genomic Location for CCL1 Gene

Chromosome:
17
Start:
34,360,328 bp from pter
End:
34,363,233 bp from pter
Size:
2,906 bases
Orientation:
Minus strand

Genomic View for CCL1 Gene

Genes around CCL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL1 Gene

Proteins for CCL1 Gene

  • Protein details for CCL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22362-CCL1_HUMAN
    Recommended name:
    C-C motif chemokine 1
    Protein Accession:
    P22362
    Secondary Accessions:
    • B2R5G9
    • Q2M309

    Protein attributes for CCL1 Gene

    Size:
    96 amino acids
    Molecular mass:
    10992 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CCL1 Gene

neXtProt entry for CCL1 Gene

Proteomics data for CCL1 Gene at MOPED

Post-translational modifications for CCL1 Gene

Other Protein References for CCL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL1 (CCL1/I-309/TCA-3)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CCL1

No data available for DME Specific Peptides for CCL1 Gene

Domains & Families for CCL1 Gene

Gene Families for CCL1 Gene

Protein Domains for CCL1 Gene

Suggested Antigen Peptide Sequences for CCL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22362

UniProtKB/Swiss-Prot:

CCL1_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL1: view

Function for CCL1 Gene

Molecular function for CCL1 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA).

Gene Ontology (GO) - Molecular Function for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CCL1: view
genes like me logo Genes that share phenotypes with CCL1: view

Animal Models for CCL1 Gene

MGI Knock Outs for CCL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCL1 Gene

Localization for CCL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCL1 Gene COMPARTMENTS Subcellular localization image for CCL1 gene
Compartment Confidence
extracellular 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for CCL1 Gene

Pathways & Interactions for CCL1 Gene

genes like me logo Genes that share pathways with CCL1: view

SIGNOR curated interactions for CCL1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CCL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IBA --
GO:0006935 chemotaxis IEA,TAS 9417093
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9417093
GO:0007186 G-protein coupled receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with CCL1: view

Drugs & Compounds for CCL1 Gene

(4) Drugs for CCL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CCL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CCL1: view

Transcripts for CCL1 Gene

mRNA/cDNA for CCL1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCL1 Gene

Chemokine (C-C motif) ligand 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCL1 Gene

No ASD Table

Relevant External Links for CCL1 Gene

GeneLoc Exon Structure for
CCL1
ECgene alternative splicing isoforms for
CCL1

Expression for CCL1 Gene

mRNA expression in normal human tissues for CCL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCL1 Gene

This gene is overexpressed in Testis (x10.6).

SOURCE GeneReport for Unigene cluster for CCL1 Gene Hs.72918

genes like me logo Genes that share expression patterns with CCL1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCL1 Gene

Orthologs for CCL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL1 35
  • 98.61 (n)
  • 97.89 (a)
CCL1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCL1 36
  • 51 (a)
OneToOne
CCL1 35
  • 69.23 (n)
  • 52.75 (a)
dog
(Canis familiaris)
Mammalia CCL1 35
  • 69.23 (n)
  • 50.55 (a)
CCL1 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccl1 36
  • 42 (a)
OneToOne
Ccl1 16
Ccl1 35
  • 62.27 (n)
  • 42.86 (a)
rat
(Rattus norvegicus)
Mammalia Ccl1 35
  • 64.1 (n)
  • 43.96 (a)
Species with no ortholog for CCL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL1 Gene

ENSEMBL:
Gene Tree for CCL1 (if available)
TreeFam:
Gene Tree for CCL1 (if available)

Paralogs for CCL1 Gene

(19) SIMAP similar genes for CCL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCL1: view

No data available for Paralogs for CCL1 Gene

Variants for CCL1 Gene

Sequence variations from dbSNP and Humsavar for CCL1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs159273 -- 34,363,666(+) CAAAT(G/T)CATAT upstream-variant-2KB
rs159279 -- 34,365,168(+) AGTCC(A/G)CTCTC upstream-variant-2KB
rs2282692 -- 34,361,164(-) CCAGA(G/T)AGTAA intron-variant
rs3136681 -- 34,360,209(+) AAAGC(G/T)TACAC downstream-variant-500B
rs3136682 -- 34,360,423(+) TGCAA(C/T)AACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCL1 Gene

Variant ID Type Subtype PubMed ID
nsv519297 CNV Gain 19592680
nsv517423 CNV Gain+Loss 19592680

Variation tolerance for CCL1 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL1 Gene

HapMap Linkage Disequilibrium report
CCL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL1 Gene

Disorders for CCL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CCL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
igg4-related sclerosing cholangitis
kaposi sarcoma
  • human herpesvirus 8
- elite association - COSMIC cancer census association via MalaCards
Search CCL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL1

Genetic Association Database (GAD)
CCL1
Human Genome Epidemiology (HuGE) Navigator
CCL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL1
genes like me logo Genes that share disorders with CCL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL1 Gene

Publications for CCL1 Gene

  1. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. (PMID: 2212659) Miller M.D. … Krangel M.S. (J. Immunol. 1990) 2 3 4 23 67
  2. Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. (PMID: 17641040) Gonzalo J.A. … Coyle A.J. (J. Immunol. 2007) 3 23
  3. Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene. (PMID: 16679317) N'Diaye M. … Fardel O. (J. Biol. Chem. 2006) 3 23
  4. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2). (PMID: 16735693) Sironi M. … Mantovani A. (J. Leukoc. Biol. 2006) 3 23
  5. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. (PMID: 15814739) Gombert M. … Homey B. (J. Immunol. 2005) 3 23

Products for CCL1 Gene

Sources for CCL1 Gene

Back to Top

Content