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CCKBR Gene

protein-coding   GIFtS: 71
GCID: GC11P006280

Cholecystokinin B Receptor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholecystokinin B Receptor1 2     CCK-B2
Cholecystokinin-2 Receptor2 3     CCK2R2
CCK-BR2 3     CCK2 Receptor2
CCK2-R2 3     Gastrin Receptor2
CCK-B Receptor2 3     Gastrin/Cholecystokinin Type B Receptor2
GASR2 5     CCKRB3

External Ids:    HGNC: 15711   Entrez Gene: 8872   Ensembl: ENSG000001101487   OMIM: 1184455   UniProtKB: P322393   

Export aliases for CCKBR gene to outside databases

Previous GC identifers: GC11P007024 GC11P006741 GC11P006240 GC11P006245 GC11P006237 GC11P005940


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCKBR Gene:
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the
brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both
sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the
gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from
colorectal and pancreatic tumors. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCKBR Gene:
CCKBR (cholecystokinin B receptor) is a protein-coding gene. Diseases associated with CCKBR include duodenal gastrinoma, and agoraphobia. GO annotations related to this gene include cholecystokinin receptor activity and phosphatidylinositol phospholipase C activity. An important paralog of this gene is GPR19.

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous
system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its
action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a
gastrin-independent mechanism

summary for CCKBR Gene:
The cholecystokinin2 receptor (CCK1 receptor, CCK-B receptor) is a member of the cholecystokinin receptor
group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain,
spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid
release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized
to chromosome 11 (11p15.4).

Gene Wiki entry for CCKBR (Cholecystokinin B receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCKBR gene promoter:
         GR   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCKBR promoter sequence
   Search Chromatin IP Primers for CCKBR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCKBR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

CCKBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCKBR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006280:  view genomic region     (about GC identifiers)

Start:
6,280,966 bp from pter      End:
6,293,357 bp from pter
Size:
12,392 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GASR_HUMAN, P32239 (See protein sequence)
Recommended Name: Gastrin/cholecystokinin type B receptor  
Size: 447 amino acids; 48419 Da
1 PDB 3D structure from and Proteopedia for CCKBR:
1L4T (3D)    
Secondary accessions: A8K7P9 O75824 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1
Alternative splicing: 3 isoforms:  P32239-1   P32239-2   P32239-3   

Explore the universe of human proteins at neXtProt for CCKBR: NX_P32239

Explore proteomics data for CCKBR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7, Asn30, Asn36
  • Modification sites at PhosphoSitePlus

  • See CCKBR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_795344.1  
    ENSEMBL proteins: 
     ENSP00000335544   ENSP00000432079   ENSP00000437001   ENSP00000435675   ENSP00000435534  
    Reactome Protein details: P32239

    CCKBR Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCKBR
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    Novus Biologicals CCKBR Proteins
    Novus Biologicals CCKBR Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CCKBR

    CCKBR Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CCKBR

    CCKBR Assay Products:

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    Cloud-Clone Corp. ELISAs for CCKBR
    Cloud-Clone Corp. CLIAs for CCKBR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CCKNR: GPCR / Class A : Cholecystokinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCK2 receptor
    Cholecystokinin receptors

    4 InterPro protein domains:
     IPR000314 Gastrin_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR009126 Cholcskin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32239

    ProtoNet protein and cluster: P32239

    1 Blocks protein domain: IPB000314 Gastrin receptor signature

    UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
    Similarity: Belongs to the G-protein coupled receptor 1 family


    CCKBR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GASR_HUMAN, P32239
    Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous
    system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its
    action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
    Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a
    gastrin-independent mechanism

         Genatlas biochemistry entry for CCKBR:
    cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol
    cycle,expressed in brain,pancreas and stomach

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004435phosphatidylinositol phospholipase C activity TAS7681836
    GO:0004930G-protein coupled receptor activity ----
    GO:0004951cholecystokinin receptor activity TAS7681836
    GO:0005515protein binding IPI16963136
    GO:0015054gastrin receptor activity IDA10913157
         
    CCKBR for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cckbr):
     behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  immune system  integument  liver/biliary system  nervous system 
     renal/urinary system 

    CCKBR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cckbrtm1Kpn for CCKBR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCKBR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCKBR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCKBR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCKBR

    miRNA
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    miRTarBase miRNAs that target CCKBR:
    hsa-mir-148a-3p (MIRT005898), hsa-mir-148b-3p (MIRT005759)

    Block miRNA regulation of human, mouse, rat CCKBR using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CCKBR:
    hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-4276 hsa-miR-512-3p hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidCCKBR 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CCKBR

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CCKBR

    Clone
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    OriGene clones in human, mouse for CCKBR (see all 7)
    OriGene ORF clones in mouse, rat for CCKBR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCKBR (NM_176875)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCKBR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKBR

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKBR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GASR_HUMAN, P32239: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC10913157
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    CCKBR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCKBR About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5VEGF Pathway
    CCKBR-Gastrin Stimulated Signaling0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CCKBR
        CCKBR-Gastrin Stimulated Signaling

    3 BioSystems Pathways for CCKBR
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    3 Reactome Pathways for CCKBR
        Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    G alpha (q) signalling events

    1 PharmGKB Pathway for CCKBR
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CCKBR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Gastric acid secretion


    CCKBR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCKBR: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCKBR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCKBR (P322391, 2, 3 ENSP000003355444) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061241, 2, 3, ENSP000003409444EBI-1753137,EBI-297779 MINT-3381410 MINT-3381756 MINT-3381499 MINT-3381872 MINT-8037752 I2D: score=2 STRING: ENSP00000340944
    ABL1P005192, 3, ENSP000003614234MINT-8110407 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111247 I2D: score=3 STRING: ENSP00000357656
    PPP1R9BQ96SB32, 3MINT-4953514 I2D: score=2 
    CCKP063073, ENSP000003356574I2D: score=2 STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001696gastric acid secretion IEA--
    GO:0007166cell surface receptor signaling pathway NAS10913157
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8455720
    GO:0007204positive regulation of cytosolic calcium ion concentration IDA10913157

    CCKBR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCKBR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    L-365,260 Selective CCK2 antagonist[118101-09-0]
    CI 988Potent and selective CCK2 antagonist[130332-27-3]
    YM 022 Highly potent, selective non-peptide CCK2 antagonist [145084-28-2]
    PD 135158Potent and selective CCK2 antagonist[130325-35-8]
    Gastrin I (human)Selective CCK2 agonist[10047-33-3]

    1 HMDB Compound for CCKBR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CCKBR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pentagastrin-- 5534-95-2targetagonist12073167 3004700 7491961 11752352 15157745 1732532

    Selected IUPHAR Ligands for CCKBR (CCK2 receptor) (see all 23)    About this table
    LigandTypeActionAffinityPubmed IDs
    CCK-8
    AgonistFull agonist9.9 - 107681836 8349705
    YF-476
    AntagonistAntagonist9.611738246
    [125I]PD142308
    AntagonistAntagonist9.6--
    GV150013
    AntagonistAntagonist9.411020274
    Z-360
    AntagonistAntagonist9.317901954
    L-740093
    AntagonistAntagonist9.211738246
    YM-022
    AntagonistAntagonist9.211738246
    CI-988
    AntagonistAntagonist9.18914862
    [3H]gastrin
    AgonistFull agonist9--
    [125I]gastrin
    AgonistFull agonist9--

    Selected Novoseek inferred chemical compound relationships for CCKBR gene (see all 78)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastrin 17 92.6 8 15128280 (2), 16143134 (2), 11551823 (1), 10477091 (1)
    ym022 90.3 16 8886928 (3), 9296353 (2), 9792209 (2), 8698625 (2) (see all 9)
    minigastrin 90.3 5 12658727 (1), 11965605 (1), 16204724 (1), 11713969 (1)
    gv 150013 88 1 17208221 (1)
    l365260 87.6 11 9834332 (2), 18310296 (1), 8208791 (1), 8663021 (1) (see all 9)
    pro-gastrin 86.6 15 19652364 (5), 10931047 (3), 10190738 (2), 12353842 (1) (see all 6)
    pd 134308 85.5 6 1628146 (1), 9489608 (1), 1881533 (1), 8914862 (1) (see all 5)
    benzotript 85.3 1 11408175 (1)
    devazepide 84.5 10 1893248 (1), 1611514 (1), 9885794 (1), 8216742 (1) (see all 9)
    pd 135158 82.7 2 7890609 (1), 1679211 (1)



    CCKBR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCKBR gene: 
    NM_176875.3  

    Unigene Cluster for CCKBR:

    Cholecystokinin B receptor
    Hs.203  [show with all ESTs]
    Unigene Representative Sequence: NM_176875
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334619(uc001mcp.3 uc001mcq.3 uc001mcr.3) ENST00000532715(uc001mct.1)
    ENST00000525014 ENST00000531712 ENST00000525462(uc001mcs.3) ENST00000532396


    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CCKBR:
    hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-4276 hsa-miR-512-3p hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidCCKBR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCKBR
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCKBR (NM_176875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCKBR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKBR
    Primer
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    OriGene qPCR primer pairs and template standards for CCKBR
    OriGene qSTAR qPCR primer pairs in human, mouse for CCKBR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCKBR
      QuantiTect SYBR Green Assays in human, mouse, rat CCKBR
      QuantiFast Probe-based Assays in human, mouse, rat CCKBR

    Additional mRNA sequence: 

    AF239668.1 AF441129.1 AK226020.1 AK292064.1 AK314266.1 AY029770.1 AY322551.1 BC000740.2 
    BT006789.1 D13305.1 DQ335648.1 DQ335649.1 DQ335650.1 DQ335651.1 L04473.1 L07746.1 
    L08112.1 S70057.1 S76072.1 Y13464.1 

    5 DOTS entries:

    DT.110406  DT.91756568  DT.120703403  DT.91756569  DT.95365965 

    Selected AceView cDNA sequences (see all 28):

    AU125231 L08112 S76072 CB155083 BF725652 Y13464 AY322551 BM709271 
    AA626526 NM_176875 AF239668 AI734207 BC000740 AF441129 AI655414 AY029770 
    D13305 S70057 BE279525 AI791122 AU132610 BT006789 L07746 L04473 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:                          -                 -                                 
    SP2:                          -     -     -     -                                 
    SP3:                          -                 -                                 
    SP4:                                                                              
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for CCKBR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CCKBR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTGACCT
    CCKBR Expression
    About this image


    CCKBR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    CCKBR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCKBR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.203

    UniProtKB/Swiss-Prot: GASR_HUMAN, P32239
    Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the
    T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer
    cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in
    NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high
    levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in
    pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is
    expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCKBR gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cckbr1 , 5 cholecystokinin B receptor1, 5 85.54(n)1
    89.66(a)1
      7 (55.86 cM)5
    124261  NM_007627.41  NP_031653.11 
     1054258175 
    chicken
    (Gallus gallus)
    Aves CCKBR1 cholecystokinin B receptor 65.79(n)
    61.96(a)
      414885  NM_001001742.1  NP_001001742.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCKBR6
    cholecystokinin B receptor
    49(a)
    1 ↔ 1
    AAWZ02039005(4432-5013)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003314651 cholecystokinin receptor-like 58.41(n)
    55.66(a)
      100331465  XM_002663315.3  XP_002663361.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CCKLR-17D11 CCK-like receptor at 17D1 50.26(n)
    40.87(a)
      32860  NM_001103551.2  NP_001097021.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39A3B.53 7 transmembrane receptor 35(a)   III(2082817-2087836)   --


    ENSEMBL Gene Tree for CCKBR (if available)
    TreeFam Gene Tree for CCKBR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCKBR gene
    GPR192  CCKAR2  
    8 SIMAP similar genes for CCKBR using alignment to 8 protein entries:     GASR_HUMAN (see all proteins):
    HTR2B    CX3CR1    GHSR    HCRTR2    CCKAR    HTR2A
    CCR3    CCR5

    CCKBR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCKBR (see all 560)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865574071,2
    --6193477(+) TGGATA/GAGCTG 1 -- us2k10--------
    rs1481536521,2
    --6193569(+) TAAATC/TCTCCA 1 -- us2k10--------
    rs1426499931,2
    --6193630(+) AAGGAA/GCATAG 1 -- us2k10--------
    rs1467042701,2
    --6193700(+) CTTAAC/TGACCA 1 -- us2k10--------
    rs1157387121,2
    F--6193702(+) TAACGA/CCCATA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1925588841,2
    --6193904(+) ATCCAA/GTGTGG 1 -- us2k10--------
    rs1392680971,2
    --6193926(+) CAGGTA/TATCTG 1 -- us2k10--------
    rs1432433891,2
    --6193963(+) AAATAA/GCAAAT 1 -- us2k10--------
    rs1504252491,2
    --6194029(+) GGAAAG/TGGGGA 1 -- us2k10--------
    rs1382417851,2
    C--6194082(+) TTTCAA/GTGCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCKBR (6280966 - 6293357 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCKBR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7656CNV Loss18451855

    Human Gene Mutation Database (HGMD): CCKBR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCKBR
    DNA2.0 Custom Variant and Variant Library Synthesis for CCKBR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118445    OMIM disorders: --

    Selected diseases for CCKBR (see all 55):    
    About MalaCards
    duodenal gastrinoma    agoraphobia    gastrinoma    panic disorder
    generalized anxiety disorder    stomach cancer    anxiety disorder    opiate dependence
    multiple chemical sensitivity    gastric ulcer    morphine dependence    pain agnosia
    gastritis    islet cell tumor    agnosia    atrophic gastritis
    pancreatic cancer    neuroendocrine tumor    peptic ulcer    thyroid cancer

    5 diseases from the University of Copenhagen DISEASES database for CCKBR:
    Panic disorder     Pain agnosia     Pancreatic cancer     Opiate dependence
    Agoraphobia

    CCKBR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CCKBR gene (see all 70)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian stromal cancer 89 6 12658727 (1), 11965605 (1), 9102227 (1), 9553173 (1) (see all 5)
    panic attacks 70.2 6 8455720 (1), 15991924 (1), 17546345 (1), 9160564 (1) (see all 6)
    thyroid carcinoma medullary 68.7 23 8782652 (3), 11713969 (3), 16832634 (2), 12658724 (1) (see all 14)
    panic disorder 64.5 31 7786960 (3), 11803530 (3), 11515749 (3), 11244486 (2) (see all 18)
    panic 62.5 10 8985712 (2), 8955527 (1), 8580227 (1), 8879478 (1) (see all 8)
    gastrinoma 56.4 4 18194935 (2), 9071943 (1)
    colon cancer 56.3 45 16998832 (6), 15694043 (4), 15951156 (3), 11059789 (2) (see all 24)
    pancreatic cancer 56.1 34 10931047 (3), 10228846 (2), 11444473 (2), 19131241 (2) (see all 21)
    gastric cancer 52 28 15040018 (4), 17064598 (2), 8844981 (2), 20150185 (1) (see all 19)
    neuroendocrine tumors 51.6 7 12658724 (1), 12658727 (1), 19853977 (1), 11965605 (1) (see all 6)

    Genetic Association Database (GAD): CCKBR
    Human Genome Epidemiology (HuGE) Navigator: CCKBR (24 documents)

    Export disorders for CCKBR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCKBR gene, integrated from 10 sources (see all 539):
    (articles sorted by number of sources associating them with CCKBR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PubMed id 1280419)1, 2, 3, 9 Pisegna J.R.... Wank S.A. (Biochem. Biophys. Res. Commun. 1992)
    2. Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PubMed id 11515749)1, 4, 9 Yamada K....Yoshikawa T. (J Neural Transm 2001)
    3. Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. (PubMed id 10913157)1, 2, 9 Hellmich M.R....Townsend C.M. Jr. (J. Biol. Chem. 2000)
    4. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. (PubMed id 7887934)1, 2, 9 Miyake A. (Biochem. Biophys. Res. Commun. 1995)
    5. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. (PubMed id 7681836)1, 2, 9 Lee Y.-M....Kopin A.S. (J. Biol. Chem. 1993)
    6. Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. (PubMed id 11926817)1, 2, 9 Giragossian C. and Mierke D.F. (Biochemistry 2002)
    7. No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (PubMed id 11244486)1, 4, 9 Hamilton S.P....Knowles J.A. (Mol. Psychiatry 2001)
    8. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)1, 4, 9 Goldman J.G....Zhou L. (Arch. Neurol. 2004)
    9. Gene variations in the cholecystokinin system in patients with panic disorder. (PubMed id 20023595)1, 4, 9 Koefoed P....Rehfeld J.F. (Psychiatr. Genet. 2010)
    10. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 9 Okubo T....Matsushita S. (Alcohol. Clin. Exp. Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 887 HGNC: 1571 AceView: CCKBR Ensembl:ENSG00000110148 euGenes: HUgn887
    ECgene: CCKBR Kegg: 887 H-InvDB: CCKBR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCKBR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCKBR Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cholecystokinin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCKBR gene:
    Search GeneIP for patents involving CCKBR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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