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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCKBR Gene

protein-coding GIFtS: 70
GCID: GC11P006280

cholecystokinin B receptor

Explore 60 diseases affiliated with
CCKBR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cholecystokinin B Receptor¹ ²		CCK-B²
Cholecystokinin-2 Receptor² ³		CCK2R²
CCK-BR² ³		CCK2 Receptor²
CCK2-R² ³		Gastrin Receptor²
CCK-B Receptor² ³		Gastrin/Cholecystokinin Type B Receptor²
GASR² ⁵		CCKRB³

External Ids:	HGNC: 1571¹	Entrez Gene: 887²	Ensembl: ENSG00000110148⁷	OMIM: 118445⁵	UniProtKB: P32239³

Export aliases for CCKBR gene to outside databases

Previous GC identifers: GC11P007024 GC11P006741 GC11P006240 GC11P006245 GC11P006237 GC11P005940

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCKBR:

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain

and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and

nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A

misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system

where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by

association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent

mechanism

summary for CCKBR:

The cholecystokinin2 receptor (CCK1 receptor, CCK-B receptor) is a member of the cholecystokinin receptor

group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain,

spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid

release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized

to chromosome 11 (11p15.4).

Gene Wiki entry for CCKBR (Cholecystokinin B receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCKBR gene promoter:
GR GR-beta STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCKBR promoter sequence

Search SABiosciences Chromatin IP Primers for CCKBR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCKBR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

CCKBR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCKBR gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P006280: view genomic region (about GC identifiers)

Start:	6,280,966 bp from pter	End:	6,293,357 bp from pter
Size:	12,392 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239 (See protein sequence)

Recommended Name: Gastrin/cholecystokinin type B receptor

Size: 447 amino acids; 48419 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for CCKBR:

1L4T (3D)

Secondary accessions: A8K7P9 O75824 Q16144 Q92492 Q96LC6 Q9NYK7 Q9UBV1

Alternative splicing: 3 isoforms: P32239-1 P32239-2 P32239-3

Explore the universe of human proteins at neXtProt for CCKBR: NX_P32239

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P32239

CCKBR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_795344.1

ENSEMBL proteins:

ENSP00000335544 ENSP00000432079 ENSP00000437001 ENSP00000435675 ENSP00000435534

Reactome Protein details: P32239
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CCKBR Protein
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	Novus Biologicals CCKBR Proteins Novus Biologicals CCKBR Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CCKBR

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IC	10913157

CCKBR for ontologies About GeneDecksing

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Assay Products for CCKBR:

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	GenScript CCKBR-overexpressing Cell Line for Assay
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CCKBR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCKBR for domains About GeneDecksing

4 InterPro domains/families:

IPR000314 Gastrin_rcpt

IPR017452 GPCR_Rhodpsn_7TM

IPR009126 Cholcskin_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P32239

ProtoNet protein and cluster: P32239

1 Blocks protein family: IPB000314 Gastrin receptor signature

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system

where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by

association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent

mechanism

Genatlas biochemistry entry for CCKBR:

cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol

cycle,expressed in brain,pancreas and stomach

miRNA Products:		miRTarBase miRNAs that target CCKBR: hsa-mir-148a (MIRT005898), hsa-mir-148b (MIRT005759)

		OriGene 3'-UTR Clone: CCKBR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCKBR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CCKBR:
		hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-4276 hsa-miR-512-3p hsa-miR-148a
		SwitchGear 3'UTR luciferase reporter plasmid: CCKBR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCKBR (see all 7) OriGene shRNA RFP: CCKBR OriGene siRNA: CCKBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCKBR

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CCKBR

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		GenScript: all cDNA clones in your preferred vector: CCKBR (NM_176875)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCKBR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKBR

Cell Line Products:		GenScript CCKBR-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for CCKBR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKBR

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004435	phosphatidylinositol phospholipase C activity	TAS	7681836
GO:0004951	cholecystokinin receptor activity	TAS	7681836
GO:0005515	protein binding	--	--
GO:0015054	gastrin receptor activity	IDA	10913157
GO:0031741	type B gastrin/cholecystokinin receptor binding	IDA	8185642

CCKBR for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cckbr^tm1Kpn for CCKBR
     11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cckbr):

behavior/neurological	cardiovascular system	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	immune system	integument	liver/biliary system	nervous system
renal/urinary system

CCKBR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
Peptide ligand-binding receptors	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Proton Pump Inhibitor Pathway, Pharmacodynamics

Proton Pump Inhibitor Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCKBR

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CCKBR

CCKBR-Gastrin Stimulated Signaling

3 BioSystems Pathways for CCKBR

	GPCRs, Other
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/8 Reactome Pathways for CCKBR (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

1 PharmGKB Pathway for CCKBR

Proton Pump Inhibitor Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for CCKBR):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion

CCKBR for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCKBR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/134 Interacting proteins for CCKBR (P32239^{2, 3} ENSP00000335544⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 134)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-3381410 MINT-3381756 MINT-3381499 MINT-3381872 MINT-8037752 I2D: score=2 STRING: ENSP00000340944
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-8110407 I2D: score=3 STRING: ENSP00000361423
FYN	P06241²^,³, ENSP00000357656⁴	MINT-8111247 I2D: score=3 STRING: ENSP00000357656
PPP1R9B	Q96SB3²^,³	MINT-4953514 I2D: score=2
CCK	P06307³, ENSP00000335657⁴	I2D: score=2 STRING: ENSP00000335657

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001821	histamine secretion	--	--
GO:0002209	behavioral defense response	--	--
GO:0006915	apoptotic process	--	--
GO:0007166	cell surface receptor signaling pathway	NAS	10913157
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	TAS	8455720

CCKBR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCKBR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CCKBR available from Tocris Bioscience About this table

Compound	Action	CAS #
L-365,260	Selective CCK2 antagonist	[118101-09-0]
YM 022	Highly potent, selective non-peptide CCK2 antagonist	[145084-28-2]
CI 988	Potent and selective CCK2 antagonist	[130332-27-3]
LY 225910	Potent CCK2 antagonist	[133040-77-4]
PD 135158	Potent and selective CCK2 antagonist	[130325-35-8]

1 HMDB Compound for CCKBR About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for CCKBR About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pentagastrin	--	5534-95-2	target	agonist	12073167 3004700 7491961 11752352 15157745 1732532

10/78 Novoseek chemical compound relationships for CCKBR gene (see all 78) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastrin 17	92.6	8	15128280 (2), 16143134 (2), 11551823 (1), 10477091 (1)
ym022	90.3	16	8886928 (3), 9296353 (2), 9792209 (2), 8698625 (2) (see all 9)
minigastrin	90.3	5	12658727 (1), 11965605 (1), 16204724 (1), 11713969 (1)
gv 150013	88	1	17208221 (1)
l365260	87.6	11	9834332 (2), 18310296 (1), 8208791 (1), 8663021 (1) (see all 9)
pro-gastrin	86.6	15	19652364 (5), 10931047 (3), 10190738 (2), 12353842 (1) (see all 6)
pd 134308	85.5	6	1628146 (1), 9489608 (1), 1881533 (1), 8914862 (1) (see all 5)
benzotript	85.3	1	11408175 (1)
devazepide	84.5	10	1893248 (1), 1611514 (1), 9885794 (1), 8216742 (1) (see all 9)
pd 135158	82.7	2	7890609 (1), 1679211 (1)

Search CenterWatch for drugs/clinical trials and news about CCKBR / GASR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCKBR gene:

NM_176875.3

Unigene Cluster for CCKBR:

Cholecystokinin B receptor

Hs.203 [show with all ESTs]

Unigene Representative Sequence: NM_176875

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000334619(uc001mcp.3 uc001mcq.3 uc001mcr.3) ENST00000532715(uc001mct.1)

ENST00000525014 ENST00000531712 ENST00000525462(uc001mcs.3) ENST00000532396

miRNA Products:		OriGene 3'-UTR Clone: CCKBR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCKBR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate CCKBR:
		hsa-miR-152 hsa-miR-1294 hsa-miR-148b hsa-miR-4276 hsa-miR-512-3p hsa-miR-148a
		SwitchGear 3'UTR luciferase reporter plasmid: CCKBR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCKBR (see all 7) OriGene shRNA RFP: CCKBR OriGene siRNA: CCKBR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCKBR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCKBR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCKBR OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CCKBR (NM_176875)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCKBR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKBR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCKBR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CCKBR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCKBR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCKBR

Additional cDNA sequence:

AF239668.1 AF441129.1 AK226020.1 AK292064.1 AK314266.1 AY029770.1 AY322551.1 BC000740.2

BT006789.1 D13305.1 DQ335648.1 DQ335649.1 DQ335650.1 DQ335651.1 L04473.1 L07746.1

L08112.1 S70057.1 S76072.1 Y13464.1

5 DOTS entries:

DT.110406 DT.91756568 DT.120703403 DT.91756569 DT.95365965

24/28 AceView cDNA sequences (see all 28):

BM709271 AU125231 S76072 Y13464 AY322551 CB155083 L08112 BF725652

BT006789 AI734207 BC000740 D13305 BE279525 NM_176875 AI791122 AU132610

AF239668 AY029770 AA626526 AF441129 S70057 AI655414 L04473 CD013884

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c
SP1:									-						-
SP2:									-		-		-		-
SP3:									-						-
SP4:
SP5:									-

ECgene alternative splicing isoforms for CCKBR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCKBR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACACTGACCT

About this image

CCKBR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Trophoblast

Mural Trophectoderm

Mural Trophectoderm Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues

Liver

Intrahepatic Biliary Tree

Biliary Epithelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation and expan...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Mesoderm-like cells (Derivation of cardio...)

See CCKBR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCKBR

SOURCE GeneReport for Unigene cluster: Hs.203

UniProtKB/Swiss-Prot: GASR_HUMAN, P32239

Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the

T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell

line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345,

NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the

mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer

cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain,

pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo

SABiosciences Expression via Pathway-Focused PCR Arrays including CCKBR:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCKBR Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCKBR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCKBR

In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKBR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CCKBR gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCKBR¹	cholecystokinin B receptor	66.19(n) 62.2(a)		414885 NM_001001742.1 NP_001001742.1
lizard (Anolis carolinensis)	Reptilia	--	--	66(a)	1 ↔ 1	AAWZ02039040(772-4766)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-1h24.2¹	si:dkey-1h24.2	59.2(n) 57.81(a)		100137117 NM_001114714.1 NP_001108186.1
fruit fly (Drosophila melanogaster)	Insecta	CCKLR-17D3⁶ CCKLR-17D1⁶	CCK-like receptor at 17D1	23(a) 19(a)	many ↔ many many ↔ many	X(18658516-18668264) X(18601527-18620605)
worm (Caenorhabditis elegans)	Secernentea	Y39A3B.5³	7 transmembrane receptor	35(a)		III(2082817-2087836) --

ENSEMBL Gene Tree for CCKBR (if available)
TreeFam Gene Tree for CCKBR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CCKBR gene

GPR22² CCKAR²

7 SIMAP similar genes for CCKBR using alignment to 8 protein entries: GASR_HUMAN (see all proteins):

HTR2B CX3CR1 GHSR CCKAR HTR2A CCR3

CCR5

CCKBR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186557407^1,2		--	6279029(+)	`TGGATA/GAGCTG`	1	--	us2k¹		0	--	--	--	--
rs148153652^1,2		--	6279121(+)	`TAAATC/TCTCCA`	1	--	us2k¹		0	--	--	--	--
rs142649993^1,2		--	6279182(+)	`AAGGAA/GCATAG`	1	--	us2k¹		0	--	--	--	--
rs146704270^1,2		--	6279252(+)	`CTTAAC/TGACCA`	1	--	us2k¹		0	--	--	--	--
rs115738712^1,2	F,	--	6279254(+)	`TAACGA/CCCATA`	1	--	us2k¹		1		WA	118
rs192558884^1,2		--	6279456(+)	`ATCCAA/GTGTGG`	1	--	us2k¹		0	--	--	--	--
rs139268097^1,2		--	6279478(+)	`CAGGTA/TATCTG`	1	--	us2k¹		0	--	--	--	--
rs143243389^1,2		--	6279515(+)	`AAATAA/GCAAAT`	1	--	us2k¹		0	--	--	--	--
rs150425249^1,2		--	6279581(+)	`GGAAAG/TGGGGA`	1	--	us2k¹		0	--	--	--	--
rs138241785^1,2		--	6279634(+)	`TTTCAA/GTGCTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCKBR (6280966 - 6293357 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCKBR: --
Human Gene Mutation Database (HGMD): CCKBR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCKBR for disorders           About GeneDecksing

OMIM gene information: 118445    OMIM disorders: --

20/60 diseases for CCKBR (see all 60):    About MalaCards

generalized anxiety disorder obsessive-compulsive disorder pancreatitis anxiety disorder

multiple chemical sensitivity morphine dependence agoraphobia gastrinoma

duodenal gastrinoma panic disorder atrophic gastritis colonic polyps

islet cell tumor peptic ulcer malignant glioma anorexia nervosa

neuroendocrine tumor esophageal squamous cell carcinoma malt lymphoma squamous cell carcinoma

5 diseases from the University of Copenhagen DISEASES database for CCKBR:

Panic disorder Pain agnosia Pancreatic cancer Agoraphobia

Opiate dependence

10/70 Novoseek disease relationships for CCKBR gene (see all 70) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian stromal cancer	89	6	12658727 (1), 11965605 (1), 9102227 (1), 9553173 (1) (see all 5)
panic attacks	70.2	6	8455720 (1), 15991924 (1), 17546345 (1), 9160564 (1) (see all 6)
thyroid carcinoma medullary	68.7	23	8782652 (3), 11713969 (3), 16832634 (2), 12658724 (1) (see all 14)
panic disorder	64.5	31	7786960 (3), 11803530 (3), 11515749 (3), 11244486 (2) (see all 18)
panic	62.5	10	8985712 (2), 8955527 (1), 8580227 (1), 8879478 (1) (see all 8)
gastrinoma	56.4	4	18194935 (2), 9071943 (1)
colon cancer	56.3	45	16998832 (6), 15694043 (4), 15951156 (3), 11059789 (2) (see all 24)
pancreatic cancer	56.1	34	10931047 (3), 10228846 (2), 11444473 (2), 19131241 (2) (see all 21)
gastric cancer	52	28	15040018 (4), 17064598 (2), 8844981 (2), 20150185 (1) (see all 19)
neuroendocrine tumors	51.6	7	12658724 (1), 12658727 (1), 19853977 (1), 11965605 (1) (see all 6)

Genetic Association Database (GAD): CCKBR
Human Genome Epidemiology (HuGE) Navigator: CCKBR (24 documents)

Export disorders for CCKBR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CCKBR gene, integrated from 9 sources (see all 536):
(articles sorted by number of sources associating them with CCKBR)

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Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PubMed id 1280419)^{1, 2, 3, 9} Pisegna J.R.... Wank S.A. (1992)
Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder. (PubMed id 11515749)^{1, 4, 9} Yamada K....Yoshikawa T. (2001)
Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth. (PubMed id 10913157)^{1, 2, 9} Hellmich M.R....Townsend C.M. Jr. (2000)
A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. (PubMed id 7887934)^{1, 2, 9} Miyake A. (1995)
The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. (PubMed id 7681836)^{1, 2, 9} Lee Y.-M....Kopin A.S. (1993)
Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. (PubMed id 11926817)^{1, 2, 9} Giragossian C. and Mierke D.F. (2002)
No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder. (PubMed id 11244486)^{1, 4, 9} Hamilton S.P....Knowles J.A. (2001)
Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)^{1, 4, 9} Goldman J.G....Zhou L. (2004)
Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)^{1, 4, 9} Okubo T....Matsushita S. (2002)
Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene. (PubMed id 7848914)^{1, 2, 9} Ito M.... Matsui T. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 887	HGNC: 1571	AceView: CCKBR	Ensembl:ENSG00000110148	euGenes: HUgn887
ECgene: CCKBR	Kegg: 887	H-InvDB: CCKBR

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CCKBR	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CCKBR	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cholecystokinin_receptor

Intellectual Property for CCKBR gene
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Patent Information for CCKBR gene:
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GeneCards and IP:
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cholecystokinin B receptor

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CCKBR Gene

cholecystokinin B receptor

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