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Aliases for CCKBR Gene

Aliases for CCKBR Gene

  • Cholecystokinin B Receptor 2 3 5
  • Cholecystokinin-2 Receptor 3 4
  • CCK-B Receptor 3 4
  • CCK-BR 3 4
  • CCK2-R 3 4
  • Gastrin Receptor 3
  • CCK2 Receptor 3
  • CCK-B 3
  • CCK2R 3
  • CCKRB 4
  • GASR 3

External Ids for CCKBR Gene

Previous GeneCards Identifiers for CCKBR Gene

  • GC11P007024
  • GC11P006741
  • GC11P006240
  • GC11P006245
  • GC11P006237
  • GC11P005940

Summaries for CCKBR Gene

Entrez Gene Summary for CCKBR Gene

  • This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]

GeneCards Summary for CCKBR Gene

CCKBR (Cholecystokinin B Receptor) is a Protein Coding gene. Diseases associated with CCKBR include Stomach Cancer and Panic Disorder. Among its related pathways are Peptide ligand-binding receptors and Proton Pump Inhibitor Pathway, Pharmacodynamics. GO annotations related to this gene include G-protein coupled receptor activity and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is NPY1R.

UniProtKB/Swiss-Prot for CCKBR Gene

  • Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  • Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Tocris Summary for CCKBR Gene

  • The cholecystokinin2 receptor (CCK2 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach and influence neurotransmission.

Gene Wiki entry for CCKBR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCKBR Gene

Genomics for CCKBR Gene

Regulatory Elements for CCKBR Gene

Enhancers for CCKBR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCKBR on UCSC Golden Path with GeneCards custom track

Genomic Location for CCKBR Gene

Chromosome:
11
Start:
6,259,611 bp from pter
End:
6,272,127 bp from pter
Size:
12,517 bases
Orientation:
Plus strand

Genomic View for CCKBR Gene

Genes around CCKBR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCKBR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCKBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCKBR Gene

Proteins for CCKBR Gene

  • Protein details for CCKBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32239-GASR_HUMAN
    Recommended name:
    Gastrin/cholecystokinin type B receptor
    Protein Accession:
    P32239
    Secondary Accessions:
    • A8K7P9
    • O75824
    • Q16144
    • Q92492
    • Q96LC6
    • Q9NYK7
    • Q9UBV1

    Protein attributes for CCKBR Gene

    Size:
    447 amino acids
    Molecular mass:
    48419 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCKBR Gene

    Alternative splice isoforms for CCKBR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCKBR Gene

Proteomics data for CCKBR Gene at MOPED

Post-translational modifications for CCKBR Gene

  • Glycosylation at Asn 7, Asn 30, and Asn 36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCKBR Gene

No data available for DME Specific Peptides for CCKBR Gene

Domains & Families for CCKBR Gene

Gene Families for CCKBR Gene

Protein Domains for CCKBR Gene

Graphical View of Domain Structure for InterPro Entry

P32239

UniProtKB/Swiss-Prot:

GASR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCKBR: view

Function for CCKBR Gene

Molecular function for CCKBR Gene

GENATLAS Biochemistry:
cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle,expressed in brain,pancreas and stomach
UniProtKB/Swiss-Prot Function:
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
UniProtKB/Swiss-Prot Function:
Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Gene Ontology (GO) - Molecular Function for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 7681836
GO:0004951 cholecystokinin receptor activity TAS 7681836
GO:0005515 protein binding IPI 16963136
GO:0031741 type B gastrin/cholecystokinin receptor binding IDA 1280419
genes like me logo Genes that share ontologies with CCKBR: view
genes like me logo Genes that share phenotypes with CCKBR: view

Animal Models for CCKBR Gene

MGI Knock Outs for CCKBR:

Animal Model Products

miRNA for CCKBR Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCKBR Gene

Localization for CCKBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCKBR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCKBR Gene COMPARTMENTS Subcellular localization image for CCKBR gene
Compartment Confidence
cytosol 5
plasma membrane 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CCKBR: view

Pathways & Interactions for CCKBR Gene

genes like me logo Genes that share pathways with CCKBR: view

SIGNOR curated interactions for CCKBR Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8455720
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 10913157
GO:0007586 digestion TAS 7681836
GO:0038188 cholecystokinin signaling pathway TAS 7681836
genes like me logo Genes that share ontologies with CCKBR: view

Drugs & Compounds for CCKBR Gene

(63) Drugs for CCKBR Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentagastrin Approved Pharma agonist, Target 0
devazepide Pharma Antagonist Selective, orally active CCK1 receptor antagonist 0
lorglumide Pharma Antagonist 0
tetronothiodin Pharma Antagonist 0
[<sup>125</sup>I]gastrin Pharma Full agonist, Agonist 0

(45) Additional Compounds for CCKBR Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 288513
147523-65-7
[<sup>125</sup>I]PD142308
Antagonist
CCK-8 (desulphated)
Full agonist, Agonist
CI 988
130332-27-3
Gastrin I (human)
10047-33-3

(5) Tocris Compounds for CCKBR Gene

Compound Action Cas Number
CI 988 Potent and selective CCK2 antagonist 130332-27-3
Gastrin I (human) Selective CCK2 agonist 10047-33-3
LY 225910 Potent CCK2 antagonist 133040-77-4
LY 288513 Selective CCK2 antagonist 147523-65-7
YM 022 Highly potent, selective non-peptide CCK2 antagonist 145084-28-2
genes like me logo Genes that share compounds with CCKBR: view

Transcripts for CCKBR Gene

Unigene Clusters for CCKBR Gene

Cholecystokinin B receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for CCKBR Gene

GeneLoc Exon Structure for
CCKBR
ECgene alternative splicing isoforms for
CCKBR

Expression for CCKBR Gene

mRNA expression in normal human tissues for CCKBR Gene

mRNA differential expression in normal tissues according to GTEx for CCKBR Gene

This gene is overexpressed in Stomach (x10.7), Brain - Cortex (x7.5), Brain - Frontal Cortex (BA9) (x6.3), and Brain - Anterior cingulate cortex (BA24) (x6.1).

SOURCE GeneReport for Unigene cluster for CCKBR Gene Hs.203

mRNA Expression by UniProt/SwissProt for CCKBR Gene

P32239-GASR_HUMAN
Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
genes like me logo Genes that share expression patterns with CCKBR: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CCKBR Gene

Orthologs for CCKBR Gene

This gene was present in the common ancestor of animals.

Orthologs for CCKBR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCKBR 35
  • 87.7 (n)
  • 91.05 (a)
CCKBR 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cckbr 35
  • 85.54 (n)
  • 89.66 (a)
Cckbr 16
Cckbr 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCKBR 35
  • 99.11 (n)
  • 99.11 (a)
CCKBR 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cckbr 35
  • 85.62 (n)
  • 90.11 (a)
dog
(Canis familiaris)
Mammalia CCKBR 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CCKBR 35
  • 65.79 (n)
  • 61.96 (a)
CCKBR 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCKBR 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100331465 35
  • 58.41 (n)
  • 55.66 (a)
CCKBR (1 of 2) 36
  • 49 (a)
OneToMany
CCKBR (2 of 2) 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CCKLR-17D1 35
  • 50.26 (n)
  • 40.87 (a)
CCKLR-17D1 36
  • 20 (a)
ManyToMany
CCKLR-17D3 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y39A3B.5 37
  • 35 (a)
ckr-1 36
  • 24 (a)
ManyToMany
ckr-2 36
  • 20 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for CCKBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCKBR Gene

ENSEMBL:
Gene Tree for CCKBR (if available)
TreeFam:
Gene Tree for CCKBR (if available)

Paralogs for CCKBR Gene

genes like me logo Genes that share paralogs with CCKBR: view

Variants for CCKBR Gene

Sequence variations from dbSNP and Humsavar for CCKBR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1805000 - 6,260,037(+) GCAAC(C/T)TCAGC reference, missense, utr-variant-5-prime
rs1805002 - 6,269,890(+) GCACC(A/G)TCATC reference, missense
rs1805004 - 6,270,328(+) GGTCC(A/G)CCAGA reference, missense
rs1805001 - 6,271,155(+) CTCCC(A/G)GCCCA reference, missense
rs35816985 - 6,269,747(-) GGACC(A/C/G)CGATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCKBR Gene

Variant ID Type Subtype PubMed ID
nsv7656 CNV Loss 18451855

Variation tolerance for CCKBR Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCKBR Gene

Human Gene Mutation Database (HGMD)
CCKBR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCKBR Gene

Disorders for CCKBR Gene

MalaCards: The human disease database

(9) MalaCards diseases for CCKBR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
stomach cancer
  • ca body - stomach
panic disorder
  • panic anxiety syndrome
pancreatic cancer
  • pancreatic carcinoma, somatic
fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
agoraphobia
  • fear of open spaces
- elite association - COSMIC cancer census association via MalaCards
Search CCKBR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCKBR

Genetic Association Database (GAD)
CCKBR
Human Genome Epidemiology (HuGE) Navigator
CCKBR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCKBR
genes like me logo Genes that share disorders with CCKBR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCKBR Gene

Publications for CCKBR Gene

  1. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PMID: 1280419) Pisegna J.R. … Wank S.A. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. (PMID: 19502590) Paillasse M.R. … Silvente-Poirot S. (J. Lipid Res. 2009) 3 23
  3. [The expression of cholecystokinin-octapeptide receptor in vascular endothelial cells induced by lipopolysaccharide]. (PMID: 19751565) Ping J. … Ling Y.L. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009) 3 23
  4. Regulation of mammalian gastrin/CCK receptor (CCK2R) expression in vitro and in vivo. (PMID: 17933865) Ashurst H.L. … Dimaline R. (Exp. Physiol. 2008) 3 23
  5. Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors. (PMID: 18444993) Liu J.F. … Wang Q.Z. (J. Gastroenterol. Hepatol. 2008) 3 23

Products for CCKBR Gene

Sources for CCKBR Gene

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