Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCKAR Gene

Aliases for CCKAR Gene

  • Cholecystokinin A Receptor 2 3 5
  • Cholecystokinin-1 Receptor 3 4
  • CCK-A Receptor 3 4
  • CCK-AR 3 4
  • CCK1-R 3 4
  • CCKRA 3 4
  • Cholecystokinin Receptor Type A 3
  • Cholecystokinin Type-A Receptor 3
  • CCK-A 3
  • CCK1R 3

External Ids for CCKAR Gene

Previous GeneCards Identifiers for CCKAR Gene

  • GC04M026632
  • GC04M026171
  • GC04M026233
  • GC04M026159
  • GC04M025821

Summaries for CCKAR Gene

Entrez Gene Summary for CCKAR Gene

  • This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCKAR Gene

CCKAR (Cholecystokinin A Receptor) is a Protein Coding gene. Diseases associated with CCKAR include Panic Disorder and Gastrointestinal System Disease. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and cholecystokinin receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot for CCKAR Gene

  • Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for CCKAR Gene

  • The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK2. CCK1 receptors play a role in food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.

Gene Wiki entry for CCKAR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCKAR Gene

Genomics for CCKAR Gene

Regulatory Elements for CCKAR Gene

Enhancers for CCKAR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G026458 1 Ensembl ENCODE 25.8 +30.7 30718 1.5 ELF3 TBP CTCF ZNF654 ZNF362 SAP130 HLF TRIM22 ZEB2 ZNF384 CCKAR GC04P026432
GH04G026457 1 Ensembl ENCODE 10.7 +32.3 32282 1.2 TBP CTCF ZSCAN4 ZNF384 ZNF2 RAD21 YY1 RARA SMC3 MAFK CCKAR GC04P026432
GH04G026781 1 ENCODE 9.8 -292.1 -292108 1.3 PKNOX1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 NCOA1 REST ZNF592 CCKAR GC04P026778 STIM2
GH04G026461 0.7 ENCODE 12.1 +27.6 27645 1.7 BCOR TFAP4 FOXA2 CBX3 SAP130 FOXA3 NRF1 MXD4 ZMYM3 PPARG CCKAR GC04P026432
GH04G026355 0.5 Ensembl dbSUPER 15.6 +134.3 134298 0.7 CCKAR LOC105374542 GC04P026432
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCKAR on UCSC Golden Path with GeneCards custom track

Genomic Location for CCKAR Gene

Chromosome:
4
Start:
26,481,396 bp from pter
End:
26,490,462 bp from pter
Size:
9,067 bases
Orientation:
Minus strand

Genomic View for CCKAR Gene

Genes around CCKAR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCKAR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCKAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCKAR Gene

Proteins for CCKAR Gene

  • Protein details for CCKAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32238-CCKAR_HUMAN
    Recommended name:
    Cholecystokinin receptor type A
    Protein Accession:
    P32238
    Secondary Accessions:
    • B2R9Z5

    Protein attributes for CCKAR Gene

    Size:
    428 amino acids
    Molecular mass:
    47841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCKAR Gene

neXtProt entry for CCKAR Gene

Post-translational modifications for CCKAR Gene

  • Glycosylation at Asn10, Asn24, and posLast=190190
  • Modification sites at PhosphoSitePlus

Other Protein References for CCKAR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CCKAR

No data available for DME Specific Peptides for CCKAR Gene

Domains & Families for CCKAR Gene

Gene Families for CCKAR Gene

Suggested Antigen Peptide Sequences for CCKAR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32238

UniProtKB/Swiss-Prot:

CCKAR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCKAR: view

Function for CCKAR Gene

Molecular function for CCKAR Gene

GENATLAS Biochemistry:
cholecystokinin A,receptor,G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function:
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004951 cholecystokinin receptor activity TAS,IBA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with CCKAR: view
genes like me logo Genes that share phenotypes with CCKAR: view

Animal Models for CCKAR Gene

MGI Knock Outs for CCKAR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCKAR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCKAR Gene

Localization for CCKAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCKAR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCKAR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8343165
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CCKAR: view

Pathways & Interactions for CCKAR Gene

genes like me logo Genes that share pathways with CCKAR: view

SIGNOR curated interactions for CCKAR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8343165
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8503909
genes like me logo Genes that share ontologies with CCKAR: view

Drugs & Compounds for CCKAR Gene

(40) Drugs for CCKAR Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ceruletide Approved Pharma agonist, Target, inducer 0
Dexloxiglumide Investigational Pharma Antagonist, antagonist, Target 0
Lintitript Investigational Pharma Antagonist, antagonist, Target 0
devazepide Pharma Antagonist CCK-A receptor antagonist, potent, Selective, orally active CCK1 receptor antagonist 0
A-71623 Pharma CCK receptor agonist,potent and selective, Potent and selective CCK1 agonist; suppresses feeding 0

(22) Additional Compounds for CCKAR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for CCKAR Gene

Compound Action Cas Number
A-71623 Potent and selective CCK1 agonist; suppresses feeding 130408-77-4
Devazepide Selective, orally active CCK1 receptor antagonist 103420-77-5
SR 27897 Potent and selective CCK1 antagonist 136381-85-6

(6) ApexBio Compounds for CCKAR Gene

Compound Action Cas Number
A-71623 CCK receptor agonist,potent and selective 130408-77-4
CCK Octapeptide, non-sulfated 25679-24-7
Devazepide CCK-A receptor antagonist, potent 103420-77-5
Proglumide sodium salt 99247-33-3
Rebamipide 90098-04-7
SR 27897 136381-85-6
genes like me logo Genes that share compounds with CCKAR: view

Drug Products

Transcripts for CCKAR Gene

mRNA/cDNA for CCKAR Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCKAR Gene

Cholecystokinin A receptor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CCKAR

Alternative Splicing Database (ASD) splice patterns (SP) for CCKAR Gene

No ASD Table

Relevant External Links for CCKAR Gene

GeneLoc Exon Structure for
CCKAR
ECgene alternative splicing isoforms for
CCKAR

Expression for CCKAR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCKAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCKAR Gene

This gene is overexpressed in Stomach (x35.1).

Protein differential expression in normal tissues from HIPED for CCKAR Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCKAR Gene



Protein tissue co-expression partners for CCKAR Gene

NURSA nuclear receptor signaling pathways regulating expression of CCKAR Gene:

CCKAR

SOURCE GeneReport for Unigene cluster for CCKAR Gene:

Hs.129

Evidence on tissue expression from TISSUES for CCKAR Gene

  • Gall bladder(4.7)
  • Stomach(4.7)
  • Nervous system(4.6)
  • Blood(4.3)
  • Intestine(2.8)
  • Pancreas(2.7)
genes like me logo Genes that share expression patterns with CCKAR: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCKAR Gene

Orthologs for CCKAR Gene

This gene was present in the common ancestor of animals.

Orthologs for CCKAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCKAR 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia CCKAR 34 35
  • 90.69 (n)
dog
(Canis familiaris)
Mammalia CCKAR 34 35
  • 89.59 (n)
rat
(Rattus norvegicus)
Mammalia Cckar 34
  • 86.89 (n)
mouse
(Mus musculus)
Mammalia Cckar 34 16 35
  • 86.21 (n)
oppossum
(Monodelphis domestica)
Mammalia CCKAR 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCKAR 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCK1R 35
  • 76 (a)
OneToOne
CCKAR 34
  • 74.49 (n)
lizard
(Anolis carolinensis)
Reptilia CCKAR 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cckar 34
  • 71.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia cckar-A 34
zebrafish
(Danio rerio)
Actinopterygii LOC569038 34
  • 66.49 (n)
CR352260.1 35
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCCK1 34
  • 49.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CCKLR-17D3 35
  • 26 (a)
ManyToMany
CCKLR-17D1 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ckr-1 34 35
  • 43.52 (n)
Y39A3B.5 36
  • 33 (a)
npr-14 35
  • 25 (a)
ManyToMany
npr-21 35
  • 23 (a)
ManyToMany
npr-20 35
  • 22 (a)
ManyToMany
ckr-2 35
  • 21 (a)
ManyToMany
npr-34 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for CCKAR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCKAR Gene

ENSEMBL:
Gene Tree for CCKAR (if available)
TreeFam:
Gene Tree for CCKAR (if available)

Paralogs for CCKAR Gene

Paralogs for CCKAR Gene

(1) SIMAP similar genes for CCKAR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCKAR: view

Variants for CCKAR Gene

Sequence variations from dbSNP and Humsavar for CCKAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs104893833 Benign 26,490,207(-) AACTC(A/C/G)GGCTC reference, missense
rs52795588 Benign 26,481,832(-) CCTGC(A/G)TCAAC reference, missense
rs1000385406 -- 26,488,053(+) ACTTA(C/T)AAGGC intron-variant
rs1000835809 -- 26,483,663(+) GCTAC(A/C)TATAG intron-variant
rs1000882061 -- 26,488,388(+) TGTTT(-/C)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCKAR Gene

Variant ID Type Subtype PubMed ID
esv275100 CNV gain+loss 21479260
esv2762417 CNV gain 21179565

Variation tolerance for CCKAR Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCKAR Gene

Human Gene Mutation Database (HGMD)
CCKAR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCKAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCKAR Gene

Disorders for CCKAR Gene

MalaCards: The human disease database

(12) MalaCards diseases for CCKAR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
panic disorder
  • panic anxiety syndrome
gastrointestinal system disease
  • alimentary system disease
exocrine pancreatic insufficiency
dyspepsia
  • dyspepsia, indigestion nos
paranoid schizophrenia
  • chronic paranoid schizophrenia
- elite association - COSMIC cancer census association via MalaCards
Search CCKAR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCKAR

Genetic Association Database (GAD)
CCKAR
Human Genome Epidemiology (HuGE) Navigator
CCKAR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCKAR
genes like me logo Genes that share disorders with CCKAR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCKAR Gene

Publications for CCKAR Gene

  1. An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males. (PMID: 19753663) Koefoed P. … Rehfeld J.F. (Acta Psychiatr Scand 2009) 3 22 46 64
  2. Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. (PMID: 17944886) Srivastava A. … Mittal B. (J. Gastroenterol. Hepatol. 2008) 3 22 46 64
  3. Association between CCK-AR gene and schizophrenia with auditory hallucinations. (PMID: 17413443) Toirac I. … de Frutos R. (Psychiatr. Genet. 2007) 3 22 46 64
  4. Association study between the cholecystokinin A receptor gene and schizophrenia in the Japanese population. (PMID: 17413452) Minato T. … Sasaki T. (Psychiatr. Genet. 2007) 3 22 46 64
  5. Cholecystokinin A receptor gene promoter polymorphism and intelligence. (PMID: 15723764) Shimokata H. … Funakoshi A. (Ann Epidemiol 2005) 3 22 46 64

Products for CCKAR Gene

  • Addgene plasmids for CCKAR

Sources for CCKAR Gene

Content
Loading form....