CCKAR Gene
protein-coding GIFtS: 66
GCID: GC04M026483
|
|
cholecystokinin A receptor
| |
Aliases
for CCKAR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cholecystokinin A Receptor1 2 | | CCK-A Receptor2 3 | | Cholecystokinin-1 Receptor2 3 | | CCK-A2 | | CCK-AR2 3 | | Cholecystokinin Receptor Type A2 | | CCK1-R2 3 | | Cholecystokinin Type-A Receptor2 | | CCKRA2 3 | | |
Export aliases for CCKAR gene to outside databasesPrevious GC identifers: GC04M026632 GC04M026171 GC04M026233 GC04M026159 GC04M025821 |
Summaries
for CCKAR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCKAR:
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family ofpeptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth musclecontraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulatessatiety and the release of beta-endorphin and dopamine. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction ofthe gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feedingand dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action byassociation with G proteins that activate a phosphatidylinositol-calcium second messenger system
 summary
for CCKAR: The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor
group of G-protein-coupled receptors that also includes CCK2. They are located primarily in the pancreas,
gall bladder, intestine and vagus nerve where they play a role in food intake, pancreatic exocrine
secretion, gall bladder contractility and GI motility. The human CCK1 receptor gene has been localized to
chromosome 4 (4p15.1-p15.2).
Gene Wiki entry for CCKAR (Cholecystokinin A receptor)
|
Genomic Views
for CCKAR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCKAR gene promoter:
E2F-4 E2F-3a E2F-5 AML1a AP-1 CUTL1 E2F-2 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCKAR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCKAR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.1-p15.2 Ensembl cytogenetic band: 4p15.2 HGNC chromosome: 4CCKAR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M026483: view genomic region
(about GC identifiers)
Start:
|
26,483,018 bp from pter |
End:
|
26,492,084 bp from pter |
Size:
|
9,067 bases |
Orientation:
|
minus strand |
|
Proteins
for CCKAR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238 (See
protein sequence)Recommended Name: Cholecystokinin receptor type A Size: 428 amino acids; 47841 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
3 PDB 3D structures from  and Proteopedia  for CCKAR:1D6G (3D)
1HZN (3D)
1PB2 (3D)
Secondary accessions: B2R9Z5Explore the universe of human proteins at neXtProt for CCKAR: NX_P32238
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P32238
CCKAR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000721.1
ENSEMBL proteins: ENSP00000295589 Reactome Protein details: P32238
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CCKAR for ontologies About GeneDecksing
CCKAR Antibody Products:
Assay Products for CCKAR: |
Protein
Domains /
Families
for CCKAR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCKAR for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P32238ProtoNet protein and cluster: P32238 1 Blocks protein family: IPB000596 Cholecystokinin type A receptor signature
UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for CCKAR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction ofthe gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feedingand dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action byassociation with G proteins that activate a phosphatidylinositol-calcium second messenger system Genatlas biochemistry entry for CCKAR:cholecystokinin A,receptor,G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle
Clone
Products: |  | EMD Millipore Clones for the Expression of CCKAR | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCKAR (NM_000730) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCKAR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKAR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKAR |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004951 | cholecystokinin receptor activity |
IEA | -- |
CCKAR for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for CCKAR: Cckartm1Kym Cckartm1Kpn
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Cckar):
CCKAR for phenotypes About GeneDecksing
|
Pathways & Interactions
for CCKAR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | G alpha (q) signalling events | | | 4 | Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q | | | 5 | Pancreatic secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CCKAR
2  BioSystems Pathways for CCKAR
5/8 
Reactome Pathways for CCKAR (see all 8)
3 
Kegg Pathways (Kegg details for CCKAR):
CCKAR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCKAR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/130 Interacting proteins for CCKAR (P322382, 3 ENSP000002955894) via UniProtKB, MINT, STRING, and/or I2D (see all 130)About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001659 | temperature homeostasis |
-- | -- | | GO:0001696 | gastric acid secretion |
-- | -- | | GO:0001764 | neuron migration |
IEA | -- | | GO:0002023 | reduction of food intake in response to dietary excess |
-- | -- | | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
TAS | 8343165 |
CCKAR for ontologies About GeneDecksing
|
Drugs & Compounds
for CCKAR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CCKAR for compounds About GeneDecksing
Compounds for CCKAR available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| CCK Octapeptide, sulfated | C-terminal octapeptide of CCK | [25126-32-3] | | A-71623 | Potent and selective CCK1 agonist. Suppresses feeding | [130408-77-4] | | Devazepide | Selective, orally active CCK1 receptor antagonist | [103420-77-5] | | SR 27897 | Potent and selective CCK1 antagonist | [136381-85-6] |
1 HMDB Compound for CCKAR About this table
1 DrugBank Compound for CCKAR About this table
10/49 Novoseek chemical compound relationships for CCKAR gene (see all 49) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| loxiglumide |
94.1 |
37 |
11123709 (2), 10026438 (2), 9305416 (2), 9391249 (1) (see all 31) |
| devazepide |
91.1 |
27 |
7881733 (2), 8029299 (2), 1893248 (1), 1611514 (1) (see all 25) |
| asperlicin |
90.8 |
3 |
10983282 (1), 11469752 (1), 1714170 (1) |
| dexloxiglumide |
83.9 |
7 |
15108219 (2), 11171824 (1), 10202210 (1), 17684117 (1) (see all 5) |
| lorglumide |
83.1 |
7 |
15327914 (2), 8942742 (1), 16150104 (1), 1612109 (1) (see all 6) |
| l365260 |
83 |
3 |
8208791 (1), 8942742 (1), 8060296 (1) |
| 1,4-benzodiazepine |
78.6 |
1 |
9873368 (1) |
| ym022 |
77.8 |
1 |
11123709 (1) |
| tetrapeptide |
59 |
6 |
8126703 (2), 9089338 (1), 10882360 (1), 7837233 (1) (see all 5) |
| caerulein |
56.6 |
3 |
9885794 (1), 7679894 (1), 2362955 (1) |
Search CenterWatch for drugs/clinical trials and news about CCKAR
|
Transcripts
for CCKAR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCKAR gene: NM_000730.2 Unigene Cluster for CCKAR: Cholecystokinin A receptor Hs.129 [show with all ESTs]Unigene Representative Sequence: L193151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000295589(uc003gse.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCKAR (NM_000730) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCKAR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKAR |
Additional cDNA sequence: AK313978.1 AY322549.1 BC074987.2 L13605.1 L19315.1 1 DOTS entry: DT.306275 5 AceView cDNA sequences: BC074987 AY322549 L13605 NM_000730 L19315
GeneLoc Exon Structure
|
Expression
for CCKAR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCKAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGGTTTCT
About this image
See CCKAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCKAR
SOURCE GeneReport for Unigene cluster: Hs.129
SABiosciences Expression via Pathway-Focused PCR Arrays including CCKAR:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCKAR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCKAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCKAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCKAR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKAR |
Orthologs
for CCKAR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCKAR gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CCKAR1 |
cholecystokinin A receptor |
74.57(n)
76.29(a) |
|
422801 NM_001081501.1 NP_001074970.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CCKAR6 |
-- |
70(a) |
1 ↔ 1 |
GL343348.1(607724-661426) |
African clawed frog
(Xenopus laevis) |
Amphibia |
cckar-A2 |
cholecystokinin A receptor |
75.85(n) |
|
U49258.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5690381 |
cholecystokinin receptor type A-like |
66.24(n)
64.03(a) |
|
569038 XM_692401.3 XP_697493.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CCKLR-17D11 |
CCK-like receptor at 17D1 |
52.79(n)
41.35(a) |
|
32860 NM_001103551.2 NP_001097021.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y39A3B.53
ckr-21 |
7 transmembrane receptor3
Protein CKR-21 |
33(a)3
47.9(n)1
39.74(a)1 |
|
III(2082817-2087836)3
1753411 NM_001038286.11 NP_001033375.11 |
ENSEMBL Gene Tree for CCKAR (if available)
TreeFam Gene Tree for CCKAR (if available) |
Paralogs
for CCKAR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCKAR gene
- GPR222 CCKBR2
1 SIMAP similar gene for CCKAR using alignment to 1 protein entry: CCKAR_HUMAN:CCKBR
CCKAR for paralogs About GeneDecksing
|
Genomic Variants
for CCKAR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Human Gene Mutation Database (HGMD): CCKAR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCKAR |
|
Disorders
/ Diseases
for CCKAR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCKAR for disorders About GeneDecksing
OMIM gene information: 118444
OMIM disorders: --
20/45  diseases for CCKAR (see all 45): About MalaCardspancreatitis gastroesophageal reflux disease eating disorder major depressive disorder
bulimia nervosa panic disorder irritable bowel syndrome sleep apnea
dyspepsia anorexia nervosa diabetes mellitus alcohol dependence
morbid obesity duodenal ulcer apnea pituitary adenoma
alcoholism cholecystitis acute pancreatitis cholelithiasis
3 diseases from the University of Copenhagen DISEASES database for CCKAR:Pancreatitis Pain agnosia Panic disorder 10/41 Novoseek disease relationships for CCKAR gene (see all 41) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| functional dyspepsia |
47.5 |
3 |
11171824 (2), 8298606 (1) |
| pancreatic cancer |
45.9 |
6 |
15682471 (1), 9094151 (1), 9041258 (1), 10436805 (1) (see all 5) |
| motility disorder |
45.8 |
5 |
10959771 (1), 12688377 (1), 17547774 (1), 17997137 (1) |
| panic disorder |
40 |
1 |
17997137 (1) |
| delirium tremens |
38.1 |
1 |
12198366 (1) |
| thyroid carcinoma medullary |
35.1 |
1 |
10452255 (1) |
| gall bladder |
33.1 |
7 |
8605955 (1), 9239407 (1), 9839529 (1), 12688377 (1) |
| hypomotility |
32.8 |
4 |
11829843 (3), 15908333 (1) |
| gastrointestinal diseases |
29.9 |
4 |
7759110 (1), 15989644 (1), 17997137 (1) |
| panic |
25.1 |
1 |
10395221 (1) |
Genetic Association Database (GAD): CCKAR
Human Genome Epidemiology (HuGE) Navigator: CCKAR (41 documents)
Export disorders for CCKAR gene to outside databases
|
Publications
for CCKAR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCKAR gene, integrated from 9 sources (see all 354):
(articles sorted by number of sources associating them with CCKAR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity. (PubMed id 7557108)1, 2, 4 Miller L.J.... Wieben E.D. (1995)
- Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. (PubMed id 8343165)1, 2, 9 Wank S.A.... Huppi K. (1993)
- Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 9 Okubo T....Matsushita S. (2002)
- Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain. (PubMed id 15340101)1, 4, 9 Koda M....Funakoshi A. (2004)
- Linked polymorphisms (-333G>T and -286A>G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia. (PubMed id 11549403)1, 4, 9 Tachikawa H....Suzuki T. (2001)
- A possible association between the CCK-AR gene and persistent auditory hallucinations in schizophrenia. (PubMed id 15363473)1, 4, 9 Sanjuan J....De Frutos R. (2004)
- Association between the CCK-A receptor gene and panic disorder. (PubMed id 12627462)1, 4, 9 Ise K....Nagayama H. (2003)
- Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor. (PubMed id 8503909)1, 2, 9 Ulrich C.D.... Miller L.J. (1993)
- Cholecystokinin A receptor gene promoter polymorphism and intelligence. (PubMed id 15723764)1, 4, 9 Shimokata H....Funakoshi A. (2005)
- Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. (PubMed id 14691070)1, 4, 9 Miyasaka K....Funakoshi A. (2004)
|
External Searches for CCKAR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCKAR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCKAR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCKAR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCKAR | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Cholecystokinin_receptor |
|
| | |
About This Section
| Patent Information for CCKAR gene:
Search GeneIP for patents involving CCKAR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CCKAR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for CCKAR | | OriGene shRNA RFP for CCKAR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCKAR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCKAR | | | OriGene Protein Over-expression Lysate for CCKAR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCKAR | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCKAR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCKAR | | OriGene Custom Protein Services for CCKAR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCKAR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCKAR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCKAR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCKAR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCKAR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCKAR |
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| | | | Tocris compounds for CCKAR |
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 | | | CCKAR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKAR |
|  |  |  | | | | ThermoFisher Antibody for CCKAR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKAR |
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