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Aliases for CCKAR Gene

Aliases for CCKAR Gene

  • Cholecystokinin A Receptor 2 3
  • Cholecystokinin-1 Receptor 3 4
  • CCK-A Receptor 3 4
  • CCK-AR 3 4
  • CCK1-R 3 4
  • CCKRA 3 4
  • Cholecystokinin Receptor Type A 3
  • Cholecystokinin Type-A Receptor 3
  • CCK-A 3
  • CCK1R 3

External Ids for CCKAR Gene

Summaries for CCKAR Gene

Entrez Gene Summary for CCKAR Gene

  • This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCKAR Gene

CCKAR (Cholecystokinin A Receptor) is a Protein Coding gene. Diseases associated with CCKAR include dyspepsia and irritable bowel syndrome. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cholecystokinin receptor activity. An important paralog of this gene is GPR19.

UniProtKB/Swiss-Prot for CCKAR Gene

  • Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for CCKAR Gene

  • The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK2. They are located primarily in the pancreas, gall bladder, intestine and vagus nerve where they play a role in food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility. The human CCK1 receptor gene has been localized to chromosome 4 (4p15.1-p15.2).

Gene Wiki entry for CCKAR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCKAR Gene

Genomics for CCKAR Gene

Genomic Location for CCKAR Gene

Start:
26,481,396 bp from pter
End:
26,490,462 bp from pter
Size:
9,067 bases
Orientation:
Minus strand

Genomic View for CCKAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCKAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCKAR Gene

Regulatory Elements for CCKAR Gene

Proteins for CCKAR Gene

  • Protein details for CCKAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32238-CCKAR_HUMAN
    Recommended name:
    Cholecystokinin receptor type A
    Protein Accession:
    P32238
    Secondary Accessions:
    • B2R9Z5

    Protein attributes for CCKAR Gene

    Size:
    428 amino acids
    Molecular mass:
    47841 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCKAR Gene

neXtProt entry for CCKAR Gene

Proteomics data for CCKAR Gene at MOPED

Post-translational modifications for CCKAR Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn10, Asn24, and Asn190

Other Protein References for CCKAR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCKAR Gene

Domains for CCKAR Gene

Gene Families for CCKAR Gene

HGNC:
  • CCKNR :GPCR / Class A : Cholecystokinin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

CCKAR_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P32238
genes like me logo Genes that share domains with CCKAR: view

Function for CCKAR Gene

Molecular function for CCKAR Gene

GENATLAS Biochemistry: cholecystokinin A,receptor,G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle
UniProtKB/Swiss-Prot Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004951 cholecystokinin receptor activity IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with CCKAR: view
genes like me logo Genes that share phenotypes with CCKAR: view

Animal Models for CCKAR Gene

MGI Knock Outs for CCKAR:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CCKAR Gene

Localization for CCKAR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCKAR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCKAR Gene COMPARTMENTS Subcellular localization image for CCKAR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8343165
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCKAR: view

Pathways for CCKAR Gene

genes like me logo Genes that share pathways with CCKAR: view

Gene Ontology (GO) - Biological Process for CCKAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8343165
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8503909
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with CCKAR: view

Compounds for CCKAR Gene

(3) Tocris Compounds for CCKAR Gene

Compound Action Cas Number
A-71623 Potent and selective CCK1 agonist. Suppresses feeding [130408-77-4]
Devazepide Selective, orally active CCK1 receptor antagonist [103420-77-5]
SR 27897 Potent and selective CCK1 antagonist [136381-85-6]

(1) HMDB Compounds for CCKAR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CCKAR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ceruletide
17650-98-5 target inducer

(8) IUPHAR Ligand for CCKAR Gene

Ligand Type Action Affinity Pubmed IDs
[3H]devazepide Antagonist Antagonist 9.7
SR146131 Agonist Full agonist 9.3
lintitript Antagonist Antagonist 8.3
JMV180 Agonist Full agonist 8.3
JNJ-17156516 Antagonist Antagonist 8
GW-5823 Agonist Full agonist 7.6
dexloxiglumide Antagonist Antagonist 7.5
Glaxo-11p Agonist Full agonist 7.2

(49) Novoseek inferred chemical compound relationships for CCKAR Gene

Compound -log(P) Hits PubMed IDs
loxiglumide 94.1 34
devazepide 91.1 27
asperlicin 90.8 3
dexloxiglumide 83.9 6
lorglumide 83.1 7
genes like me logo Genes that share compounds with CCKAR: view

Transcripts for CCKAR Gene

mRNA/cDNA for CCKAR Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCKAR Gene

Cholecystokinin A receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCKAR Gene

No ASD Table

Relevant External Links for CCKAR Gene

GeneLoc Exon Structure for
CCKAR
ECgene alternative splicing isoforms for
CCKAR

Expression for CCKAR Gene

mRNA expression in normal human tissues for CCKAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCKAR Gene

This gene is overexpressed in Stomach (35.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCKAR Gene

SOURCE GeneReport for Unigene cluster for CCKAR Gene Hs.129

genes like me logo Genes that share expressions with CCKAR: view

Orthologs for CCKAR Gene

This gene was present in the common ancestor of animals.

Orthologs for CCKAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCKAR 36
  • 99.69 (n)
  • 99.53 (a)
CCKAR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCKAR 36
  • 90.69 (n)
  • 92.55 (a)
CCKAR 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCKAR 36
  • 89.59 (n)
  • 91.53 (a)
CCKAR 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cckar 36
  • 86.21 (n)
  • 90.89 (a)
Cckar 16
Cckar 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCKAR 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCKAR 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cckar 36
  • 86.89 (n)
  • 91.8 (a)
chicken
(Gallus gallus)
Aves CCK1R 37
  • 76 (a)
OneToOne
CCKAR 36
  • 74.49 (n)
  • 76.29 (a)
lizard
(Anolis carolinensis)
Reptilia CCKAR 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cckar-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cckar 36
  • 71.37 (n)
  • 72.77 (a)
zebrafish
(Danio rerio)
Actinopterygii CR352260.1 37
  • 59 (a)
OneToOne
LOC569038 36
  • 66.49 (n)
  • 64.72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCCK1 36
  • 49.71 (n)
  • 40.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CCKLR-17D1 37
  • 22 (a)
ManyToMany
CCKLR-17D3 37
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ckr-1 36
  • 43.52 (n)
  • 36.42 (a)
ckr-1 37
  • 25 (a)
ManyToMany
ckr-2 37
  • 21 (a)
ManyToMany
npr-14 37
  • 25 (a)
ManyToMany
npr-20 37
  • 22 (a)
ManyToMany
npr-21 37
  • 23 (a)
ManyToMany
npr-34 37
  • 16 (a)
ManyToMany
Y39A3B.5 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
Species with no ortholog for CCKAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCKAR Gene

ENSEMBL:
Gene Tree for CCKAR (if available)
TreeFam:
Gene Tree for CCKAR (if available)

Paralogs for CCKAR Gene

Paralogs for CCKAR Gene

Selected SIMAP similar genes for CCKAR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCKAR: view

Variants for CCKAR Gene

Sequence variations from dbSNP and Humsavar for CCKAR Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs915889 -- 26,484,572(-) CTGAA(C/T)GTCAG intron-variant
rs1042012 -- 26,481,955(-) TCTTC(C/T)TGTGC reference, synonymous-codon
rs1799723 -- 26,490,553(-) GCCCT(A/G)AGACT upstream-variant-2KB
rs1800857 -- 26,489,489(-) CTCTC(C/T)GCAGA intron-variant
rs1800908 -- 26,490,600(-) CACAC(G/T)CTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCKAR Gene

Variant ID Type Subtype PubMed ID
esv275100 CNV Gain+Loss 21479260

Relevant External Links for CCKAR Gene

HapMap Linkage Disequilibrium report
CCKAR
Human Gene Mutation Database (HGMD)
CCKAR

Disorders for CCKAR Gene

(4) University of Copenhagen DISEASES for CCKAR Gene

(41) Novoseek inferred disease relationships for CCKAR Gene

Disease -log(P) Hits PubMed IDs
functional dyspepsia 47.5 3
pancreatic cancer 45.9 5
motility disorder 45.8 4
panic disorder 40 1
delirium tremens 38.1 1

Relevant External Links for CCKAR

Genetic Association Database (GAD)
CCKAR
Human Genome Epidemiology (HuGE) Navigator
CCKAR
genes like me logo Genes that share disorders with CCKAR: view

No data available for UniProtKB/Swiss-Prot for CCKAR Gene

Publications for CCKAR Gene

  1. Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor. (PMID: 8503909) Ulrich C.D. … Miller L.J. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  2. Novel polymorphisms of the human cholecystokinin A receptor gene: an association analysis with schizophrenia. (PMID: 10893485) Tachikawa H. … Shiraishi H. (Am. J. Med. Genet. 2000) 3 23 49
  3. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. (PMID: 8343165) Wank S.A. … Huppi K. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  4. Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor. (PMID: 11300760) Giragossian C. … Mierke D.F. (Biochemistry 2001) 3 4 23
  5. No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PMID: 11368834) Vanakoski J. … Goldman D. (Psychiatry Res 2001) 3 23 49

Products for CCKAR Gene

Sources for CCKAR Gene

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