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CCKAR Gene

protein-coding   GIFtS: 68
GCID: GC04M026483

Cholecystokinin A Receptor

  See CCKAR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholecystokinin A Receptor1 2     CCK-A Receptor2 3
Cholecystokinin-1 Receptor2 3     CCK-A2
CCK-AR2 3     Cholecystokinin Receptor Type A2
CCK1-R2 3     Cholecystokinin Type-A Receptor2
CCKRA2 3     

External Ids:    HGNC: 15701   Entrez Gene: 8862   Ensembl: ENSG000001633947   OMIM: 1184445   UniProtKB: P322383   

Export aliases for CCKAR gene to outside databases

Previous GC identifers: GC04M026632 GC04M026171 GC04M026233 GC04M026159 GC04M025821


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCKAR Gene:
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family
of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth
muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor
regulates satiety and the release of beta-endorphin and dopamine. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCKAR Gene:
CCKAR (cholecystokinin A receptor) is a protein-coding gene. Diseases associated with CCKAR include dyspepsia, and paranoid schizophrenia. GO annotations related to this gene include cholecystokinin receptor activity. An important paralog of this gene is CCKBR.

UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238
Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction
of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates
feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its
action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

summary for CCKAR Gene:
The cholecystokinin1 receptor (CCK1 receptor, CCK-A receptor) is a member of the cholecystokinin receptor
group of G-protein-coupled receptors that also includes CCK2. They are located primarily in the pancreas,
gall bladder, intestine and vagus nerve where they play a role in food intake, pancreatic exocrine
secretion, gall bladder contractility and GI motility. The human CCK1 receptor gene has been localized to
chromosome 4 (4p15.1-p15.2).

Gene Wiki entry for CCKAR (Cholecystokinin A receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006316.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCKAR gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   AP-1   CUTL1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCKAR promoter sequence
   Search Chromatin IP Primers for CCKAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCKAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

CCKAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCKAR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M026483:  view genomic region     (about GC identifiers)

Start:
26,483,018 bp from pter      End:
26,492,084 bp from pter
Size:
9,067 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238 (See protein sequence)
Recommended Name: Cholecystokinin receptor type A  
Size: 428 amino acids; 47841 Da
3 PDB 3D structures from and Proteopedia for CCKAR:
1D6G (3D)        1HZN (3D)        1PB2 (3D)    
Secondary accessions: B2R9Z5

Explore the universe of human proteins at neXtProt for CCKAR: NX_P32238

Explore proteomics data for CCKAR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn24, Asn190
  • Modification sites at PhosphoSitePlus

  • See CCKAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000721.1  
    ENSEMBL proteins: 
     ENSP00000295589  
    Reactome Protein details: P32238

    CCKAR Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CCKAR Protein
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    Search eBioscience for ELISAs for CCKAR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CCKNR: GPCR / Class A : Cholecystokinin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: CCK1 receptor
    Cholecystokinin receptors

    5 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000596 Cholcy_rcpt_A
     IPR015276 CholecystokininA_recpt_N
     IPR009126 Cholcskin_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32238

    ProtoNet protein and cluster: P32238

    1 Blocks protein domain: IPB000596 Cholecystokinin type A receptor signature

    UniProtKB/Swiss-Prot: CCKAR_HUMAN, P32238
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with CCKAR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCKAR_HUMAN, P32238
    Function: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction
    of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates
    feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its
    action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for CCKAR:
    cholecystokinin A,receptor,G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004951cholecystokinin receptor activity IEA--
         
    Find genes that share ontologies with CCKAR           About GenesLikeMe


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cckar):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  liver/biliary system  nervous system  renal/urinary system 
     respiratory system  taste/olfaction 

    Find genes that share phenotypes with CCKAR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CCKAR: Cckartm1Kym Cckartm1Kpn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCKAR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCKAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCKAR

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CCKAR:
    hsa-miR-1236
    SwitchGear 3'UTR luciferase reporter plasmidCCKAR 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat CCKAR

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    GenScript: all cDNA clones in your preferred vector: CCKAR (NM_000730)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCKAR

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKAR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCKAR_HUMAN, P32238: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8343165
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with CCKAR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCKAR About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Insulin secretion
    Insulin secretion0.36


    Find genes that share SuperPaths with CCKAR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CCKAR
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for CCKAR
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    4 Kegg Pathways  (Kegg details for CCKAR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Insulin secretion
    Pancreatic secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCKAR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCKAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCKAR (P322382, 3 ENSP000002955894) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R9BQ96SB32, 3MINT-4953493 I2D: score=2 
    CCKBRP322393, ENSP000003355444I2D: score=2 STRING: ENSP00000335544
    CCKP063073, ENSP000003356574I2D: score=2 STRING: ENSP00000335657
    ADRA1BENSP000003066624STRING: ENSP00000306662
    ADRA1DENSP000003687664STRING: ENSP00000368766
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8343165
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS8503909
    GO:0007409axonogenesis IEA--

    Find genes that share ontologies with CCKAR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCKAR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A-71623Potent and selective CCK1 agonist. Suppresses feeding[130408-77-4]
    Devazepide Selective, orally active CCK1 receptor antagonist [103420-77-5]
    SR 27897Potent and selective CCK1 antagonist[136381-85-6]

    1 HMDB Compound for CCKAR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CCKAR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Ceruletide-- 17650-98-5targetinducer1356589 2087492 2587420 8182534 1620654 3440035

    8 IUPHAR Ligands for CCKAR (CCK1 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]devazepide
    AntagonistAntagonist9.73018478
    SR146131
    AgonistFull agonist9.310215648
    lintitript
    AntagonistAntagonist8.310988332
    JMV180
    AgonistFull agonist8.37654246
    JNJ-17156516
    AntagonistAntagonist817684117
    GW-5823
    AgonistFull agonist7.69276016
    dexloxiglumide
    AntagonistAntagonist7.517684117
    Glaxo-11p
    AgonistFull agonist7.28558528

    Selected Novoseek inferred chemical compound relationships for CCKAR gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    loxiglumide 94.1 37 11123709 (2), 10026438 (2), 9305416 (2), 9391249 (1) (see all 31)
    devazepide 91.1 27 7881733 (2), 8029299 (2), 1893248 (1), 1611514 (1) (see all 25)
    asperlicin 90.8 3 10983282 (1), 11469752 (1), 1714170 (1)
    dexloxiglumide 83.9 7 15108219 (2), 11171824 (1), 10202210 (1), 17684117 (1) (see all 5)
    lorglumide 83.1 7 15327914 (2), 8942742 (1), 16150104 (1), 1612109 (1) (see all 6)
    l365260 83 3 8208791 (1), 8942742 (1), 8060296 (1)
    1,4-benzodiazepine 78.6 1 9873368 (1)
    ym022 77.8 1 11123709 (1)
    tetrapeptide 59 6 8126703 (2), 9089338 (1), 10882360 (1), 7837233 (1) (see all 5)
    caerulein 56.6 3 9885794 (1), 7679894 (1), 2362955 (1)



    Find genes that share compounds with CCKAR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCKAR gene: 
    NM_000730.2  

    Unigene Cluster for CCKAR:

    Cholecystokinin A receptor
    Hs.129  [show with all ESTs]
    Unigene Representative Sequence: L19315
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000295589(uc003gse.1)
    miRNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CCKAR

    Additional mRNA sequence: 

    AK313978.1 AY322549.1 BC074987.2 L13605.1 L19315.1 

    1 DOTS entry:

    DT.306275 

    5 AceView cDNA sequences:

    L13605 AY322549 BC074987 L19315 NM_000730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCKAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGGTTTCT
    CCKAR Expression
    About this image


    CCKAR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Lung (Respiratory System)
     
     Kidney (Urinary System)
    CCKAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCKAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CCKAR: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CCKAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCKAR
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCKAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCKAR gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cckar1 , 5 cholecystokinin A receptor1, 5 86.21(n)1
    90.89(a)1
      5 (29.52 cM)5
    124251  NM_009827.21  NP_033957.11 
     536984855 
    chicken
    (Gallus gallus)
    Aves CCKAR1 cholecystokinin A receptor 74.49(n)
    76.29(a)
      422801  NM_001081501.1  NP_001074970.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCKAR6
    cholecystokinin A receptor
    70(a)
    1 ↔ 1
    GL343348.1(607724-661663)
    African clawed frog
    (Xenopus laevis)
    Amphibia cckar-A2 cholecystokinin A receptor 75.85(n)    U49258.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5690381 cholecystokinin receptor type A-like 66.49(n)
    64.72(a)
      569038  XM_692401.4  XP_697493.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CCKLR-17D36
    CCKLR-17D16
    CCK-like receptor at 17D1
    26(a)
    22(a)
    many ↔ many
    many ↔ many
    X(18658516-18668264)
    X(18601527-18620605)
    worm
    (Caenorhabditis elegans)
    Secernentea Y39A3B.53
    ckr-11
    7 transmembrane receptor3
    ckr-11
    33(a)3
    43.52(n)1
    36.42(a)1
      III(2082817-2087836)3
    1887741  NM_059517.31  NP_491918.31 


    ENSEMBL Gene Tree for CCKAR (if available)
    TreeFam Gene Tree for CCKAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCKAR gene
    CCKBR2  GPR192  
    1 SIMAP similar gene for CCKAR using alignment to 1 protein entry:     CCKAR_HUMAN:
    CCKBR

    Find genes that share paralogs with CCKAR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCKAR (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs527955881,2
    C,Fnon-pathogenic126424951(-) CCTGCG/ATCAAC 2 /I /V mis15Minor allele frequency- A:0.01NA WA 5094
    rs1048938331,2
    C,Fnon-pathogenic126433327(-) AACTCG/CGGCTC 2 /R /G mis11Minor allele frequency- C:0.00NA 4550
    rs766581541,2
    --26424073(+) AAAAAA/GAAAAG 1 -- ds50010--------
    rs1853612451,2
    --26424132(+) ATGCTA/TTTCTG 1 -- ds50010--------
    rs1897632091,2
    --26424205(+) CTGTCC/GTACCC 1 -- ds50010--------
    rs1813102751,2
    --26424236(+) GGTTTG/TCTTCC 1 -- ds50010--------
    rs1456757341,2
    C--26424265(+) AATGAA/GGTGGA 1 -- ds50010--------
    rs1855358631,2
    --26424287(+) GATACA/GTGATA 1 -- ds50010--------
    rs1880407111,2
    C--26424532(+) GTTACC/TTAACA 1 -- ut310--------
    rs286360171,2
    C,F--26424575(+) TGGCCC/TCACTG 1 -- ut31 ese32Minor allele frequency- T:0.05CSA WA 123

    HapMap Linkage Disequilibrium report for CCKAR (26483018 - 26492084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCKAR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv275100CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): CCKAR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCKAR
    DNA2.0 Custom Variant and Variant Library Synthesis for CCKAR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118444    OMIM disorders: --

    10 diseases for CCKAR:    
    About MalaCards
    dyspepsia    paranoid schizophrenia    gastroesophageal reflux disease    irritable bowel syndrome
    panic disorder    pain agnosia    gallbladder cancer    pancreatic cancer
    schizophrenia    obesity

    4 diseases from the University of Copenhagen DISEASES database for CCKAR:
    Pancreatitis     Pain agnosia     Panic disorder     Pancreatic cancer

    Find genes that share disorders with CCKAR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CCKAR gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    functional dyspepsia 47.5 3 11171824 (2), 8298606 (1)
    pancreatic cancer 45.9 6 15682471 (1), 9094151 (1), 9041258 (1), 10436805 (1) (see all 5)
    motility disorder 45.8 5 10959771 (1), 12688377 (1), 17547774 (1), 17997137 (1)
    panic disorder 40 1 17997137 (1)
    delirium tremens 38.1 1 12198366 (1)
    thyroid carcinoma medullary 35.1 1 10452255 (1)
    gall bladder 33.1 7 8605955 (1), 9239407 (1), 9839529 (1), 12688377 (1)
    hypomotility 32.8 4 11829843 (3), 15908333 (1)
    gastrointestinal diseases 29.9 4 7759110 (1), 15989644 (1), 17997137 (1)
    panic 25.1 1 10395221 (1)

    Genetic Association Database (GAD): CCKAR
    Human Genome Epidemiology (HuGE) Navigator: CCKAR (41 documents)

    Export disorders for CCKAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCKAR gene, integrated from 10 sources (see all 358):
    (articles sorted by number of sources associating them with CCKAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity. (PubMed id 7557108)1, 2, 4 Miller L.J.... Wieben E.D. (Gastroenterology 1995)
    2. Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. (PubMed id 8343165)1, 2, 9 Wank S.A.... Huppi K. (Biochem. Biophys. Res. Commun. 1993)
    3. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 9 Okubo T....Matsushita S. (Alcohol. Clin. Exp. Res. 2002)
    4. Association of cholecystokinin 1 receptor and beta3-adrenergic receptor polymorphisms with midlife weight gain. (PubMed id 15340101)1, 4, 9 Koda M....Funakoshi A. (Obes. Res. 2004)
    5. Association between CCK-AR gene and schizophrenia with auditory hallucinations. (PubMed id 17413443)1, 4, 9 Toirac I....de Frutos R. (Psychiatr. Genet. 2007)
    6. Linked polymorphisms (-333G&gt;T and -286A&gt;G) in the promoter region of the CCK-A receptor gene may be associated with schizophrenia. (PubMed id 11549403)1, 4, 9 Tachikawa H....Suzuki T. (Psychiatry Res 2001)
    7. An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males. (PubMed id 19753663)1, 4, 9 Koefoed P....Rehfeld J.F. (Acta Psychiatr Scand 2009)
    8. Cholecystokinin receptor A gene polymorphism in gallstone disease and gallbladder cancer. (PubMed id 17944886)1, 4, 9 Srivastava A....Mittal B. (J. Gastroenterol. Hepatol. 2008)
    9. Association study between the cholecystokinin A receptor gene and schizophrenia in the Japanese population. (PubMed id 17413452)1, 4, 9 Minato T....Sasaki T. (Psychiatr. Genet. 2007)
    10. A possible association between the CCK-AR gene and persistent auditory hallucinations in schizophrenia. (PubMed id 15363473)1, 4, 9 Sanjuan J....De Frutos R. (Eur. Psychiatry 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 886 HGNC: 1570 AceView: CCKAR Ensembl:ENSG00000163394 euGenes: HUgn886
    ECgene: CCKAR Kegg: 886 H-InvDB: CCKAR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCKAR Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Cholecystokinin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCKAR gene:
    Search GeneIP for patents involving CCKAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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