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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCK Gene

protein-coding   GIFtS: 62
GCID: GC03M042274

Cholecystokinin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
cholecystokinin1 2
Cholecystokinin Triacontatriapeptide1 2
prepro-cholecystokinin1 2

External Ids:    HGNC: 15691   Entrez Gene: 8852   Ensembl: ENSG000001870947   OMIM: 1184405   UniProtKB: P063073   

Export aliases for CCK gene to outside databases

Previous GC identifers: GC03P041561 GC03U900036 GC03M9D0028


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCK Gene:
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the
contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is
processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been
found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for CCK Gene: 
CCK (cholecystokinin) is a protein-coding gene. Diseases associated with CCK include cholecystitis, and acalculous cholecystitis, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neuropeptide hormone activity and hormone activity.

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307
Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.
Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas,
binding to CCK-B receptors stimulates gastric acid secretion

summary for CCK Gene:
Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and
gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells
and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of
biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK
receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin.
The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar
affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK (Cholecystokinin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCK gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   CREB   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCK promoter sequence
   Search SABiosciences Chromatin IP Primers for CCK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

CCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M042274:  view genomic region     (about GC identifiers)

Start:
42,299,317 bp from pter      End:
42,307,699 bp from pter
Size:
8,383 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307 (See protein sequence)
Recommended Name: Cholecystokinin precursor  
Size: 115 amino acids; 12669 Da
Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity)
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CCK: NX_P06307

Explore proteomics data for CCK at MOPED 

Post-translational modifications:

  • UniProtKB: The precursor is cleaved by proteases to produce a number of active cholecystokinins
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06307

  • CCK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000720.1  NP_001167609.1  

    ENSEMBL proteins: 
     ENSP00000335657   ENSP00000379472   ENSP00000409124  
    Reactome Protein details: P06307
    Human Recombinant Protein Products for CCK: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCK 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0030424axon ISS15152034
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body ----

    CCK for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CCK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR015499 CCK
     IPR001651 Gastrin
     IPR013152 Gastrin/cholecystokinin_CS

    Graphical View of Domain Structure for InterPro Entry P06307

    ProtoNet protein and cluster: P06307

    1 Blocks protein domain: IPB001651 Gastrin/cholecystokinin peptide hormone

    UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307
    Similarity: Belongs to the gastrin/cholecystokinin family


    CCK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCKN_HUMAN, P06307
    Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.
    Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas,
    binding to CCK-B receptors stimulates gastric acid secretion

         Genatlas biochemistry entry for CCK:
    cholecystokinin

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS10320330
    GO:0005184neuropeptide hormone activity ISS15374756
    GO:0005515protein binding IPI--
         
    CCK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCK:
     Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cck):
     endocrine/exocrine gland  homeostasis/metabolism  nervous system  no phenotypic analysis 

    CCK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCK 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCK
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCK:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCCK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CCK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4VEGF Family Ligands and Receptor Interactions
    CCKBR-Gastrin Stimulated Signaling0.36
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CCK
        Selected targets of CREB1

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CCK
        CCKBR-Gastrin Stimulated Signaling

    5/8        Reactome Pathways for CCK (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    CCK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for CCK (P063073 ENSP000003356574) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCKBRP322393, ENSP000003355444I2D: score=2 STRING: ENSP00000335544
    ENPEPQ070753, ENSP000002651624I2D: score=1 STRING: ENSP00000265162
    CCKARP322383, ENSP000002955894I2D: score=2 STRING: ENSP00000295589
    CPEP168703, ENSP000003861044I2D: score=1 STRING: ENSP00000386104
    MEP1AQ168193, ENSP000002305884I2D: score=1 STRING: ENSP00000230588
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0001764neuron migration ISS15152034
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006915apoptotic process ----
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--

    CCK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CCK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CCK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCK Octapeptide, sulfated C-terminal octapeptide of CCK[25126-32-3]
    CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide[25679-24-7]
    Proglumide sodium saltNon-selective CCK antagonist; orally active[99247-33-3]

    10/150 Novoseek inferred chemical compound relationships for CCK gene (see all 150)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    loxiglumide 93.4 185 1291406 (5), 8243522 (4), 2378793 (4), 1996640 (4) (see all 74)
    devazepide 83.4 34 8033071 (2), 1996645 (2), 7861766 (2), 1504732 (2) (see all 23)
    sincalide 82.4 13 9252846 (2), 1932168 (2), 2183285 (1), 1860640 (1) (see all 9)
    oxyntomodulin 80.2 45 15082874 (2), 8418694 (2), 2192696 (1), 8223069 (1) (see all 26)
    dexloxiglumide 79.3 3 16163898 (1), 16484960 (1)
    caerulein 79.2 31 1708407 (2), 7679894 (2), 2362955 (2), 2394497 (1) (see all 26)
    minigastrin 76.2 6 17707803 (2), 17896914 (1), 17934729 (1), 19601842 (1)
    lorglumide 75.9 19 2364292 (3), 8942742 (2), 1504732 (2), 2299627 (2) (see all 12)
    pancreozymin 73.4 5 2288654 (1), 9183670 (1), 8689664 (1), 8721092 (1) (see all 5)
    enterostatin 73.4 11 9344422 (1), 15998351 (1), 17044813 (1), 9017279 (1) (see all 10)

    Search CenterWatch for drugs/clinical trials and news about CCK / CCKN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCK gene (2 alternative transcripts): 
    NM_000729.4  NM_001174138.1  

    Unigene Cluster for CCK:

    Cholecystokinin
    Hs.458426  [show with all ESTs]
    Unigene Representative Sequence: BC111026
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334681 ENST00000396169(uc003cld.1) ENST00000434608(uc021wwk.1)
    ENST00000484359(uc011azk.1)

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCK:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCCK 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK289716.1 AK300784.1 BC008283.1 BC093055.1 BC111026.1 BT006991.1 CR542226.1 

    5 DOTS entries:

    DT.214017  DT.100752141  DT.95189754  DT.97780058  DT.436880 

    24/84 AceView cDNA sequences (see all 84):

    BX281746 AA376289 CR542226 BM725598 BC008283 CB154424 CB117972 AU077189 
    CB154571 BM817700 BI754947 BM833562 BT006991 AW043690 BI602158 H46007 
    BI670409 AW205841 T28007 CB961869 CD110041 BI757432 BI667924 BM724466 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCK expression in normal human tissues (normalized intensities)      CCK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGATGG
    CCK Expression
    About this image


    CCK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 34 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             Globus Pallidus   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer

    See CCK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCK

    SOURCE GeneReport for Unigene cluster: Hs.458426
        SABiosciences Expression via Pathway-Focused PCR Array including CCK: 
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCK gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cck1 , 5 cholecystokinin1, 5 82.9(n)1
    80.87(a)1
      9 (72.43 cM)5
    124241  NM_031161.31  NP_112438.11 
     1214898255 
    chicken
    (Gallus gallus)
    Aves CCK1 cholecystokinin 66.96(n)
    57.39(a)
      414884  NM_001001741.1  NP_001001741.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCK6
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343224.1(1385171-1392674)
    zebrafish
    (Danio rerio)
    Actinopterygii cck6
    CCK (1 of 2)6
    cholecystokinin
    39(a)
    38(a)
    many → 1
    many → 1
    16(7030820-7035044)
    19(50222655-50228069)


    ENSEMBL Gene Tree for CCK (if available)
    TreeFam Gene Tree for CCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/229 SNPs in CCK are shown (see all 229)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115718821,2
    C,F,H--42298834(-) CGGGAC/GCTTCA 2 -- ds50015Minor allele frequency- G:0.01NS EA 598
    rs115718811,2
    C,F--42298840(-) GGCTAT/CCGGGA 2 -- ds50011Minor allele frequency- C:0.01NS 178
    rs730603851,2
    --42298846(+) TAGCCC/TAGGAA 2 -- ds50010--------
    rs115718801,2
    C,F,H--42299083(-) TCCCCG/AATCTT 2 -- ds50017Minor allele frequency- A:0.07NS EA CSA WA 714
    rs115718791,2
    C,F,H--42299094(-) GGCCAC/ACCTGA 2 -- ds50016Minor allele frequency- A:0.02NS EA WA 698
    rs1858176991,2
    --42299127(+) CACAGA/GTGGCC 2 -- ds50010--------
    rs1902483761,2
    --42299241(+) GCATCC/TATCAG 2 -- ds50010--------
    rs115718781,2
    C,F,H--42299276(-) TCCATT/GTGGTC 2 -- ds50016Minor allele frequency- G:0.01NS EA WA 714
    rs1123162581,2
    F--42299301(+) GTAGAC/TGCAGG 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs115718771,2
    C,F,H--42299315(-) CTGCCC/ATGTCG 2 -- ds500119Minor allele frequency- A:0.03NS EA NA WA 2154

    HapMap Linkage Disequilibrium report for CCK (42299317 - 42307699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCK:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834671CNV Gain17160897


    Human Gene Mutation Database (HGMD): CCK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCK
    DNA2.0 Custom Variant and Variant Library Synthesis for CCK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118440    OMIM disorders: --

    20/120 diseases for CCK (see all 120):    About MalaCards
    cholecystitis    acalculous cholecystitis    biliary dyskinesia    opioid abuse
    dyspepsia    bile reflux    leptin deficiency    panic disorder
    irritable bowel syndrome    gallbladder disease    alcoholic pancreatitis    cholelithiasis
    neuroepithelioma    social phobia    gastroparesis    duodenal ulcer
    eating disorder    bulimia nervosa    short bowel syndrome    bladder disease

    19 diseases from the University of Copenhagen DISEASES database for CCK:
    Pancreatitis     Biliary dyskinesia     Cholecystitis     Panic disorder
    Pain agnosia     Irritable bowel syndrome     Cholelithiasis     Pancreatic cancer
    Dyspepsia     Steatorrhea     Schizophrenia     Constipation
    Exocrine pancreatic insufficiency     Peptic ulcer     Duodenogastric reflux     Gastroparesis
    Diabetes mellitus     Morphine dependence     Bile reflux

    CCK for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for CCK gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliary dyskinesia 80 6 8273847 (1), 15054652 (1), 9374365 (1), 15322841 (1) (see all 5)
    ovarian stromal cancer 75.5 1 9575243 (1)
    gall bladder 70.6 69 12477770 (6), 8174967 (4), 7890230 (4), 7548456 (3) (see all 32)
    pancreas exocrine 70.3 29 18165448 (2), 1438984 (1), 10981031 (1), 1318128 (1) (see all 20)
    pancreatic insufficiency 63.9 15 9140152 (3), 17460968 (1), 9539652 (1), 7611207 (1) (see all 10)
    chronic cholecystitis 63.9 4 2375327 (1), 9596151 (1), 16954554 (1)
    panic disorder 63.6 86 9754694 (4), 9603610 (3), 15354400 (3), 11244486 (2) (see all 44)
    chronic pancreatitis 63.1 49 1916033 (4), 10919050 (4), 10438157 (3), 2188821 (3) (see all 23)
    panic attacks 62.7 30 11244486 (2), 8372405 (2), 8317587 (1), 12007753 (1) (see all 19)
    neuroepithelioma 60.1 19 1631063 (3), 7694875 (2), 2384178 (1), 1977617 (1) (see all 9)

    Genetic Association Database (GAD): CCK
    Human Genome Epidemiology (HuGE) Navigator: CCK (52 documents)

    Export disorders for CCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCK gene, integrated from 9 sources (see all 1854):
    (articles sorted by number of sources associating them with CCK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. (PubMed id 3856870)1, 2, 3 Takahashi Y.... Matsubara K. (1985)
    2. Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. (PubMed id 15354400)1, 4, 9 Hosing V.G....Deckert J. (2004)
    3. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)1, 4, 9 Goldman J.G....Zhou L. (2004)
    4. No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PubMed id 11368834)1, 4, 9 Vanakoski J....Goldman D. (2001)
    5. Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PubMed id 15740988)1, 4, 9 Takimoto T....Iwahashi K. (2005)
    6. Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PubMed id 15837012)1, 4, 9 Shindo S. and Yoshioka N. (2005)
    7. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. (PubMed id 12777967)1, 4, 9 Wang J....Yu L. (2003)
    8. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 9 Okubo T....Matsushita S. (2002)
    9. Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PubMed id 11803530)1, 4, 9 Hattori E....Yoshikawa T. (2001)
    10. Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. (PubMed id 11443535)1, 4, 9 Hattori E....Yoshikawa T. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 885 HGNC: 1569 AceView: CCK Ensembl:ENSG00000187094 euGenes: HUgn885
    ECgene: CCK H-InvDB: CCK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCK Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cck/
    Wikipedia http://en.wikipedia.org/wiki/Cholecystokinin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCK gene:
    Search GeneIP for patents involving CCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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