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CCK Gene

protein-coding   GIFtS: 60
GCID: GC03M042274

Cholecystokinin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
cholecystokinin1 2
Cholecystokinin Triacontatriapeptide1 2
prepro-cholecystokinin1 2

External Ids:    HGNC: 15691   Entrez Gene: 8852   Ensembl: ENSG000001870947   OMIM: 1184405   UniProtKB: P063073   

Export aliases for CCK gene to outside databases

Previous GC identifers: GC03P041561 GC03U900036 GC03M9D0028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCK Gene:
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the
contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is
processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been
found for this gene. (provided by RefSeq, Mar 2010)

GeneCards Summary for CCK Gene:
CCK (cholecystokinin) is a protein-coding gene. Diseases associated with CCK include cholecystitis, and biliary dyskinesia. GO annotations related to this gene include neuropeptide hormone activity and hormone activity.

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307
Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.
Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas,
binding to CCK-B receptors stimulates gastric acid secretion

summary for CCK Gene:
Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and
gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells
and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of
biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK
receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin.
The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar
affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK (Cholecystokinin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCK gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   CREB   deltaCREB   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCK promoter sequence
   Search Chromatin IP Primers for CCK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

CCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCK gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M042274:  view genomic region     (about GC identifiers)

Start:
42,299,317 bp from pter      End:
42,307,699 bp from pter
Size:
8,383 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307 (See protein sequence)
Recommended Name: Cholecystokinin precursor  
Size: 115 amino acids; 12669 Da
Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity)

Explore the universe of human proteins at neXtProt for CCK: NX_P06307

Explore proteomics data for CCK at MOPED

Post-translational modifications: 

  • The precursor is cleaved by proteases to produce a number of active cholecystokinins1
  • Modification sites at neXtProt

  • See CCK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000720.1  NP_001167609.1  

    ENSEMBL proteins: 
     ENSP00000335657   ENSP00000379472   ENSP00000409124  
    Reactome Protein details: P06307

    CCK Human Recombinant Protein Products:

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    Novus Biologicals CCK Protein
    Novus Biologicals CCK Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CCK

    CCK Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CCK

    CCK Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCK
    Cloud-Clone Corp. CLIAs for CCK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR015499 CCK
     IPR001651 Gastrin
     IPR013152 Gastrin/cholecystokinin_CS

    Graphical View of Domain Structure for InterPro Entry P06307

    ProtoNet protein and cluster: P06307

    1 Blocks protein domain: IPB001651 Gastrin/cholecystokinin peptide hormone

    UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307
    Similarity: Belongs to the gastrin/cholecystokinin family


    CCK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCKN_HUMAN, P06307
    Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut.
    Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas,
    binding to CCK-B receptors stimulates gastric acid secretion

         Genatlas biochemistry entry for CCK:
    cholecystokinin

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS10320330
    GO:0005184neuropeptide hormone activity ISS15374756
    GO:0005515protein binding IPI--
         
    CCK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCK:
     Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cck):
     endocrine/exocrine gland  homeostasis/metabolism  nervous system  no phenotypic analysis 

    CCK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCK

    miRNA
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    Block miRNA regulation of human, mouse, rat CCK using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CCK:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCCK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCK
    Predesigned siRNA for gene silencing in human, mouse, rat CCK

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCK (NM_000729)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCK

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCKN_HUMAN, P06307: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2
    cytosol1
    golgi apparatus1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0030424axon ISS15152034
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body ----

    CCK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CCK About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4VEGF Pathway
    CCKBR-Gastrin Stimulated Signaling0.36
    5Selected targets of CREB1
    Selected targets of CREB1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CCK
        CCKBR-Gastrin Stimulated Signaling

    2 Reactome Pathways for CCK
        Peptide ligand-binding receptors
    G alpha (q) signalling events



    CCK for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CCK: 
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CCK (P063073 ENSP000003356574) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCKBRP322393, ENSP000003355444I2D: score=2 STRING: ENSP00000335544
    ENPEPQ070753, ENSP000002651624I2D: score=1 STRING: ENSP00000265162
    CCKARP322383, ENSP000002955894I2D: score=2 STRING: ENSP00000295589
    CPEP168703, ENSP000003861044I2D: score=1 STRING: ENSP00000386104
    MEP1AQ168193, ENSP000002305884I2D: score=1 STRING: ENSP00000230588
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001662behavioral fear response IEA--
    GO:0001764neuron migration ISS15152034
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0006915apoptotic process ----
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IEA--

    CCK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CCK available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCK Octapeptide, sulfated C-terminal octapeptide of CCK[25126-32-3]
    CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide[25679-24-7]
    Proglumide sodium saltNon-selective CCK antagonist; orally active[99247-33-3]

    Selected Novoseek inferred chemical compound relationships for CCK gene (see all 150)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    loxiglumide 93.4 185 1291406 (5), 8243522 (4), 2378793 (4), 1996640 (4) (see all 74)
    devazepide 83.4 34 8033071 (2), 1996645 (2), 7861766 (2), 1504732 (2) (see all 23)
    sincalide 82.4 13 9252846 (2), 1932168 (2), 2183285 (1), 1860640 (1) (see all 9)
    oxyntomodulin 80.2 45 15082874 (2), 8418694 (2), 2192696 (1), 8223069 (1) (see all 26)
    dexloxiglumide 79.3 3 16163898 (1), 16484960 (1)
    caerulein 79.2 31 1708407 (2), 7679894 (2), 2362955 (2), 2394497 (1) (see all 26)
    minigastrin 76.2 6 17707803 (2), 17896914 (1), 17934729 (1), 19601842 (1)
    lorglumide 75.9 19 2364292 (3), 8942742 (2), 1504732 (2), 2299627 (2) (see all 12)
    pancreozymin 73.4 5 2288654 (1), 9183670 (1), 8689664 (1), 8721092 (1) (see all 5)
    enterostatin 73.4 11 9344422 (1), 15998351 (1), 17044813 (1), 9017279 (1) (see all 10)



    CCK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCK gene (2 alternative transcripts): 
    NM_000729.4  NM_001174138.1  

    Unigene Cluster for CCK:

    Cholecystokinin
    Hs.458426  [show with all ESTs]
    Unigene Representative Sequence: BC111026
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334681 ENST00000396169(uc003cld.1) ENST00000434608(uc021wwk.1)
    ENST00000484359(uc011azk.1)
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate CCK:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidCCK 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCK (NM_000729)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCK
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCK
      QuantiTect SYBR Green Assays in human, mouse, rat CCK
      QuantiFast Probe-based Assays in human, mouse, rat CCK

    Additional mRNA sequence: 

    AK289716.1 AK300784.1 BC008283.1 BC093055.1 BC111026.1 BT006991.1 CR542226.1 

    5 DOTS entries:

    DT.214017  DT.100752141  DT.95189754  DT.97780058  DT.436880 

    Selected AceView cDNA sequences (see all 84):

    BM817700 CB117972 AA376289 BT006991 BM725598 BM833562 BC008283 CB154424 
    BI754947 BX281746 CB154571 AU077189 CR542226 AW043690 BI756101 AW956319 
    BI667924 NM_000729 CD110041 BQ011214 BI602158 T28007 CD250282 N30191 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGATGG
    CCK Expression
    About this image


    CCK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Neurons
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cholinergic Amacrine Cells Inner Nuclear Layer
    CCK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458426
        Pathway & Disease-focused RT2 Profiler PCR Array including CCK: 
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCK
    OriGene qSTAR qPCR primer pairs in human, mouse for CCK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCK
    QuantiTect SYBR Green Assays in human, mouse, rat CCK
    QuantiFast Probe-based Assays in human, mouse, rat CCK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCK gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cck1 , 5 cholecystokinin1, 5 82.9(n)1
    80.87(a)1
      9 (72.43 cM)5
    124241  NM_031161.41  NP_112438.11 
     1214898255 
    chicken
    (Gallus gallus)
    Aves CCK1 cholecystokinin 66.96(n)
    57.39(a)
      414884  NM_001001741.1  NP_001001741.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCK6
    cholecystokinin
    41(a)
    1 ↔ 1
    GL343224.1(1385171-1392674)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004978151 cholecystokinin B-like 55.65(n)
    49.57(a)
      100497815  XM_004915360.1  XP_004915417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CCK (1 of 2)6
    cck6
    cholecystokinin
    38(a)
    35(a)
    many → 1
    many → 1
    19(50222655-50228069) ENSDARG00000038634
    16(7030820-7035044) ENSDARG00000070810


    ENSEMBL Gene Tree for CCK (if available)
    TreeFam Gene Tree for CCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCK (see all 229)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115718821,2
    C,F,H--42298834(-) CGGGAC/GCTTCA 2 -- ds50015Minor allele frequency- G:0.01NS EA 598
    rs115718811,2
    C,F--42298840(-) GGCTAT/CCGGGA 2 -- ds50011Minor allele frequency- C:0.01NS 178
    rs730603851,2
    --42298846(+) TAGCCC/TAGGAA 2 -- ds50010--------
    rs115718801,2
    C,F,H--42299083(-) TCCCCG/AATCTT 2 -- ds50017Minor allele frequency- A:0.07NS EA CSA WA 714
    rs115718791,2
    C,F,H--42299094(-) GGCCAC/ACCTGA 2 -- ds50016Minor allele frequency- A:0.02NS EA WA 698
    rs1858176991,2
    --42299127(+) CACAGA/GTGGCC 2 -- ds50010--------
    rs1902483761,2
    --42299241(+) GCATCC/TATCAG 2 -- ds50010--------
    rs115718781,2
    C,F,H--42299276(-) TCCATT/GTGGTC 2 -- ds50016Minor allele frequency- G:0.01NS EA WA 714
    rs1123162581,2
    F--42299301(+) GTAGAC/TGCAGG 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs115718771,2
    C,F,H--42299315(-) CTGCCC/ATGTCG 2 -- ds500119Minor allele frequency- A:0.03NS EA NA WA 2154

    HapMap Linkage Disequilibrium report for CCK (42299317 - 42307699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834671CNV Gain17160897

    Human Gene Mutation Database (HGMD): CCK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCK
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118440    OMIM disorders: --

    Selected diseases for CCK (see all 118):    
    About MalaCards
    cholecystitis    biliary dyskinesia    opioid abuse    acalculous cholecystitis
    bile reflux    gallbladder disease    gastroparesis    dyspepsia
    panic disorder    cholelithiasis    eating disorder    bladder disease
    leptin deficiency    postcholecystectomy syndrome    neuroepithelioma    exocrine pancreatic insufficiency
    irritable bowel syndrome    duodenal ulcer    short bowel syndrome    social phobia

    19 diseases from the University of Copenhagen DISEASES database for CCK:
    Pancreatitis     Biliary dyskinesia     Cholecystitis     Panic disorder
    Pain agnosia     Irritable bowel syndrome     Cholelithiasis     Pancreatic cancer
    Dyspepsia     Steatorrhea     Schizophrenia     Constipation
    Exocrine pancreatic insufficiency     Peptic ulcer     Duodenogastric reflux     Gastroparesis
    Diabetes mellitus     Morphine dependence     Bile reflux

    CCK for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CCK gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biliary dyskinesia 80 6 8273847 (1), 15054652 (1), 9374365 (1), 15322841 (1) (see all 5)
    ovarian stromal cancer 75.5 1 9575243 (1)
    gall bladder 70.6 69 12477770 (6), 8174967 (4), 7890230 (4), 7548456 (3) (see all 32)
    pancreas exocrine 70.3 29 18165448 (2), 1438984 (1), 10981031 (1), 1318128 (1) (see all 20)
    pancreatic insufficiency 63.9 15 9140152 (3), 17460968 (1), 9539652 (1), 7611207 (1) (see all 10)
    chronic cholecystitis 63.9 4 2375327 (1), 9596151 (1), 16954554 (1)
    panic disorder 63.6 86 9754694 (4), 9603610 (3), 15354400 (3), 11244486 (2) (see all 44)
    chronic pancreatitis 63.1 49 1916033 (4), 10919050 (4), 10438157 (3), 2188821 (3) (see all 23)
    panic attacks 62.7 30 11244486 (2), 8372405 (2), 8317587 (1), 12007753 (1) (see all 19)
    neuroepithelioma 60.1 19 1631063 (3), 7694875 (2), 2384178 (1), 1977617 (1) (see all 9)

    Genetic Association Database (GAD): CCK
    Human Genome Epidemiology (HuGE) Navigator: CCK (52 documents)

    Export disorders for CCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCK gene, integrated from 10 sources (see all 1856):
    (articles sorted by number of sources associating them with CCK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. (PubMed id 3856870)1, 2, 3 Takahashi Y.... Matsubara K. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. (PubMed id 15354400)1, 4, 9 HAPsing V.G....Deckert J. (J. Neural Transm. Suppl. 2004)
    3. Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)1, 4, 9 Goldman J.G....Zhou L. (Arch. Neurol. 2004)
    4. No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PubMed id 11368834)1, 4, 9 Vanakoski J....Goldman D. (Psychiatry Res 2001)
    5. Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PubMed id 15740988)1, 4, 9 Takimoto T....Iwahashi K. (Psychiatry Res 2005)
    6. Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PubMed id 15837012)1, 4, 9 Shindo S. and Yoshioka N. (Forensic Sci. Int. 2005)
    7. Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. (PubMed id 12777967)1, 4, 9 Wang J....Yu L. (Pharmacogenetics 2003)
    8. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)1, 4, 9 Okubo T....Matsushita S. (Alcohol. Clin. Exp. Res. 2002)
    9. Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PubMed id 11803530)1, 4, 9 Hattori E....Yoshikawa T. (Am. J. Med. Genet. 2001)
    10. Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. (PubMed id 11443535)1, 4, 9 Hattori E....Yoshikawa T. (Mol. Psychiatry 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 885 HGNC: 1569 AceView: CCK Ensembl:ENSG00000187094 euGenes: HUgn885
    ECgene: CCK H-InvDB: CCK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCK Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/cck/
    Wikipedia http://en.wikipedia.org/wiki/Cholecystokinin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCK gene:
    Search GeneIP for patents involving CCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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