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Aliases for CCK Gene

Aliases for CCK Gene

  • Cholecystokinin 2 3
  • Cholecystokinin Triacontatriapeptide 2 3
  • Prepro-Cholecystokinin 2 3

External Ids for CCK Gene

Previous GeneCards Identifiers for CCK Gene

  • GC03P041561
  • GC03U900036
  • GC03M9D0028

Summaries for CCK Gene

Entrez Gene Summary for CCK Gene

  • Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for CCK Gene

CCK (Cholecystokinin) is a Protein Coding gene. Diseases associated with CCK include cholecystitis and bladder disease. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CCK Gene

  • This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Tocris Summary for CCK Gene

  • Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCK Gene

Genomics for CCK Gene

Regulatory Elements for CCK Gene

Genomic Location for CCK Gene

Start:
42,257,825 bp from pter
End:
42,266,207 bp from pter
Size:
8,383 bases
Orientation:
Minus strand

Genomic View for CCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCK Gene

Proteins for CCK Gene

  • Protein details for CCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06307-CCKN_HUMAN
    Recommended name:
    Cholecystokinin
    Protein Accession:
    P06307
    Secondary Accessions:

    Protein attributes for CCK Gene

    Size:
    115 amino acids
    Molecular mass:
    12669 Da
    Quaternary structure:
    • Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.

neXtProt entry for CCK Gene

Proteomics data for CCK Gene at MOPED

Post-translational modifications for CCK Gene

  • The precursor is cleaved by proteases to produce a number of active cholecystokinins
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCK Gene

Domains for CCK Gene

Gene Families for CCK Gene

HGNC:

Protein Domains for CCK Gene

Suggested Antigen Peptide Sequences for CCK Gene

Graphical View of Domain Structure for InterPro Entry

P06307

UniProtKB/Swiss-Prot:

CCKN_HUMAN :
  • P06307
Family:
  • Belongs to the gastrin/cholecystokinin family.
genes like me logo Genes that share domains with CCK: view

Function for CCK Gene

Molecular function for CCK Gene

GENATLAS Biochemistry: cholecystokinin
UniProtKB/Swiss-Prot Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Gene Ontology (GO) - Molecular Function for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 10320330
GO:0005184 neuropeptide hormone activity ISS 15374756
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with CCK: view
genes like me logo Genes that share phenotypes with CCK: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCK Gene

Localization for CCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCK Gene COMPARTMENTS Subcellular localization image for CCK gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2
cytosol 1
golgi apparatus 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0030424 axon ISS 15152034
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body --
genes like me logo Genes that share ontologies with CCK: view

Pathways for CCK Gene

genes like me logo Genes that share pathways with CCK: view

Gene Ontology (GO) - Biological Process for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001764 neuron migration ISS 15152034
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0006915 apoptotic process --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
genes like me logo Genes that share ontologies with CCK: view

Compounds for CCK Gene

(3) Tocris Compounds for CCK Gene

Compound Action Cas Number
CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide [25679-24-7]
CCK Octapeptide, sulfated C-terminal octapeptide of CCK [25126-32-3]
Proglumide sodium salt Non-selective CCK antagonist; orally active [99247-33-3]

(150) Novoseek inferred chemical compound relationships for CCK Gene

Compound -log(P) Hits PubMed IDs
loxiglumide 93.4 127
devazepide 83.4 30
sincalide 82.4 11
oxyntomodulin 80.2 28
dexloxiglumide 79.3 2
genes like me logo Genes that share compounds with CCK: view

Transcripts for CCK Gene

Unigene Clusters for CCK Gene

Cholecystokinin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCK Gene

No ASD Table

Relevant External Links for CCK Gene

GeneLoc Exon Structure for
CCK
ECgene alternative splicing isoforms for
CCK

Expression for CCK Gene

mRNA expression in normal human tissues for CCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCK Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (12.0), Brain - Cortex (10.9), Brain - Anterior cingulate cortex (BA24) (10.6), Brain - Amygdala (7.3), and Brain - Hippocampus (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCK Gene

SOURCE GeneReport for Unigene cluster for CCK Gene Hs.458426

genes like me logo Genes that share expressions with CCK: view

No data available for mRNA Expression by UniProt/SwissProt for CCK Gene

Orthologs for CCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCK 35
  • 99.71 (n)
  • 99.13 (a)
CCK 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCK 35
  • 85.51 (n)
  • 80.87 (a)
CCK 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCK 35
  • 88.6 (n)
  • 87.72 (a)
CCK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cck 35
  • 82.9 (n)
  • 80.87 (a)
Cck 16
Cck 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCK 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCK 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cck 35
  • 81.45 (n)
  • 78.26 (a)
chicken
(Gallus gallus)
Aves CCK 35
  • 66.96 (n)
  • 57.39 (a)
CCK 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCK 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497815 35
  • 55.65 (n)
  • 49.57 (a)
zebrafish
(Danio rerio)
Actinopterygii cck 36
  • 35 (a)
OneToMany
CCK (1 of 2) 36
  • 38 (a)
OneToMany
Species with no ortholog for CCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCK Gene

ENSEMBL:
Gene Tree for CCK (if available)
TreeFam:
Gene Tree for CCK (if available)

Paralogs for CCK Gene

No data available for Paralogs for CCK Gene

Variants for CCK Gene

Sequence variations from dbSNP and Humsavar for CCK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs747455 -- 42,264,472(-) ATTAA(A/G)GGATG intron-variant, upstream-variant-2KB
rs747456 -- 42,264,266(-) TGCAC(A/G)GGGCT intron-variant, upstream-variant-2KB
rs754635 -- 42,263,639(+) TGTAG(C/G)GAGCA intron-variant
rs1050815 -- 42,258,034(-) TAAGA(A/C)AACAA utr-variant-3-prime
rs1799923 -- 42,264,802(-) CCGGG(C/T)GGGGC utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCK Gene

Variant ID Type Subtype PubMed ID
nsv834671 CNV Gain 17160897

Relevant External Links for CCK Gene

HapMap Linkage Disequilibrium report
CCK
Human Gene Mutation Database (HGMD)
CCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCK Gene

Disorders for CCK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (33) Diseases for CCK Gene including...

Search for CCK Gene in MalaCards »

(96) Novoseek inferred disease relationships for CCK Gene

Disease -log(P) Hits PubMed IDs
biliary dyskinesia 80 5
ovarian stromal cancer 75.5 1
gall bladder 70.6 52
pancreas exocrine 70.3 21
pancreatic insufficiency 63.9 12

Relevant External Links for CCK

Genetic Association Database (GAD)
CCK
Human Genome Epidemiology (HuGE) Navigator
CCK
genes like me logo Genes that share disorders with CCK: view

No data available for UniProtKB/Swiss-Prot for CCK Gene

Publications for CCK Gene

  1. Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells. (PMID: 11076522) Vishnuvardhan D. … Beinfeld M.C. (Biochemistry 2000) 3 4 23
  2. No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PMID: 11368834) Vanakoski J. … Goldman D. (Psychiatry Res 2001) 3 23 48
  3. Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. (PMID: 11443535) Hattori E. … Yoshikawa T. (Mol. Psychiatry 2001) 3 23 48
  4. Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PMID: 11803530) Hattori E. … Yoshikawa T. (Am. J. Med. Genet. 2001) 3 23 48
  5. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PMID: 12198366) Okubo T. … Matsushita S. (Alcohol. Clin. Exp. Res. 2002) 3 23 48

Products for CCK Gene

Sources for CCK Gene

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