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CCK Gene

protein-coding GIFtS: 62

GC03M042274

cholecystokinin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC117187 ^²
OTTHUMP00000162607 ^²
cholecystokinin ^²

External Ids
HGNC: 1569¹
Entrez Gene: 885²
UniProtKB: P06307³
Ensembl: ENSG00000187094⁷

Search outside databases for aliases for CCK gene

Previous GC identifers: GC03P041561 GC03U900036 GC03M9D0028

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for CCK:

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes

and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The

cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. [provided by

RefSeq]

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic

enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates

amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Gene Wiki entry for CCK (Cholecystokinin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CCK gene

Entrez Gene cytogenetic band: 3p22-p21.3 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3pter-p21

CCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M042274: (about GC identifiers)

Start:	42,274,321 bp from pter
End:	42,282,666 bp from pter
Size:	8,346 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307 (See protein sequence)

Recommended Name: Cholecystokinin precursor

Size: 115 amino acids; 12669 Da

Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity)

Subcellular location: Secreted

Post-translational modifications:

The precursor is cleaved by proteases to produce a number of active cholecystokinins¹

REFSEQ proteins: NP_000720.1

ENSEMBL proteins:

ENSP00000379472 ENSP00000335657

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN for CCK
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Cholecystokinin 39, Cholecystokinin, Cholecystokinin 8)
	Human Recombinant Proteins from Abnova (CCK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0030424	axon	IEA	--

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Antibodies for CCK:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CCK
	Sigma-Aldrich Antibodies for CCK
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Cholecystokinin 39, Cholecystokinin, Cholecystokinin 8), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CCK)
	Novus Biologicals Antibodies for CCK

Assays for CCK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P06307

ProtoNet protein and cluster: P06307

1 Blocks protein family: IPB001651 Gastrin/cholecystokinin peptide hormone

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307

Similarity: Belongs to the gastrin/cholecystokinin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000729

Applied Biosystems Silencer® siRNAs for CCK

Sigma-Aldrich siRNA and siRNA Panels for CCK

Sigma-Aldrich shRNA Panels and shRNA for CCK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CCK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000729
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000729
untagged cDNA clone in CMV expression vector: NM_000729

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000729

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic

enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates

amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Genatlas biochemistry entry for CCK:

cholecystokinin

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cck):

digestive/alimentary

endocrine/exocrine gland

homeostasis/metabolism

nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CCK (Your Favorite Gene powered by Ingenuity)

Cholecystokinin/Gastrin-mediated Signaling

GeneDecks CCK for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CCK

5/43 Interacting proteins for CCK (ENSP00000335657³) via UniProtKB, MINT, and/or STRING (see all 43 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCKBR	ENSP00000335544³	STRING (score=.999)
SST	ENSP00000287641³	STRING (score=.957)
FOS	ENSP00000306245³	STRING (score=.956)
DBI	ENSP00000311117³	STRING (score=.896)
NPY	ENSP00000242152³	STRING (score=.812)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0007165	signal transduction	TAS	10320330
GO:0007409	axonogenesis	IEA	--
GO:0042755	eating behavior	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CCK available from Tocris Bioscience

Compound	Action	CAS number
YM 022	Highly potent, selective non-peptide CCK2 antagonist	[145084-28-2]
Butabindide oxalate	CCK-inactivating serine protease inhibitor	[175553-48-7]
Devazepide	Selective, orally active CCK1 receptor antagonist	[103420-77-5]
LY 225910	Potent CCK2 antagonist	[133040-77-4]
WIN 64338 hydrochloride	Bradykinin B2 antagonist	[151039-63-3]

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10/50 Novoseek chemical compound relationships for CCK gene (see all 50 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sincalide	81.79	10	9252846 (2), 1932168 (2), 2183285 (1), 1860640 (1) (see all 7)
oxyntomodulin	79.46	36	15082874 (2), 8418694 (2), 2192696 (1), 8223069 (1) (see all 23)
caerulein	79.33	31	1708407 (2), 7679894 (2), 2362955 (2), 2394497 (1) (see all 26)
dexloxiglumide	77.30	3	16163898 (1), 16484960 (1)
minigastrin	75.64	3	17707803 (2), 17896914 (1), 17934729 (1)
enterostatin	73.93	11	9344422 (1), 15998351 (1), 17044813 (1), 9017279 (1) (see all 10)
cck-9	72.03	4	8094956 (2), 16326901 (1)
epft	68.01	1	15481311 (1)
l365260	67.98	6	8942742 (2), 11559776 (1), 7890609 (1), 7973426 (1) (see all 5)
cholecystokinin tetrapeptide	66.90	1	8580227 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CCK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CCK)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000729

Sigma-Aldrich siRNA and siRNA Panels for CCK

Sigma-Aldrich shRNA Panels and shRNA for CCK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000729

REFSEQ mRNAs for CCK gene:

NM_000729.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000729

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000729
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000729
                                 untagged cDNA clone in CMV expression vector: NM_000729

Additional cDNA sequence:

AK289716.1 AK300784.1 BC008283.1 BC093055.1 BC111026.1 BT006991.1 CR542226.1

5 DOTS entries:

DT.214017 DT.100752141 DT.97780058 DT.436880 DT.95189754

24/84 AceView cDNA sequences (see all 84 ):

BT006991 AU077189 BM817700 BM725598 CB117972 BX281746 CB154424 AA376289

CB154571 BC008283 CR542226 BM833562 BI754947 CD250282 CF527983 AW043690

BI824082 AW956319 BI756101 BM753873 N30191 BI670261 BM724466 NM_000729

highest scoring ESTs for CCK:

AA376289 AU077189 AW043690 AW956319 BG621508 BG621883 BI599664 BI602158 BI667924 BI669286

Unigene Cluster for CCK:

Cholecystokinin

Hs.458426 [show with all ESTs]

Unigene Representative Sequence: BC111026

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000396169 ENST00000334681

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CCK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CCK

¹ / ² / ³

3 probe-sets matching CCK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37572_at²^{, 3}	U95-A	2	1.00	0.97	1.00	1.00	AW043690	0.80	1.00	0.91	1
205827_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_000729	0.60	1.00	0.82	1
205827_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks CCK for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTGGATGG

SOURCE GeneReport for Unigene cluster: Hs.458426
Expression variation in blood from EXPOLDB for CCK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CCK gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CCK¹	--	cholecystokinin	88.6(n) 87.72(a)	609547 XM_846822.1 XP_851915.1
chimpanzee (Pan troglodytes)	CCK¹	--	cholecystokinin	99.71(n) 99.13(a)	460290 XM_516386.2 XP_516386.1
cow (Bos taurus)	CCK¹	--	cholecystokinin	85.51(n) 80.87(a)	617510 NM_001046603.1 NP_001040068.1
rat (Rattus norvegicus)	Cck¹	--	cholecystokinin	81.74(n) 78.26(a)	25298 NM_012829.1 NP_036961.1
mouse (Mus musculus)	Cck^{1, 5}	9 (71.00 cM)⁵	cholecystokinin^{1, 5}	82.9(n)¹ 80.87(a)¹	12424¹ NM_031161.2¹ NP_112438.1¹ AK002677⁵ AV140386⁵ (see all 10)

About this table Species with no ortholog for CCK

ENSEMBL Gene Tree for CCK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/100 NCBI SNPs in CCK are shown (see all 100 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1799923^1,2	A,C,F,H	42281298(-)	`CCGGGC/TGGGGC`	1	--	ut5¹		10	EA NS EU WA	2494
	rs3774395^1,2	C,F,H	42274659(+)	`GTCCCG/AGTCAC`	1	W/R	mis¹ ese³		12	EA NA EU WA	2478
	rs11571842^1,2	C,F,H	42281450(-)	`GCGTGG/AGAGGG`	1	--	ng3¹		8	NS NA EU EA WA	736
	rs8192473^1,2	C,F,H	42274403(-)	`ATTGTG/ACAAAT`	1	--	ut3¹		8	EU EA WA NS NA	734
	rs13069836^1,2	C,F,H	42282913(+)	`AAAAAT/GAGTCT`	1	--	ng3¹		4	EU EA WA	418
	rs11571877^1,2	C,F,H	42274319(-)	`CTGCCC/ATGTCG`	1	--	ng5¹		11	NS EU EA WA	1260
	rs11571876^1,2	F,H	42274389(-)	`AGACAA/GAATGT`	1	--	ut3¹		5	NS EU EA WA	588
	rs11571880^1,2	F,H	42274087(-)	`TCCCCG/AATCTT`	1	--	ng5¹		5	NS EU EA WA	594
	rs11571840^1,2	F,H	42281607(-)	`ACTAAG/CCTAGC`	1	--	ng3¹		5	NS EU EA WA	598
	rs3806691^1,2	F,H	42281886(+)	`AAAGGG/TCTCTG`	1	--	ng3¹		5	EA EU WA	1886

About this table

HapMap Linkage Disequilibrium images for CCK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118440

10/95 Novoseek disease relationships for CCK gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
biliary dyskinesia	80.13	6	8273847 (1), 15054652 (1), 9374365 (1), 15322841 (1) (see all 5)
ovarian stromal cancer	75.88	1	9575243 (1)
pancreas exocrine	71.05	29	18165448 (2), 1438984 (1), 10981031 (1), 1318128 (1) (see all 20)
gall bladder	70.95	67	12477770 (6), 8174967 (4), 7890230 (4), 7548456 (3) (see all 30)
chronic cholecystitis	64.92	4	2375327 (1), 9596151 (1), 16954554 (1)
pancreatic insufficiency	64.70	15	9140152 (3), 17460968 (1), 9539652 (1), 7611207 (1) (see all 10)
panic attacks	63.66	30	11244486 (2), 8372405 (2), 8317587 (1), 12007753 (1) (see all 19)
panic disorder	63.55	83	9754694 (4), 9603610 (3), 15354400 (3), 11244486 (2) (see all 41)
chronic pancreatitis	63.48	49	1916033 (4), 10919050 (4), 10438157 (3), 2188821 (3) (see all 23)
neuroepithelioma	60.81	19	1631063 (3), 7694875 (2), 2384178 (1), 1977617 (1) (see all 9)

About this table

Human Gene Mutation Database: CCK
Genetic Association Database: CCK
Human Genome Epidemiology Navigator: CCK (33 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1517 PubMed articles for CCK gene (see all 1517 ):

Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. (PubMed id 3856870)^{2, 3, 4} Takahashi Y.... Matsubara K. (1985)
Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. (PubMed id 15354400)^{1, 3, 6} Hosing V.G....Deckert J. (2004)
Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)^{1, 3, 6} Goldman J.G....Zhou L. (2004)
No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PubMed id 11368834)^{1, 3, 6} Vanakoski J....Goldman D. (2001)
Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)^{1, 3, 6} Okubo T....Matsushita S. (2002)
Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PubMed id 11803530)^{1, 3, 6} Hattori E....Yoshikawa T. (2001)
Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. (PubMed id 11443535)^{1, 3, 6} Hattori E....Yoshikawa T. (2001)
Role of tyrosine sulfation and serine phosphorylation in the processing of procholecystokinin to amidated cholecystokinin and its secretion in transfected AtT-20 cells. (PubMed id 11076522)^{1, 3, 4} Vishnuvardhan D. and Beinfeld M.C. (2000)
Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PubMed id 15740988)^{3, 6} Takimoto T....Iwahashi K. (2005)
Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PubMed id 15837012)^{3, 6} Shindo S. and Yoshioka N. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 885	HGNC: 1569	AceView: CCK	Ensembl:ENSG00000187094	euGenes: HUgn885
ECgene: CCK	H-InvDB: CCK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/cck/
Wikipedia	http://en.wikipedia.org/wiki/Cholecystokinin

Licensable Technologies for CCK
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CCK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CCK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CCK		Antibodies for CCK
	Explore super-pooled esiRNAs		Proteins for CCK
	Lentivirus-delivered shRNAs for CCK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CCK)
	Antibodies (CCK)
	Chimera RNAi (CCK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Cholecystokinin 39, Cholecystokinin, Cholecystokinin 8)
	Antibodies (Cholecystokinin 39, Cholecystokinin, Cholecystokinin 8)

Search OriGene for CCK

Tocris compounds for CCK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CCK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CCK Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for CCK

Summaries
for CCK

Genomic Location
for CCK

Proteins
for CCK

Protein Domains/
Families
for CCK

Gene Function
for CCK

Pathways & Interactions
for CCK

Drugs & Compounds
for CCK

Transcripts
for CCK

Expression
for CCK

Orthologs
for CCK

Paralogs
for CCK

SNPs/Variants
for CCK

Disorders & Mutations
for CCK

Medical News
for CCK

Publications
for CCK

Search for CCK

Genome Databases showing CCK

Other Databases showing CCK

Specialized Databases showing CCK

Licensable Technologies
for CCK

Services
for CCK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CCK Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor CCK

Summariesfor CCK

Genomic Locationfor CCK

Proteinsfor CCK

Protein Domains/Familiesfor CCK

Gene Functionfor CCK

Pathways & Interactionsfor CCK

Drugs & Compoundsfor CCK

Transcriptsfor CCK

Expression for CCK

Orthologsfor CCK

Paralogsfor CCK

SNPs/Variantsfor CCK

Disorders & Mutationsfor CCK

Medical Newsfor CCK

Publicationsfor CCK

Search for CCK

Genome Databases showing CCK

Other Databases showing CCK

Specialized Databases showing CCK

Licensable Technologiesfor CCK

Servicesfor CCK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CCK

Summaries
for CCK

Genomic Location
for CCK

Proteins
for CCK

Protein Domains/
Families
for CCK

Gene Function
for CCK

Pathways & Interactions
for CCK

Drugs & Compounds
for CCK

Transcripts
for CCK

Expression
for CCK

Orthologs
for CCK

Paralogs
for CCK

SNPs/Variants
for CCK

Disorders & Mutations
for CCK

Medical News
for CCK

Publications
for CCK

Licensable Technologies
for CCK

Services
for CCK