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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCK Gene

protein-coding GIFtS: 61
GCID: GC03M042274

cholecystokinin

Explore 132 diseases affiliated with
CCK via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cholecystokinin¹
Cholecystokinin Triacontatriapeptide²
Prepro-Cholecystokinin¹

External Ids:	HGNC: 1569¹	Entrez Gene: 885²	Ensembl: ENSG00000187094⁷	OMIM: 118440⁵	UniProtKB: P06307³

Export aliases for CCK gene to outside databases

Previous GC identifers: GC03P041561 GC03U900036 GC03M9D0028

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCK:

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of

the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo-

and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene.

(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its

function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding

to CCK-B receptors stimulates gastric acid secretion

summary for CCK:

Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and

gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells

and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of

biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK

receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin.

The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar

affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK (Cholecystokinin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCK gene promoter:
c-Fos STAT1 AP-1 ATF-2 CREB deltaCREB STAT3 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCK promoter sequence

Search SABiosciences Chromatin IP Primers for CCK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p22.1

CCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCK gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M042274: view genomic region (about GC identifiers)

Start:	42,299,317 bp from pter	End:	42,307,699 bp from pter
Size:	8,383 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307 (See protein sequence)

Recommended Name: Cholecystokinin precursor

Size: 115 amino acids; 12669 Da

Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity)

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for CCK: NX_P06307

Post-translational modifications:

The precursor is cleaved by proteases to produce a number of active cholecystokinins¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P06307

CCK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000720.1 NP_001167609.1

ENSEMBL proteins:

ENSP00000379472 ENSP00000335657 ENSP00000409124

Reactome Protein details: P06307
Human Recombinant Protein Products for CCK:

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	Uscn Proteins for CCK

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0030424	axon	ISS	15152034
GO:0030425	dendrite	IEA	--
GO:0043025	neuronal cell body	--	--

CCK for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CCK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCK for domains About GeneDecksing

3 InterPro domains/families:

IPR015499 CCK

IPR001651 Gastrin

IPR013152 Gastrin/cholecystokinin_CS

Graphical View of Domain Structure for InterPro Entry P06307

ProtoNet protein and cluster: P06307

1 Blocks protein family: IPB001651 Gastrin/cholecystokinin peptide hormone

UniProtKB/Swiss-Prot: CCKN_HUMAN, P06307

Similarity: Belongs to the gastrin/cholecystokinin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CCKN_HUMAN, P06307

Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its

function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding

to CCK-B receptors stimulates gastric acid secretion

Genatlas biochemistry entry for CCK:

cholecystokinin

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	TAS	10320330
GO:0005184	neuropeptide hormone activity	ISS	15374756
GO:0005515	protein binding	--	--

CCK for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CCK:

Increased S DNA content

4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cck):

endocrine/exocrine gland

homeostasis/metabolism

nervous system

no phenotypic analysis

CCK for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCK

miRNA Products:		OriGene 3'-UTR Clone: CCK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCK
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCK:
		hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: CCK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CCK
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Selected targets of CREB1

Selected targets of CREB1

1.00

VEGF Family Ligands and Receptor Interactions

CCKBR-Gastrin Stimulated Signaling

0.28

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CCK

Selected targets of CREB1

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CCK

CCKBR-Gastrin Stimulated Signaling

5/8 Reactome Pathways for CCK (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

CCK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCK

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/142 Interacting proteins for CCK (P06307³ ENSP00000335657⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 142)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCKBR	P32239³, ENSP00000335544⁴	I2D: score=2 STRING: ENSP00000335544
ENPEP	Q07075³, ENSP00000265162⁴	I2D: score=1 STRING: ENSP00000265162
CCKAR	P32238³, ENSP00000295589⁴	I2D: score=2 STRING: ENSP00000295589
CPE	P16870³, ENSP00000386104⁴	I2D: score=1 STRING: ENSP00000386104
MEP1A	Q16819³, ENSP00000230588⁴	I2D: score=1 STRING: ENSP00000230588

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001662	behavioral fear response	IEA	--
GO:0001764	neuron migration	ISS	15152034
GO:0001836	release of cytochrome c from mitochondria	IEA	--
GO:0006915	apoptotic process	--	--
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	--

CCK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CCK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CCK available from Tocris Bioscience About this table

Compound	Action	CAS #
YM 022	Highly potent, selective non-peptide CCK2 antagonist	[145084-28-2]
LY 225910	Potent CCK2 antagonist	[133040-77-4]
WIN 64338 hydrochloride	Bradykinin B2 antagonist	[151039-63-3]
Devazepide	Selective, orally active CCK1 receptor antagonist	[103420-77-5]
Butabindide oxalate	CCK-inactivating serine protease inhibitor	[175553-48-7]

10/150 Novoseek chemical compound relationships for CCK gene (see all 150) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
loxiglumide	93.4	185	1291406 (5), 8243522 (4), 2378793 (4), 1996640 (4) (see all 74)
devazepide	83.4	34	8033071 (2), 1996645 (2), 7861766 (2), 1504732 (2) (see all 23)
sincalide	82.4	13	9252846 (2), 1932168 (2), 2183285 (1), 1860640 (1) (see all 9)
oxyntomodulin	80.2	45	15082874 (2), 8418694 (2), 2192696 (1), 8223069 (1) (see all 26)
dexloxiglumide	79.3	3	16163898 (1), 16484960 (1)
caerulein	79.2	31	1708407 (2), 7679894 (2), 2362955 (2), 2394497 (1) (see all 26)
minigastrin	76.2	6	17707803 (2), 17896914 (1), 17934729 (1), 19601842 (1)
lorglumide	75.9	19	2364292 (3), 8942742 (2), 1504732 (2), 2299627 (2) (see all 12)
pancreozymin	73.4	5	2288654 (1), 9183670 (1), 8689664 (1), 8721092 (1) (see all 5)
enterostatin	73.4	11	9344422 (1), 15998351 (1), 17044813 (1), 9017279 (1) (see all 10)

Search CenterWatch for drugs/clinical trials and news about CCK / CCKN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCK gene (2 alternative transcripts):

NM_000729.4 NM_001174138.1

Unigene Cluster for CCK:

Cholecystokinin

Hs.458426 [show with all ESTs]

Unigene Representative Sequence: BC111026

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396169(uc003cld.1) ENST00000334681 ENST00000434608(uc021wwk.1)

ENST00000484359(uc011azk.1)

miRNA Products:		OriGene 3'-UTR Clone: CCK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCK
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CCK:
		hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-3121-3p hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: CCK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK289716.1 AK300784.1 BC008283.1 BC093055.1 BC111026.1 BT006991.1 CR542226.1

5 DOTS entries:

DT.214017 DT.100752141 DT.95189754 DT.97780058 DT.436880

24/84 AceView cDNA sequences (see all 84):

BM833562 CB154571 BX281746 AA376289 CB117972 CR542226 AU077189 BM725598

BT006991 BM817700 BI754947 CB154424 BC008283 BI755000 BI756101 AW205841

AI745597 BM724466 BI822911 BI602158 BM753873 AI799838 H46007 BI667924

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGGATGG

About this image

CCK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Eye

Inner Nuclear Layer

Mature Rod Bipolar Cells

Bipolar, Retina

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Cardiomyocyte-like cells (Spontaneous differen...)

See CCK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCK

SOURCE GeneReport for Unigene cluster: Hs.458426

SABiosciences Expression via Pathway-Focused PCR Array including CCK:

Obesity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCK gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cck^{1 , 5}	cholecystokinin^{1, 5}	82.9(n)¹ 80.87(a)¹		9 (72.43 cM)⁵ 12424¹ NM_031161.3¹ NP_112438.1¹ 121489825⁵
chicken (Gallus gallus)	Aves	CCK¹	cholecystokinin	66.96(n) 57.39(a)		414884 NM_001001741.1 NP_001001741.1
lizard (Anolis carolinensis)	Reptilia	CCK⁶	--	43(a)	1 ↔ 1	GL343224.1(1385892-1390713)
zebrafish (Danio rerio)	Actinopterygii	wu:fq26c12⁶ cck⁶	cholecystokinin	42(a) 37(a)	many → 1 many → 1	19(50222655-50228069) 16(7030820-7035044)

ENSEMBL Gene Tree for CCK (if available)
TreeFam Gene Tree for CCK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11571882^1,2	C,F,H	--	42298834(-)	`CGGGAC/GCTTCA`	2	--	ds500¹		5		NS EA	598
rs11571881^1,2	C	--	42298840(-)	`GGCTAT/CCGGGA`	2	--	ds500¹		1		NS	178
rs73060385^1,2		--	42298846(+)	`TAGCCC/TAGGAA`	2	--	ds500¹		0	--	--	--	--
rs11571880^1,2	C,F,H	--	42299083(-)	`TCCCCG/AATCTT`	2	--	ds500¹		7		NS EA CSA WA	714
rs11571879^1,2	C,F,H	--	42299094(-)	`GGCCAC/ACCTGA`	2	--	ds500¹		6		NS EA WA	698
rs185817699^1,2		--	42299127(+)	`CACAGA/GTGGCC`	2	--	ds500¹		0	--	--	--	--
rs190248376^1,2		--	42299241(+)	`GCATCC/TATCAG`	2	--	ds500¹		0	--	--	--	--
rs11571878^1,2	C,F,H	--	42299276(-)	`TCCATT/GTGGTC`	2	--	ds500¹		6		NS EA WA	714
rs112316258^1,2		--	42299301(+)	`GTAGAC/TGCAGG`	2	--	ds500¹		1		CSA	2
rs11571877^1,2	C,F,H	--	42299315(-)	`CTGCCC/ATGTCG`	2	--	ds500¹		19		NS EA NA WA	2154

HapMap Linkage Disequilibrium report for CCK (42299317 - 42307699 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCK: --
Human Gene Mutation Database (HGMD): CCK

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCK

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCK for disorders           About GeneDecksing

OMIM gene information: 118440    OMIM disorders: --

20/132 diseases for CCK (see all 132):    About MalaCards

protein-energy malnutrition pancreatitis prader-willi syndrome opioid abuse

exocrine pancreatic insufficiency obsessive-compulsive disorder subependymal giant cell astrocytoma gastroesophageal reflux disease

acalculous cholecystitis bile reflux acute mountain sickness social phobia

bulimia nervosa cholecystitis eating disorder congenital diaphragmatic hernia

duodenogastric reflux autonomic neuropathy biliary dyskinesia short bowel syndrome

19 diseases from the University of Copenhagen DISEASES database for CCK:

Pancreatitis Biliary dyskinesia Cholecystitis Panic disorder

Pain agnosia Cholelithiasis Irritable bowel syndrome Pancreatic cancer

Dyspepsia Schizophrenia Steatorrhea Constipation

Exocrine pancreatic insufficiency Peptic ulcer Duodenogastric reflux Morphine dependence

Gastroparesis Diabetes mellitus Bile reflux

10/96 Novoseek disease relationships for CCK gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
biliary dyskinesia	80	6	8273847 (1), 15054652 (1), 9374365 (1), 15322841 (1) (see all 5)
ovarian stromal cancer	75.5	1	9575243 (1)
gall bladder	70.6	69	12477770 (6), 8174967 (4), 7890230 (4), 7548456 (3) (see all 32)
pancreas exocrine	70.3	29	18165448 (2), 1438984 (1), 10981031 (1), 1318128 (1) (see all 20)
pancreatic insufficiency	63.9	15	9140152 (3), 17460968 (1), 9539652 (1), 7611207 (1) (see all 10)
chronic cholecystitis	63.9	4	2375327 (1), 9596151 (1), 16954554 (1)
panic disorder	63.6	86	9754694 (4), 9603610 (3), 15354400 (3), 11244486 (2) (see all 44)
chronic pancreatitis	63.1	49	1916033 (4), 10919050 (4), 10438157 (3), 2188821 (3) (see all 23)
panic attacks	62.7	30	11244486 (2), 8372405 (2), 8317587 (1), 12007753 (1) (see all 19)
neuroepithelioma	60.1	19	1631063 (3), 7694875 (2), 2384178 (1), 1977617 (1) (see all 9)

Genetic Association Database (GAD): CCK
Human Genome Epidemiology (HuGE) Navigator: CCK (52 documents)

Export disorders for CCK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCK gene, integrated from 9 sources (see all 1849):
(articles sorted by number of sources associating them with CCK)

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world of online information

Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. (PubMed id 3856870)^{1, 2, 3} Takahashi Y.... Matsubara K. (1985)
Cholecystokinin- and cholecystokinin-B-receptor gene polymorphisms in panic disorder. (PubMed id 15354400)^{1, 4, 9} Hosing V.G....Deckert J. (2004)
Genetic polymorphisms in Parkinson disease subjects with and without hallucinations: an analysis of the cholecystokinin system. (PubMed id 15313848)^{1, 4, 9} Goldman J.G....Zhou L. (2004)
No association of CCK and CCK(B) receptor polymorphisms with alcohol dependence. (PubMed id 11368834)^{1, 4, 9} Vanakoski J....Goldman D. (2001)
Cholecystokinin (CCK) and the CCKA receptor gene polymorphism, and smoking behavior. (PubMed id 15740988)^{1, 4, 9} Takimoto T....Iwahashi K. (2005)
Polymorphisms of the cholecystokinin gene promoter region in suicide victims in Japan. (PubMed id 15837012)^{1, 4, 9} Shindo S. and Yoshioka N. (2005)
Cholecystokinin, cholecystokinin-A receptor and cholecystokinin-B receptor gene polymorphisms in Parkinson's disease. (PubMed id 12777967)^{1, 4, 9} Wang J....Yu L. (2003)
Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. (PubMed id 12198366)^{1, 4, 9} Okubo T....Matsushita S. (2002)
Association studies of the CT repeat polymorphism in the 5' upstream region of the cholecystokinin B receptor gene with panic disorder and schizophrenia in Japanese subjects. (PubMed id 11803530)^{1, 4, 9} Hattori E....Yoshikawa T. (2001)
Identification of a compound short tandem repeat stretch in the 5'-upstream region of the cholecystokinin gene, and its association with panic disorder but not with schizophrenia. (PubMed id 11443535)^{1, 4, 9} Hattori E....Yoshikawa T. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 885	HGNC: 1569	AceView: CCK	Ensembl:ENSG00000187094	euGenes: HUgn885
ECgene: CCK	H-InvDB: CCK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCK	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/cck/
Wikipedia	http://en.wikipedia.org/wiki/Cholecystokinin

Intellectual Property for CCK gene
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Patent Information for CCK gene:
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Steatorrhea
Protein-Energy Malnutrition
Gastroesophageal reflux disease
Hyperinsulinemia
Anxiety Disorders
Prematurity
Herpes Simplex
Obesity Morbid
Eating Disorders
Binge eating disorder
Binge Eating
ADENOCARCINOMA LUNG
Bile Duct Obstruction
Biliary Dyskinesia
biliary obstruction
hypomotility
Edema
Gastrointestinal Diseases
Schizophrenia
Cholestasis
Adenocarcinoma
Pyloroplasty
Hyperalgesia
THYROID CARCINOMA MEDULLARY
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Respiratory failure
Pancreatitis Alcoholic
Bulimia
Opioid abuse
GASTRIC CARCINOMA
Pancreatitis
Cholelithiasis
motility disorder
acute cholecystitis
acute pancreatitis
hypermotility
Liver Failure
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Epilepsy
PANCREAS EXOCRINE
Malnutrition
Hyperglycemia
Neuroepithelioma
psychiatric disorder
AUTONOMIC NEUROPATHY
HEMORRHAGIC PANCREATITIS
Bulimia Nervosa
Panic Disorder
Celiac Disease
PANCREATITIS EDEMATOUS ACUTE
Glioblastoma
FUNCTIONAL BOWEL DISORDER
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Anorexia Nervosa
Malabsorption
distention
ovarian stromal cancer
Gall Bladder
MOTOR DISORDER
Acromegaly
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APECED
Carcinoid
Glucagonoma
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Cancer Lung
small cell lung cancer
chronic pancreatitis
Neuroendocrine Tumors
FUNCTIONAL DYSPEPSIA
Alcohol withdrawal
Pancreatic tumor
stasis
Delirium Tremens
Exocrine pancreatic insufficiency
OBESITY
Gastritis
Jaundice Obstructive
PANCREATIC CARCINOMA
Chronic cholecystitis
Panic
bowel disease
Pancreatic Diseases
Cholera
NIDDM
Prader-Willi Syndrome
Duodenal Ulcer
Cholecystitis
Functional gastrointestinal disorder
Psychotic

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CCK Gene

cholecystokinin

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