CCIN Gene
protein-coding GIFtS: 49
GCID: GC09P036159
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calicin
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Aliases
for CCIN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Export aliases for CCIN gene to outside databasesPrevious GC identifers: GC09P036481 GC09P036338 |
Summaries
for CCIN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCIN:
The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeatsand a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CALI_HUMAN, Q13939Function: Possible morphogenetic cytoskeletal element in spermiogenic differentiation
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Genomic Views
for CCIN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCIN gene promoter:
NF-1 Tal-1 AML1a ATF-2 XBP-1 CUTL1 E47 C/EBPalpha SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCIN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCIN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p13.1CCIN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P036159: view genomic region
(about GC identifiers)
Start:
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36,169,389 bp from pter |
End:
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36,171,331 bp from pter |
Size:
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1,943 bases |
Orientation:
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plus strand |
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Proteins
for CCIN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CALI_HUMAN, Q13939 (See
protein sequence)Recommended Name: Calicin Size: 588 amino acids; 66582 Da
Subcellular location: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightlyassociated to the nucleus
Secondary accessions: Q9BXG7Explore the universe of human proteins at neXtProt for CCIN: NX_Q13939
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13939
CCIN Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005884.2
ENSEMBL proteins: ENSP00000334996
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005856 | cytoskeleton |
NAS | -- | | GO:0033150 | cytoskeletal calyx |
IEA | -- |
CCIN for ontologies About GeneDecksing
CCIN Antibody Products:
Assay Products for CCIN: |
Protein
Domains /
Families
for CCIN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCIN for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13939ProtoNet protein and cluster: Q13939 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: CALI_HUMAN, Q13939Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for CCIN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CALI_HUMAN, Q13939Function: Possible morphogenetic cytoskeletal element in spermiogenic differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CCIN (NM_005893) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCIN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCIN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCIN |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005200 | structural constituent of cytoskeleton |
NAS | -- |
CCIN for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CCIN:
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Pathways & Interactions
for CCIN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCIN
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CCIN (Q139393 ENSP000003349964) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
NAS | -- | | GO:0030154 | cell differentiation |
IEA | -- |
CCIN for ontologies About GeneDecksing
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Drugs & Compounds
for CCIN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCIN
Search CenterWatch for drugs/clinical trials and news about CCIN / CALI
|
Transcripts
for CCIN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCIN gene: NM_005893.2 Unigene Cluster for CCIN: Calicin Hs.115460 [show with all ESTs]Unigene Representative Sequence: NM_0058931 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000335119(uc003zzb.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCIN (NM_005893) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCIN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCIN |
Additional cDNA sequence: AF333334.1 AK313763.1 BC019251.2 Z46967.1 4 DOTS entries: DT.407880 DT.100673016 DT.100676563 DT.121155343 24/36 AceView cDNA sequences (see all 36): BM564063 BI826975 BP371354 BI829423 NM_005893 BX106803 AA420997 BM554512 BI825638 BI828812 BC019251 BM564310 Z46967 CD251977 BI827210 BI831707 BI561092 BI826408 BM563612 AF333334 BG724007 AA421077 BI831628 BP368804
GeneLoc Exon Structure
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Expression
for CCIN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTATATGCTC
About this image
See CCIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCIN
SOURCE GeneReport for Unigene cluster: Hs.115460
UniProtKB/Swiss-Prot: CALI_HUMAN, Q13939Tissue specificity: Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads ofmalformed spermatozoa
SABiosciences Custom PCR Arrays for CCIN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCIN
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCIN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCIN |
Orthologs
for CCIN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCIN gene from 1/13 species (see all 13) About this table
ENSEMBL Gene Tree for CCIN (if available)
TreeFam Gene Tree for CCIN (if available) |
Paralogs
for CCIN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCIN gene
- KLHL382 KLHL212 KLHL292 KLHL62 KLHL232 KBTBD32 KLHL112 KLHL242
- KLHL252 KLHL302 KLHL352 ENC12
1 SIMAP similar gene for CCIN using alignment to 3 protein entries: CALI_HUMAN (see all proteins):KBTBD3
CCIN for paralogs About GeneDecksing
|
Genomic Variants
for CCIN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCIN (36169389 - 36171331 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCIN
1 CNV: 47924 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CCIN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCIN for disorders About GeneDecksing
OMIM gene information: 603960
OMIM disorders: --
1  disease for CCIN: About MalaCardsshigellosis
1 disease from the University of Copenhagen DISEASES database for CCIN:Varicocele Export disorders for CCIN gene to outside databases
|
Publications
for CCIN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCIN gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCIN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton. (PubMed id 7641791)1, 2, 3, 9 von Buelow M.... Franke W.W. (1995)
- Actin-binding properties and colocalization with actin during spermiogenesis of mammalian sperm calicin. (PubMed id 11090452)1, 9 Lecuyer C....Rousseaux-Prevost R. (2000)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Calicin in human sperm fertilizing zona-free hamster eggs in vitro. (PubMed id 7569061)9 Paranko J. and Salonen I. (1995)
- Presence and localization of the 60 KD calicin in hum an spermatozoa presenting postacrosomal sheath defects: preliminary results. (PubMed id 2015086)9 Courtot A.M. (1991)
- CP beta3, a novel isoform of an actin-binding protein, is a component of the cytoskeletal calyx of the mammalian sperm head. (PubMed id 9184090)9 von Bulow M....Franke W.W. (1997)
- The protein complexity of the cytoskeleton of bovine and human sperm heads: the identification and characterization of cylicin II. (PubMed id 7737358)9 Hess H.... Franke W.W. (1995)
- The cytoskeleton of mammalian spermatozoa. (PubMed id 7849610)9 Fouquet J.P. and Kann M.L. (1994)
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External Searches for CCIN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CCIN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCIN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCIN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCIN | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCIN gene:
Search GeneIP for patents involving CCIN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCIN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCIN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCIN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCIN | | | OriGene Protein Over-expression Lysate for CCIN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCIN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCIN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCIN | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCIN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCIN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCIN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCIN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCIN |
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 | | | CCIN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCIN |
|  |  |  | | | | Search ThermoFisher Antibodies for CCIN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCIN |
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