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Aliases for CCIN Gene

Aliases for CCIN Gene

  • Calicin 2 3
  • KBTBD14 3
  • BTBD20 3

External Ids for CCIN Gene

Summaries for CCIN Gene

Entrez Gene Summary for CCIN Gene

  • The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCIN Gene

CCIN (Calicin) is a Protein Coding gene. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is KLHL11.

UniProtKB/Swiss-Prot for CCIN Gene

  • Possible morphogenetic cytoskeletal element in spermiogenic differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCIN Gene

Genomics for CCIN Gene

Genomic Location for CCIN Gene

36,169,392 bp from pter
36,171,334 bp from pter
1,943 bases
Plus strand

Genomic View for CCIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCIN Gene

Regulatory Elements for CCIN Gene

Proteins for CCIN Gene

  • Protein details for CCIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q9BXG7

    Protein attributes for CCIN Gene

    588 amino acids
    Molecular mass:
    66582 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCIN Gene

Proteomics data for CCIN Gene at MOPED

Post-translational modifications for CCIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCIN Gene

Domains for CCIN Gene

Gene Families for CCIN Gene

  • BTBD :BTB/POZ domain containing

Suggested Antigen Peptide Sequences for CCIN Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q13939
  • Contains 1 BTB (POZ) domain.:
    • Q13939
  • Contains 6 Kelch repeats.:
    • Q13939
genes like me logo Genes that share domains with CCIN: view

Function for CCIN Gene

Molecular function for CCIN Gene

UniProtKB/Swiss-Prot Function: Possible morphogenetic cytoskeletal element in spermiogenic differentiation

Gene Ontology (GO) - Molecular Function for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CCIN: view

Phenotypes for CCIN Gene

GenomeRNAi human phenotypes for CCIN:
genes like me logo Genes that share phenotypes with CCIN: view

miRNA for CCIN Gene

miRTarBase miRNAs that target CCIN

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCIN Gene

Localization for CCIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCIN Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus.

Subcellular locations from

Jensen Localization Image for CCIN Gene COMPARTMENTS Subcellular localization image for CCIN gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005856 cytoskeleton --
GO:0033150 cytoskeletal calyx IEA --
genes like me logo Genes that share ontologies with CCIN: view

Pathways for CCIN Gene

SuperPathways for CCIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with CCIN: view

No data available for Pathways by source for CCIN Gene

Transcripts for CCIN Gene

mRNA/cDNA for CCIN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCIN Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCIN Gene

No ASD Table

Relevant External Links for CCIN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCIN Gene

mRNA expression in normal human tissues for CCIN Gene

mRNA differential expression in normal tissues according to GTEx for CCIN Gene

This gene is overexpressed in Testis (46.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCIN Gene

SOURCE GeneReport for Unigene cluster for CCIN Gene Hs.115460

mRNA Expression by UniProt/SwissProt for CCIN Gene

Tissue specificity: Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa.
genes like me logo Genes that share expressions with CCIN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCIN Gene

Orthologs for CCIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCIN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCIN 35
  • 99.6 (n)
  • 99.66 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CCIN 35
  • 90.59 (n)
  • 91.33 (a)
  • 91 (a)
(Canis familiaris)
Mammalia CCIN 35
  • 90.87 (n)
  • 93.2 (a)
  • 93 (a)
(Mus musculus)
Mammalia Ccin 35
  • 88.49 (n)
  • 93.03 (a)
Ccin 16
Ccin 36
  • 93 (a)
(Monodelphis domestica)
Mammalia CCIN 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CCIN 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Ccin 35
  • 88.49 (n)
  • 93.03 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
-- 36
  • 60 (a)
Species with no ortholog for CCIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCIN Gene

Gene Tree for CCIN (if available)
Gene Tree for CCIN (if available)

Paralogs for CCIN Gene

Paralogs for CCIN Gene

Selected SIMAP similar genes for CCIN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCIN: view

Variants for CCIN Gene

Sequence variations from dbSNP and Humsavar for CCIN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1054007 -- 36,170,961(+) GGCAG(A/G)GTGTG reference, missense
rs2149007 -- 36,167,800(+) AGCAC(C/T)GGCCG upstream-variant-2KB
rs2149008 -- 36,167,813(+) CACGG(G/T)GGCTC upstream-variant-2KB
rs2182819 -- 36,167,572(+) CCCGG(A/C)GCATT upstream-variant-2KB
rs3739609 -- 36,169,601(-) TCCAC(A/G)CTCAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CCIN Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv528600 CNV Loss 19592680

Relevant External Links for CCIN Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCIN Gene

Disorders for CCIN Gene

(1) University of Copenhagen DISEASES for CCIN Gene

Relevant External Links for CCIN

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CCIN: view

No data available for UniProtKB/Swiss-Prot for CCIN Gene

Publications for CCIN Gene

  1. Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton. (PMID: 7641791) von Buelow M. … Franke W.W. (Exp. Cell Res. 1995) 2 3 4 23
  2. Actin-binding properties and colocalization with actin during spermiogenesis of mammalian sperm calicin. (PMID: 11090452) LAccuyer C. … Rousseaux-PrAcvost R. (Biol. Reprod. 2000) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CCIN Gene

Sources for CCIN Gene

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