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Aliases for CCIN Gene

Aliases for CCIN Gene

  • Calicin 2 3 5
  • Testis Tissue Sperm-Binding Protein Li 65n 3
  • KBTBD14 3
  • BTBD20 3

External Ids for CCIN Gene

Previous GeneCards Identifiers for CCIN Gene

  • GC09P036481
  • GC09P036338

Summaries for CCIN Gene

Entrez Gene Summary for CCIN Gene

  • The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCIN Gene

CCIN (Calicin) is a Protein Coding gene. Diseases associated with CCIN include Pelvic Varices. An important paralog of this gene is KLHL11.

UniProtKB/Swiss-Prot for CCIN Gene

  • Possible morphogenetic cytoskeletal element in spermiogenic differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCIN Gene

Genomics for CCIN Gene

Regulatory Elements for CCIN Gene

Enhancers for CCIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCIN on UCSC Golden Path with GeneCards custom track

Genomic Location for CCIN Gene

Chromosome:
9
Start:
36,169,392 bp from pter
End:
36,171,334 bp from pter
Size:
1,943 bases
Orientation:
Plus strand

Genomic View for CCIN Gene

Genes around CCIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCIN Gene

Proteins for CCIN Gene

  • Protein details for CCIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13939-CALI_HUMAN
    Recommended name:
    Calicin
    Protein Accession:
    Q13939
    Secondary Accessions:
    • Q9BXG7

    Protein attributes for CCIN Gene

    Size:
    588 amino acids
    Molecular mass:
    66582 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCIN Gene

Proteomics data for CCIN Gene at MOPED

Post-translational modifications for CCIN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCIN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCIN Gene

Domains & Families for CCIN Gene

Gene Families for CCIN Gene

Protein Domains for CCIN Gene

Suggested Antigen Peptide Sequences for CCIN Gene

Graphical View of Domain Structure for InterPro Entry

Q13939

UniProtKB/Swiss-Prot:

CALI_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with CCIN: view

Function for CCIN Gene

Molecular function for CCIN Gene

UniProtKB/Swiss-Prot Function:
Possible morphogenetic cytoskeletal element in spermiogenic differentiation.

Gene Ontology (GO) - Molecular Function for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with CCIN: view
genes like me logo Genes that share phenotypes with CCIN: view

Animal Model Products

miRNA for CCIN Gene

miRTarBase miRNAs that target CCIN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCIN Gene

Localization for CCIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCIN Gene

Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure tightly associated to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCIN Gene COMPARTMENTS Subcellular localization image for CCIN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033150 cytoskeletal calyx IEA --
genes like me logo Genes that share ontologies with CCIN: view

Pathways & Interactions for CCIN Gene

SuperPathways for CCIN Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with CCIN: view

No data available for Pathways by source and SIGNOR curated interactions for CCIN Gene

Drugs & Compounds for CCIN Gene

No Compound Related Data Available

Transcripts for CCIN Gene

mRNA/cDNA for CCIN Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(36) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCIN Gene

Calicin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCIN Gene

No ASD Table

Relevant External Links for CCIN Gene

GeneLoc Exon Structure for
CCIN
ECgene alternative splicing isoforms for
CCIN

Expression for CCIN Gene

mRNA expression in normal human tissues for CCIN Gene

mRNA differential expression in normal tissues according to GTEx for CCIN Gene

This gene is overexpressed in Testis (x46.9).

Protein differential expression in normal tissues from HIPED for CCIN Gene

This gene is overexpressed in Testis (46.3) and Monocytes (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCIN Gene



SOURCE GeneReport for Unigene cluster for CCIN Gene Hs.115460

mRNA Expression by UniProt/SwissProt for CCIN Gene

Q13939-CALI_HUMAN
Tissue specificity: Testis. Not detectable or shows a drastically altered pattern of arrangement in the heads of malformed spermatozoa.
genes like me logo Genes that share expression patterns with CCIN: view

Protein tissue co-expression partners for CCIN Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCIN Gene

Orthologs for CCIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCIN 35
  • 90.59 (n)
  • 91.33 (a)
CCIN 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCIN 35
  • 90.87 (n)
  • 93.2 (a)
CCIN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccin 35
  • 88.49 (n)
  • 93.03 (a)
Ccin 16
Ccin 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCIN 35
  • 99.6 (n)
  • 99.66 (a)
CCIN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccin 35
  • 88.49 (n)
  • 93.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CCIN 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCIN 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
Species with no ortholog for CCIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCIN Gene

ENSEMBL:
Gene Tree for CCIN (if available)
TreeFam:
Gene Tree for CCIN (if available)

Paralogs for CCIN Gene

Paralogs for CCIN Gene

(1) SIMAP similar genes for CCIN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCIN: view

Variants for CCIN Gene

Sequence variations from dbSNP and Humsavar for CCIN Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs34789048 - 36,169,726(-) GGTAA(C/T)TGGTG reference, missense
rs1054007 -- 36,170,961(+) GGCAG(A/G)GTGTG reference, missense
rs7860866 -- 36,167,500(+) cccaa(A/G)gtgct upstream-variant-2KB
rs113121379 -- 36,168,987(+) TGCTC(A/G)GCTTC upstream-variant-2KB
rs113222879 -- 36,171,200(+) CCTCC(A/G)CCAGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCIN Gene

Variant ID Type Subtype PubMed ID
nsv893049 CNV Gain 21882294
esv34080 CNV Loss 18971310
nsv528600 CNV Loss 19592680

Variation tolerance for CCIN Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCIN Gene

Disorders for CCIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
pelvic varices
- elite association - COSMIC cancer census association via MalaCards
Search CCIN in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCIN

Genetic Association Database (GAD)
CCIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCIN
genes like me logo Genes that share disorders with CCIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCIN Gene

Publications for CCIN Gene

  1. Molecular nature of calicin, a major basic protein of the mammalian sperm head cytoskeleton. (PMID: 7641791) von Buelow M. … Franke W.W. (Exp. Cell Res. 1995) 2 3 4 23 67
  2. Actin-binding properties and colocalization with actin during spermiogenesis of mammalian sperm calicin. (PMID: 11090452) LAccuyer C. … Rousseaux-PrAcvost R. (Biol. Reprod. 2000) 3 23
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for CCIN Gene

Sources for CCIN Gene

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