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CCHCR1 Gene

protein-coding   GIFtS: 57
GCID: GC06M031110

Coiled-Coil Alpha-Helical Rod Protein 1

(Previous name: chromosome 6 open reading frame 18)
(Previous symbol: C6orf18)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Alpha-Helical Rod Protein 11 2     SBP2
C6orf181 2 3     HCR (A-Helix Coiled-Coil Rod Homologue)2
HCR2 3 5     pg82
Alpha-Helical Coiled-Coil Rod Protein2 3     StAR-Binding Protein2
Putative Gene 8 Protein2 3     Pg83
Chromosome 6 Open Reading Frame 181     C6ORF185

External Ids:    HGNC: 139301   Entrez Gene: 545352   Ensembl: ENSG000002045367   OMIM: 6053105   UniProtKB: Q8TD313   

Export aliases for CCHCR1 gene to outside databases

Previous GC identifers: GC06M031219 GC06M030912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCHCR1 Gene:
CCHCR1 (coiled-coil alpha-helical rod protein 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: CCHCR_HUMAN, Q8TD31
Function: May be a regulator of keratinocyte proliferation or differentiation

Gene Wiki entry for CCHCR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCHCR1 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCHCR1 promoter sequence
   Search Chromatin IP Primers for CCHCR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCHCR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

CCHCR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCHCR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031110:  view genomic region     (about GC identifiers)

Start:
31,110,216 bp from pter      End:
31,126,015 bp from pter
Size:
15,800 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167246 2,458,574-2,474,393      Chr6-,NT_167247 2,492,152-2,507,972      Chr6-,NT_167245 2,407,346-2,423,143     
Chr6-,NT_167248 2,406,050-2,421,866      Chr6-,NT_113891.2 2,624,976-2,640,772     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCHCR_HUMAN, Q8TD31 (See protein sequence)
Recommended Name: Coiled-coil alpha-helical rod protein 1  
Size: 782 amino acids; 88671 Da
Sequence caution: Sequence=AAF74221.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA81890.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA82158.1;
Type=Erroneous gene model prediction; Sequence=BAA91236.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAB63313.1; Type=Erroneous gene model prediction; Sequence=BAC54937.1;
Type=Erroneous gene model prediction;
Secondary accessions: A2ABH6 E9PE84 Q2TB67 Q5SQ82 Q5STE9 Q9NRK8 Q9NWY9 Q9NXJ4 Q9NXK3 Q9Y6W1
Q9Y6W2
Alternative splicing: 3 isoforms:  Q8TD31-1   Q8TD31-2   Q8TD31-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CCHCR1: NX_Q8TD31

Explore proteomics data for CCHCR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys119, Lys402
  • Modification sites at PhosphoSitePlus

  • See CCHCR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001099033.1  NP_001099034.1  NP_061925.2  

    ENSEMBL proteins: 
     ENSP00000379566   ENSP00000365442   ENSP00000379561   ENSP00000401039   ENSP00000426883  
     ENSP00000422503   ENSP00000421523   ENSP00000414323   ENSP00000421393   ENSP00000390027  
     ENSP00000425682   ENSP00000421992   ENSP00000420941   ENSP00000398715   ENSP00000425595  
     ENSP00000402432   ENSP00000425377   ENSP00000420911   ENSP00000389303   ENSP00000424335  
     ENSP00000422000   ENSP00000424164   ENSP00000425435  

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    antibodies-online antibodies for CCHCR1 (10 products) 

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    antibodies-online kits for CCHCR1 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009800 HCR

    Graphical View of Domain Structure for InterPro Entry Q8TD31

    ProtoNet protein and cluster: Q8TD31

    1 Blocks protein domain: IPB009800 Alpha helical coiled-coil rod


    Find genes that share domains with CCHCR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCHCR_HUMAN, Q8TD31
    Function: May be a regulator of keratinocyte proliferation or differentiation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CCHCR1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCHCR1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCHCR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCHCR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCHCR1

    miRNA
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    miRTarBase miRNAs that target CCHCR1:
    hsa-mir-346 (MIRT042719), hsa-mir-615-3p (MIRT040226)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCHCR_HUMAN, Q8TD31: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005814centriole IDA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with CCHCR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCHCR1
    Interactions:

        GeneGlobe Interaction Network for CCHCR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CCHCR1 (Q8TD312, 3 ENSP000003795664) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCGP051292, 3, ENSP000002634314MINT-2873755 I2D: score=3 STRING: ENSP00000263431
    POLR2CP193873, ENSP000002192524I2D: score=3 STRING: ENSP00000219252
    STARP496753, ENSP000002764494I2D: score=2 STRING: ENSP00000276449
    TRAF4Q9BUZ43, ENSP000002623954I2D: score=3 STRING: ENSP00000262395
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006611protein export from nucleus IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with CCHCR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCHCR1 (CCHCR)

    2 Novoseek inferred chemical compound relationships for CCHCR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 21.5 3 17221218 (2)
    cholesterol 11.1 1 17221218 (1)

    1 PharmGKB related drug/compound annotation for CCHCR1 gene    About this table
    Drug/compound PharmGKB Annotation
    nevirapineCA  



    Find genes that share compounds with CCHCR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCHCR1 gene (3 alternative transcripts): 
    NM_001105563.1  NM_001105564.1  NM_019052.3  

    Unigene Cluster for CCHCR1:

    Coiled-coil alpha-helical rod protein 1
    Hs.485075  [show with all ESTs]
    Unigene Representative Sequence: NM_001105564
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000396268(uc003nsq.4 uc003nsp.4) ENST00000376266(uc003nsr.4)
    ENST00000396263 ENST00000451521 ENST00000467553 ENST00000486060 ENST00000509552(uc010jsk.1)
    ENST00000480060 ENST00000512418 ENST00000508852 ENST00000507459 ENST00000464012
    ENST00000505392 ENST00000448141 ENST00000508683 ENST00000448162 ENST00000513222
    ENST00000503420
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      QuantiTect SYBR Green Assays in human, mouse, rat CCHCR1
      QuantiFast Probe-based Assays in human, mouse, rat CCHCR1

    Additional mRNA sequence: 

    AB029331.1 AB112474.1 AB112475.1 AF216493.1 AK000204.1 AK000217.1 AK000533.1 AK289446.1 
    AK295494.1 AK310626.1 AY029160.1 BC110534.1 BC110535.1 CR457227.1 

    18 DOTS entries:

    DT.411976  DT.100648749  DT.91752756  DT.121337487  DT.91752761  DT.95356762  DT.100748104  DT.121337480 
    DT.91752755  DT.100815372  DT.100766123  DT.121337491  DT.121337509  DT.411974  DT.75102096  DT.91737395 
    DT.95093399  DT.95278560 

    20 AceView cDNA sequences:

    BX094003 BX372240 AK000217 AF216493 AK000533 AW365870 AB112475 CR457227 
    BX444927 NM_019052 AB112474 AK000204 AY029160 AB029331 AW375340 BV178608 
    BX386673 BX435108 AW009022 BF901504 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCHCR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCACCT
    CCHCR1 Expression
    About this image


    CCHCR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    CCHCR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCHCR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485075

    UniProtKB/Swiss-Prot: CCHCR_HUMAN, Q8TD31
    Tissue specificity: Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and
    pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCHCR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cchcr11 , 5 coiled-coil alpha-helical rod protein 11, 5 80.46(n)1
    75.1(a)1
      17 (18.69 cM)5
    2400841  NM_146248.21  NP_666360.21 
     355171005 
    lizard
    (Anolis carolinensis)
    Reptilia CCHCR16
    coiled-coil alpha-helical rod protein 1
    36(a)
    1 ↔ 1
    GL343623.1(262745-283452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cchcr11 coiled-coil alpha-helical rod protein 1 44.28(n)
    37.95(a)
      100144685  NM_001123446.1  NP_001116918.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CCHCR1 (1 of 2)6
    CCHCR1 (2 of 2)6
    coiled-coil alpha-helical rod protein 1
    32(a)
    31(a)
    1 ↔ many
    1 ↔ many
    5(25126047-25133905) ENSDARG00000092464
    5(25136980-25142247) ENSDARG00000093389


    ENSEMBL Gene Tree for CCHCR1 (if available)
    TreeFam Gene Tree for CCHCR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCHCR1 gene
    3 SIMAP similar genes for CCHCR1 using alignment to 26 protein entries:     CCHCR_HUMAN (see all proteins):
    C6orf18    SBP 1b    HCR

    Find genes that share paralogs with CCHCR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CCHCR_HUMAN, Q8TD31: HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory
    dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red,
    scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe
    arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into
    the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present
    at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with Cw*06:02
    (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development


    Selected SNPs for CCHCR1 (see all 458)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420564111,2
    C--31109739(+) CCCACC/TTCAGG 3 -- int10--------
    rs92637381,2
    C,F,H--31109767(+) TCCCCT/CGCTCA 3 -- int110Minor allele frequency- C:0.14NS EA WA NA CSA 784
    rs12650871,2
    C,F,A,H--31109810(-) CAGTAC/TGATGA 3 -- int128Minor allele frequency- T:0.23MN NS EA NA CSA WA 3124
    rs1876141331,2
    --31109846(+) AAACGA/CTCTCG 3 -- int10--------
    rs1431573581,2
    C--31109851(+) ATCTCA/GTTCAT 3 -- int10--------
    rs1482414461,2
    --31109909(+) TCTCAA/GGGTCC 3 -- int10--------
    rs1918917621,2
    --31109941(+) AGTGCC/TTAGCT 3 -- int10--------
    rs31325401,2
    C,F,A,H--31109943(-) AGAGCC/TAGGCA 3 -- int112Minor allele frequency- T:0.17EA NS NA WA CSA 548
    rs25238341,2
    C,F--31109946(-) GTCAGA/TGCTAG 3 -- int15Minor allele frequency- T:0.19NA WA EA 362
    rs25238331,2
    C,F,A,H--31109947(-) TGTCAG/AAGCTA 3 -- int17Minor allele frequency- A:0.14EA NS NA WA 536

    HapMap Linkage Disequilibrium report for CCHCR1 (31110216 - 31126015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CCHCR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731791CNV Deletion23290073
    nsv884138CNV Loss21882294
    nsv525933CNV Loss19592680
    nsv524061CNV Loss19592680
    nsv884137CNV Loss21882294
    esv33724CNV Gain17666407
    nsv428140CNV Gain+Loss18775914
    esv690CNV CNV17122850
    dgv1919e1CNV Complex17122850
    dgv1918e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CCHCR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCHCR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CCHCR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605310    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CCHCR1:
    Psoriasis

    Find genes that share disorders with CCHCR1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CCHCR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 68.4 24 17221218 (5), 11348465 (4), 10888604 (3), 11875053 (2) (see all 6)

    Genetic Association Database (GAD): CCHCR1
    Human Genome Epidemiology (HuGE) Navigator: CCHCR1 (12 documents)

    Export disorders for CCHCR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCHCR1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CCHCR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. (PubMed id 10888604)1, 2, 3, 9 Asumalahti K.... Kere J. (Hum. Mol. Genet. 2000)
    2. Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111kb segment telomeric to the HLA-C gene. (PubMed id 10545595)1, 2, 3 Oka A....Inoko H. (Hum. Mol. Genet. 1999)
    3. The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene. (PubMed id 11348465)1, 2, 9 O'Brien K.P.... Staahle-Baeckdahl M. (J. Invest. Dermatol. 2001)
    4. Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. (PubMed id 11875053)1, 2, 9 Asumalahti K.... Kere J. (Hum. Mol. Genet. 2002)
    5. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. (PubMed id 21743467)1, 4 Kote-Jarai Z....TybjA ( 2011)
    6. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. (PubMed id 21810746)1, 4 Chantarangsu S....Nakamura Y. (Clin. Infect. Dis. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. (PubMed id 19915573)1, 4 Asano K....Kubo M. (Nat. Genet. 2009)
    9. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    10. The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality. (PubMed id 19242354)1, 4 Read R.C....Wilson A.G. (Crit. Care Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54535 HGNC: 13930 AceView: C6orf18 Ensembl:ENSG00000204536 euGenes: HUgn54535
    ECgene: CCHCR1 H-InvDB: CCHCR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCHCR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCHCR1 gene:
    Search GeneIP for patents involving CCHCR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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