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Aliases for CCDC94 Gene

Aliases for CCDC94 Gene

  • Coiled-Coil Domain Containing 94 2 3 5

External Ids for CCDC94 Gene

Previous GeneCards Identifiers for CCDC94 Gene

  • GC19P004194
  • GC19P004039

Summaries for CCDC94 Gene

GeneCards Summary for CCDC94 Gene

CCDC94 (Coiled-Coil Domain Containing 94) is a Protein Coding gene. An important paralog of this gene is CCDC130.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC94 Gene

Genomics for CCDC94 Gene

Regulatory Elements for CCDC94 Gene

Enhancers for CCDC94 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F004246 1.2 ENCODE 19.4 +0.3 254 2.2 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 NFYC CCDC94 LOC100287614 ENSG00000266959 LOC105372244 FZR1 ENSG00000267030 CACTIN ENSG00000267769 ENSG00000269318 ENSG00000280247
GH19F004227 1.2 Ensembl ENCODE 13.8 -17.6 -17634 4.2 HDGF PKNOX1 YBX1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 ZNF263 ZNF202 CACTIN CACTIN-AS1 ENSG00000267030 CCDC94 ENSG00000267769 ENSG00000268670 MATK APBA3 GC19M004230 EBI3
GH19F004208 0.8 ENCODE 19.3 -38.3 -38321 1.4 ELF3 BCOR CTCF TEAD4 ZMYM3 RAD21 ADNP ZNF143 SMC3 ZNF391 CCDC94 EBI3 SIRT6 ANKRD24 CREB3L3 SNORD37 TMIGD2 FSD1 GC19P004210 GC19M004225
GH19F004204 1.2 Ensembl ENCODE 12.3 -42.2 -42202 1.0 TBP PKNOX1 TBL1XR1 ZNF76 ZNF2 ZSCAN9 THRB RAD21 RFX5 SLC30A9 DPP9-AS1 ENSG00000267030 APBA3 ANKRD24 SIRT6 CREB3L3 ENSG00000267769 EBI3 CCDC94 CACTIN-AS1
GH19F004359 0.8 ENCODE 11.8 +114.1 114140 3.5 CTCF TEAD4 ZIC2 HIC1 ZFHX2 GLIS2 POLR2A PATZ1 ZNF600 E2F6 ENSG00000267769 CHAF1A UBXN6 SH3GL1 TMIGD2 FSD1 CCDC94 EBI3 ENSG00000267980 ENSG00000269318
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC94 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC94 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214266 221 1801 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 NFYC

Genomic Location for CCDC94 Gene

Chromosome:
19
Start:
4,247,079 bp from pter
End:
4,269,090 bp from pter
Size:
22,012 bases
Orientation:
Plus strand

Genomic View for CCDC94 Gene

Genes around CCDC94 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC94 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC94 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC94 Gene

Proteins for CCDC94 Gene

  • Protein details for CCDC94 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW85-CCD94_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 94
    Protein Accession:
    Q9BW85
    Secondary Accessions:
    • O75270
    • Q9H862
    • Q9NW16

    Protein attributes for CCDC94 Gene

    Size:
    323 amino acids
    Molecular mass:
    37086 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72949.1; Type=Frameshift; Positions=285; Evidence={ECO:0000305};

neXtProt entry for CCDC94 Gene

Post-translational modifications for CCDC94 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC94 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC94 Gene

Domains & Families for CCDC94 Gene

Protein Domains for CCDC94 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC94 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW85

UniProtKB/Swiss-Prot:

CCD94_HUMAN :
  • Belongs to the CWC16 family.
Family:
  • Belongs to the CWC16 family.
genes like me logo Genes that share domains with CCDC94: view

No data available for Gene Families for CCDC94 Gene

Function for CCDC94 Gene

Gene Ontology (GO) - Molecular Function for CCDC94 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC94: view
genes like me logo Genes that share phenotypes with CCDC94: view

Animal Models for CCDC94 Gene

MGI Knock Outs for CCDC94:

Animal Model Products

miRNA for CCDC94 Gene

miRTarBase miRNAs that target CCDC94

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC94 Gene

Localization for CCDC94 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC94 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC94 Gene

Pathways & Interactions for CCDC94 Gene

SuperPathways for CCDC94 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC94 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC94 Gene

Transcripts for CCDC94 Gene

mRNA/cDNA for CCDC94 Gene

Unigene Clusters for CCDC94 Gene

Coiled-coil domain containing 94:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC94 Gene

No ASD Table

Relevant External Links for CCDC94 Gene

GeneLoc Exon Structure for
CCDC94
ECgene alternative splicing isoforms for
CCDC94

Expression for CCDC94 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC94 Gene

Protein differential expression in normal tissues from HIPED for CCDC94 Gene

This gene is overexpressed in Spleen (16.4), Peripheral blood mononuclear cells (12.8), Adrenal (10.0), and CD8 Tcells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC94 Gene



Protein tissue co-expression partners for CCDC94 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC94 Gene:

CCDC94

SOURCE GeneReport for Unigene cluster for CCDC94 Gene:

Hs.21811
genes like me logo Genes that share expression patterns with CCDC94: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC94 Gene

Orthologs for CCDC94 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC94 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC94 34 35
  • 92.21 (n)
cow
(Bos Taurus)
Mammalia CCDC94 34 35
  • 85.1 (n)
dog
(Canis familiaris)
Mammalia CCDC94 34 35
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Ccdc94 34 16 35
  • 82.38 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc94 34
  • 81.58 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC94 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC94 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC94 34 35
  • 75.84 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC94 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc94 34
  • 65.21 (n)
Str.3695 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24272 34
zebrafish
(Danio rerio)
Actinopterygii ccdc94 34 35
  • 68.35 (n)
zgc55914 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3443 34
fruit fly
(Drosophila melanogaster)
Insecta CG8435 34 35
  • 70.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012306 34
  • 59.83 (n)
worm
(Caenorhabditis elegans)
Secernentea F37C12.1 34 35
  • 47.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YJU2 35
  • 26 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9263 34
barley
(Hordeum vulgare)
Liliopsida Hv.2576 34
rice
(Oryza sativa)
Liliopsida Os.24549 34
wheat
(Triticum aestivum)
Liliopsida Ta.14364 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2229 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6066 34
Species where no ortholog for CCDC94 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CCDC94 Gene

ENSEMBL:
Gene Tree for CCDC94 (if available)
TreeFam:
Gene Tree for CCDC94 (if available)

Paralogs for CCDC94 Gene

Paralogs for CCDC94 Gene

(1) SIMAP similar genes for CCDC94 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC94: view

Variants for CCDC94 Gene

Sequence variations from dbSNP and Humsavar for CCDC94 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403080 -- 4,250,580(+) GAGCA(A/G)AGGCC intron-variant
rs10405644 -- 4,254,130(+) CAGAT(A/G)AGAAG intron-variant
rs10406032 -- 4,253,074(+) taaga(A/T)actaa intron-variant
rs10406315 -- 4,264,147(+) gtccc(A/C)gctac intron-variant
rs10406574 -- 4,245,095(+) tccca(A/G)gcagc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC94 Gene

Variant ID Type Subtype PubMed ID
esv2718000 CNV deletion 23290073
esv2718001 CNV deletion 23290073
esv2718002 CNV deletion 23290073
esv28436 CNV loss 19812545
nsv578442 CNV loss 21841781
nsv833716 CNV loss 17160897
nsv833717 CNV loss 17160897
nsv833718 CNV loss 17160897

Variation tolerance for CCDC94 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC94 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC94

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC94 Gene

Disorders for CCDC94 Gene

Relevant External Links for CCDC94

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC94

No disorders were found for CCDC94 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC94 Gene

Publications for CCDC94 Gene

  1. Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. (PMID: 22952453) Sorrells S. … Jette C. (PLoS Genet. 2012) 2 3 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64

Products for CCDC94 Gene

Sources for CCDC94 Gene

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