CCDC94 Gene
protein-coding GIFtS: 40
GCID: GC19P004247
|
|
coiled-coil domain containing 94
| |
Aliases
for CCDC94 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 941 2 | | FLJ103741 | | Coiled-Coil Domain-Containing Protein 942 |
Export aliases for CCDC94 gene to outside databasesPrevious GC identifers: GC19P004194 GC19P004039 |
Summaries
for CCDC94 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC94 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC94 gene promoter:
HOXA3 Pax-2 Pax-2a STAT5A AP-4 GATA-1 YY1 HEN1 Pax-2b CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC94
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC94 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3CCDC94 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P004247: view genomic region
(about GC identifiers)
Start:
|
4,247,087 bp from pter |
End:
|
4,269,085 bp from pter |
Size:
|
21,999 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC94 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD94_HUMAN, Q9BW85 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 94 Size: 323 amino acids; 37086 Da
Sequence caution: Sequence=AAC72949.1; Type=Frameshift; Positions=285;
Secondary accessions: O75270 Q9H862 Q9NW16Explore the universe of human proteins at neXtProt for CCDC94: NX_Q9BW85
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BW85
CCDC94 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060544.2
ENSEMBL proteins: ENSP00000262962
Human Recombinant Protein Products for CCDC94:
CCDC94 Antibody Products:
Assay Products for CCDC94: |
Protein
Domains /
Families
for CCDC94 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC94 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BW85ProtoNet protein and cluster: Q9BW85 UniProtKB/Swiss-Prot: CCD94_HUMAN, Q9BW85Similarity: Belongs to the CWC16 family |
Function
for CCDC94 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC94 (NM_018074) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC94 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC94 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC94 |
|
Pathways & Interactions
for CCDC94 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC94
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/10 Interacting proteins for CCDC94 (ENSP000002629624) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for CCDC94 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC94
Search CenterWatch for drugs/clinical trials and news about CCDC94 / CCD94
|
Transcripts
for CCDC94 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC94 gene: NM_018074.4 Unigene Cluster for CCDC94: Coiled-coil domain containing 94 Hs.21811 [show with all ESTs]Unigene Representative Sequence: BC0190961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000262962(uc002lzv.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC94 (NM_018074) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC94 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC94 |
Additional cDNA sequence: AF091080.1 AK001236.1 AK023988.1 AK098628.1 BC000561.2 BC019096.2 7 DOTS entries: DT.311765 DT.95373241 DT.97842857 DT.100824632 DT.92429386 DT.95373242 DT.100707444 24/164 AceView cDNA sequences (see all 164): BQ772840 BI770930 BU957428 BU621802 AW303404 BI756304 AW449993 AU142613 BX098750 BP361964 BE793861 AI949878 BC019096 AW572054 CF528441 CD722077 CD365874 BU956806 CR619668 BQ014801 BU857693 BX403583 BE256806 AK023988
GeneLoc Exon Structure
|
Expression
for CCDC94 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC94 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGTGCTGG
About this image
See CCDC94 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC94
SOURCE GeneReport for Unigene cluster: Hs.21811
SABiosciences Custom PCR Arrays for CCDC94
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC94
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC94 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC94 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC94 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC94 |
Orthologs
for CCDC94 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCDC94 gene from 8/35 species (see all 35) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CCDC941 |
coiled-coil domain containing 94 |
75.84(n)
76.66(a) |
|
425754 XM_423475.3 XP_423475.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CCDC946 |
-- |
71(a) |
1 ↔ 1 |
GL344608.1(1249-11788) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.242722 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.73(n) |
|
BU909883.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc559142 |
hypothetical protein MGC55914 |
82.67(n) |
|
393117 BC044536.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG84351 |
CG8435 |
58.6(n)
54.46(a) |
|
36789 NM_137248.3 NP_611092.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
F37C12.16 |
-- |
39(a) |
1 ↔ 1 |
III(7184286-7187803) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G171301 |
hypothetical protein |
49.78(n)
44.7(a) |
|
838283 NM_001084081.1 NP_001077550.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.245492 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.62(n) |
|
AK066951.1 |
ENSEMBL Gene Tree for CCDC94 (if available)
TreeFam Gene Tree for CCDC94 (if available) |
Paralogs
for CCDC94 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC94 gene
- CCDC1302
CCDC94 for paralogs About GeneDecksing
|
Genomic Variants
for CCDC94 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC94 (4247087 - 4269085 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC94
1 CNV: 5074
1 Indel: 73294 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC94 |
|
Disorders
/ Diseases
for CCDC94 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC94 for disorders About GeneDecksing
1  disease for CCDC94: About MalaCardsmalaria
Export disorders for CCDC94 gene to outside databases
|
Publications
for CCDC94 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC94 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC94) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for CCDC94 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC94 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC94 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC94 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC94 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC94 gene:
Search GeneIP for patents involving CCDC94
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC94 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC94 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC94 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC94 | | | OriGene Protein Over-expression Lysate for CCDC94 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC94 | | OriGene 3'-UTR Clone for CCDC94 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC94 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC94 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC94 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC94 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC94 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC94 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC94 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC94 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC94 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC94 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC94 |
|  |  |  |  | | | | ThermoFisher Antibodies for CCDC94 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC94 |
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