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Aliases for CCDC93 Gene

Aliases for CCDC93 Gene

  • Coiled-Coil Domain Containing 93 2 3 5

External Ids for CCDC93 Gene

Previous GeneCards Identifiers for CCDC93 Gene

  • GC02M118389
  • GC02M118673
  • GC02M111000

Summaries for CCDC93 Gene

GeneCards Summary for CCDC93 Gene

CCDC93 (Coiled-Coil Domain Containing 93) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC93 Gene

  • Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with FAM21C (PubMed:25355947).

Gene Wiki entry for CCDC93 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC93 Gene

Genomics for CCDC93 Gene

Regulatory Elements for CCDC93 Gene

Promoters for CCDC93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC93 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC93 Gene

Chromosome:
2
Start:
117,915,478 bp from pter
End:
118,014,163 bp from pter
Size:
98,686 bases
Orientation:
Minus strand

Genomic View for CCDC93 Gene

Genes around CCDC93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC93 Gene

Proteins for CCDC93 Gene

  • Protein details for CCDC93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q567U6-CCD93_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 93
    Protein Accession:
    Q567U6
    Secondary Accessions:
    • A8K3V7
    • Q4LE78
    • Q53TJ2
    • Q8TBX5
    • Q9H6R5
    • Q9NV15

    Protein attributes for CCDC93 Gene

    Size:
    631 amino acids
    Molecular mass:
    73198 Da
    Quaternary structure:
    • Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASH1. Interacts directly with FAM21C. Interacts with CCDC93 and C16orf62; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62; in the complex interacts directly with CCDC22 (PubMed:25355947).
    SequenceCaution:
    • Sequence=BAB15188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CCDC93 Gene

Proteomics data for CCDC93 Gene at MOPED

Post-translational modifications for CCDC93 Gene

  • Ubiquitination at Lys 601
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC93 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC93 Gene

Domains & Families for CCDC93 Gene

Protein Domains for CCDC93 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC93 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q567U6

UniProtKB/Swiss-Prot:

CCD93_HUMAN :
  • Belongs to the CCDC93 family.
Family:
  • Belongs to the CCDC93 family.
genes like me logo Genes that share domains with CCDC93: view

No data available for Gene Families for CCDC93 Gene

Function for CCDC93 Gene

Molecular function for CCDC93 Gene

UniProtKB/Swiss-Prot Function:
Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with FAM21C (PubMed:25355947).
genes like me logo Genes that share phenotypes with CCDC93: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC93 Gene

Localization for CCDC93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC93 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC93 Gene COMPARTMENTS Subcellular localization image for CCDC93 gene
Compartment Confidence
endosome 4
nucleus 3
cytosol 2
lysosome 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CCDC93 Gene

Pathways & Interactions for CCDC93 Gene

SuperPathways for CCDC93 Gene

No Data Available

Interacting Proteins for CCDC93 Gene

Gene Ontology (GO) - Biological Process for CCDC93 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC93 Gene

Drugs & Compounds for CCDC93 Gene

No Compound Related Data Available

Transcripts for CCDC93 Gene

Unigene Clusters for CCDC93 Gene

Coiled-coil domain containing 93:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC93 Gene

No ASD Table

Relevant External Links for CCDC93 Gene

GeneLoc Exon Structure for
CCDC93
ECgene alternative splicing isoforms for
CCDC93

Expression for CCDC93 Gene

mRNA expression in normal human tissues for CCDC93 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC93 Gene

This gene is overexpressed in Heart (13.9), Peripheral blood mononuclear cells (8.9), and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC93 Gene



SOURCE GeneReport for Unigene cluster for CCDC93 Gene Hs.107845

genes like me logo Genes that share expression patterns with CCDC93: view

Protein tissue co-expression partners for CCDC93 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC93 Gene

Orthologs for CCDC93 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC93 36
  • 100 (a)
OneToOne
CCDC93 35
  • 99.52 (n)
  • 99.68 (a)
cow
(Bos Taurus)
Mammalia CCDC93 36
  • 94 (a)
OneToOne
CCDC93 35
  • 90.39 (n)
  • 93.82 (a)
dog
(Canis familiaris)
Mammalia CCDC93 35
  • 91.92 (n)
  • 95.4 (a)
CCDC93 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc93 16
Ccdc93 36
  • 92 (a)
OneToOne
Ccdc93 35
  • 86.8 (n)
  • 92.05 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC93 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC93 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc93 35
  • 86.7 (n)
  • 93 (a)
chicken
(Gallus gallus)
Aves CCDC93 35
  • 75.27 (n)
  • 80.84 (a)
CCDC93 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC93 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc93 35
  • 69.17 (n)
  • 73.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc93 36
  • 68 (a)
OneToOne
ccdc93 35
  • 67.15 (n)
  • 70.24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009044 35
  • 53.6 (n)
  • 45.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta fidipidine 36
  • 39 (a)
OneToOne
fidipidine 35
  • 51.27 (n)
  • 42.21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32560 35
  • 46.13 (n)
  • 32.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2439 35
Species with no ortholog for CCDC93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC93 Gene

ENSEMBL:
Gene Tree for CCDC93 (if available)
TreeFam:
Gene Tree for CCDC93 (if available)

Paralogs for CCDC93 Gene

Pseudogenes.org Pseudogenes for CCDC93 Gene

genes like me logo Genes that share paralogs with CCDC93: view

No data available for Paralogs for CCDC93 Gene

Variants for CCDC93 Gene

Sequence variations from dbSNP and Humsavar for CCDC93 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035499 A colorectal cancer sample
rs33975708 - 117,986,054(+) CCGAC(A/G)GGGCT reference, missense
rs34095554 - 117,978,014(+) CTGGC(A/G)GCTAA reference, missense
rs17512204 - 117,975,255(+) CTGCT(A/G)GAAGT reference, missense
rs17047557 - 117,944,044(+) CTTGT(A/G)AAGTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CCDC93 Gene

Variant ID Type Subtype PubMed ID
nsv515493 CNV Loss 19592680
esv2177498 CNV Deletion 18987734

Variation tolerance for CCDC93 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC93 Gene

HapMap Linkage Disequilibrium report
CCDC93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC93 Gene

Disorders for CCDC93 Gene

Relevant External Links for CCDC93

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC93

No disorders were found for CCDC93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC93 Gene

Publications for CCDC93 Gene

  1. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CCDC93 Gene

Sources for CCDC93 Gene

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