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Aliases for CCDC93 Gene

Aliases for CCDC93 Gene

  • Coiled-Coil Domain Containing 93 2 3

External Ids for CCDC93 Gene

Previous GeneCards Identifiers for CCDC93 Gene

  • GC02M118389
  • GC02M118673
  • GC02M111000

Summaries for CCDC93 Gene

GeneCards Summary for CCDC93 Gene

CCDC93 (Coiled-Coil Domain Containing 93) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC93 Gene

  • Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with FAM21C (PubMed:25355947).

Gene Wiki entry for CCDC93 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC93 Gene

Genomics for CCDC93 Gene

Regulatory Elements for CCDC93 Gene

Genomic Location for CCDC93 Gene

Start:
117,915,478 bp from pter
End:
118,014,163 bp from pter
Size:
98,686 bases
Orientation:
Minus strand

Genomic View for CCDC93 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC93 Gene

Proteins for CCDC93 Gene

  • Protein details for CCDC93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q567U6-CCD93_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 93
    Protein Accession:
    Q567U6
    Secondary Accessions:
    • A8K3V7
    • Q4LE78
    • Q53TJ2
    • Q8TBX5
    • Q9H6R5
    • Q9NV15

    Protein attributes for CCDC93 Gene

    Size:
    631 amino acids
    Molecular mass:
    73198 Da
    Quaternary structure:
    • Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10, WASH1. Interacts directly with FAM21C. Interacts with CCDC93 and C16orf62; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62; in the complex interacts directly with CCDC22 (PubMed:25355947).
    SequenceCaution:
    • Sequence=BAB15188.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06075.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CCDC93 Gene

Proteomics data for CCDC93 Gene at MOPED

Post-translational modifications for CCDC93 Gene

  • Ubiquitination at Lys601
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC93 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC93 Gene

Domains for CCDC93 Gene

Protein Domains for CCDC93 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC93 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q567U6

UniProtKB/Swiss-Prot:

CCD93_HUMAN :
  • Q567U6
Family:
  • Belongs to the CCDC93 family.
genes like me logo Genes that share domains with CCDC93: view

No data available for Gene Families for CCDC93 Gene

Function for CCDC93 Gene

Molecular function for CCDC93 Gene

UniProtKB/Swiss-Prot Function: Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes and is dependent on its interaction with FAM21C (PubMed:25355947).

Gene Ontology (GO) - Molecular Function for CCDC93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25355947
genes like me logo Genes that share ontologies with CCDC93: view

Phenotypes for CCDC93 Gene

genes like me logo Genes that share phenotypes with CCDC93: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC93 Gene

Localization for CCDC93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC93 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC93 Gene COMPARTMENTS Subcellular localization image for CCDC93 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CCDC93: view

Pathways for CCDC93 Gene

SuperPathways for CCDC93 Gene

No Data Available

Interacting Proteins for CCDC93 Gene

Gene Ontology (GO) - Biological Process for CCDC93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IMP 25355947
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with CCDC93: view

No data available for Pathways by source for CCDC93 Gene

Transcripts for CCDC93 Gene

Unigene Clusters for CCDC93 Gene

Coiled-coil domain containing 93:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC93 Gene

No ASD Table

Relevant External Links for CCDC93 Gene

GeneLoc Exon Structure for
CCDC93
ECgene alternative splicing isoforms for
CCDC93

Expression for CCDC93 Gene

mRNA expression in normal human tissues for CCDC93 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC93 Gene

SOURCE GeneReport for Unigene cluster for CCDC93 Gene Hs.107845

genes like me logo Genes that share expressions with CCDC93: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC93 Gene

Orthologs for CCDC93 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC93 35
  • 99.52 (n)
  • 99.68 (a)
CCDC93 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC93 35
  • 90.39 (n)
  • 93.82 (a)
CCDC93 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC93 35
  • 91.92 (n)
  • 95.4 (a)
CCDC93 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc93 35
  • 86.8 (n)
  • 92.05 (a)
Ccdc93 16
Ccdc93 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC93 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC93 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc93 35
  • 86.7 (n)
  • 93 (a)
chicken
(Gallus gallus)
Aves CCDC93 35
  • 75.27 (n)
  • 80.84 (a)
CCDC93 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC93 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc93 35
  • 69.17 (n)
  • 73.17 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc93 35
  • 67.15 (n)
  • 70.24 (a)
ccdc93 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009044 35
  • 53.6 (n)
  • 45.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta fidipidine 35
  • 51.27 (n)
  • 42.21 (a)
fidipidine 36
  • 39 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G32560 35
  • 46.13 (n)
  • 32.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2439 35
Species with no ortholog for CCDC93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC93 Gene

ENSEMBL:
Gene Tree for CCDC93 (if available)
TreeFam:
Gene Tree for CCDC93 (if available)

Paralogs for CCDC93 Gene

Pseudogenes.org Pseudogenes for CCDC93 Gene

genes like me logo Genes that share paralogs with CCDC93: view

No data available for Paralogs for CCDC93 Gene

Variants for CCDC93 Gene

Sequence variations from dbSNP and Humsavar for CCDC93 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3066 -- 117,931,470(+) GAGAC(A/G)GTTTT intron-variant
rs736750 -- 117,970,759(+) CTCAG(C/T)GGTCT intron-variant
rs748767 -- 117,973,997(+) GCTCT(A/G)CAAGT intron-variant
rs889899 -- 117,977,819(-) ACAGA(C/T)TGGGG intron-variant
rs889900 -- 117,971,336(-) cccag(G/T)caaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC93 Gene

Variant ID Type Subtype PubMed ID
nsv515493 CNV Loss 19592680
esv2177498 CNV Deletion 18987734

Relevant External Links for CCDC93 Gene

HapMap Linkage Disequilibrium report
CCDC93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC93 Gene

Disorders for CCDC93 Gene

No disorders were found for CCDC93 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC93 Gene

Publications for CCDC93 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3 4

Products for CCDC93 Gene

Sources for CCDC93 Gene

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