Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC92 Gene

Aliases for CCDC92 Gene

  • Coiled-Coil Domain Containing 92 2 3 5
  • Limkain Beta 2 2
  • Limkain Beta-2 4

External Ids for CCDC92 Gene

Previous GeneCards Identifiers for CCDC92 Gene

  • GC12M122986
  • GC12M124420
  • GC12M121383
  • GC12M124403

Summaries for CCDC92 Gene

GeneCards Summary for CCDC92 Gene

CCDC92 (Coiled-Coil Domain Containing 92) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC92 Gene

Genomics for CCDC92 Gene

Regulatory Elements for CCDC92 Gene

Enhancers for CCDC92 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F123941 0.7 ENCODE 27.6 +30.5 30497 2.3 BCOR CBX3 TAL1 JUN ZMYM3 NFXL1 ZIC2 CTBP1 CBX5 POLR2A CCDC92 DNAH10 DNAH10OS ZNF664 ENSG00000270028 PIR34615 PIR47036
GH12F123937 1.2 Ensembl ENCODE 27 +34.8 34791 2.0 HDGF PKNOX1 CREB3L1 SIN3A ZNF2 YY1 GLIS2 ZNF766 KLF7 FOS CCDC92 DNAH10OS ZNF664 PIR47036 PIR34615
GH12F124029 0.8 Ensembl ENCODE 20 -57.8 -57779 1.8 SIN3A ZBTB40 SCRT2 FOS OVOL3 USF2 ZNF623 RAD51 SMARCA4 MYNN CCDC92 RFLNA ZNF664 DNAH10OS PIR55353 ENSG00000275389
GH12F124005 0.9 Ensembl ENCODE 19.1 -34.2 -34244 2.7 HDAC1 ATF1 CBX3 NFXL1 RAD21 YY1 GATA2 ZNF366 KLF13 CREM CCDC92 DNAH10 DNAH10OS ZNF664 RFLNA PIR55353 ENSG00000275389
GH12F123968 1.3 Ensembl ENCODE 17.4 +3.7 3663 1.0 HDGF PKNOX1 KLF17 SIN3A RAD21 GLIS2 ETV6 FOS CREM DEK CCDC92 ENSG00000269938 ENSG00000270061
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC92 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC92 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438759 185 3601 HDGF ARID4B SIN3A ZNF48 ETS1 YY1 ZNF121 GLIS2 ZNF207 ZNF143

Genomic Location for CCDC92 Gene

Chromosome:
12
Start:
123,918,660 bp from pter
End:
123,972,985 bp from pter
Size:
54,326 bases
Orientation:
Minus strand

Genomic View for CCDC92 Gene

Genes around CCDC92 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC92 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC92 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC92 Gene

Proteins for CCDC92 Gene

  • Protein details for CCDC92 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53HC0-CCD92_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 92
    Protein Accession:
    Q53HC0
    Secondary Accessions:
    • B3KNQ0
    • Q9H697

    Protein attributes for CCDC92 Gene

    Size:
    331 amino acids
    Molecular mass:
    36961 Da
    Quaternary structure:
    • Interacts with CEP164.
    SequenceCaution:
    • Sequence=BAD96381.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC92 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC92 Gene

Post-translational modifications for CCDC92 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC92 Gene

Domains & Families for CCDC92 Gene

Protein Domains for CCDC92 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC92 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC92: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC92 Gene

Function for CCDC92 Gene

Gene Ontology (GO) - Molecular Function for CCDC92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with CCDC92: view
genes like me logo Genes that share phenotypes with CCDC92: view

Animal Models for CCDC92 Gene

MGI Knock Outs for CCDC92:

Animal Model Products

miRNA for CCDC92 Gene

miRTarBase miRNAs that target CCDC92

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC92 Gene

Localization for CCDC92 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC92 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC92 Gene COMPARTMENTS Subcellular localization image for CCDC92 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC92 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA,IDA 22863007
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC92: view

Pathways & Interactions for CCDC92 Gene

SuperPathways for CCDC92 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC92 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC92 Gene

Transcripts for CCDC92 Gene

mRNA/cDNA for CCDC92 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC92 Gene

Coiled-coil domain containing 92:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC92 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9:
SP10:

Relevant External Links for CCDC92 Gene

GeneLoc Exon Structure for
CCDC92
ECgene alternative splicing isoforms for
CCDC92

Expression for CCDC92 Gene

mRNA expression in normal human tissues for CCDC92 Gene

Protein differential expression in normal tissues from HIPED for CCDC92 Gene

This gene is overexpressed in Ovary (31.3) and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC92 Gene



Protein tissue co-expression partners for CCDC92 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC92 Gene:

CCDC92

SOURCE GeneReport for Unigene cluster for CCDC92 Gene:

Hs.713131
genes like me logo Genes that share expression patterns with CCDC92: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC92 Gene

Orthologs for CCDC92 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC92 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC92 34 35
  • 98.29 (n)
cow
(Bos Taurus)
Mammalia CCDC92 34 35
  • 87.15 (n)
dog
(Canis familiaris)
Mammalia CCDC92 34 35
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC92 35
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc92 34
  • 82 (n)
mouse
(Mus musculus)
Mammalia Ccdc92 34 16 35
  • 81.58 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC92 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC92 34 35
  • 75.48 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC92 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc92 34
  • 72.9 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc92 34 35
  • 66.77 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7515 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for CCDC92 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC92 Gene

ENSEMBL:
Gene Tree for CCDC92 (if available)
TreeFam:
Gene Tree for CCDC92 (if available)

Paralogs for CCDC92 Gene

No data available for Paralogs for CCDC92 Gene

Variants for CCDC92 Gene

Sequence variations from dbSNP and Humsavar for CCDC92 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1053928 -- 123,968,320(-) AAACA(G/T)TTTAC intron-variant
rs10732228 -- 123,965,404(+) TTTAT(C/T)GCTCT intron-variant
rs10773048 -- 123,959,862(+) GCATT(C/T)AGAAC intron-variant
rs11057398 -- 123,936,096(+) GACCA(C/G)TGGTC downstream-variant-500B
rs11057399 -- 123,940,531(+) GCTTC(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC92 Gene

Variant ID Type Subtype PubMed ID
esv1305470 CNV insertion 17803354
esv3302753 CNV tandem duplication 20981092
nsv1115971 CNV insertion 24896259
nsv1116712 CNV tandem duplication 24896259
nsv522321 CNV loss 19592680

Variation tolerance for CCDC92 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.63; 86.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC92 Gene

Human Gene Mutation Database (HGMD)
CCDC92
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC92

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC92 Gene

Disorders for CCDC92 Gene

Relevant External Links for CCDC92

Genetic Association Database (GAD)
CCDC92
Human Genome Epidemiology (HuGE) Navigator
CCDC92
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC92

No disorders were found for CCDC92 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC92 Gene

Publications for CCDC92 Gene

  1. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PMID: 22863007) Chaki M. … Hildebrandt F. (Cell 2012) 3 4 64
  2. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for CCDC92 Gene

Sources for CCDC92 Gene

Content
Loading form....