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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC92 Gene

protein-coding   GIFtS: 45
GCID: GC12M124403

coiled-coil domain containing 92

 Explore 1 disease affiliated with
CCDC92 via our new
 Human Malady Compendium 
Biological research products
for CCDC92
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 921 2
Limkain Beta-22 3
FLJ224711
Coiled-Coil Domain-Containing Protein 922
Limkain Beta 22

External Ids:    HGNC: 295631   Entrez Gene: 802122   Ensembl: ENSG000001192427   UniProtKB: Q53HC03   

Export aliases for CCDC92 gene to outside databases

Previous GC identifers: GC12M122986 GC12M124420 GC12M121383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC92 gene promoter:
         STAT5A   E4BP4   c-Ets-1   Evi-1   Arnt   Hand1   Sox9   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC92 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC92

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC92


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

CCDC92 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC92 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M124403:  view genomic region     (about GC identifiers)

Start:
124,403,207 bp from pter      End:
124,457,378 bp from pter
Size:
54,172 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCD92_HUMAN, Q53HC0 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 92  
Size: 331 amino acids; 36961 Da
Subunit: Interacts with CEP164
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole
Caution: It is uncertain whether Met-1 or Met-18 is the initiator
Sequence caution: Sequence=BAD96381.1; Type=Erroneous initiation;
Secondary accessions: Q9H697

Explore the universe of human proteins at neXtProt for CCDC92: NX_Q53HC0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53HC0

  • CCDC92 Protein expression data from MOPED and PaxDb:    About this image 
    CCDC92 Protein Expression
    REFSEQ proteins: NP_079416.1  
    ENSEMBL proteins: 
     ENSP00000238156   ENSP00000439526   ENSP00000440024   ENSP00000439441   ENSP00000438281  
     ENSP00000442369   ENSP00000440203  

    Human Recombinant Protein Products for CCDC92: 
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    Uscn Proteins for CCDC92

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005814centriole IDA--

    CCDC92 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CCDC92


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q53HC0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CCDC92 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CCDC92 

    miRNA
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    OriGene 3'-UTR Clone: CCDC92
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    hsa-miR-142-5p hsa-miR-495 hsa-miR-181c hsa-miR-657 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCDC92 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC92 (see all 7)
    OriGene shRNA RFP: CCDC92
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC92 

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC92


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC92

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CCDC92 (Q53HC01, 2, 3 ENSP000002381564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-65500 I2D: score=5 
    PLEKHA5Q9HAU03, ENSP000002992754I2D: score=3 STRING: ENSP00000299275
    CEP164Q9UPV01EBI-719994,EBI-3937015
    RHOXF2ENSP000003604414STRING: ENSP00000360441
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC92
    Search CenterWatch for drugs/clinical trials and news about CCDC92 / CCD92 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC92 gene: 
    NM_025140.1  

    Unigene Cluster for CCDC92:

    Coiled-coil domain containing 92
    Hs.713131  [show with all ESTs]
    Unigene Representative Sequence: AK125866
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542348 ENST00000544798 ENST00000238156(uc001ufw.1 uc001ufx.1)
    ENST00000545135(uc001ufv.1) ENST00000545891 ENST00000539761 ENST00000535556
    ENST00000539551 ENST00000545037

    miRNA
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    OriGene 3'-UTR Clone: CCDC92
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC92
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC92 (see all 26):
    hsa-miR-142-5p hsa-miR-495 hsa-miR-181c hsa-miR-657 hsa-miR-1271 hsa-miR-128 hsa-miR-450b-3p hsa-miR-548s
    SwitchGear 3'UTR luciferase reporter plasmidCCDC92 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC92 (see all 7)
    OriGene shRNA RFP: CCDC92
    OriGene siRNA: CCDC92
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC92
    Sirion Biotech Custom design and validation of potent shRNA sequences against CCDC92 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC92 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC92
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC92
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC92

    Additional cDNA sequence: 

    AB015292.1 AK026124.1 AK054680.1 AK124358.1 AK125866.1 AK222661.1 BC017186.2 

    16 DOTS entries:

    DT.100807651  DT.116997  DT.100807652  DT.121181357  DT.95188846  DT.97824143  DT.101957962  DT.92431952 
    DT.121181342  DT.92431949  DT.100694037  DT.121181388  DT.97803349  DT.100807653  DT.40254034  DT.95186409 

    1 AceView cDNA sequence:

    NM_025140 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC92 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g · 10h
    SP1:              -     -     -     -     -           -     -     -                                                                                 
    SP2:                          -     -     -           -                                                                                             
    SP3:                                            -     -     -     -                                                                                 
    SP4:              -     -     -     -     -     -     -     -     -                                                                                 
    SP5:              -     -     -     -     -     -     -     -     -     -                                                                           


    ECgene alternative splicing isoforms for CCDC92

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC92 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAACACTT
    CCDC92 Expression
    About this image

    CCDC92 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)

    See CCDC92 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC92

    SOURCE GeneReport for Unigene cluster: Hs.713131
        SABiosciences Custom PCR Arrays for CCDC92
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC92

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC92 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc921 , 5 coiled-coil domain containing 921, 5 81.58(n)1
    87.22(a)1
      5 (63.85 cM)5
    2157071  NM_144819.21  NP_659068.11 
     1248344185 
    chicken
    (Gallus gallus)
    Aves CCDC921 coiled-coil domain containing 92 75.48(n)
    86.94(a)
      416817  XM_415108.2  XP_415108.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC926
    --
    84(a)
    1 ↔ 1
    LGb(1654367-1657111)
    zebrafish
    (Danio rerio)
    Actinopterygii BI476566.12   -- 72.47(n)    BI476566.1 


    ENSEMBL Gene Tree for CCDC92 (if available)
    TreeFam Gene Tree for CCDC92 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/617 NCBI SNPs in CCDC92 are shown (see all 617    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73117481,2
    C--121417949(+) AATACA/GCAGAG 3 -- us2k10--------
    rs778815811,2
    --121421344(+) CCGACT/CATTAT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1870595471,2
    --124420472(+) CACCTC/GGAGCC 2 -- int10--------
    rs1457512351,2
    --124420474(+) CCTGGA/TGCCAC 2 -- int10--------
    rs1172667251,2
    F--124420563(+) AGTGTT/GTAGTT 2 -- int11Minor allele frequency- G:0.02NA 120
    rs1919025391,2
    --124420653(+) CACTGA/GGCACC 2 -- int10--------
    rs1386198161,2
    --124420669(+) CCTCTA/GTGCAC 2 -- int10--------
    rs1852652891,2
    --124420771(+) AGTGGC/GCAGGG 1 -- int10--------
    rs1411627791,2
    --124420818(+) AGGAGA/CGCAGC 1 -- int10--------
    rs1507330721,2
    --124420857(+) AGGAGA/GCCGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCDC92 (124403207 - 124457378 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCDC92: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC92
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC92

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCDC92 for disorders           About GeneDecksing

    1 disease for CCDC92:    About MalaCards
    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: CCDC92 (1 document)

    Export disorders for CCDC92 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC92 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CCDC92)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. (PubMed id 22863007)2 Chaki M....Hildebrandt F. (2012)
    5. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    6. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
    7. Forty-three loci associated with plasma lipoprotein s ize, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222)1 Chasman D.I....Ridker P.M. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80212 HGNC: 29563 AceView: FLJ22471 Ensembl:ENSG00000119242 euGenes: HUgn80212
    ECgene: CCDC92 H-InvDB: CCDC92

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC92 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC92 gene:
    Search GeneIP for patents involving CCDC92

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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