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Aliases for CCDC91 Gene

Aliases for CCDC91 Gene

  • Coiled-Coil Domain Containing 91 2 3 5
  • P56 Accessory Protein 3 4
  • GGA-Binding Partner 3 4
  • Coiled-Coil Domain-Containing Protein 91 3
  • GGA Binding Partner 2
  • GGABP 4
  • HSD8 3
  • P56 3

External Ids for CCDC91 Gene

Previous GeneCards Identifiers for CCDC91 Gene

  • GC12P028302
  • GC12P028410
  • GC12P028179

Summaries for CCDC91 Gene

GeneCards Summary for CCDC91 Gene

CCDC91 (Coiled-Coil Domain Containing 91) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for CCDC91 Gene

  • Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC91 Gene

Genomics for CCDC91 Gene

Regulatory Elements for CCDC91 Gene

Enhancers for CCDC91 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G028126 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -3.7 -3655 6.8 HDGF ATF1 CREB3L1 ARNT SIN3A TCF12 ZNF766 ELK1 GATA2 FOS STK38L CCDC91 REP15 PTHLH LOC105369710
GH12G028189 1.4 ENCODE dbSUPER 14.7 +57.7 57708 3.3 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 MEF2D SSRP1 ZNF610 CCDC91 ENSG00000247934 PIR31956
GH12G028202 0.8 ENCODE 13.1 +69.6 69580 0.7 SOX13 CTCF FOXA2 THRB RAD21 RARA GATA3 NCOR1 RERE NR2F6 CCDC91 PIR31956 ENSG00000247934
GH12G028459 0.8 ENCODE dbSUPER 11.2 +327.6 327561 2.2 MTA2 BHLHE40 TBX21 EP300 CCDC91 RNA5SP355 RNU4-54P
GH12G027998 0.8 ENCODE dbSUPER 11.2 -133.6 -133635 2.0 ZNF217 FOSL1 GATA3 ZBTB33 TCF7L2 FOXA1 PTHLH CCDC91 ENSG00000257042 LOC105369710
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC91 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC91 Gene

Chromosome:
12
Start:
28,133,249 bp from pter
End:
28,581,511 bp from pter
Size:
448,263 bases
Orientation:
Plus strand

Genomic View for CCDC91 Gene

Genes around CCDC91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC91 Gene

Proteins for CCDC91 Gene

  • Protein details for CCDC91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6B0-CCD91_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 91
    Protein Accession:
    Q7Z6B0
    Secondary Accessions:
    • B3KSA3
    • C9JR07
    • Q68D43
    • Q6IA78
    • Q8NEN7
    • Q9NUW9

    Protein attributes for CCDC91 Gene

    Size:
    441 amino acids
    Molecular mass:
    49971 Da
    Quaternary structure:
    • Homodimer. Interacts with GGA1, GGA2 and AP1G1.
    SequenceCaution:
    • Sequence=BAA91995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCDC91 Gene

    Alternative splice isoforms for CCDC91 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC91 Gene

Post-translational modifications for CCDC91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC91 Gene

Domains & Families for CCDC91 Gene

Protein Domains for CCDC91 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC91: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC91 Gene

Function for CCDC91 Gene

Molecular function for CCDC91 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).

Gene Ontology (GO) - Molecular Function for CCDC91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with CCDC91: view
genes like me logo Genes that share phenotypes with CCDC91: view

Animal Model Products

CRISPR Products

miRNA for CCDC91 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC91 Gene

Localization for CCDC91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC91 Gene

Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Colocalizes with GGA1 and GGA2. May be recruited to the TGN by GGA1 and GGA2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC91 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CCDC91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005802 trans-Golgi network IDA 17596511
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCDC91: view

Pathways & Interactions for CCDC91 Gene

SuperPathways for CCDC91 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0090160 Golgi to lysosome transport IMP 17596511
genes like me logo Genes that share ontologies with CCDC91: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC91 Gene

Transcripts for CCDC91 Gene

Unigene Clusters for CCDC91 Gene

Coiled-coil domain containing 91:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC91 Gene

No ASD Table

Relevant External Links for CCDC91 Gene

GeneLoc Exon Structure for
CCDC91
ECgene alternative splicing isoforms for
CCDC91

Expression for CCDC91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC91 Gene

Protein differential expression in normal tissues from HIPED for CCDC91 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (34.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC91 Gene



Protein tissue co-expression partners for CCDC91 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC91 Gene:

CCDC91

SOURCE GeneReport for Unigene cluster for CCDC91 Gene:

Hs.653125

mRNA Expression by UniProt/SwissProt for CCDC91 Gene:

Q7Z6B0-CCD91_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for CCDC91 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with CCDC91: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC91 Gene

Orthologs for CCDC91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC91 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC91 34 35
  • 97.1 (n)
dog
(Canis familiaris)
Mammalia CCDC91 34 35
  • 94.56 (n)
cow
(Bos Taurus)
Mammalia CCDC91 34 35
  • 92.52 (n)
mouse
(Mus musculus)
Mammalia Ccdc91 34 16 35
  • 77.4 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc91 34
  • 76.57 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC91 35
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC91 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC91 34
  • 69.3 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC91 35
  • 52 (a)
OneToOne
Species where no ortholog for CCDC91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC91 Gene

ENSEMBL:
Gene Tree for CCDC91 (if available)
TreeFam:
Gene Tree for CCDC91 (if available)

Paralogs for CCDC91 Gene

No data available for Paralogs for CCDC91 Gene

Variants for CCDC91 Gene

Sequence variations from dbSNP and Humsavar for CCDC91 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000008383 -- 28,383,941(+) ATCAG(C/T)TTATT intron-variant
rs1000012984 -- 28,493,479(+) ATATA(-/TG)TACAC intron-variant
rs1000031235 -- 28,516,397(+) CAGGA(A/G)TTCAA intron-variant
rs1000036983 -- 28,252,834(+) GGCAC(G/T)AATAA intron-variant
rs1000044833 -- 28,509,557(+) AGTGA(A/C)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC91 Gene

Variant ID Type Subtype PubMed ID
dgv1408n100 CNV gain 25217958
dgv190n27 CNV loss 19166990
dgv191n27 CNV loss 19166990
dgv2434n54 CNV loss 21841781
dgv2435n54 CNV loss 21841781
dgv2436n54 CNV loss 21841781
dgv2437n54 CNV gain 21841781
dgv93n21 CNV loss 19592680
esv1402084 CNV insertion 17803354
esv3304110 CNV mobile element insertion 20981092
esv3304556 CNV mobile element insertion 20981092
esv3307294 CNV mobile element insertion 20981092
esv3307638 CNV mobile element insertion 20981092
esv3342264 CNV insertion 20981092
esv3343158 CNV insertion 20981092
esv3372141 CNV insertion 20981092
esv3396129 CNV insertion 20981092
esv3400173 CNV insertion 20981092
esv3407308 CNV insertion 20981092
esv3446167 CNV insertion 20981092
esv3628963 CNV loss 21293372
esv3628965 CNV loss 21293372
esv3628966 CNV loss 21293372
esv3628970 CNV loss 21293372
esv3628971 CNV gain 21293372
esv3892168 CNV loss 25118596
nsv1038470 CNV loss 25217958
nsv1043710 CNV loss 25217958
nsv1046821 CNV gain 25217958
nsv469179 CNV loss 19166990
nsv469181 CNV loss 19166990
nsv469188 CNV loss 19166990
nsv469189 CNV gain 19166990
nsv516088 CNV gain 19592680
nsv519119 CNV gain 19592680
nsv521777 CNV loss 19592680
nsv523622 CNV gain 19592680
nsv523992 CNV loss 19592680
nsv527047 CNV loss 19592680
nsv557864 CNV gain 21841781
nsv557876 CNV gain 21841781
nsv557879 CNV loss 21841781
nsv557882 CNV loss 21841781
nsv653 CNV deletion 18451855
nsv654 CNV insertion 18451855
nsv826290 CNV loss 20364138
nsv973985 CNV duplication 23825009

Variation tolerance for CCDC91 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC91

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC91 Gene

Disorders for CCDC91 Gene

Relevant External Links for CCDC91

Genetic Association Database (GAD)
CCDC91
Human Genome Epidemiology (HuGE) Navigator
CCDC91
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC91

No disorders were found for CCDC91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC91 Gene

Publications for CCDC91 Gene

  1. Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. (PMID: 12808037) Lui W.W.Y. … Robinson M.S. (Mol. Biol. Cell 2003) 2 3 4 64
  2. Structural basis for binding of accessory proteins by the appendage domain of GGAs. (PMID: 12858163) Collins B.M. … Owen D.J. (Nat. Struct. Biol. 2003) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 46 64
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64

Products for CCDC91 Gene

Sources for CCDC91 Gene

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