CCDC91 Gene
protein-coding GIFtS: 44
GCID: GC12P028302
|
|
coiled-coil domain containing 91
| |
Aliases
for CCDC91 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 911 2 | | FLJ110881 | | P561 | | Coiled-Coil Domain-Containing Protein 912 | | GGA-Binding Partner2 3 | | GGA Binding Partner2 | | P56 Accessory Protein2 3 | | GGABP3 | | DKFZp779L15581 | | |
Export aliases for CCDC91 gene to outside databasesPrevious GC identifers: GC12P028410 GC12P028179 |
Summaries
for CCDC91 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CCD91_HUMAN, Q7Z6B0Function: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN)
|
Genomic Views
for CCDC91 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC91 gene promoter:
Pax-2b AML1a Pax-2 Pax-2a ZID NF-AT
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC91
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC91 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11.22 Ensembl cytogenetic band: 12p11.22 HGNC cytogenetic band: 12p11.22CCDC91 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P028302: view genomic region
(about GC identifiers)
Start:
|
28,286,182 bp from pter |
End:
|
28,732,883 bp from pter |
Size:
|
446,702 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC91 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD91_HUMAN, Q7Z6B0 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 91 Size: 441 amino acids; 49971 Da
Subunit: Homodimer. Interacts with GGA1, GGA2 and AP1G1
Subcellular location: Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheralmembrane protein. Note=Colocalizes with GGA1 and GGA2. May be recruited to the TGN by GGA1 and GGA2
Sequence caution: Sequence=BAA91995.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for CCDC91:1OM9 (3D)
Secondary accessions: B3KSA3 C9JR07 Q68D43 Q6IA78 Q8NEN7 Q9NUW9Alternative splicing: 3 isoforms: Q7Z6B0-1 Q7Z6B0-2 Q7Z6B0-3 (Does not bind GGAs)Explore the universe of human proteins at neXtProt for CCDC91: NX_Q7Z6B0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z6B0
CCDC91 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060788.3
ENSEMBL proteins: ENSP00000441714 ENSP00000440194 ENSP00000444440 ENSP00000438558 ENSP00000440513 ENSP00000445660 ENSP00000438040 ENSP00000446045 ENSP00000441651 ENSP00000442544 ENSP00000445999 ENSP00000442473 ENSP00000444038 ENSP00000446329 ENSP00000439935 ENSP00000446059 ENSP00000370658 ENSP00000370655 ENSP00000305075
Human Recombinant Protein Products for CCDC91:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CCDC91 for ontologies About GeneDecksing
CCDC91 Antibody Products:
Assay Products for CCDC91: |
Protein
Domains /
Families
for CCDC91 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q7Z6B0 |
Function
for CCDC91 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCD91_HUMAN, Q7Z6B0Function: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042802 | identical protein binding |
IEA | -- |
CCDC91 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC91 (NM_018318) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC91 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC91 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC91 |
|
Pathways & Interactions
for CCDC91 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC91
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/8 Interacting proteins for CCDC91 (Q7Z6B02, 3 ENSP000003706584) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- |
CCDC91 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC91 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC91
Search CenterWatch for drugs/clinical trials and news about CCDC91 / CCD91
|
Transcripts
for CCDC91 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC91 gene: NM_018318.3 Unigene Cluster for CCDC91: Coiled-coil domain containing 91 Hs.653125 [show with all ESTs]Unigene Representative Sequence: BC03516818/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000540794 ENST00000538586 ENST00000536154 ENST00000535520 ENST00000539107(uc009zjl.3)
ENST00000536442 ENST00000544649 ENST00000545336(uc001rio.3 uc009zjk.3 uc001riq.3)
ENST00000544780 ENST00000543534 ENST00000543809 ENST00000545737(uc001rip.1)
ENST00000540401 ENST00000539904 ENST00000535212 ENST00000542801 ENST00000542814
ENST00000539270
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC91 (NM_018318) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC91 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC91 |
Additional cDNA sequence: AK001950.1 AK093152.1 AK309181.1 AY251168.1 AY289196.1 BC018679.1 BC028682.2 BC035168.1 CR457277.1 CR749586.1 17 DOTS entries: DT.95372624 DT.312407 DT.100780042 DT.100780040 DT.95261953 DT.100023552 DT.121164164 DT.86836842 DT.95372619 DT.100009204 DT.121164165 DT.75178400 DT.100780044 DT.121164095 DT.40301714 DT.95219627 DT.121164137 24/142 AceView cDNA sequences (see all 142): AW275236 AI802999 AU120242 BG219692 BQ434941 AA721285 AW469214 AL544393 AA215390 AW275212 AA749018 BF058503 AI700920 AA889709 CR603339 AY251168 AA805624 AW275229 AA767888 AK001950 AI271949 AW575490 BG682293 BU739164
GeneLoc Exon Structure
|
Expression
for CCDC91 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC91 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTTTGTAC
About this image
See CCDC91 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC91
SOURCE GeneReport for Unigene cluster: Hs.653125
UniProtKB/Swiss-Prot: CCD91_HUMAN, Q7Z6B0Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for CCDC91
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC91
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC91 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC91 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC91 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC91 |
Orthologs
for CCDC91 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC91 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for CCDC91 (if available)
TreeFam Gene Tree for CCDC91 (if available) |
Paralogs
for CCDC91 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC91 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC91 (28286182 - 28536182 bp, first 250kb of CCDC91)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CCDC91
3 CNVs: 53386 49041 53193 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC91 |
|
Disorders
/ Diseases
for CCDC91 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC91 for disorders About GeneDecksing
2  diseases for CCDC91: About MalaCardspolycystic kidney disease kidney disease
Human Genome Epidemiology (HuGE) Navigator: CCDC91 (2 documents)
Export disorders for CCDC91 gene to outside databases
|
Publications
for CCDC91 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC91 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CCDC91) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. (PubMed id 12808037)1, 2, 3 Lui W.W.Y.... Robinson M.S. (2003)
- Structural basis for binding of accessory proteins by the appendage domain of GGAs. (PubMed id 12858163)1, 2, 9 Collins B.M.... Owen D.J. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. (PubMed id 17596511)1, 9 Mardones G.A....Bonifacino J.S. (2007)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1 Chen X....Kong X. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
|
External Searches for CCDC91 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC91 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC91 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC91 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC91 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC91 gene:
Search GeneIP for patents involving CCDC91
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC91 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC91 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC91 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC91 | | | OriGene Protein Over-expression Lysate for CCDC91 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC91 | | OriGene 3'-UTR Clone for CCDC91 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC91 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC91 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC91 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC91 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC91 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC91 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC91 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC91 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC91 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC91 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCDC91 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC91 |
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