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Aliases for CCDC91 Gene

Aliases for CCDC91 Gene

  • Coiled-Coil Domain Containing 91 2 3 5
  • P56 Accessory Protein 3 4
  • GGA Binding Partner 2 3
  • GGA-Binding Partner 3 4
  • GGABP 4
  • HSD8 3
  • P56 3

External Ids for CCDC91 Gene

Previous GeneCards Identifiers for CCDC91 Gene

  • GC12P028302
  • GC12P028410
  • GC12P028179

Summaries for CCDC91 Gene

GeneCards Summary for CCDC91 Gene

CCDC91 (Coiled-Coil Domain Containing 91) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for CCDC91 Gene

  • Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC91 Gene

Genomics for CCDC91 Gene

Regulatory Elements for CCDC91 Gene

Enhancers for CCDC91 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC91 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC91 Gene

28,133,249 bp from pter
28,581,511 bp from pter
448,263 bases
Plus strand

Genomic View for CCDC91 Gene

Genes around CCDC91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC91 Gene

Proteins for CCDC91 Gene

  • Protein details for CCDC91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 91
    Protein Accession:
    Secondary Accessions:
    • B3KSA3
    • C9JR07
    • Q68D43
    • Q6IA78
    • Q8NEN7
    • Q9NUW9

    Protein attributes for CCDC91 Gene

    441 amino acids
    Molecular mass:
    49971 Da
    Quaternary structure:
    • Homodimer. Interacts with GGA1, GGA2 and AP1G1.
    • Sequence=BAA91995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCDC91 Gene

    Alternative splice isoforms for CCDC91 Gene


neXtProt entry for CCDC91 Gene

Proteomics data for CCDC91 Gene at MOPED

Post-translational modifications for CCDC91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC91 Gene

Domains & Families for CCDC91 Gene

Protein Domains for CCDC91 Gene


Suggested Antigen Peptide Sequences for CCDC91 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC91: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC91 Gene

Function for CCDC91 Gene

Molecular function for CCDC91 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of membrane traffic through the trans-Golgi network (TGN).
genes like me logo Genes that share phenotypes with CCDC91: view

Animal Model Products

miRNA for CCDC91 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC91 Gene

Localization for CCDC91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC91 Gene

Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Colocalizes with GGA1 and GGA2. May be recruited to the TGN by GGA1 and GGA2.

Subcellular locations from

Jensen Localization Image for CCDC91 Gene COMPARTMENTS Subcellular localization image for CCDC91 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for CCDC91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CCDC91: view

Pathways & Interactions for CCDC91 Gene

SuperPathways for CCDC91 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC91 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC91 Gene

Drugs & Compounds for CCDC91 Gene

No Compound Related Data Available

Transcripts for CCDC91 Gene

Unigene Clusters for CCDC91 Gene

Coiled-coil domain containing 91:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC91 Gene

No ASD Table

Relevant External Links for CCDC91 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC91 Gene

mRNA expression in normal human tissues for CCDC91 Gene

Protein differential expression in normal tissues from HIPED for CCDC91 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (34.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC91 Gene

SOURCE GeneReport for Unigene cluster for CCDC91 Gene Hs.653125

mRNA Expression by UniProt/SwissProt for CCDC91 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CCDC91: view

Protein tissue co-expression partners for CCDC91 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCDC91 Gene

Orthologs for CCDC91 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC91 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC91 35
  • 92.52 (n)
  • 93.2 (a)
CCDC91 36
  • 93 (a)
(Canis familiaris)
Mammalia CCDC91 35
  • 94.56 (n)
  • 94.33 (a)
CCDC91 36
  • 94 (a)
(Mus musculus)
Mammalia Ccdc91 35
  • 77.4 (n)
  • 79.14 (a)
Ccdc91 16
Ccdc91 36
  • 79 (a)
(Pan troglodytes)
Mammalia CCDC91 35
  • 97.1 (n)
  • 95.64 (a)
CCDC91 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ccdc91 35
  • 76.57 (n)
  • 78.23 (a)
(Monodelphis domestica)
Mammalia CCDC91 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC91 36
  • 53 (a)
(Gallus gallus)
Aves CCDC91 35
  • 69.3 (n)
  • 58.7 (a)
(Anolis carolinensis)
Reptilia CCDC91 36
  • 52 (a)
Species with no ortholog for CCDC91:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC91 Gene

Gene Tree for CCDC91 (if available)
Gene Tree for CCDC91 (if available)

Paralogs for CCDC91 Gene

No data available for Paralogs for CCDC91 Gene

Variants for CCDC91 Gene

Sequence variations from dbSNP and Humsavar for CCDC91 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1133028 - 28,450,179(+) TTGAA(A/G)TGCTA reference, missense
rs10771427 - 28,452,493(+) AAGCA(A/G)TGAAG reference, missense
rs1922684 -- 28,201,397(-) TGCCC(C/G/T)GCCGC intron-variant
rs1949978 -- 28,443,951(-) CAGGT(C/T)CTGCA intron-variant
rs1967383 -- 28,363,719(+) aataa(A/T)acaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC91 Gene

Variant ID Type Subtype PubMed ID
esv268389 CNV Insertion 20981092
esv1402084 CNV Insertion 17803354
nsv653 CNV Loss 18451855
esv271912 CNV Insertion 20981092
nsv527047 CNV Loss 19592680
nsv469179 CNV Loss 19166990
nsv523622 CNV Gain 19592680
dgv1398n71 CNV Loss 21882294
dgv93n21 CNV Loss 19592680
esv268834 CNV Insertion 20981092
nsv469181 CNV Loss 19166990
dgv1399n71 CNV Loss 21882294
dgv190n27 CNV Loss 19166990
esv271570 CNV Insertion 20981092
nsv523992 CNV Loss 19592680
nsv898948 CNV Loss 21882294
dgv191n27 CNV Loss 19166990
nsv898949 CNV Loss 21882294
nsv521777 CNV Loss 19592680
nsv654 CNV Insertion 18451855
nsv519119 CNV Gain 19592680
nsv469188 CNV Loss 19166990
nsv516088 CNV Gain 19592680
nsv826290 CNV Loss 20364138
nsv898950 CNV Gain 21882294
nsv469189 CNV Gain 19166990

Variation tolerance for CCDC91 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.99; 84.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC91 Gene

Disorders for CCDC91 Gene

Relevant External Links for CCDC91

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC91 Gene

Publications for CCDC91 Gene

  1. Binding partners for the COOH-terminal appendage domains of the GGAs and gamma-adaptin. (PMID: 12808037) Lui W.W.Y. … Robinson M.S. (Mol. Biol. Cell 2003) 2 3 4 67
  2. The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting. (PMID: 17596511) Mardones G.A. … Bonifacino J.S. (Mol. Biol. Cell 2007) 3 23
  3. Structural basis for binding of accessory proteins by the appendage domain of GGAs. (PMID: 12858163) Collins B.M. … Owen D.J. (Nat. Struct. Biol. 2003) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. (PMID: 25064007) Nakajima M. … Ikegawa S. (Nat. Genet. 2014) 3

Products for CCDC91 Gene

Sources for CCDC91 Gene