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Aliases for CCDC89 Gene

Aliases for CCDC89 Gene

  • Coiled-Coil Domain Containing 89 2 3 5
  • Bc8 Orange-Interacting Protein 4
  • BOIP 4

External Ids for CCDC89 Gene

Previous GeneCards Identifiers for CCDC89 Gene

  • GC11M085073
  • GC11M085394
  • GC11M081692

Summaries for CCDC89 Gene

GeneCards Summary for CCDC89 Gene

CCDC89 (Coiled-Coil Domain Containing 89) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC89 Gene

Genomics for CCDC89 Gene

Regulatory Elements for CCDC89 Gene

Enhancers for CCDC89 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC89 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC89 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC89 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC89 Gene

Chromosome:
11
Start:
85,683,844 bp from pter
End:
85,686,277 bp from pter
Size:
2,434 bases
Orientation:
Minus strand

Genomic View for CCDC89 Gene

Genes around CCDC89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC89 Gene

Proteins for CCDC89 Gene

  • Protein details for CCDC89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N998-CCD89_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 89
    Protein Accession:
    Q8N998

    Protein attributes for CCDC89 Gene

    Size:
    374 amino acids
    Molecular mass:
    43809 Da
    Quaternary structure:
    • Interacts with HEY1.

neXtProt entry for CCDC89 Gene

Proteomics data for CCDC89 Gene at MOPED

Post-translational modifications for CCDC89 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC89 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC89 Gene

Domains & Families for CCDC89 Gene

Protein Domains for CCDC89 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N998

UniProtKB/Swiss-Prot:

CCD89_HUMAN :
  • Belongs to the CCDC89 family.
Family:
  • Belongs to the CCDC89 family.
genes like me logo Genes that share domains with CCDC89: view

No data available for Gene Families for CCDC89 Gene

Function for CCDC89 Gene

genes like me logo Genes that share phenotypes with CCDC89: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC89 Gene

Localization for CCDC89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC89 Gene

Cytoplasm. Nucleus. Note=Uniformly distributed within the cell, but becomes recruited to the nucleus upon binding to HEY1. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC89 Gene COMPARTMENTS Subcellular localization image for CCDC89 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CCDC89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCDC89: view

Pathways & Interactions for CCDC89 Gene

SuperPathways for CCDC89 Gene

No Data Available

Interacting Proteins for CCDC89 Gene

Selected Interacting proteins: Q8N998-CCD89_HUMAN for CCDC89 Gene via I2D

Symbol External ID(s) Details
BMPR2

Gene Ontology (GO) - Biological Process for CCDC89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC89 Gene

Drugs & Compounds for CCDC89 Gene

No Compound Related Data Available

Transcripts for CCDC89 Gene

mRNA/cDNA for CCDC89 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC89 Gene

Coiled-coil domain containing 89:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC89 Gene

No ASD Table

Relevant External Links for CCDC89 Gene

GeneLoc Exon Structure for
CCDC89
ECgene alternative splicing isoforms for
CCDC89

Expression for CCDC89 Gene

mRNA expression in normal human tissues for CCDC89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC89 Gene

This gene is overexpressed in Testis (x21.9).

Protein differential expression in normal tissues from HIPED for CCDC89 Gene

This gene is overexpressed in Ovary (50.8) and Colon muscle (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC89 Gene



SOURCE GeneReport for Unigene cluster for CCDC89 Gene Hs.376241

genes like me logo Genes that share expression patterns with CCDC89: view

Protein tissue co-expression partners for CCDC89 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC89 Gene

Orthologs for CCDC89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC89 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC89 35
  • 82.36 (n)
  • 77.01 (a)
CCDC89 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC89 35
  • 87.03 (n)
  • 82.7 (a)
CCDC89 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc89 35
  • 80.27 (n)
  • 77.84 (a)
Ccdc89 16
Ccdc89 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc89 35
  • 80.54 (n)
  • 78.38 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC89 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC89 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC89 35
  • 61.65 (n)
  • 50.64 (a)
CCDC89 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC89 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia boip 35
zebrafish
(Danio rerio)
Actinopterygii zgc:172182 35
  • 53.52 (n)
  • 46.06 (a)
CCDC89 36
  • 40 (a)
OneToOne
Species with no ortholog for CCDC89:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC89 Gene

ENSEMBL:
Gene Tree for CCDC89 (if available)
TreeFam:
Gene Tree for CCDC89 (if available)

Paralogs for CCDC89 Gene

No data available for Paralogs for CCDC89 Gene

Variants for CCDC89 Gene

Sequence variations from dbSNP and Humsavar for CCDC89 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs619018 -- 85,684,485(-) TAGCT(G/T)GGAAA utr-variant-3-prime
rs675688 -- 85,687,286(-) TGACC(A/C)ATTGG upstream-variant-2KB
rs676227 -- 85,687,095(-) ATGTC(A/C)AGAAA upstream-variant-2KB
rs677680 -- 85,687,203(-) GGGAC(A/C)AAGTA upstream-variant-2KB
rs677713 -- 85,687,184(-) ATTCC(A/C)AGTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC89 Gene

Variant ID Type Subtype PubMed ID
dgv1246n71 CNV Loss 21882294
essv7704 CNV CNV 17122850
esv678 CNV CNV 17122850
essv22464 CNV CNV 17122850
nsv468768 CNV Loss 19166990

Variation tolerance for CCDC89 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC89 Gene

HapMap Linkage Disequilibrium report
CCDC89

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC89 Gene

Disorders for CCDC89 Gene

Relevant External Links for CCDC89

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC89

No disorders were found for CCDC89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC89 Gene

Publications for CCDC89 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. (PMID: 15188402) Hassel S. … Souchelnytskyi S. (Proteomics 2004) 3

Products for CCDC89 Gene

Sources for CCDC89 Gene

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