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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC88C Gene

protein-coding   GIFtS: 48
GCID: GC14M091737

Coiled-Coil Domain Containing 88C

(Previous name: KIAA1509)
(Previous symbol: KIAA1509)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 88C1 2     HKRP22
KIAA15091 2 3     Protein Daple2
Dvl-Associating Protein With A High Frequency Of Leucine Residues1 2 3     HkRP23
Hook-Related Protein 22 3     Coiled-Coil Domain-Containing Protein 88C3
DAPLE2 3     hDaple3

External Ids:    HGNC: 199671   Entrez Gene: 4401932   Ensembl: ENSG000000151337   OMIM: 6112045   UniProtKB: Q9P2193   

Export aliases for CCDC88C gene to outside databases

Previous GC identifers: GC14M090809 GC14M071913


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCDC88C Gene:
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the
dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene
has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein.
Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling
pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations
in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized
by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. (provided by RefSeq, Jan 2013)

GeneCards Summary for CCDC88C Gene: 
CCDC88C (coiled-coil domain containing 88C) is a protein-coding gene. Diseases associated with CCDC88C include congenital non-communicating hydrocephalus, and diverticulitis. GO annotations related to this gene include microtubule binding and protein self-association. An important paralog of this gene is HOOK2.

UniProtKB/Swiss-Prot: DAPLE_HUMAN, Q9P219
Function: Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit
CTNNB1/Beta-catenin stabilization (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC88C gene promoter:
         Sox5   AML1a   ATF-2   MyoD   Ik-3   PPAR-gamma1   FOXO1a   PPAR-gamma2   ATF6   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCDC88C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC88C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.12

CCDC88C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC88C gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M091737:  view genomic region     (about GC identifiers)

Start:
91,737,667 bp from pter      End:
91,884,188 bp from pter
Size:
146,522 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAPLE_HUMAN, Q9P219 (See protein sequence)
Recommended Name: Protein Daple  
Size: 2028 amino acids; 228230 Da
Subunit: Homooligomer. Interacts with the PDZ domain of DVL1 (By similarity)
Sequence caution: Sequence=BAA96033.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=CAH10602.1; Type=Frameshift; Positions=1738;
Secondary accessions: Q69YK1 Q7L1M2 Q86SX7 Q8IYG8
Alternative splicing: 3 isoforms:  Q9P219-1   Q9P219-2   Q9P219-3   (Due to intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC88C: NX_Q9P219

Explore proteomics data for CCDC88C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P219

  • CCDC88C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC88C Protein Expression
    REFSEQ proteins: NP_001073883.2  
    ENSEMBL proteins: 
     ENSP00000452406   ENSP00000374507   ENSP00000374506   ENSP00000451392   ENSP00000330332  

    Human Recombinant Protein Products for CCDC88C: 
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    Cloud-Clone Corp. Proteins for CCDC88C 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    CCDC88C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008636 HOOK/CCDC88

    Graphical View of Domain Structure for InterPro Entry Q9P219

    ProtoNet protein and cluster: Q9P219

    UniProtKB/Swiss-Prot: DAPLE_HUMAN, Q9P219
    Similarity: Belongs to the CCDC88 family


    CCDC88C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAPLE_HUMAN, Q9P219
    Function: Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit
    CTNNB1/Beta-catenin stabilization (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding ----
    GO:0016491oxidoreductase activity ----
    GO:0030165PDZ domain binding ISS14750955
    GO:0043621protein self-association ISS14750955
         
    CCDC88C for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC88C 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC88C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CCDC88C (Q9P2192, 3 ENSP000003745074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8P459832, 3, ENSP000003534834MINT-8262286 I2D: score=2 STRING: ENSP00000353483
    DVL1O146403, ENSP000003681694I2D: score=1 STRING: ENSP00000368169
    ITSN2ENSP000003472444STRING: ENSP00000347244
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0001932regulation of protein phosphorylation ISS14750955
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0031648protein destabilization ISS14750955
    GO:0051260protein homooligomerization ISS14750955

    CCDC88C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC88C (DAPLE)

    Search CenterWatch for drugs/clinical trials and news about CCDC88C / DAPLE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC88C gene: 
    NM_001080414.3  

    Unigene Cluster for CCDC88C:

    Coiled-coil domain containing 88C
    Hs.525536  [show with all ESTs]
    Unigene Representative Sequence: NM_001080414
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556726(uc001xzi.3 uc001xzj.3) ENST00000389857(uc010aty.3)
    ENST00000334448 ENST00000557455 ENST00000555995 ENST00000557507 ENST00000554051
    ENST00000554872(uc010twk.1) ENST00000553437 ENST00000389856(uc021ryl.1)
    ENST00000553403(uc001xzl.4) ENST00000554165 ENST00000556767 ENST00000331194

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC88C (see all 21):
    hsa-miR-15a hsa-miR-1271 hsa-miR-128 hsa-miR-520a-5p hsa-miR-424 hsa-miR-199b-5p hsa-miR-3143 hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AF070587.1 AK022593.1 AK302839.1 AL137353.1 AL833046.1 BC028565.2 BC032316.1 BC035914.1 
    BC127900.1 BX248302.1 

    24/28 DOTS entries (see all 28):

    DT.100813801  DT.70105186  DT.95306960  DT.91663408  DT.100035841  DT.70105506  DT.95369555  DT.100698924 
    DT.101973783  DT.120790477  DT.95320301  DT.120790454  DT.432982  DT.120790459  DT.95208652  DT.95370610 
    DT.97842695  DT.100045864  DT.121178639  DT.121178670  DT.121178687  DT.40120584  DT.40292868  DT.91781259 

    24/47 AceView cDNA sequences (see all 47):

    BM770056 BE673405 BM770751 BM760140 BM771792 BM754793 AI686509 BF475370 
    AI670941 BM760124 BF002813 BQ058180 AA113276 BM770156 BM740067 BX103204 
    CR606047 BM771134 CR607628 BM918945 AF070587 AI380740 BM747410 BC032316 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC88C (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                                                                                            -     -     -     -     -                 -     -               
    SP2:                                                                                                                    -                 -     -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                            -                       -                                       

    ExUns: 18a · 18b · 18c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CCDC88C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC88C expression in normal human tissues (normalized intensities)      CCDC88C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATATGT
    CCDC88C Expression
    About this image


    CCDC88C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             stem cells (umbilical cord cd34+)   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H7 (WA07)
     
     Lymph (Hematopoietic System)

    See CCDC88C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC88C

    SOURCE GeneReport for Unigene cluster: Hs.525536
        SABiosciences Custom PCR Arrays for CCDC88C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC88C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC88C gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc88c1 , 5 coiled-coil domain containing 88C1, 5 84.11(n)1
    83.12(a)1
      12 (51.11 cM)5
    683391  NM_026681.41  NP_080957.21 
     1009127005 
    chicken
    (Gallus gallus)
    Aves CCDC88C1 coiled-coil domain containing 88C 68.17(n)
    68.75(a)
      423410  XM_421320.3  XP_421320.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC88C6
    Uncharacterized protein
    65(a)
    1 ↔ 1
    1(12032305-12167448)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5532311 uncharacterized LOC553231 59.98(n)
    55.4(a)
      553231  XM_001921892.2  XP_001921927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Girdin6
    Girdin
    27(a)
    1 → many
    3L(3178930-3185287)
    worm
    (Caenorhabditis elegans)
    Secernentea Y51A2D.156
    Protein Y51A2D.15, isoform a
    20(a)
    possible ortholog
    V(18592757-18613944)


    ENSEMBL Gene Tree for CCDC88C (if available)
    TreeFam Gene Tree for CCDC88C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC88C gene
    HOOK22  HOOK12  CCDC88A2  HOOK32  CCDC88B2  
    2 SIMAP similar genes for CCDC88C using alignment to 4 protein entries:     DAPLE_HUMAN (see all proteins):
    CCDC88A    KIAA1212

    CCDC88C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3541 SNPs in CCDC88C are shown (see all 3541)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497257381,2
    C--71913462(+) TGCAGA/GGGGAG 1 -- int10--------
    rs80161591,2
    C--71913507(+) aggggC/Tgcaga 1 -- int10--------
    rs1810206111,2
    C--71913585(+) AGGGGC/TGCAGA 1 -- int10--------
    rs714154401,2
    C,F--71913618(+) GGGGCA/GCAGGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1894671321,2
    --71913636(+) GGGGCA/GCAGGG 1 -- int10--------
    rs2017260791,2
    --71998548(+) GGGGG-/TTAA  
            
    GTGAG
    1 -- int10--------
    rs351105231,2
    C--71998549(+) GGGGTTAAG/-  
            
    TGAGA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs564050051,2
    C--71998550(+) GGGTT-/AAGT  
            
    GAGAC
    1 -- int10--------
    rs2002218541,2
    --72002044(+) GCAAG-/CTCCGC
            
    CTCCG
    1 -- cds10--------
    rs2016657731,2
    --72002049(+) CTCCG-/CCTCCC
            
    GGCCA
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for CCDC88C (91737667 - 91884188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for CCDC88C (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749016CNV Deletion23290073
    esv2749015CNV Deletion23290073
    esv272545CNV Insertion20981092
    esv1637561CNV Insertion17803354
    esv1730768CNV Insertion17803354
    nsv1395CNV Insertion18451855
    esv25253CNV Loss19812545
    nsv456394CNV Loss19166990
    nsv456393CNV Loss19166990
    nsv517700CNV Loss19592680


    Human Gene Mutation Database (HGMD): CCDC88C
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC88C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611204    OMIM disorders: --

    UniProtKB/Swiss-Prot: DAPLE_HUMAN, Q9P219
  • Hydrocephalus, non-syndromic, autosomal recessive 1 (HYC1) [MIM:236600]: A disease characterized by a
    disturbance of cerebrospinal fluid circulation causing accumulation of ventricular cerebrospinal fluid, which
    results in progressive ventricular dilatation with onset in utero. Affected individuals may have neurologic
    impairment. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for CCDC88C:    About MalaCards
    congenital non-communicating hydrocephalus    diverticulitis    hydrocephalus


    CCDC88C for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC88C

    Export disorders for CCDC88C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC88C gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with CCDC88C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel CCDC88C mutations confirm the role of DAPLE in autosomal recessive congenital hydrocephalus. (PubMed id 23042809)1, 2 Drielsma A....Edvardson S. (2012)
    2. Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticul um. (PubMed id 21031079)1, 2 Ekici A.B....Rauch A. (2010)
    3. Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways. (PubMed id 17185515)1, 3 Enomoto A.... Takahashi M. (2006)
    4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    5. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    6. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    7. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    8. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 440193 HGNC: 19967 AceView: LOC440193 Ensembl:ENSG00000015133 euGenes: HUgn440193
    ECgene: CCDC88C H-InvDB: CCDC88C

    (According to HUGE)
    About This Section
    HUGE: KIAA1509

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC88C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC88C gene:
    Search GeneIP for patents involving CCDC88C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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