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Aliases for CCDC88B Gene

Aliases for CCDC88B Gene

  • Coiled-Coil Domain Containing 88B 2 3
  • GRP78-Interacting Protein Induced By ER Stress 2 3
  • Brain Leucine Zipper Domain-Containing Protein 3 4
  • Coiled-Coil Domain Containing 88 2 3
  • Brain Leucine Zipper Protein 2 3
  • Hook-Related Protein 3 3 4
  • HKRP3 3 4
  • Gipie 3 6
  • BRLZ 3 4
  • 78 KDa Glucose-Regulated Protein [GRP78]-Interacting Protein Induced By ER Stress 3
  • Coiled-Coil Domain-Containing Protein 88B 3
  • CCDC88 3

External Ids for CCDC88B Gene

Previous HGNC Symbols for CCDC88B Gene

  • CCDC88

Previous GeneCards Identifiers for CCDC88B Gene

  • GC11P063866
  • GC11P064107
  • GC11P060435

Summaries for CCDC88B Gene

Entrez Gene Summary for CCDC88B Gene

  • This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]

GeneCards Summary for CCDC88B Gene

CCDC88B (Coiled-Coil Domain Containing 88B) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is CCDC88A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC88B Gene

Genomics for CCDC88B Gene

Regulatory Elements for CCDC88B Gene

Genomic Location for CCDC88B Gene

Start:
64,340,218 bp from pter
End:
64,357,534 bp from pter
Size:
17,317 bases
Orientation:
Plus strand

Genomic View for CCDC88B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC88B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC88B Gene

Proteins for CCDC88B Gene

  • Protein details for CCDC88B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NC98-CC88B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 88B
    Protein Accession:
    A6NC98
    Secondary Accessions:
    • A5D8Y5
    • B5MDM2
    • Q05BL2
    • Q6RUV3
    • Q8N1Q6
    • Q8NF44
    • Q9H0H1

    Protein attributes for CCDC88B Gene

    Size:
    1476 amino acids
    Molecular mass:
    164809 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03417.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC88B Gene

neXtProt entry for CCDC88B Gene

Proteomics data for CCDC88B Gene at MOPED

Post-translational modifications for CCDC88B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC88B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC88B Gene

Domains for CCDC88B Gene

Protein Domains for CCDC88B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC88B Gene

Graphical View of Domain Structure for InterPro Entry

A6NC98

UniProtKB/Swiss-Prot:

CC88B_HUMAN :
  • A6NC98
Family:
  • Belongs to the CCDC88 family.
genes like me logo Genes that share domains with CCDC88B: view

No data available for Gene Families for CCDC88B Gene

Function for CCDC88B Gene

miRNA for CCDC88B Gene

miRTarBase miRNAs that target CCDC88B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC88B Gene

Localization for CCDC88B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC88B Gene COMPARTMENTS Subcellular localization image for CCDC88B gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCDC88B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC88B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC88B Gene

Pathways for CCDC88B Gene

SuperPathways for CCDC88B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC88B Gene

None

No data available for Pathways by source for CCDC88B Gene

Transcripts for CCDC88B Gene

Unigene Clusters for CCDC88B Gene

Coiled-coil domain containing 88B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC88B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a ·
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: - - -
SP13:
SP14:
SP15:

ExUns: 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c · 23d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CCDC88B Gene

GeneLoc Exon Structure for
CCDC88B
ECgene alternative splicing isoforms for
CCDC88B

Expression for CCDC88B Gene

mRNA expression in normal human tissues for CCDC88B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC88B Gene

This gene is overexpressed in Whole Blood (14.3), Brain - Cerebellum (5.4), Brain - Cerebellar Hemisphere (5.3), and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC88B Gene

SOURCE GeneReport for Unigene cluster for CCDC88B Gene Hs.98564

genes like me logo Genes that share expressions with CCDC88B: view

No data available for mRNA Expression by UniProt/SwissProt for CCDC88B Gene

Orthologs for CCDC88B Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC88B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC88B 35
  • 99.46 (n)
  • 98.98 (a)
CCDC88B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC88B 35
  • 85.5 (n)
  • 83.17 (a)
CCDC88B 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC88B 35
  • 84.52 (n)
  • 82.47 (a)
CCDC88B 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc88b 35
  • 80.48 (n)
  • 78.43 (a)
Ccdc88b 16
Ccdc88b 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC88B 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc88b 35
  • 80.46 (n)
  • 78.4 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC88B 36
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccdc88b 35
  • 51.77 (n)
  • 40.96 (a)
ccdc88b 36
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Girdin 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grdn-1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3137 36
  • 23 (a)
OneToMany
Species with no ortholog for CCDC88B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCDC88B Gene

ENSEMBL:
Gene Tree for CCDC88B (if available)
TreeFam:
Gene Tree for CCDC88B (if available)

Paralogs for CCDC88B Gene

Paralogs for CCDC88B Gene

Selected SIMAP similar genes for CCDC88B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCDC88B: view

Variants for CCDC88B Gene

Sequence variations from dbSNP and Humsavar for CCDC88B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs489419 -- 64,352,963(+) TCCTG(C/T)CTGGC intron-variant
rs497595 -- 64,356,415(-) TTGTA(G/T)TTTTA intron-variant
rs510372 -- 64,347,665(-) AGGTC(A/G)CCCGG intron-variant
rs534222 -- 64,351,968(+) GCCTC(C/T)GGCTG intron-variant
rs558105 -- 64,345,434(-) AAGGA(A/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC88B Gene

Variant ID Type Subtype PubMed ID
dgv1156n71 CNV Loss 21882294
dgv1163n71 CNV Loss 21882294
dgv1166n71 CNV Loss 21882294
nsv832186 CNV Loss 17160897
nsv897685 CNV Loss 21882294
nsv358 CNV Insertion 18451855
dgv13n64 CNV Loss 17921354
dgv1169n71 CNV Loss 21882294
dgv1170n71 CNV Loss 21882294
nsv832187 CNV Loss 17160897

Relevant External Links for CCDC88B Gene

HapMap Linkage Disequilibrium report
CCDC88B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC88B Gene

Disorders for CCDC88B Gene

No disorders were found for CCDC88B Gene.

No data available for UniProtKB/Swiss-Prot for CCDC88B Gene

Publications for CCDC88B Gene

  1. Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells. (PMID: 21289099) Matsushita E. … Takahashi M. (Mol. Biol. Cell 2011) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A novel hook-related protein family and the characterization of hook- related protein 1. (PMID: 15882442) Simpson F. … Wicking C. (Traffic 2005) 2 3
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC88B Gene

Sources for CCDC88B Gene

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