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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC88A Gene

protein-coding GIFtS: 50
GCID: GC02M055514

coiled-coil domain containing 88A

(Previous name: KIAA1212 )
(Previous symbol: KIAA1212)

Explore 5 diseases affiliated with
CCDC88A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 88A¹ ²		Hook-Related Protein 1² ³
APE¹ ² ³ ⁵		GIRDIN² ⁵
GIV¹ ² ³ ⁵		FLJ10392¹
KIAA1212¹ ² ³ ⁵		AKT-Phosphorylation Enhancer²
GRDN¹ ² ³		Girdin¹
HkRP1¹ ² ³		Akt Phosphorylation Enhancer³
G Alpha-Interacting Vesicle-Associated Protein² ³		Coiled-Coil Domain-Containing Protein 88A³
Girders Of Actin Filament² ³		HKRP1⁵

External Ids:	HGNC: 25523¹	Entrez Gene: 55704²	Ensembl: ENSG00000115355⁷	OMIM: 609736⁵	UniProtKB: Q3V6T2³

Export aliases for CCDC88A gene to outside databases

Previous GC identifers: GC02M055368 GC02M055250

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCDC88A:

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an

actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling

and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase

(PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors.

Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis.

Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by

RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: GRDN_HUMAN, Q3V6T2

Function: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of

newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and

synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of

AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation

of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity).

Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress

fibers and lamellipodia. May be involved in membrane sorting in the early endosome

Gene Wiki entry for CCDC88A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC88A gene promoter:
CUTL1 E47 FOXL1 RORalpha2 PPAR-alpha SRY FOXO4 Hand1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC88A promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC88A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC88A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p16.3

CCDC88A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC88A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M055514: view genomic region (about GC identifiers)

Start:	55,514,978 bp from pter	End:	55,647,057 bp from pter
Size:	132,080 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GRDN_HUMAN, Q3V6T2 (See protein sequence)

Recommended Name: Girdin

Size: 1871 amino acids; 216042 Da

Subunit: Interacts (via C-terminus) with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction

is inhibited in presence of DISC1 (By similarity). Homodimer. The non-phosphorylated form interacts with

phosphatidylinositol 4-phosphate [PI(4)P] and weakly with phosphatidylinositol 3-phosphate [PI(3)P]. Interacts with

microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB

Subcellular location: Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium.

Note=Localizes to the cell membrane through interaction with phosphoinositides

Sequence caution: Sequence=AAY14932.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAD97945.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus; Sequence=CAI46020.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A1IGE7 B7ZM78 C9JG83 Q53SF1 Q581G3 Q5HYD0 Q7Z339 Q7Z3C5

Alternative splicing: 5 isoforms: Q3V6T2-1 Q3V6T2-2 Q3V6T2-3 Q3V6T2-4 Q3V6T2-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC88A: NX_Q3V6T2

Post-translational modifications:

Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner.

Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3V6T2

CCDC88A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001129069.1 NP_001241872.1 NP_060554.3

ENSEMBL proteins:

ENSP00000338728 ENSP00000263630 ENSP00000413401 ENSP00000390012 ENSP00000405080

ENSP00000415267 ENSP00000399237 ENSP00000410608 ENSP00000404431 ENSP00000387974

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	Uscn Proteins for CCDC88A

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	IDA	15882442
GO:0005794	Golgi apparatus	IDA	15882442
GO:0005829	cytosol	IDA	15749703
GO:0005886	plasma membrane	IDA	15882442

CCDC88A for ontologies About GeneDecksing

CCDC88A Antibody Products:

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	Uscn ELISAs and CLIAs for CCDC88A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCDC88A for domains About GeneDecksing

1 InterPro domain/family:

IPR008636 HOOK

Graphical View of Domain Structure for InterPro Entry Q3V6T2

ProtoNet protein and cluster: Q3V6T2

UniProtKB/Swiss-Prot: GRDN_HUMAN, Q3V6T2

Similarity: Belongs to the CCDC88 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: GRDN_HUMAN, Q3V6T2

Function: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of

newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and

synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of

AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation

of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity).

Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress

fibers and lamellipodia. May be involved in membrane sorting in the early endosome

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC88A

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	16139227
GO:0005515	protein binding	--	--
GO:0008017	microtubule binding	ISS	--
GO:0035091	phosphatidylinositol binding	IDA	16139227
GO:0042803	protein homodimerization activity	IPI	16139227

CCDC88A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ccdc88a^tm2.1Mat for CCDC88A
     7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ccdc88a):

behavior/neurological	cardiovascular system	cellular	growth/size	mortality/aging
nervous system	vision/eye

CCDC88A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CCDC88A

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/24 Interacting proteins for CCDC88A (Q3V6T2³ ENSP00000338728⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	Q9NRI5³, ENSP00000355596⁴	I2D: score=2 STRING: ENSP00000355596
NDEL1	Q9GZM8³, ENSP00000333982⁴	I2D: score=2 STRING: ENSP00000333982
PARD3	Q8TEW0³, ENSP00000363921⁴	I2D: score=2 STRING: ENSP00000363921
PRKACA	P17612³, ENSP00000309591⁴	I2D: score=2 STRING: ENSP00000309591
YWHAH	Q04917³, ENSP00000248975⁴	I2D: score=2 STRING: ENSP00000248975

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--
GO:0001932	regulation of protein phosphorylation	ISS	--
GO:0006260	DNA replication	IEA	--
GO:0006275	regulation of DNA replication	ISS	--
GO:0010975	regulation of neuron projection development	ISS	--

CCDC88A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCDC88A
Search CenterWatch for drugs/clinical trials and news about CCDC88A / GRDN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCDC88A gene (3 alternative transcripts):

NM_001135597.1 NM_001254943.1 NM_018084.4

Unigene Cluster for CCDC88A:

Coiled-coil domain containing 88A

Hs.292925 [show with all ESTs]

Unigene Representative Sequence: NM_001135597

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336838(uc002ryt.2 uc010fbw.2 uc002rys.3 uc002ryu.2)

ENST00000263630 ENST00000444458 ENST00000412148 ENST00000426576(uc010fby.1 uc002ryw.3)

ENST00000456975 ENST00000474059 ENST00000476903 ENST00000468534 ENST00000430086

ENST00000471947(uc010fbz.3) ENST00000436346(uc010ypa.1 uc002ryv.2 uc010yoz.1)

ENST00000413716(uc010ypb.1) ENST00000422883

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Additional cDNA sequence:

AB033038.2 AB125644.1 AB201172.1 AF112218.1 AK001254.1 AK024717.1 AK025723.1 AK124603.1

AK299823.1 AK307964.1 BC014905.1 BC015539.1 BC032683.1 BC041160.1 BC045829.1 BC056885.1

BC060037.1 BC078168.1 BC092515.1 BC132736.1 BC142646.1 BC142700.1 BC144320.1 BX537985.1

BX538154.1 BX647874.1 BX648138.1 D64159.1

19 DOTS entries:

DT.40271507 DT.95099688 DT.40119135 DT.91911308 DT.100645964 DT.306982 DT.120951222 DT.86853997

DT.100645965 DT.120951189 DT.75149823 DT.97819542 DT.120951263 DT.451778 DT.91663454 DT.95303896

DT.120951243 DT.91922408 DT.97790164

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC88A (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19	^	20	^	21a	·	21b	^
SP1:																																							-
SP2:
SP3:
SP4:
SP5:																																													-

ExUns:	22a	·	22b	^	23	^	24	^	25a	·	25b	·	25c	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31a	·	31b	^	32a	·	32b	·	32c	·	32d	^	33	^	34	^	35a	·	35b
SP1:	-																								-		-
SP2:	-																-								-		-										-				-
SP3:	-																-								-		-										-
SP4:
SP5:	-																-								-		-

ECgene alternative splicing isoforms for CCDC88A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC88A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAGATATT

About this image

CCDC88A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC88A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC88A

SOURCE GeneReport for Unigene cluster: Hs.292925

UniProtKB/Swiss-Prot: GRDN_HUMAN, Q3V6T2

Tissue specificity: Expressed ubiquitously

SABiosciences Custom PCR Arrays for CCDC88A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC88A gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCDC88A¹	coiled-coil domain containing 88A	79.51(n) 82.99(a)		421210 XM_003640878.1 XP_003640926.1
lizard (Anolis carolinensis)	Reptilia	CCDC88A⁶	--	84(a)	1 ↔ 1	1(255800999-255896794)
zebrafish (Danio rerio)	Actinopterygii	BX324134.1⁶	--	57(a)	1 ↔ 1	6(6218335-6262806)
fruit fly (Drosophila melanogaster)	Insecta	Girdin⁶	Girdin	22(a)	1 → many	3L(3178930-3185287)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G31570⁶	uncharacterized protein	6(a)	1 → many	4(15297014-15306410)
rice (Oryza sativa)	Liliopsida	--	expressed protein	7(a)	1 → many	2(2656063-2659126)

ENSEMBL Gene Tree for CCDC88A (if available)
TreeFam Gene Tree for CCDC88A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCDC88A gene

HOOK2² HOOK1² CCDC88C² HOOK3² CCDC88B²

3 SIMAP similar genes for CCDC88A using alignment to 10 protein entries: GRDN_HUMAN (see all proteins):

KIAA1212 CCDC88C CCDC88B

CCDC88A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs59695161^1,2	C,F,	--	55249599(+)	`ATACTC/TGGTAT`	3	--	ds500¹		3	WA CSA	122
rs11899921^1,2	C,F,H,	--	55249722(+)	`CCTTAT/CAGTGA`	3	--	ds500¹		13	NS EA NA WA CSA	1318
rs12621338^1,2	H	--	55250055(+)	`CTTGGT/GTTTAT`	3	--	ut3¹		4	NS EA	418
rs1062936^1,2	H	--	55250278(-)	`TAATAT/AAAAAG`	3	--	ut3¹ ese³		6	MN NS EA NA	566
rs113702848^1,2		--	55250319(+)	`TACAAC/TGGTAG`	3	--	ut3¹		1	CSA	2
rs115327043^1,2	C,F,	--	55250362(+)	`AAAAGA/GCAATT`	3	--	ut3¹		1	WA	118
rs1045658^1,2	H	--	55250387(-)	`CACCCT/CTCAAC`	3	--	ut3¹ ese³		6	MN NS EA NA	602
rs74971692^1,2		--	55251254(+)	`TCAGGG/CTCAGC`	3	--	ut3¹		1	NA	120
rs77490309^1,2		--	55251262(+)	`AGCCTA/GCTCAG`	3	--	ut3¹		1	WA	118
rs75314859^1,2	C,F,	--	55251326(+)	`CTTAAC/TCCAGC`	3	--	ut3¹		1	WA	118

HapMap Linkage Disequilibrium report for CCDC88A (55514978 - 55647057 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC88A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC88A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCDC88A for disorders           About GeneDecksing

OMIM gene information: 609736    OMIM disorders: --

5 diseases for CCDC88A:    About MalaCards

colon cancer breast cancer glioblastoma schizophrenia

neuronitis

1 Novoseek disease relationship for CCDC88A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	3	20515748 (3), 18316593 (1)

Human Genome Epidemiology (HuGE) Navigator: CCDC88A (1 document)

Export disorders for CCDC88A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC88A gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with CCDC88A)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of GIV, a novel Galpha i/s- interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. (PubMed id 15749703)^{1, 2, 3} Le-Niculescu H.... Farquhar M.G. (2005)
A novel hook-related protein family and the characterization of hook- related protein 1. (PubMed id 15882442)^{1, 2, 9} Simpson F.... Wicking C. (2005)
Akt/PKB regulates actin organization and cell motility via Girdin/APE. (PubMed id 16139227)^{1, 2, 9} Enomoto A.... Takahashi M. (2005)
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. (PubMed id 15753085)^{1, 3} Anai M....Asano T. (2005)
An actin-binding protein Girdin regulates the motility of breast cancer cells. (PubMed id 18316593)^{1, 9} Jiang P....Takahashi M. (2008)
dGirdin a new player of Akt /PKB signaling in Drosoph ila Melanogaster. (PubMed id 20515748)^{1, 9} Yamaguchi M....Takahashi M. (2010)
A structural determinant that renders G alpha(i) sens itive to activation by GIV/girdin is required to promote cell migration. (PubMed id 20157114)^{1, 9} Garcia-Marcos M....Farquhar M.G. (2010)
GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling. (PubMed id 19211784)^{1, 9} Garcia-Marcos M....Farquhar M.G. (2009)
Activation of Galphai3 triggers cell migration via regulation of GIV. (PubMed id 18663145)^{1, 9} Ghosh P....Farquhar M.G. (2008)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55704	HGNC: 25523	Ensembl:ENSG00000115355	euGenes: HUgn55704	ECgene: CCDC88A
H-InvDB: CCDC88A

(According to HUGE)
About This Section

HUGE: KIAA1212

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC88A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC88A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC88A gene:
Search GeneIP for patents involving CCDC88A

GeneCards and IP:
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CCDC88A Gene

coiled-coil domain containing 88A

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CCDC88A Gene

coiled-coil domain containing 88A

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