CCDC86 Gene
protein-coding GIFtS : 47
GCID: GC11 P060609
coiled-coil domain containing 86
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Aliasesfor CCDC86 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coiled-Coil Domain Containing 86 1 2 Cytokine-Induced Protein With Coiled-Coil Domain2 3 MGC25741 Coiled-Coil Domain-Containing Protein 862 Cyclon1 CYCLON3
Export aliases for CCDC86 gene to outside databases Previous GC identifers: GC11P060367 GC11P056955
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Summariesfor CCDC86 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CCDC86 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCDC86 gene promoter: c-Fos AP-1 GATA-3 GATA-1 GATA-2 FOXC1 c-Jun ATF Other transcription factors Search SABiosciences Chromatin IP Primers for CCDC86 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC86
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2 CCDC86 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P060609: view genomic region
(about GC identifiers )
Start:
60,609,429 bp from pter
End:
60,618,561 bp from pter
Size:
9,133 bases
Orientation:
plus strand
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Proteinsfor CCDC86 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CCD86_HUMAN, Q9H6F5 (See
protein sequence )Recommended Name: Coiled-coil domain-containing protein 86 Size : 360 amino acids; 40236 Da
Subunit : Interacts with hepatitis C virus (HCV) protein NS5A
Subcellular location : Nucleus (By similarity)Explore the universe of human proteins at neXtProt for CCDC86: NX_Q9H6F5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H6F5 CCDC86 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_077003.1 ENSEMBL proteins: ENSP00000227520 ENSP00000442111 ENSP00000440906 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
CCDC86 for ontologies About GeneDecksing CCDC86 Antibody Products: Assay Products for CCDC86:
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Protein
Domains / Familiesfor CCDC86 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CCDC86 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H6F5 ProtoNet protein and cluster: Q9H6F5
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Functionfor CCDC86 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC86 (NM_024098 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC86 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC86
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC86
2 GenomeRNAi human phenotypes for CCDC86 :Animal Models: Mouse knock-out Ccdc86 tm1Hfuj for CCDC86 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccdc86) :
CCDC86 for phenotypes About GeneDecksing
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Pathways & Interactionsfor CCDC86 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC86 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)4 Interacting proteins for CCDC86 (Q9H6F5 2 , 3 ENSP00000227520 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0019048 virus-host interaction
IEA -- GO:0044419 interspecies interaction between organisms
-- --
CCDC86 for ontologies About GeneDecksing
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Drugs & Compoundsfor CCDC86 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCDC86 Search CenterWatch for drugs/clinical trials and news about CCDC86 / CCD86
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Transcriptsfor CCDC86 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCDC86 gene: NM_024098.3 Unigene Cluster for CCDC86:
Coiled-coil domain containing 86 Hs.4253 [show with all ESTs ] Unigene Representative Sequence: NM_024098 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000227520 (uc001nqa.2 ) ENST00000545219 ENST00000535217 ENST00000545580 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC86 (NM_024098 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC86 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC86
Additional cDNA sequence: AK025974.1 AK123775.1 AK302329.1 BC001378.1
12 DOTS entries : DT.97763001 DT.117491
DT.97776929 DT.102830892 DT.100775809 DT.97846469 DT.40106554 DT.95370369 DT.100808501 DT.101965880 DT.120716266 DT.95370371 24/318 AceView cDNA sequences (see all 318 ):
BG385373 BM794772 CR596012 BQ956110 CR622897 BM827913 CR592065 BF980767 BE795888 BF339992 BI223233 BE303032 CR620265 BE276408 CR590195 CR613603 CR602235 CR599766 BQ049383 CR624452 BE272589 BE277244 CR624036 BU859888 GeneLoc Exon Structure
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Expression for CCDC86 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCDC86 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTGTCCAGT
About this image CCDC86 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Epithelial Tubule Kidney Kidney Renal Vesicle Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
See CCDC86 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCDC86 SOURCE GeneReport for Unigene cluster: Hs.4253 SABiosciences Custom PCR Arrays for CCDC86 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC86Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCDC86 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC86 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC86 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC86
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Orthologsfor CCDC86 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CCDC86 gene from 7/20 species (see all 20 ) About this table
ENSEMBL Gene Tree for CCDC86 (if available)TreeFam Gene Tree for CCDC86 (if available)
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Paralogsfor CCDC86 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CCDC86 gene
CCDC86 for paralogs About GeneDecksing 4 Pseudogenes.org Pseudogenes for CCDC86 PGOHUM00000263146 PGOHUM00000235485 PGOHUM00000235860 PGOHUM00000232629
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Genomic Variantsfor CCDC86 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCDC86 (60609429 - 60618561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CCDC86: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC86
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Disorders
/ Diseasesfor CCDC86 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCDC86 for disorders About GeneDecksing
OMIM gene information: 611293
OMIM disorders : --2 diseases for CCDC86 : About MalaCards hepatitis c hepatitis Human Genome Epidemiology (HuGE) Navigator: CCDC86 (5 documents) Export disorders for CCDC86 gene to outside databases
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Publicationsfor CCDC86 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCDC86 gene, integrated from 9 sources (see all 25 ): (articles sorted by number of sources associating them with CCDC86) Utopia : connect your pdf to the dynamic world of online information
Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. (PubMed id 17300783) 1 , 2 Hoshino A. and Fujii H. (2007) Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. (PubMed id 15607035) 1 , 2 Ahn J.... Hoe K.-L. (2004) Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326) 1 Tsai Y.C....Cristea I.M. (2012) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296) 1 Oguri M....Yamada Y. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315) 1 Yoshida T....Yamada Y. (2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009)
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External Searches for CCDC86 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCDC86 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCDC86 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CCDC86 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCDC86 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CCDC86 gene: Search GeneIP for patents involving CCDC86 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCDC86 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCDC86 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCDC86 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC86 OriGene Protein Over-expression Lysate for CCDC86 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCDC86 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC86 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCDC86 OriGene Custom Protein Services for CCDC86 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC86 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC86 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC86 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCDC86 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC86 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC86
Search Tocris compounds for CCDC86
CCDC86 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC86
ThermoFisher Antibody for CCDC86
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC86
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Aliases for CCDC86
Databases for CCDC86
Disorders / Diseases for CCDC86
Domains / Families for CCDC86
Drugs / Compounds for CCDC86
Expression for CCDC86
Function for CCDC86
Genomic Views for CCDC86
Intellectual Property for CCDC86
Orthologs for CCDC86
Paralogs for CCDC86
Pathways / Interactions for CCDC86
Products for CCDC86
Proteins for CCDC86
Publications for CCDC86
Search Box for CCDC86
Summaries for CCDC86
Transcripts for CCDC86
Variants for CCDC86
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