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Aliases for CCDC86 Gene

Aliases for CCDC86 Gene

  • Coiled-Coil Domain Containing 86 2 3 5
  • Cytokine-Induced Protein With Coiled-Coil Domain 3 4
  • Cyclon 3 4

External Ids for CCDC86 Gene

Previous GeneCards Identifiers for CCDC86 Gene

  • GC11P060367
  • GC11P060609
  • GC11P056955

Summaries for CCDC86 Gene

GeneCards Summary for CCDC86 Gene

CCDC86 (Coiled-Coil Domain Containing 86) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC86 Gene

Genomics for CCDC86 Gene

Regulatory Elements for CCDC86 Gene

Promoters for CCDC86 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC86 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC86 Gene

Chromosome:
11
Start:
60,841,956 bp from pter
End:
60,851,088 bp from pter
Size:
9,133 bases
Orientation:
Plus strand

Genomic View for CCDC86 Gene

Genes around CCDC86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC86 Gene

Proteins for CCDC86 Gene

  • Protein details for CCDC86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6F5-CCD86_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 86
    Protein Accession:
    Q9H6F5
    Secondary Accessions:
    • B4DY99

    Protein attributes for CCDC86 Gene

    Size:
    360 amino acids
    Molecular mass:
    40236 Da
    Quaternary structure:
    • Interacts with hepatitis C virus (HCV) protein NS5A.

    Alternative splice isoforms for CCDC86 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC86 Gene

Proteomics data for CCDC86 Gene at MOPED

Post-translational modifications for CCDC86 Gene

Other Protein References for CCDC86 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC86 Gene

Domains & Families for CCDC86 Gene

Protein Domains for CCDC86 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC86 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC86: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC86 Gene

Function for CCDC86 Gene

Gene Ontology (GO) - Molecular Function for CCDC86 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC86: view
genes like me logo Genes that share phenotypes with CCDC86: view

Animal Models for CCDC86 Gene

MGI Knock Outs for CCDC86:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC86 Gene

Localization for CCDC86 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC86 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC86 Gene COMPARTMENTS Subcellular localization image for CCDC86 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for CCDC86 Gene

Pathways & Interactions for CCDC86 Gene

SuperPathways for CCDC86 Gene

No Data Available

Interacting Proteins for CCDC86 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000227520%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000329466%0d%0a
Selected Interacting proteins: Q9H6F5-CCD86_HUMAN ENSP00000227520 for CCDC86 Gene via UniProtKB I2D MINT STRING

Gene Ontology (GO) - Biological Process for CCDC86 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC86 Gene

Drugs & Compounds for CCDC86 Gene

No Compound Related Data Available

Transcripts for CCDC86 Gene

mRNA/cDNA for CCDC86 Gene

Unigene Clusters for CCDC86 Gene

Coiled-coil domain containing 86:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC86 Gene

No ASD Table

Relevant External Links for CCDC86 Gene

GeneLoc Exon Structure for
CCDC86
ECgene alternative splicing isoforms for
CCDC86

Expression for CCDC86 Gene

mRNA expression in normal human tissues for CCDC86 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC86 Gene

This gene is overexpressed in Lung (28.2) and Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC86 Gene



SOURCE GeneReport for Unigene cluster for CCDC86 Gene Hs.4253

genes like me logo Genes that share expression patterns with CCDC86: view

Protein tissue co-expression partners for CCDC86 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC86 Gene

Orthologs for CCDC86 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC86 36
  • 99 (a)
OneToOne
CCDC86 35
  • 98.98 (n)
  • 98.89 (a)
cow
(Bos Taurus)
Mammalia CCDC86 35
  • 83.62 (n)
  • 76.84 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCDC86 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc86 16
Ccdc86 36
  • 59 (a)
OneToOne
Ccdc86 35
  • 77.4 (n)
  • 74.5 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC86 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc86 35
  • 77.97 (n)
  • 73.45 (a)
chicken
(Gallus gallus)
Aves CCDC86 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC86 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733466 35
  • 65.61 (n)
  • 71.58 (a)
Str.10541 35
zebrafish
(Danio rerio)
Actinopterygii CCDC86 36
  • 35 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14210 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y40B1B.7 36
  • 42 (a)
OneToOne
Species with no ortholog for CCDC86:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC86 Gene

ENSEMBL:
Gene Tree for CCDC86 (if available)
TreeFam:
Gene Tree for CCDC86 (if available)

Paralogs for CCDC86 Gene

Pseudogenes.org Pseudogenes for CCDC86 Gene

genes like me logo Genes that share paralogs with CCDC86: view

No data available for Paralogs for CCDC86 Gene

Variants for CCDC86 Gene

Sequence variations from dbSNP and Humsavar for CCDC86 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2074421 - 60,842,583(-) GGTAG(C/G)TGATG reference, missense
rs500659 -- 60,841,939(-) TGCGC(A/G)TGCGC upstream-variant-2KB
rs533736 -- 60,840,594(-) TTGCC(C/T)TGCCT upstream-variant-2KB
rs537024 -- 60,846,873(-) AGATC(A/G)GCCGG intron-variant
rs561285 -- 60,841,460(-) GTGAG(G/T)GAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC86 Gene

Variant ID Type Subtype PubMed ID
nsv897598 CNV Loss 21882294

Variation tolerance for CCDC86 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC86 Gene

HapMap Linkage Disequilibrium report
CCDC86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC86 Gene

Disorders for CCDC86 Gene

Relevant External Links for CCDC86

Genetic Association Database (GAD)
CCDC86
Human Genome Epidemiology (HuGE) Navigator
CCDC86
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC86

No disorders were found for CCDC86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC86 Gene

Publications for CCDC86 Gene

  1. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for CCDC86 Gene

Sources for CCDC86 Gene

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