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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC86 Gene

protein-coding   GIFtS: 47
GCID: GC11P060609

coiled-coil domain containing 86

 Explore 2 diseases affiliated with
CCDC86 via our new
 Human Malady Compendium 
Biological research products
for CCDC86
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 861 2
Cytokine-Induced Protein With Coiled-Coil Domain2 3
MGC25741
Coiled-Coil Domain-Containing Protein 862
Cyclon1
CYCLON3

External Ids:    HGNC: 283591   Entrez Gene: 790802   Ensembl: ENSG000001101047   OMIM: 6112935   UniProtKB: Q9H6F53   

Export aliases for CCDC86 gene to outside databases

Previous GC identifers: GC11P060367 GC11P056955


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC86 gene promoter:
         c-Fos   AP-1   GATA-3   GATA-1   GATA-2   FOXC1   c-Jun   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC86 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC86

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC86


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

CCDC86 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC86 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060609:  view genomic region     (about GC identifiers)

Start:
60,609,429 bp from pter      End:
60,618,561 bp from pter
Size:
9,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCD86_HUMAN, Q9H6F5 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 86  
Size: 360 amino acids; 40236 Da
Subunit: Interacts with hepatitis C virus (HCV) protein NS5A
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for CCDC86: NX_Q9H6F5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H6F5

  • CCDC86 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_077003.1  
    ENSEMBL proteins: 
     ENSP00000227520   ENSP00000442111   ENSP00000440906  

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    Uscn Proteins for CCDC86

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--


    CCDC86 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CCDC86 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026570 CCDC86

    Graphical View of Domain Structure for InterPro Entry Q9H6F5

    ProtoNet protein and cluster: Q9H6F5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC86
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    hsa-miR-194* hsa-miR-124 hsa-miR-506 hsa-miR-1207-5p
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    Inhib. RNA
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    2 GenomeRNAi human phenotypes for CCDC86:
     Decreased viability of wild-ty  Large cells 

    Animal Models:
         Mouse knock-out Ccdc86tm1Hfuj for CCDC86
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccdc86):
     cellular  hematopoietic system  immune system  mortality/aging 

    CCDC86 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC86

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for CCDC86 (Q9H6F52, 3 ENSP000002275204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLSTP369573I2D: score=4 
    SIRT7ENSP000003294664STRING: ENSP00000329466
    --Q86TQ83, 2MINT-65501 I2D: score=1 
    --Q86TQ83, 2MINT-65501 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    CCDC86 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC86
    Search CenterWatch for drugs/clinical trials and news about CCDC86 / CCD86 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC86 gene: 
    NM_024098.3  

    Unigene Cluster for CCDC86:

    Coiled-coil domain containing 86
    Hs.4253  [show with all ESTs]
    Unigene Representative Sequence: NM_024098
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000227520(uc001nqa.2) ENST00000545219 ENST00000535217 ENST00000545580


    miRNA
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    hsa-miR-194* hsa-miR-124 hsa-miR-506 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidCCDC86 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC86
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    Additional cDNA sequence: 

    AK025974.1 AK123775.1 AK302329.1 BC001378.1 

    12 DOTS entries:

    DT.97763001  DT.117491  DT.97776929  DT.102830892  DT.100775809  DT.97846469  DT.40106554  DT.95370369 
    DT.100808501  DT.101965880  DT.120716266  DT.95370371 

    24/318 AceView cDNA sequences (see all 318):

    BG385373 BM794772 CR596012 BQ956110 CR622897 BM827913 CR592065 BF980767 
    BE795888 BF339992 BI223233 BE303032 CR620265 BE276408 CR590195 CR613603 
    CR602235 CR599766 BQ049383 CR624452 BE272589 BE277244 CR624036 BU859888 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC86 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGTCCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CCDC86 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyEpithelial TubuleKidney
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See CCDC86 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC86

    SOURCE GeneReport for Unigene cluster: Hs.4253
        SABiosciences Custom PCR Arrays for CCDC86
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC86

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC86 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc861 , 5 coiled-coil domain containing 861, 5 76.64(n)1
    73.36(a)1
      19 (7.41 cM)5
    1086731  NM_023731.31  NP_076220.21 
     109414815 
    chicken
    (Gallus gallus)
    Aves CCDC861 coiled-coil domain containing 86 66.28(n)
    60.82(a)
      425097  XM_003641273.1  XP_003641321.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC866
    --
    66(a)
    1 ↔ 1
    GL343235.1(312919-317032)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.105412 Transcribed sequence with moderate similarity to protein more 73.29(n)    137710604 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-217k17.76
    si:ch211-217k17.7
    33(a)
    1 ↔ 1
    1(52946673-52955985)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142101 CG14210 54.47(n)
    45.53(a)
      32958  NM_134484.2  NP_608328.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y40B1B.71 Protein Y40B1B.7 51.92(n)
    46.15(a)
      173211  NM_060962.2  NP_493363.1 


    ENSEMBL Gene Tree for CCDC86 (if available)
    TreeFam Gene Tree for CCDC86 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC86 gene

    CCDC86 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CCDC86
    PGOHUM00000263146 PGOHUM00000235485 PGOHUM00000235860 PGOHUM00000232629


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 NCBI SNPs in CCDC86 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs414968481,2
    C,F,--56963459(+) CGCTCG/ACACTC 1 -- int12Minor allele frequency- A:0.02WA NA 238
    rs44068441,2
    ----56963315(+) CCTCTC/TAACAT 1 -- int10--------
    rs353363271,2
    ----56963473(+) TGGGG-/CCTGAG 1 -- int10--------
    rs11270381,2
    ----56963985(+) CGCTGC/ATCAGA 1 -- ut313Minor allele frequency- A:0.00MN NA 188
    rs1114023671,2
    ----56963127(+) CAGCAC/GGACTC 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1134556901,2
    ----56963891(+) GCAGCT/CGCCCC 2 /P /L mis11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for CCDC86 (60609429 - 60618561 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCDC86: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCDC86 for disorders           About GeneDecksing

    OMIM gene information: 611293    OMIM disorders: --

    2 diseases for CCDC86:    About MalaCards
    hepatitis c    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: CCDC86 (5 documents)

    Export disorders for CCDC86 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC86 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CCDC86)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Redundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclon. (PubMed id 17300783)1, 2 Hoshino A. and Fujii H. (2007)
    2. Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus. (PubMed id 15607035)1, 2 Ahn J.... Hoe K.-L. (2004)
    3. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79080 HGNC: 28359 AceView: MGC2574 Ensembl:ENSG00000110104 euGenes: HUgn79080
    ECgene: CCDC86 H-InvDB: CCDC86

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC86 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC86 gene:
    Search GeneIP for patents involving CCDC86

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
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    von Willebrand factor
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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