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CCDC85C Gene

protein-coding   GIFtS: 37
GCID: GC14M099978

Coiled-Coil Domain Containing 85C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 85C1 2
Coiled-Coil Domain-Containing Protein 85C2

External Ids:    HGNC: 354591   Entrez Gene: 3177622   Ensembl: ENSG000002054767   UniProtKB: A6NKD93   

Export aliases for CCDC85C gene to outside databases

Previous GC identifers: GC14M099052 GC14M080161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC85C Gene:
CCDC85C (coiled-coil domain containing 85C) is a protein-coding gene. An important paralog of this gene is CCDC85B.

UniProtKB/Swiss-Prot: CC85C_HUMAN, A6NKD9
Function: May play an important role in cortical development, especially in the maintenance of radial glia (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC85C gene promoter:
         Max   FOXO1a   Nkx2-5   FOXO1   Egr-4   c-Myc   GATA-1   YY1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC85C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC85C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.31

CCDC85C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC85C gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M099978:  view genomic region     (about GC identifiers)

Start:
99,977,603 bp from pter      End:
100,070,727 bp from pter
Size:
93,125 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC85C_HUMAN, A6NKD9 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 85C  
Size: 419 amino acids; 45210 Da

Explore the universe of human proteins at neXtProt for CCDC85C: NX_A6NKD9

Explore proteomics data for CCDC85C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC85C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138467.1  
    ENSEMBL proteins: 
     ENSP00000369592   ENSP00000450850   ENSP00000452496   ENSP00000450602   ENSP00000451294  
     ENSP00000452300   ENSP00000451718  

    CCDC85C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CCDC85C

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019359 DUF2216_coiled-coil

    Graphical View of Domain Structure for InterPro Entry A6NKD9

    ProtoNet protein and cluster: A6NKD9

    UniProtKB/Swiss-Prot: CC85C_HUMAN, A6NKD9
    Similarity: Belongs to the CCDC85 family


    Find genes that share domains with CCDC85C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC85C_HUMAN, A6NKD9
    Function: May play an important role in cortical development, especially in the maintenance of radial glia (By
    similarity)

    Animal Models:

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    hsa-miR-411* hsa-miR-140-5p hsa-miR-607 hsa-miR-411 hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CC85C_HUMAN, A6NKD9: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction of
    radial glia in the wall of lateral ventricles of the developing brain (By similarity). Colocalizes with TJP1 on
    the meshwork-like structure of adherens junctions on the lateral ventricles wall (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction IEA--
    GO:0043296apical junction complex ISS--

    Find genes that share ontologies with CCDC85C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC85C
    Interactions:

        Search GeneGlobe Interaction Network for CCDC85C

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CCDC85C (ENSP000003695924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL3ENSP000003160544STRING: ENSP00000316054
    DIXDC1ENSP000003943524STRING: ENSP00000394352
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021987cerebral cortex development ISS--

    Find genes that share ontologies with CCDC85C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC85C (CC85C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC85C gene: 
    NM_001144995.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380243(uc010avr.3) ENST00000557769 ENST00000557576 ENST00000555822
    ENST00000554996 ENST00000554877 ENST00000556348
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CCDC85C (see all 83):
    hsa-miR-411* hsa-miR-140-5p hsa-miR-607 hsa-miR-411 hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC85C (NM_001144995)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85C
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CCDC85C
      QuantiFast Probe-based Assays in human, mouse, rat CCDC85C

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC85C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCAGAGC
    CCDC85C Expression
    About this image

    CCDC85C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC85C Protein Expression
        Custom PCR Arrays for CCDC85C
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CCDC85C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC85C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCDC85C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc85c1 , 5 coiled-coil domain containing 85C1, 5 90.45(n)1
    93.33(a)1
      12 (59.23 cM)5
    6681581  NM_001159910.11  NP_001153382.11 
     1082063455 
    chicken
    (Gallus gallus)
    Aves CCDC85C1 coiled-coil domain containing 85C 74.54(n)
    73.23(a)
      423447  XM_421357.3  XP_421357.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC85C6
    coiled-coil domain containing 85C
    71(a)
    1 ↔ 1
    GL343270.1(1616281-1807292)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccdc85c1 coiled-coil domain containing 85C 66.05(n)
    69.55(a)
      779899  NM_001078977.1  NP_001072445.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc85ca1 coiled-coil domain containing 85C, a 64.91(n)
    65.44(a)
      751667  NM_001045384.1  NP_001038849.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172651 CG17265 52.23(n)
    41.73(a)
      33509  NM_134890.3  NP_608734.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F29G9.26
    Protein F29G9.2, isoform b (F29G9.2) mRNA, complet...
    18(a)
    1 → many
    V(6018994-6026341) WBGene00017931


    ENSEMBL Gene Tree for CCDC85C (if available)
    TreeFam Gene Tree for CCDC85C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC85C gene
    CCDC85B2  CCDC85A2  
    2 SIMAP similar genes for CCDC85C using alignment to 6 protein entries:     CC85C_HUMAN (see all proteins):
    CCDC85B    CCDC85A

    Find genes that share paralogs with CCDC85C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC85C (see all 2059)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39949761,2
    C--80970719(+) GGATC-/AAA   
       
    /AAAA
    TCCCT
    2 -- ut310--------
    rs1884857091,2
    --99978469(+) ATGTTC/TTTACC 1 -- ut310--------
    rs1931445531,2
    --99978604(+) TCCAGG/TTCTCA 1 -- ut310--------
    rs1849385861,2
    --99978735(+) CCTCTA/GCCGCT 1 -- ut310--------
    rs39181331,2
    C,F--99978753(+) CATGCA/GTTTAG 1 -- ut312Minor allele frequency- G:0.02NS NA 178
    rs1898804851,2
    --99978768(+) AAGAAA/TAAAAA 1 -- ut310--------
    rs1810408751,2
    --99978881(+) AAAAAA/GGTGCC 1 -- ut310--------
    rs1409857301,2
    --99978949(+) TGGGGC/TGAAAG 1 -- ut310--------
    rs1836957571,2
    --99978981(+) GGAAAC/TTGAAG 1 -- ut310--------
    rs39181351,2
    C,F--99979113(+) GGTCGC/TCCTGC 1 -- ut312Minor allele frequency- T:0.08NS EA 276

    HapMap Linkage Disequilibrium report for CCDC85C (99977603 - 100070727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCDC85C (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2227205CNV Deletion18987734
    esv2749101CNV Deletion23290073
    esv2749100CNV Deletion23290073
    nsv85788CNV Loss16902084
    nsv456423CNV Loss19166990
    dgv1978n71CNV Loss21882294
    esv23792CNV Loss19812545
    dgv1977n71CNV Loss21882294
    nsv456422CNV Loss19166990
    nsv902220CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCDC85C
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC85C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC85C gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CCDC85C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    2. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    6. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 317762 HGNC: 35459 Ensembl:ENSG00000205476 euGenes: HUgn317762 ECgene: CCDC85C
    H-InvDB: CCDC85C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC85C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC85C gene:
    Search GeneIP for patents involving CCDC85C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCDC85C  
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     Block miRNA regulation of human, mouse, rat CCDC85C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCDC85C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC85C Predesigned siRNA for gene silencing in human, mouse, rat CCDC85C
     QuantiFast Probe-based Assays in human, mouse, rat CCDC85C QuantiTect SYBR Green Assays in human, mouse, rat CCDC85C
     Custom PCR Arrays for CCDC85C Search Chromatin IP Primers for CCDC85C
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC85C
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     Search Addgene for plasmids for CCDC85C
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