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Aliases for CCDC85C Gene

Aliases for CCDC85C Gene

  • Coiled-Coil Domain Containing 85C 2 3

External Ids for CCDC85C Gene

Summaries for CCDC85C Gene

GeneCards Summary for CCDC85C Gene

CCDC85C (Coiled-Coil Domain Containing 85C) is a Protein Coding gene. An important paralog of this gene is CCDC85B.

UniProtKB/Swiss-Prot for CCDC85C Gene

  • May play an important role in cortical development, especially in the maintenance of radial glia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85C Gene

Genomics for CCDC85C Gene

Genomic Location for CCDC85C Gene

Start:
99,500,180 bp from pter
End:
99,604,390 bp from pter
Size:
104,211 bases
Orientation:
Minus strand

Genomic View for CCDC85C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC85C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85C Gene

Regulatory Elements for CCDC85C Gene

Proteins for CCDC85C Gene

  • Protein details for CCDC85C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKD9-CC85C_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 85C
    Protein Accession:
    A6NKD9
    Secondary Accessions:

    Protein attributes for CCDC85C Gene

    Size:
    419 amino acids
    Molecular mass:
    45210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC85C Gene

Proteomics data for CCDC85C Gene at MOPED

Post-translational modifications for CCDC85C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85C Gene

No data available for DME Specific Peptides for CCDC85C Gene

Domains for CCDC85C Gene

Protein Domains for CCDC85C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC85C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKD9

UniProtKB/Swiss-Prot:

CC85C_HUMAN
Family:
  • Belongs to the CCDC85 family.:
    • A6NKD9
genes like me logo Genes that share domains with CCDC85C: view

No data available for Gene Families for CCDC85C Gene

Function for CCDC85C Gene

Molecular function for CCDC85C Gene

UniProtKB/Swiss-Prot Function: May play an important role in cortical development, especially in the maintenance of radial glia.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC85C Gene

Localization for CCDC85C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85C Gene

Cell junction, tight junction. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC85C Gene COMPARTMENTS Subcellular localization image for CCDC85C gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC85C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IEA --
GO:0043296 apical junction complex ISS --
genes like me logo Genes that share ontologies with CCDC85C: view

Pathways for CCDC85C Gene

SuperPathways for CCDC85C Gene

No Data Available

Interacting Proteins for CCDC85C Gene

Gene Ontology (GO) - Biological Process for CCDC85C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021987 cerebral cortex development ISS --
genes like me logo Genes that share ontologies with CCDC85C: view

No data available for Pathways by source for CCDC85C Gene

Transcripts for CCDC85C Gene

mRNA/cDNA for CCDC85C Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC85C Gene

Coiled-coil domain containing 85C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85C Gene

No ASD Table

Relevant External Links for CCDC85C Gene

GeneLoc Exon Structure for
CCDC85C
ECgene alternative splicing isoforms for
CCDC85C

Expression for CCDC85C Gene

mRNA expression in normal human tissues for CCDC85C Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC85C Gene

SOURCE GeneReport for Unigene cluster for CCDC85C Gene Hs.709288

genes like me logo Genes that share expressions with CCDC85C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC85C Gene

Orthologs for CCDC85C Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC85C 35
  • 99.82 (n)
  • 100 (a)
CCDC85C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC85C 35
  • 90.29 (n)
  • 92.84 (a)
CCDC85C 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC85C 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc85c 35
  • 90.45 (n)
  • 93.33 (a)
Ccdc85c 16
Ccdc85c 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC85C 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC85C 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc85c 35
  • 90.57 (n)
  • 94.34 (a)
chicken
(Gallus gallus)
Aves CCDC85C 35
  • 74.54 (n)
  • 73.23 (a)
CCDC85C 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC85C 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc85c 35
  • 66.05 (n)
  • 69.55 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc85ca 35
  • 64.91 (n)
  • 65.44 (a)
ccdc85ca 36
  • 66 (a)
OneToMany
ccdc85cb 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17265 35
  • 52.23 (n)
  • 41.73 (a)
CG17265 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F29G9.2 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 36
  • 43 (a)
OneToMany
Species with no ortholog for CCDC85C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC85C Gene

ENSEMBL:
Gene Tree for CCDC85C (if available)
TreeFam:
Gene Tree for CCDC85C (if available)

Paralogs for CCDC85C Gene

Paralogs for CCDC85C Gene

Selected SIMAP similar genes for CCDC85C Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC85C: view

Variants for CCDC85C Gene

Sequence variations from dbSNP and Humsavar for CCDC85C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs755480 -- 99,582,180(-) TGGTA(A/C)CCCCA intron-variant
rs755814 -- 99,581,576(+) GCCAC(C/T)GCACA intron-variant
rs880959 -- 99,544,978(-) TGTGG(A/G)AGTGT intron-variant
rs941543 -- 99,548,101(-) GCGTT(C/T)GTAAT intron-variant
rs941544 -- 99,543,282(-) GACGG(C/G)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC85C Gene

Variant ID Type Subtype PubMed ID
dgv1977n71 CNV Loss 21882294
esv2749100 CNV Deletion 23290073
esv2227205 CNV Deletion 18987734
esv2749101 CNV Deletion 23290073
nsv85788 CNV Loss 16902084
nsv456422 CNV Loss 19166990
nsv456423 CNV Loss 19166990
nsv902220 CNV Loss 21882294
dgv1978n71 CNV Loss 21882294
nsv827050 CNV Gain 20364138
nsv827051 CNV Gain 20364138
esv23792 CNV Loss 19812545

Relevant External Links for CCDC85C Gene

HapMap Linkage Disequilibrium report
CCDC85C
Human Gene Mutation Database (HGMD)
CCDC85C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85C Gene

Disorders for CCDC85C Gene

No disorders were found for CCDC85C Gene.

No data available for UniProtKB/Swiss-Prot for CCDC85C Gene

Publications for CCDC85C Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for CCDC85C Gene

Sources for CCDC85C Gene

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