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Aliases for CCDC85C Gene

Aliases for CCDC85C Gene

  • Coiled-Coil Domain Containing 85C 2 3 5

External Ids for CCDC85C Gene

Previous GeneCards Identifiers for CCDC85C Gene

  • GC14M099052
  • GC14M099978
  • GC14M080161

Summaries for CCDC85C Gene

GeneCards Summary for CCDC85C Gene

CCDC85C (Coiled-Coil Domain Containing 85C) is a Protein Coding gene. An important paralog of this gene is CCDC85B.

UniProtKB/Swiss-Prot for CCDC85C Gene

  • May play an important role in cortical development, especially in the maintenance of radial glia.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85C Gene

Genomics for CCDC85C Gene

Regulatory Elements for CCDC85C Gene

Enhancers for CCDC85C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC85C on UCSC Golden Path with GeneCards custom track

Promoters for CCDC85C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC85C on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC85C Gene

99,500,180 bp from pter
99,604,390 bp from pter
104,211 bases
Minus strand

Genomic View for CCDC85C Gene

Genes around CCDC85C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC85C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC85C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85C Gene

Proteins for CCDC85C Gene

  • Protein details for CCDC85C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 85C
    Protein Accession:

    Protein attributes for CCDC85C Gene

    419 amino acids
    Molecular mass:
    45210 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC85C Gene

Proteomics data for CCDC85C Gene at MOPED

Post-translational modifications for CCDC85C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85C Gene

No data available for DME Specific Peptides for CCDC85C Gene

Domains & Families for CCDC85C Gene

Protein Domains for CCDC85C Gene


Suggested Antigen Peptide Sequences for CCDC85C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC85 family.
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85C: view

No data available for Gene Families for CCDC85C Gene

Function for CCDC85C Gene

Molecular function for CCDC85C Gene

UniProtKB/Swiss-Prot Function:
May play an important role in cortical development, especially in the maintenance of radial glia.

Phenotypes for CCDC85C Gene

GenomeRNAi human phenotypes for CCDC85C:
genes like me logo Genes that share phenotypes with CCDC85C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85C Gene

Localization for CCDC85C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85C Gene

Cell junction, tight junction. Note=Localizes to the apical junction of radial glia in the wall of lateral ventricles of the developing brain. Colocalizes with TJP1 on the meshwork-like structure of adherens junctions on the lateral ventricles wall. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CCDC85C Gene COMPARTMENTS Subcellular localization image for CCDC85C gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC85C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with CCDC85C: view

Pathways & Interactions for CCDC85C Gene

SuperPathways for CCDC85C Gene

No Data Available

Interacting Proteins for CCDC85C Gene

Gene Ontology (GO) - Biological Process for CCDC85C Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC85C Gene

Drugs & Compounds for CCDC85C Gene

No Compound Related Data Available

Transcripts for CCDC85C Gene

mRNA/cDNA for CCDC85C Gene

(4) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC85C Gene

Coiled-coil domain containing 85C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85C Gene

No ASD Table

Relevant External Links for CCDC85C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC85C Gene

mRNA expression in normal human tissues for CCDC85C Gene

Protein differential expression in normal tissues from HIPED for CCDC85C Gene

This gene is overexpressed in Retina (41.2), Testis (8.9), and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC85C Gene

SOURCE GeneReport for Unigene cluster for CCDC85C Gene Hs.709288

genes like me logo Genes that share expression patterns with CCDC85C: view

Protein tissue co-expression partners for CCDC85C Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC85C Gene

Orthologs for CCDC85C Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC85C 35
  • 90.29 (n)
  • 92.84 (a)
CCDC85C 36
  • 91 (a)
(Mus musculus)
Mammalia Ccdc85c 35
  • 90.45 (n)
  • 93.33 (a)
Ccdc85c 16
Ccdc85c 36
  • 92 (a)
(Pan troglodytes)
Mammalia CCDC85C 35
  • 99.82 (n)
  • 100 (a)
CCDC85C 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccdc85c 35
  • 90.57 (n)
  • 94.34 (a)
(Canis familiaris)
Mammalia CCDC85C 36
  • 87 (a)
(Monodelphis domestica)
Mammalia CCDC85C 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC85C 36
  • 68 (a)
(Gallus gallus)
Aves CCDC85C 35
  • 74.54 (n)
  • 73.23 (a)
CCDC85C 36
  • 73 (a)
(Anolis carolinensis)
Reptilia CCDC85C 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc85c 35
  • 66.05 (n)
  • 69.55 (a)
(Danio rerio)
Actinopterygii ccdc85ca 35
  • 64.91 (n)
  • 65.44 (a)
ccdc85ca 36
  • 66 (a)
ccdc85cb 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17265 35
  • 52.23 (n)
  • 41.73 (a)
CG17265 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea F29G9.2 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 36
  • 43 (a)
Species with no ortholog for CCDC85C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC85C Gene

Gene Tree for CCDC85C (if available)
Gene Tree for CCDC85C (if available)

Paralogs for CCDC85C Gene

Paralogs for CCDC85C Gene

(2) SIMAP similar genes for CCDC85C Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC85C: view

Variants for CCDC85C Gene

Sequence variations from dbSNP and Humsavar for CCDC85C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140345 -- 99,551,573(+) TGCAG(G/T)TGAGT intron-variant
rs7140670 -- 99,574,070(+) CTCAG(C/T)GCACA intron-variant
rs7141325 -- 99,551,568(+) gggtg(A/T)gcagg intron-variant
rs8017438 -- 99,571,465(+) GCCGT(A/T)CTGTA intron-variant
rs8017663 -- 99,589,207(+) ACGGC(A/C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC85C Gene

Variant ID Type Subtype PubMed ID
dgv1977n71 CNV Loss 21882294
esv2749100 CNV Deletion 23290073
esv2227205 CNV Deletion 18987734
esv2749101 CNV Deletion 23290073
nsv85788 CNV Loss 16902084
nsv456422 CNV Loss 19166990
nsv456423 CNV Loss 19166990
nsv902220 CNV Loss 21882294
dgv1978n71 CNV Loss 21882294
nsv827050 CNV Gain 20364138
nsv827051 CNV Gain 20364138
esv23792 CNV Loss 19812545

Variation tolerance for CCDC85C Gene

Gene Damage Index Score: 4.60; 65.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC85C Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85C Gene

Disorders for CCDC85C Gene

Relevant External Links for CCDC85C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC85C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC85C Gene

Publications for CCDC85C Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 67
  2. Genetic Determinants of Survival in Patients with Alzheimer's Disease. (PMID: 25649651) Wang X. … Kamboh M.I. (J. Alzheimers Dis. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for CCDC85C Gene

Sources for CCDC85C Gene