CCDC85B Gene
protein-coding GIFtS: 48
GCID: GC11P065657
|
|
coiled-coil domain containing 85B
| |
Aliases
for CCDC85B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 85B1 2 | | DIPA1 2 3 5 | | Delta-Interacting Protein A2 3 | | Hepatitis Delta Antigen-Interacting Protein A2 3 | | Coiled-Coil Domain-Containing Protein 85B2 | | Hepatitis Delta Antigen Interacting Protein A2 |
Export aliases for CCDC85B gene to outside databasesPrevious GC identifers: GC11P065415 GC11P061984 |
Summaries
for CCDC85B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCDC85B:
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plantviroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitisdelta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner andthus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion
Gene Wiki entry for CCDC85B
|
Genomic Views
for CCDC85B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC85B gene promoter:
STAT1 p53 ATF-2 p300 STAT1beta c-Jun STAT1alpha C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC85B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC85B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1CCDC85B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065657: view genomic region
(about GC identifiers)
Start:
|
65,657,875 bp from pter |
End:
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65,659,106 bp from pter |
Size:
|
1,232 bases |
Orientation:
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plus strand |
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Proteins
for CCDC85B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 85B Size: 202 amino acids; 22091 Da
Subunit: Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1. Interactswith TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). Thisinteraction affects viral genomic replication in intact cells
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome
Miscellaneous: May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression ofHDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA
Secondary accessions: B2R598 Q96HA0Explore the universe of human proteins at neXtProt for CCDC85B: NX_Q15834
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15834
CCDC85B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006839.2
ENSEMBL proteins: ENSP00000311695
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CCDC85B for ontologies About GeneDecksing
CCDC85B Antibody Products:
Assay Products for CCDC85B: |
Protein
Domains /
Families
for CCDC85B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC85B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15834ProtoNet protein and cluster: Q15834 UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834Similarity: Belongs to the CCDC85 family |
Function
for CCDC85B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner andthus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansionInduction: Up-regulated by doxorubicin
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC85B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC85B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CCDC85B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CCDC85B:
|
Pathways & Interactions
for CCDC85B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC85B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/206 Interacting proteins for CCDC85B (Q158341, 2, 3 ENSP000003116954) via UniProtKB, MINT, STRING, and/or I2D (see all 206)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CHCHD3 | Q9NX631, 2, 3, ENSP000002625704 | EBI-739674,EBI-743375 MINT-66631 I2D:
score=6 STRING: ENSP00000262570 | | KRT17 | Q046951, 2, 3, ENSP000003084524 | EBI-739674,EBI-297873 MINT-67143 I2D:
score=6 STRING: ENSP00000308452 | | PKN1 | Q165121, 2, 3, ENSP000003433254 | EBI-739674,EBI-748186 MINT-67214 I2D:
score=6 STRING: ENSP00000343325 | | DUSP13 | Q6B8I12, 3, ENSP000003617874 | I2D:
score=4 MINT-67607 I2D:
score=1 STRING: ENSP00000361787 | | AKAP17A | Q020402, 3, ENSP000003248274 | MINT-66309 I2D:
score=5 STRING: ENSP00000324827 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CCDC85B for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC85B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC85B
Search CenterWatch for drugs/clinical trials and news about CCDC85B / CC85B
|
Transcripts
for CCDC85B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC85B gene: NM_006848.2 Unigene Cluster for CCDC85B: Coiled-coil domain containing 85B Hs.66713 [show with all ESTs]Unigene Representative Sequence: BM5586001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000312579(uc001ogf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC85B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC85B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC85B (NM_006848) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC85B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B |
Additional cDNA sequence: AK312109.1 BC008796.2 U63825.1 3 DOTS entries: DT.91807043 DT.115680 DT.95168758 24/145 AceView cDNA sequences (see all 145): AI832068 BU846029 BC008796 BU844443 AI765367 AI650386 AI739656 AI942226 AI380225 BU845228 BM718366 AI343294 BU195848 CA423787 BF064090 BF591224 AW237536 BU073257 AI738695 AI867397 BQ063118 BM969101 BQ186275 CD675090
GeneLoc Exon Structure
|
Expression
for CCDC85B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC85B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTAAGAAA
About this image
See CCDC85B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC85B
SOURCE GeneReport for Unigene cluster: Hs.66713
UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834Tissue specificity: Widely expressed including liver
SABiosciences Custom PCR Arrays for CCDC85B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC85B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC85B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC85B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC85B |
Orthologs
for CCDC85B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC85B gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
ccdc85b1 |
coiled-coil domain containing 85B |
62.61(n)
61.38(a) |
|
564324 NM_001166154.1 NP_001159626.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG172656 |
-- |
11(a) |
1 → many |
2L(2999286-3016069) |
worm
(Caenorhabditis elegans) |
Secernentea |
F29G9.26 |
Protein F29G9.2, isoform b |
11(a) |
1 → many |
V(6018975-6026324) |
ENSEMBL Gene Tree for CCDC85B (if available)
TreeFam Gene Tree for CCDC85B (if available) |
Paralogs
for CCDC85B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC85B gene
- CCDC85C2 CCDC85A2
2 SIMAP similar genes for CCDC85B using alignment to 1 protein entry: CC85B_HUMAN:CCDC85A CCDC85C
CCDC85B for paralogs About GeneDecksing
|
Genomic Variants
for CCDC85B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC85B (65657875 - 65659106 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC85B
1 CNV: 3855 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC85B |
|
Disorders
/ Diseases
for CCDC85B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC85B for disorders About GeneDecksing
OMIM gene information: 605360
OMIM disorders: --
4  diseases for CCDC85B: About MalaCardshepatitis relapsing fever hemorrhagic disease ataxia
1 disease from the University of Copenhagen DISEASES database for CCDC85B:Relapsing fever Export disorders for CCDC85B gene to outside databases
|
Publications
for CCDC85B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC85B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CCDC85B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PubMed id 17873903)1, 2, 3 Iwai A.... Shimotohno K. (2008)
- A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PubMed id 8810253)1, 2, 3 Brazas R. and Ganem D. (1996)
- DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PubMed id 17014843)1, 2 Du X.... Greene M.I. (2006)
- Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PubMed id 15644333)1, 3 Bezy O....Amri E.Z. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. (PubMed id 15605074)1 Schumacher B....Shaham S. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for CCDC85B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC85B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC85B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC85B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC85B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC85B gene:
Search GeneIP for patents involving CCDC85B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC85B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC85B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC85B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC85B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC85B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC85B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC85B |
| |
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| |  |  |  |  | | | | |
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| | | |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B |
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