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CCDC85B Gene

protein-coding   GIFtS: 49
GCID: GC11P065657

Coiled-Coil Domain Containing 85B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 85B1 2
DIPA2 3 5
Hepatitis Delta Antigen Interacting Protein A1 2
Delta-Interacting Protein A2 3
Hepatitis Delta Antigen-Interacting Protein A2 3
Coiled-Coil Domain-Containing Protein 85B2

External Ids:    HGNC: 249261   Entrez Gene: 110072   Ensembl: ENSG000001756027   OMIM: 6053605   UniProtKB: Q158343   

Export aliases for CCDC85B gene to outside databases

Previous GC identifers: GC11P065415 GC11P061984


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCDC85B Gene:
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of
plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to
hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication
in vitro. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCDC85B Gene:
CCDC85B (coiled-coil domain containing 85B) is a protein-coding gene. Diseases associated with CCDC85B include hepatitis, and relapsing fever. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner
and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal
expansion

Gene Wiki entry for CCDC85B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC85B gene promoter:
         STAT1   p53   ATF-2   p300   STAT1beta   c-Jun   STAT1alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC85B promoter sequence
   Search Chromatin IP Primers for CCDC85B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC85B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

CCDC85B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC85B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065657:  view genomic region     (about GC identifiers)

Start:
65,657,875 bp from pter      End:
65,659,106 bp from pter
Size:
1,232 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 85B  
Size: 202 amino acids; 22091 Da
Subunit: Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1.
Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen
(HDAG). This interaction affects viral genomic replication in intact cells
Miscellaneous: May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas
overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a
complex with DIPA
Secondary accessions: B2R598 Q96HA0

Explore the universe of human proteins at neXtProt for CCDC85B: NX_Q15834

Explore proteomics data for CCDC85B at MOPED


See CCDC85B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006839.2  
ENSEMBL proteins: 
 ENSP00000311695  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR019359 DUF2216_coiled-coil

Graphical View of Domain Structure for InterPro Entry Q15834

ProtoNet protein and cluster: Q15834

UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
Similarity: Belongs to the CCDC85 family


CCDC85B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CC85B_HUMAN, Q15834
Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner
and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal
expansion
Induction: Up-regulated by doxorubicin

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI16189514
     
CCDC85B for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CCDC85B:
 Metaphase cells 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC85B
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GenScript: all cDNA clones in your preferred vector: CCDC85B (NM_006848)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC85B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CC85B_HUMAN, Q15834: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
nucleus5
extracellular3
vacuole2
cytosol1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA17014843
GO:0005737cytoplasm IEA--
GO:0005813centrosome IDA17014843

CCDC85B for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC85B
Interactions:

    Search GeneGlobe Interaction Network for CCDC85B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CCDC85B (Q158341, 2, 3 ENSP000003116954) via UniProtKB, MINT, STRING, and/or I2D (see all 213)
InteractantInteraction Details
GeneCardExternal ID(s)
KRT17Q046951, 2, 3, ENSP000003084524EBI-739674,EBI-297873 MINT-67143 I2D: score=6 STRING: ENSP00000308452
PKN1Q165121, 2, 3, ENSP000003433254EBI-739674,EBI-602382 MINT-67214 I2D: score=6 STRING: ENSP00000343325
ENSG00000223932O958722, 3, ENSP000004128844MINT-68152 I2D: score=5 STRING: ENSP00000412884
ENSG00000232312O958722, 3, ENSP000003907464MINT-68152 I2D: score=5 STRING: ENSP00000390746
GPANK1O958722, 3, ENSP000003650574MINT-68152 I2D: score=5 STRING: ENSP00000365057
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0030154cell differentiation IEA--
GO:0030308negative regulation of cell growth IDA17873903
GO:0045599negative regulation of fat cell differentiation ISS--
GO:0045892negative regulation of transcription, DNA-templated IDA17014843

CCDC85B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCDC85B (CC85B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CCDC85B gene: 
NM_006848.2  

Unigene Cluster for CCDC85B:

Coiled-coil domain containing 85B
Hs.66713  [show with all ESTs]
Unigene Representative Sequence: BM558600
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000312579(uc001ogf.3)
miRNA
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat CCDC85B

Additional mRNA sequence: 

AK312109.1 BC008796.2 U63825.1 

3 DOTS entries:

DT.91807043  DT.115680  DT.95168758 

Selected AceView cDNA sequences (see all 145):

BM718366 BM969101 NM_006848 AI343294 AI738695 AI765367 AI832068 AI201995 
BC008796 CD675090 BU846029 BU633466 AI380411 AI863906 AI867397 AI589826 
BU787570 AI867421 AI380958 BU195848 BQ063118 AI739656 AW237536 BU073257 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCDC85B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GACTAAGAAA
CCDC85B Expression
About this image

CCDC85B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCDC85B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.66713

UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
Tissue specificity: Widely expressed including liver

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QuantiFast Probe-based Assays in human, mouse, rat CCDC85B
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CCDC85B gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccdc85b1 , 5 coiled-coil domain containing 85B1, 5 90.76(n)1
98.51(a)1
  19 (4.33 cM)5
2405141  NM_198616.41  NP_941018.11 
 54567895 
tropical clawed frog
(Xenopus tropicalis)
Amphibia ccdc85b1 coiled-coil domain containing 85B 59.82(n)
64.21(a)
  779472  NM_001172300.1  NP_001165771.1 
zebrafish
(Danio rerio)
Actinopterygii ccdc85b1 coiled-coil domain containing 85B 62.26(n)
60.85(a)
  564324  NM_001166154.1  NP_001159626.1 
fruit fly
(Drosophila melanogaster)
Insecta CG172656
--
12(a)
1 → many
2L(2999286-3016069)
worm
(Caenorhabditis elegans)
Secernentea F29G9.26
Protein F29G9.2, isoform b (F29G9.2) mRNA, complet...
10(a)
1 → many
V(6018994-6026341) WBGene00017931


ENSEMBL Gene Tree for CCDC85B (if available)
TreeFam Gene Tree for CCDC85B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CCDC85B gene
CCDC85C2  CCDC85A2  
2 SIMAP similar genes for CCDC85B using alignment to 1 protein entry:     CC85B_HUMAN:
CCDC85A    CCDC85C

CCDC85B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCDC85B (see all 18)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs10489241,2
C,F--65658157(+) GCCGCG/TTGCGG 1 -- ut51 ese35Minor allele frequency- T:0.10MN NA WA 308
rs115447321,2
C--65658274(+) AGGCGG/TCCTGG 2 G V mis1 ese31Minor allele frequency- T:0.00EA 168
rs2020180781,2
--65658407(+) AATCGA/GCAGCT 2 R syn10--------
rs1488026561,2
C--65658714(+) GCGGCC/GCCAGC 2 P A mis10--------
rs755562851,2
C--65658722(+) AGCGGT/CGCCGG 2 /G syn12Minor allele frequency- C:0.33WA CSA 3
rs1389800151,2
F--65658812(+) ACTGGC/GAGCGT 2 G syn11Minor allele frequency- G:0.00NA 4074
rs2015175141,2
--65658845(+) CTGGCC/TTGTTC 2 A syn10--------
rs618938941,2
C--65659093(+) AAACCC/TGGACG 1 -- ut312Minor allele frequency- T:0.06NA 122
rs1912081671,2
--65659172(+) TGATAC/TAGGGT 1 -- int10--------
rs3747228221,2
----65658871(+) GCACTA/GCTTCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for CCDC85B (65657875 - 65659106 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CCDC85B:    About this table    
Variant IDTypeSubtypePubMed ID
nsv897764CNV Loss21882294
nsv832191CNV Loss17160897
dgv1185n71CNV Loss21882294
nsv897736CNV Loss21882294
dgv393e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCDC85B
DNA2.0 Custom Variant and Variant Library Synthesis for CCDC85B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605360    OMIM disorders: --

5 diseases for CCDC85B:    
About MalaCards
hepatitis    relapsing fever    hemorrhagic disease    inflammatory bowel disease
ataxia

1 disease from the University of Copenhagen DISEASES database for CCDC85B:
Relapsing fever

CCDC85B for disorders           About GeneDecksing


Export disorders for CCDC85B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCDC85B gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with CCDC85B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PubMed id 17873903)1, 2, 3 Iwai A.... Shimotohno K. (Oncogene 2008)
  2. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PubMed id 8810253)1, 2, 3 Brazas R. and Ganem D. (Science 1996)
  3. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PubMed id 17014843)1, 2 Du X.... Greene M.I. (Exp. Mol. Pathol. 2006)
  4. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PubMed id 15644333)1, 3 Bezy O....Amri E.Z. (J. Biol. Chem. 2005)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
  7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
  10. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. (PubMed id 15605074)1 Schumacher B....Shaham S. (Cell Death Differ. 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11007 HGNC: 24926 AceView: DIPA Ensembl:ENSG00000175602 euGenes: HUgn11007
ECgene: CCDC85B H-InvDB: CCDC85B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCDC85B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCDC85B gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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