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Aliases for CCDC85B Gene

Aliases for CCDC85B Gene

  • Coiled-Coil Domain Containing 85B 2 3 5
  • Hepatitis Delta Antigen-Interacting Protein A 3 4
  • Delta-Interacting Protein A 3 4
  • DIPA 3 4
  • Hepatitis Delta Antigen Interacting Protein A 2
  • Coiled-Coil Domain-Containing Protein 85B 3

External Ids for CCDC85B Gene

Previous GeneCards Identifiers for CCDC85B Gene

  • GC11P065415
  • GC11P065657
  • GC11P061984

Summaries for CCDC85B Gene

Entrez Gene Summary for CCDC85B Gene

  • Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCDC85B Gene

CCDC85B (Coiled-Coil Domain Containing 85B) is a Protein Coding gene. Diseases associated with CCDC85B include Hepatitis. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot for CCDC85B Gene

  • Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.

Gene Wiki entry for CCDC85B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85B Gene

Genomics for CCDC85B Gene

Regulatory Elements for CCDC85B Gene

Enhancers for CCDC85B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065927 1.4 FANTOM5 Ensembl ENCODE 12.4 +38.1 38115 2.5 HDGF NFRKB THAP11 CBFB SP1 NFIL3 ZNF589 SMARCA4 RCOR2 IKZF1 EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11F065932 1.2 Ensembl ENCODE 12.3 +42.3 42303 0.8 CTCF USF1 L3MBTL2 MAX USF2 REST SREBF1 RAD51 GLIS1 ZBTB33 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 PACS1 ENSG00000255320
GH11F065931 0.9 Ensembl 12.3 +41.6 41589 0.2 SREBF1 CCDC85B FIBP CTSW FOSL1 SART1 CFL1 MUS81 SNX32 EIF1AD PACS1
GH11F065940 0.5 Ensembl ENCODE 11.7 +51.5 51465 2.4 HDAC1 ATF1 PKNOX1 CBX3 ARNT TBL1XR1 NFXL1 BMI1 RARA ELK1 CTSW SART1 C11orf68 DRAP1 FOSL1 CCDC85B FIBP EFEMP2 CFL1 BANF1
GH11F065945 1.2 Ensembl ENCODE 11.2 +55.7 55698 1.3 HDGF PKNOX1 ATF1 ZNF76 SIN3A RARA ZNF121 SCRT2 SP3 ZBTB11 C11orf68 DRAP1 FOSL1 BANF1 EIF1AD CST6 CTSW EFEMP2 CFL1 MUS81
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC85B on UCSC Golden Path with GeneCards custom track

Promoters for CCDC85B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001769322 1088 2001 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF207 KLF13 PAF1
ENSR00001769321 -1412 1801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CCDC85B Gene

Chromosome:
11
Start:
65,890,112 bp from pter
End:
65,891,635 bp from pter
Size:
1,524 bases
Orientation:
Plus strand

Genomic View for CCDC85B Gene

Genes around CCDC85B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC85B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC85B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85B Gene

Proteins for CCDC85B Gene

  • Protein details for CCDC85B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15834-CC85B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 85B
    Protein Accession:
    Q15834
    Secondary Accessions:
    • B2R598
    • Q96HA0

    Protein attributes for CCDC85B Gene

    Size:
    202 amino acids
    Molecular mass:
    22091 Da
    Quaternary structure:
    • Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.
    Miscellaneous:
    • May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA.

neXtProt entry for CCDC85B Gene

Post-translational modifications for CCDC85B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC85B Gene

Domains & Families for CCDC85B Gene

Protein Domains for CCDC85B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC85B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15834

UniProtKB/Swiss-Prot:

CC85B_HUMAN :
  • Belongs to the CCDC85 family.
Family:
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85B: view

No data available for Gene Families for CCDC85B Gene

Function for CCDC85B Gene

Molecular function for CCDC85B Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.
UniProtKB/Swiss-Prot Induction:
Up-regulated by doxorubicin.

Gene Ontology (GO) - Molecular Function for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC85B: view
genes like me logo Genes that share phenotypes with CCDC85B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC85B Gene

Localization for CCDC85B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85B Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC85B Gene COMPARTMENTS Subcellular localization image for CCDC85B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 3
cytosol 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17014843
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17014843
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC85B: view

Pathways & Interactions for CCDC85B Gene

SuperPathways for CCDC85B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 17873903
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with CCDC85B: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC85B Gene

Transcripts for CCDC85B Gene

mRNA/cDNA for CCDC85B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(145) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC85B Gene

Coiled-coil domain containing 85B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85B Gene

No ASD Table

Relevant External Links for CCDC85B Gene

GeneLoc Exon Structure for
CCDC85B
ECgene alternative splicing isoforms for
CCDC85B

Expression for CCDC85B Gene

mRNA expression in normal human tissues for CCDC85B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC85B Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC85B Gene:

CCDC85B

SOURCE GeneReport for Unigene cluster for CCDC85B Gene:

Hs.66713

mRNA Expression by UniProt/SwissProt for CCDC85B Gene:

Q15834-CC85B_HUMAN
Tissue specificity: Widely expressed including liver.
genes like me logo Genes that share expression patterns with CCDC85B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for CCDC85B Gene

Orthologs for CCDC85B Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC85B 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia CCDC85B 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC85B 34 35
  • 93.89 (n)
mouse
(Mus musculus)
Mammalia Ccdc85b 34 16 35
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc85b 34
  • 90.76 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC85B 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc85b 34
  • 59.82 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc85b 34 35
  • 62.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17265 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F29G9.2 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 35
  • 33 (a)
OneToMany
Species where no ortholog for CCDC85B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC85B Gene

ENSEMBL:
Gene Tree for CCDC85B (if available)
TreeFam:
Gene Tree for CCDC85B (if available)

Paralogs for CCDC85B Gene

Paralogs for CCDC85B Gene

(2) SIMAP similar genes for CCDC85B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCDC85B: view

Variants for CCDC85B Gene

Sequence variations from dbSNP and Humsavar for CCDC85B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1048923 -- 65,890,883(-) GCGCG(C/T)CGCCT reference, missense
rs1048924 -- 65,890,686(+) GCCGC(G/T)TGCGG utr-variant-5-prime
rs112021491 -- 65,889,813(+) CGACA(C/T)ATCTG upstream-variant-2KB
rs112280459 -- 65,890,505(+) CACCC(A/G)GAGTG upstream-variant-2KB, utr-variant-5-prime
rs113688549 -- 65,888,602(+) GAGAG(C/G)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC85B Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for CCDC85B Gene

Gene Damage Index Score: 1.19; 23.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC85B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC85B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85B Gene

Disorders for CCDC85B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC85B Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis
  • acute and subacute liver necrosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCDC85B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC85B
genes like me logo Genes that share disorders with CCDC85B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC85B Gene

Publications for CCDC85B Gene

  1. Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PMID: 17873903) Iwai A. … Shimotohno K. (Oncogene 2008) 2 3 4 64
  2. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PMID: 8810253) Brazas R. … Ganem D. (Science 1996) 2 3 4 64
  3. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PMID: 17014843) Du X. … Greene M.I. (Exp. Mol. Pathol. 2006) 3 4 64
  4. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PMID: 15644333) Bezy O. … Amri E.Z. (J. Biol. Chem. 2005) 2 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CCDC85B Gene

Sources for CCDC85B Gene

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