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Aliases for CCDC85B Gene

Aliases for CCDC85B Gene

  • Coiled-Coil Domain Containing 85B 2 3
  • DIPA 3 4 6
  • Hepatitis Delta Antigen Interacting Protein A 2 3
  • Hepatitis Delta Antigen-Interacting Protein A 3 4
  • Delta-Interacting Protein A 3 4
  • Coiled-Coil Domain-Containing Protein 85B 3

External Ids for CCDC85B Gene

Previous GeneCards Identifiers for CCDC85B Gene

  • GC11P065415
  • GC11P065657
  • GC11P061984

Summaries for CCDC85B Gene

Entrez Gene Summary for CCDC85B Gene

  • Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCDC85B Gene

CCDC85B (Coiled-Coil Domain Containing 85B) is a Protein Coding gene. Diseases associated with CCDC85B include hepatitis and relapsing fever. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot for CCDC85B Gene

  • Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.

Gene Wiki entry for CCDC85B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC85B Gene

Genomics for CCDC85B Gene

Regulatory Elements for CCDC85B Gene

Genomic Location for CCDC85B Gene

Start:
65,890,112 bp from pter
End:
65,891,635 bp from pter
Size:
1,524 bases
Orientation:
Plus strand

Genomic View for CCDC85B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC85B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC85B Gene

Proteins for CCDC85B Gene

  • Protein details for CCDC85B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15834-CC85B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 85B
    Protein Accession:
    Q15834
    Secondary Accessions:
    • B2R598
    • Q96HA0

    Protein attributes for CCDC85B Gene

    Size:
    202 amino acids
    Molecular mass:
    22091 Da
    Quaternary structure:
    • Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1. Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen (HDAG). This interaction affects viral genomic replication in intact cells.
    Miscellaneous:
    • May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a complex with DIPA

neXtProt entry for CCDC85B Gene

Proteomics data for CCDC85B Gene at MOPED

Post-translational modifications for CCDC85B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC85B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC85B Gene

Domains for CCDC85B Gene

Protein Domains for CCDC85B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC85B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15834

UniProtKB/Swiss-Prot:

CC85B_HUMAN :
  • Q15834
Family:
  • Belongs to the CCDC85 family.
genes like me logo Genes that share domains with CCDC85B: view

No data available for Gene Families for CCDC85B Gene

Function for CCDC85B Gene

Molecular function for CCDC85B Gene

UniProtKB/Swiss-Prot Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal expansion.
UniProtKB/Swiss-Prot Induction: Up-regulated by doxorubicin.

Gene Ontology (GO) - Molecular Function for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC85B: view

Phenotypes for CCDC85B Gene

GenomeRNAi human phenotypes for CCDC85B:
genes like me logo Genes that share phenotypes with CCDC85B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC85B Gene

Localization for CCDC85B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC85B Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC85B Gene COMPARTMENTS Subcellular localization image for CCDC85B gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 3
vacuole 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17014843
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17014843
genes like me logo Genes that share ontologies with CCDC85B: view

Pathways for CCDC85B Gene

SuperPathways for CCDC85B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC85B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0030308 negative regulation of cell growth IDA 17873903
GO:0045599 negative regulation of fat cell differentiation ISS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 17014843
genes like me logo Genes that share ontologies with CCDC85B: view

No data available for Pathways by source for CCDC85B Gene

Transcripts for CCDC85B Gene

mRNA/cDNA for CCDC85B Gene

(145) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC85B Gene

Coiled-coil domain containing 85B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC85B Gene

No ASD Table

Relevant External Links for CCDC85B Gene

GeneLoc Exon Structure for
CCDC85B
ECgene alternative splicing isoforms for
CCDC85B

Expression for CCDC85B Gene

mRNA expression in normal human tissues for CCDC85B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC85B Gene

SOURCE GeneReport for Unigene cluster for CCDC85B Gene Hs.66713

mRNA Expression by UniProt/SwissProt for CCDC85B Gene

Q15834-CC85B_HUMAN
Tissue specificity: Widely expressed including liver
genes like me logo Genes that share expressions with CCDC85B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CCDC85B Gene

Orthologs for CCDC85B Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC85B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC85B 35
  • 99.34 (n)
  • 99.5 (a)
CCDC85B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC85B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC85B 35
  • 93.89 (n)
  • 98.02 (a)
CCDC85B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc85b 35
  • 90.76 (n)
  • 98.51 (a)
Ccdc85b 16
Ccdc85b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC85B 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc85b 35
  • 90.76 (n)
  • 98.51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc85b 35
  • 59.82 (n)
  • 64.21 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc85b 35
  • 62.26 (n)
  • 60.85 (a)
ccdc85b 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17265 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F29G9.2 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4851 36
  • 33 (a)
OneToMany
Species with no ortholog for CCDC85B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC85B Gene

ENSEMBL:
Gene Tree for CCDC85B (if available)
TreeFam:
Gene Tree for CCDC85B (if available)

Paralogs for CCDC85B Gene

Paralogs for CCDC85B Gene

Selected SIMAP similar genes for CCDC85B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCDC85B: view

Variants for CCDC85B Gene

Sequence variations from dbSNP and Humsavar for CCDC85B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1048923 -- 65,890,883(-) GCGCG(C/T)CGCCT missense, reference
rs1048924 -- 65,890,686(+) GCCGC(G/T)TGCGG utr-variant-5-prime
rs11544732 -- 65,890,803(+) AGGCG(G/T)CCTGG reference, missense
rs11544733 -- 65,890,734(-) CAGGA(A/G)CCCCA utr-variant-5-prime
rs61893894 -- 65,891,622(+) AAACC(C/T)GGACG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC85B Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897

Relevant External Links for CCDC85B Gene

HapMap Linkage Disequilibrium report
CCDC85B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC85B Gene

Disorders for CCDC85B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CCDC85B Gene including...

Search for CCDC85B Gene in MalaCards »

(1) University of Copenhagen DISEASES for CCDC85B Gene

genes like me logo Genes that share disorders with CCDC85B: view

No data available for UniProtKB/Swiss-Prot for CCDC85B Gene

Publications for CCDC85B Gene

  1. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PMID: 8810253) Brazas R. … Ganem D. (Science 1996) 2 3 4
  2. Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PMID: 17873903) Iwai A. … Shimotohno K. (Oncogene 2008) 2 3 4
  3. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PMID: 17014843) Du X. … Greene M.I. (Exp. Mol. Pathol. 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PMID: 15644333) Bezy O. … Amri E.Z. (J. Biol. Chem. 2005) 2 3

Products for CCDC85B Gene

Sources for CCDC85B Gene

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