Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC85B Gene

protein-coding   GIFtS: 50
GCID: GC11P065657

Coiled-Coil Domain Containing 85B

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 85B1 2
DIPA2 3 5
Hepatitis Delta Antigen Interacting Protein A1 2
Delta-Interacting Protein A2 3
Hepatitis Delta Antigen-Interacting Protein A2 3
Coiled-Coil Domain-Containing Protein 85B2

External Ids:    HGNC: 249261   Entrez Gene: 110072   Ensembl: ENSG000001756027   OMIM: 6053605   UniProtKB: Q158343   

Export aliases for CCDC85B gene to outside databases

Previous GC identifers: GC11P065415 GC11P061984


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CCDC85B Gene:
Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of
plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to
hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication
in vitro. (provided by RefSeq, Jul 2008)

GeneCards Summary for CCDC85B Gene: 
CCDC85B (coiled-coil domain containing 85B) is a protein-coding gene. Diseases associated with CCDC85B include hepatitis, and relapsing fever. GO annotations related to this gene include protein binding. An important paralog of this gene is CCDC85C.

UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner
and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal
expansion

Gene Wiki entry for CCDC85B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC85B gene promoter:
         STAT1   p53   ATF-2   p300   STAT1beta   c-Jun   STAT1alpha   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC85B promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC85B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC85B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

CCDC85B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC85B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065657:  view genomic region     (about GC identifiers)

Start:
65,657,875 bp from pter      End:
65,659,106 bp from pter
Size:
1,232 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 85B  
Size: 202 amino acids; 22091 Da
Subunit: Interacts with CEBPB (By similarity). May interact with CEBPD (By similarity). Interacts with MCRS1.
Interacts with TCF7L2; competes with CTNNB1. Interacts with the viral phosphoprotein hepatitis delta antigen
(HDAG). This interaction affects viral genomic replication in intact cells
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Miscellaneous: May be the cellular homolog of HDAG. Overexpression inhibited HDV replication, whereas
overexpression of HDAG reversed the inhibition, suggesting that HDAG may assist HDV replication by forming a
complex with DIPA
Secondary accessions: B2R598 Q96HA0

Explore the universe of human proteins at neXtProt for CCDC85B: NX_Q15834

Explore proteomics data for CCDC85B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15834

  • CCDC85B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC85B Protein Expression
    REFSEQ proteins: NP_006839.2  
    ENSEMBL proteins: 
     ENSP00000311695  

    Human Recombinant Protein Products for CCDC85B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CCDC85B
    GenScript Custom Purified and Recombinant Proteins Services for CCDC85B
    Novus Biologicals CCDC85B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC85B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17014843
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA17014843

    CCDC85B for ontologies           About GeneDecksing



    CCDC85B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCDC85B
    GenScript Custom Superior Antibodies Services for CCDC85B
    Novus Biologicals CCDC85B Antibody
    Abcam antibodies for CCDC85B
    Cloud-Clone Corp. Antibodies for CCDC85B 
    ThermoFisher Antibody for CCDC85B
    LSBio Antibodies in human, mouse, rat for CCDC85B 

    Assay Products for CCDC85B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCDC85B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCDC85B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCDC85B 
    Cloud-Clone Corp. CLIAs for CCDC85B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019359 DUF2216_coiled-coil

    Graphical View of Domain Structure for InterPro Entry Q15834

    ProtoNet protein and cluster: Q15834

    UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
    Similarity: Belongs to the CCDC85 family


    CCDC85B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CC85B_HUMAN, Q15834
    Function: Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner
    and thus regulate cell growth. May function in adipocyte differentiation, negatively regulating mitotic clonal
    expansion
    Induction: Up-regulated by doxorubicin

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    CCDC85B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC85B:
     Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC85B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC85B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC85B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC85B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC85B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCDC85B
    SwitchGear 3'UTR luciferase reporter plasmidCCDC85B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCDC85B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC85B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCDC85B
    Sirion Biotech Customized adenovirus for overexpression of CCDC85B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CCDC85B (see all 5)
    OriGene ORF clones in mouse, rat for CCDC85B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC85B (NM_006848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC85B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC85B 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC85B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCDC85B
    Search LifeMap BioReagents cell lines for CCDC85B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC85B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC85B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/209 Interacting proteins for CCDC85B (Q158341, 2, 3 ENSP000003116954) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT17Q046951, 2, 3, ENSP000003084524EBI-739674,EBI-297873 MINT-67143 I2D: score=6 STRING: ENSP00000308452
    PKN1Q165121, 2, 3, ENSP000003433254EBI-739674,EBI-602382 MINT-67214 I2D: score=6 STRING: ENSP00000343325
    ENSG00000223932O958722, 3, ENSP000004128844MINT-68152 I2D: score=5 STRING: ENSP00000412884
    ENSG00000232312O958722, 3, ENSP000003907464MINT-68152 I2D: score=5 STRING: ENSP00000390746
    GPANK1O958722, 3, ENSP000003650574MINT-68152 I2D: score=5 STRING: ENSP00000365057
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0030154cell differentiation IEA--
    GO:0030308negative regulation of cell growth IDA17873903
    GO:0045599negative regulation of fat cell differentiation ISS--
    GO:0045892negative regulation of transcription, DNA-dependent IDA17014843

    CCDC85B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC85B (CC85B)

    Search CenterWatch for drugs/clinical trials and news about CCDC85B / CC85B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC85B gene: 
    NM_006848.2  

    Unigene Cluster for CCDC85B:

    Coiled-coil domain containing 85B
    Hs.66713  [show with all ESTs]
    Unigene Representative Sequence: BM558600
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312579(uc001ogf.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CCDC85B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCDC85B
    SwitchGear 3'UTR luciferase reporter plasmidCCDC85B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCDC85B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC85B
    Clone
    Products:
         
    OriGene clones in human, mouse for CCDC85B (see all 5)
    OriGene ORF clones in mouse, rat for CCDC85B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC85B (NM_006848)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC85B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC85B 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC85B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCDC85B
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC85B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC85B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC85B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC85B

    Additional mRNA sequence: 

    AK312109.1 BC008796.2 U63825.1 

    3 DOTS entries:

    DT.91807043  DT.115680  DT.95168758 

    24/145 AceView cDNA sequences (see all 145):

    NM_006848 AI201995 BM969101 AI863906 BC008796 BU787570 AI589826 BM971509 
    AI867421 AI380958 BI770254 AW197359 BU632758 BU073257 BU844443 BU845228 
    AW237536 BF591224 CA423787 AI380225 BU195848 BM718366 BQ063118 AI867397 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC85B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAAGAAA
    CCDC85B Expression
    About this image


    See CCDC85B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC85B

    SOURCE GeneReport for Unigene cluster: Hs.66713

    UniProtKB/Swiss-Prot: CC85B_HUMAN, Q15834
    Tissue specificity: Widely expressed including liver

        SABiosciences Custom PCR Arrays for CCDC85B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCDC85B
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC85B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC85B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC85B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC85B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC85B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC85B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc85b1 , 5 coiled-coil domain containing 85B1, 5 90.76(n)1
    98.51(a)1
      19 (4.33 cM)5
    2405141  NM_198616.41  NP_941018.11 
     54567895 
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc85b1 coiled-coil domain containing 85B 62.61(n)
    61.38(a)
      564324  NM_001166154.1  NP_001159626.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172656
    --
    10(a)
    1 → many
    2L(2999286-3016069)
    worm
    (Caenorhabditis elegans)
    Secernentea F29G9.26
    Protein F29G9.2, isoform a
    10(a)
    1 → many
    V(6018992-6026341)


    ENSEMBL Gene Tree for CCDC85B (if available)
    TreeFam Gene Tree for CCDC85B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC85B gene
    CCDC85C2  CCDC85A2  
    2 SIMAP similar genes for CCDC85B using alignment to 1 protein entry:     CC85B_HUMAN:
    CCDC85A    CCDC85C

    CCDC85B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 SNPs in CCDC85B are shown (see all 18)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10489241,2
    C,F--65658157(+) GCCGCG/TTGCGG 1 -- ut51 ese35Minor allele frequency- T:0.10MN NA WA 308
    rs115447321,2
    C--65658274(+) AGGCGG/TCCTGG 2 G V mis1 ese31Minor allele frequency- T:0.00EA 168
    rs2020180781,2
    --65658407(+) AATCGA/GCAGCT 2 R syn10--------
    rs1488026561,2
    C--65658714(+) GCGGCC/GCCAGC 2 P A mis10--------
    rs755562851,2
    C--65658722(+) AGCGGT/CGCCGG 2 /G syn12Minor allele frequency- C:0.33WA CSA 3
    rs1389800151,2
    F--65658812(+) ACTGGC/GAGCGT 2 G syn11Minor allele frequency- G:0.00NA 4074
    rs2015175141,2
    --65658845(+) CTGGCC/TTGTTC 2 A syn10--------
    rs618938941,2
    C--65659093(+) AAACCC/TGGACG 1 -- ut312Minor allele frequency- T:0.06NA 122
    rs1912081671,2
    --65659172(+) TGATAC/TAGGGT 1 -- int10--------
    rs3747228221,2
    ----65658871(+) GCACTA/GCTTCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC85B (65657875 - 65659106 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCDC85B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897764CNV Loss21882294
    nsv832191CNV Loss17160897
    dgv1185n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv393e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC85B
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC85B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605360    OMIM disorders: --

    3 diseases for CCDC85B:    About MalaCards
    hepatitis    relapsing fever    hemorrhagic disease

    1 disease from the University of Copenhagen DISEASES database for CCDC85B:
    Relapsing fever

    CCDC85B for disorders           About GeneDecksing


    Export disorders for CCDC85B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC85B gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CCDC85B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner. (PubMed id 17873903)1, 2, 3 Iwai A.... Shimotohno K. (2008)
    2. A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution. (PubMed id 8810253)1, 2, 3 Brazas R. and Ganem D. (1996)
    3. DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. (PubMed id 17014843)1, 2 Du X.... Greene M.I. (2006)
    4. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. (PubMed id 15644333)1, 3 Bezy O....Amri E.Z. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    9. C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. (PubMed id 15605074)1 Schumacher B....Shaham S. (2005)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11007 HGNC: 24926 AceView: DIPA Ensembl:ENSG00000175602 euGenes: HUgn11007
    ECgene: CCDC85B H-InvDB: CCDC85B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC85B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC85B gene:
    Search GeneIP for patents involving CCDC85B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCDC85B  
     OriGene qPCR primer pairs and template standards for CCDC85B   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCDC85B  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCDC85B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCDC85B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCDC85B   OriGene Custom Protein Services for CCDC85B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC85B
     QIAGEN SeqTarget long-range PCR primers for resequencing CCDC85B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC85B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC85B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC85B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC85B
     GenScript Custom Purified and Recombinant Proteins Services for CCDC85B GenScript cDNA clones with any tag delivered in your preferred vector for CCDC85B
     GenScript Custom Assay Services for CCDC85B GenScript Custom Superior Antibodies Services for CCDC85B
     GenScript Custom overexpressing Cell Line Services for CCDC85B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CCDC85B promoter
     Search Chromatin IP Primers for CCDC85B
     RT2 qPCR Primer Assay in human, mouse, rat CCDC85B
     Search GNC Networks for CCDC85B
     SABiosciences Custom PCR Arrays for CCDC85B
     Search Tocris compounds for CCDC85B (CC85B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CCDC85B antibodies
     CCDC85B proteins
     Antibodies for CCDC85B
     See all of Abcam's Antibodies, Kits and Proteins for CCDC85B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CCDC85B
     Antibodies for CCDC85B
     ELISAs for CCDC85B
     CLIAs for CCDC85B
     Search LifeMap BioReagents cell lines for CCDC85B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC85B
     SwitchGear 3'UTR luciferase reporter plasmids for CCDC85B
     SwitchGear Promoter luciferase reporter plasmids for CCDC85B
     ThermoFisher Antibody for CCDC85B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC85B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC85B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC85B
    Customized:
     lentivirus for stable overexpression of CCDC85B
     lentivirus expression plasmids for stable overexpression of CCDC85B
     adenovirus for overexpression of CCDC85B
     LSBio Antibodies in human, mouse, rat for CCDC85B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCDC85B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4