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Aliases for CCDC84 Gene

Aliases for CCDC84 Gene

  • Coiled-Coil Domain Containing 84 2 3 5
  • Coiled-Coil Domain-Containing Protein 84 3
  • DLNB14 3

External Ids for CCDC84 Gene

Previous GeneCards Identifiers for CCDC84 Gene

  • GC11P118377
  • GC11P118868
  • GC11P114808
  • GC11P118998
  • GC11P118999

Summaries for CCDC84 Gene

Entrez Gene Summary for CCDC84 Gene

  • This gene encodes a protein thought to contain a coiled coil motif. No function has been determined for the encoded protein. A pseudogene of this gene is located on chromosome 20. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CCDC84 Gene

CCDC84 (Coiled-Coil Domain Containing 84) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC84 Gene

Genomics for CCDC84 Gene

Regulatory Elements for CCDC84 Gene

Enhancers for CCDC84 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F118571 0.2 ENCODE 23 -421.7 -421688 2.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SP3 JUNB IFT46 CCDC84 HINFP ENSG00000255121 RPL5P30 LOC101929133 BCL9L UBE4A ENSG00000254909 RPL23AP64
GH11F118906 1.5 FANTOM5 Ensembl ENCODE 16.8 -75.6 -75561 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LOC101929133 RPS25 HINFP CCDC84 CXCR5 DPAGT1 UBE4A HMBS IFT46 ENSG00000222529
GH11F118868 1.2 FANTOM5 Ensembl ENCODE 16.1 -123.5 -123532 5.6 HDAC1 ATF1 PKNOX1 WRNIP1 SIN3A RAD21 ZBTB40 ETV6 CREM JUNB DDX6 CCDC84 TREHP1 UPK2 ENSG00000222529 FOXR1 BCL9L RN7SL688P ENSG00000255176 MIR6716
GH11F118698 1.2 FANTOM5 Ensembl ENCODE 15.4 -294.6 -294583 2.7 ZNF146 ZFP64 ZNF140 ZNF316 NR2F6 ZNF584 ZNF433 ZBTB11 NR2F1 CEBPB LOC105369519 RPL5P30 CCDC84 IFT46 ENSG00000255121 TREH HINFP ENSG00000272186 CD3E CD3G
GH11F119087 0.2 ENCODE 13.2 +94.3 94348 1.8 HDGF ATF1 PKNOX1 ARNT SIN3A ELK1 GATA2 KLF13 JUNB NCOA1 VPS11 HMBS HINFP CCDC84 TRAPPC4 ENSG00000255121 GC11M119097
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC84 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC84 Gene

Chromosome:
11
Start:
118,994,353 bp from pter
End:
119,015,793 bp from pter
Size:
21,441 bases
Orientation:
Plus strand

Genomic View for CCDC84 Gene

Genes around CCDC84 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC84 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC84 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC84 Gene

Proteins for CCDC84 Gene

  • Protein details for CCDC84 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UT8-CCD84_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 84
    Protein Accession:
    Q86UT8

    Protein attributes for CCDC84 Gene

    Size:
    332 amino acids
    Molecular mass:
    37974 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC84 Gene

Post-translational modifications for CCDC84 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC84 Gene

No data available for DME Specific Peptides for CCDC84 Gene

Domains & Families for CCDC84 Gene

Protein Domains for CCDC84 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC84 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC84: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC84 Gene

Function for CCDC84 Gene

genes like me logo Genes that share phenotypes with CCDC84: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC84 Gene

Localization for CCDC84 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC84 Gene COMPARTMENTS Subcellular localization image for CCDC84 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC84 Gene

Pathways & Interactions for CCDC84 Gene

SuperPathways for CCDC84 Gene

No Data Available

Interacting Proteins for CCDC84 Gene

Selected Interacting proteins: Q86UT8-CCD84_HUMAN for CCDC84 Gene via IID

Gene Ontology (GO) - Biological Process for CCDC84 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC84 Gene

Transcripts for CCDC84 Gene

Unigene Clusters for CCDC84 Gene

Coiled-coil domain containing 84:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC84 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for CCDC84 Gene

GeneLoc Exon Structure for
CCDC84
ECgene alternative splicing isoforms for
CCDC84

Expression for CCDC84 Gene

mRNA expression in normal human tissues for CCDC84 Gene

Protein differential expression in normal tissues from HIPED for CCDC84 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.9), Cerebrospinal fluid (10.9), and Bone marrow stromal cell (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC84 Gene



Protein tissue co-expression partners for CCDC84 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC84 Gene:

CCDC84

SOURCE GeneReport for Unigene cluster for CCDC84 Gene:

Hs.534613
genes like me logo Genes that share expression patterns with CCDC84: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC84 Gene

Orthologs for CCDC84 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC84 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC84 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia CCDC84 34 35
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia CCDC84 34 35
  • 90.56 (n)
mouse
(Mus musculus)
Mammalia Ccdc84 34 16 35
  • 85.14 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc84 34
  • 84.84 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC84 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC84 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC84 34 35
  • 60.42 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC84 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc84 34
  • 58.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30684 34
zebrafish
(Danio rerio)
Actinopterygii ccdc84 34 35
  • 56.16 (n)
Species where no ortholog for CCDC84 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC84 Gene

ENSEMBL:
Gene Tree for CCDC84 (if available)
TreeFam:
Gene Tree for CCDC84 (if available)

Paralogs for CCDC84 Gene

Pseudogenes.org Pseudogenes for CCDC84 Gene

genes like me logo Genes that share paralogs with CCDC84: view

No data available for Paralogs for CCDC84 Gene

Variants for CCDC84 Gene

Sequence variations from dbSNP and Humsavar for CCDC84 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs386352288 Uncertain significance 119,015,316(+) AAAAC(A/G)GAAGT nc-transcript-variant, downstream-variant-500B, reference, missense
rs10111 -- 119,015,407(+) GGCCG(C/T)GTCTG nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs10680026 -- 119,014,963(+) AAAAA(-/AAA)GCCTT intron-variant
rs10718631 -- 119,002,682(+) GTTGG(-/T)TTTTT intron-variant, downstream-variant-500B
rs10892319 -- 118,999,703(+) AGTGG(C/T)GCGAT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC84 Gene

Variant ID Type Subtype PubMed ID
esv3627880 CNV loss 21293372
nsv1127234 CNV deletion 24896259
nsv975231 CNV duplication 23825009
nsv983067 CNV duplication 23825009

Variation tolerance for CCDC84 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC84 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC84

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC84 Gene

Disorders for CCDC84 Gene

Relevant External Links for CCDC84

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC84

No disorders were found for CCDC84 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC84 Gene

Publications for CCDC84 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. (PMID: 24129315) Guo A. … Comb M.J. (Mol. Cell. Proteomics 2014) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCDC84 Gene

Sources for CCDC84 Gene

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