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Aliases for CCDC83 Gene

Aliases for CCDC83 Gene

  • Coiled-Coil Domain Containing 83 2 3 5
  • Coiled-Coil Domain-Containing Protein 83 3
  • CT148 3
  • HSD9 3

External Ids for CCDC83 Gene

Previous GeneCards Identifiers for CCDC83 Gene

  • GC11P085244
  • GC11P085566
  • GC11P081863

Summaries for CCDC83 Gene

GeneCards Summary for CCDC83 Gene

CCDC83 (Coiled-Coil Domain Containing 83) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC83 Gene

Genomics for CCDC83 Gene

Regulatory Elements for CCDC83 Gene

Enhancers for CCDC83 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G085825 1.4 Ensembl ENCODE dbSUPER 25.4 -25.9 -25897 7.4 PKNOX1 SIN3A FEZF1 BRCA1 FOS ZHX2 ZNF592 SREBF1 MBD2 SMARCA4 CCDC83 CCDC89 CREBZF SYTL2 ENSG00000279742
GH11G085889 0.8 ENCODE 25.8 +35.1 35129 0.9 JUN RAD21 RFX5 FOSL1 GATA3 ZNF316 FOSL2 FOS ZNF600 MAFK CCDC83 ENSG00000255005 AHCYP6
GH11G085843 1.4 Ensembl ENCODE dbSUPER 13.5 -10.6 -10575 2.3 TBP PKNOX1 NFIB BRCA1 RAD21 RFX5 GATA2 ZNF366 RCOR1 FOS CCDC83 ENSG00000279742 SYTL2
GH11G085854 1.1 ENCODE 16.7 -0.1 -57 1.7 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 DEK ZNF263 CCDC83 CCDC89 CREBZF ENSG00000279742
GH11G086060 1.4 ENCODE dbSUPER 11 +211.1 211125 10.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D EED CCDC83 PICALM SLC25A1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC83 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC83 Gene

Chromosome:
11
Start:
85,855,055 bp from pter
End:
85,920,021 bp from pter
Size:
64,967 bases
Orientation:
Plus strand

Genomic View for CCDC83 Gene

Genes around CCDC83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC83 Gene

Proteins for CCDC83 Gene

  • Protein details for CCDC83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWF9-CCD83_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 83
    Protein Accession:
    Q8IWF9
    Secondary Accessions:
    • B2RA49
    • Q6X7T2
    • Q6ZVT5
    • Q8N9Y1

    Protein attributes for CCDC83 Gene

    Size:
    413 amino acids
    Molecular mass:
    48851 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04154.1; Type=Frameshift; Positions=225; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC83 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC83 Gene

Post-translational modifications for CCDC83 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC83 Gene

Domains & Families for CCDC83 Gene

Protein Domains for CCDC83 Gene

Suggested Antigen Peptide Sequences for CCDC83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC83: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC83 Gene

Function for CCDC83 Gene

Phenotypes for CCDC83 Gene

GenomeRNAi human phenotypes for CCDC83:
genes like me logo Genes that share phenotypes with CCDC83: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC83 Gene

Localization for CCDC83 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC83 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC83 Gene

Pathways & Interactions for CCDC83 Gene

SuperPathways for CCDC83 Gene

No Data Available

Interacting Proteins for CCDC83 Gene

Gene Ontology (GO) - Biological Process for CCDC83 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC83 Gene

Drugs & Compounds for CCDC83 Gene

No Compound Related Data Available

Transcripts for CCDC83 Gene

Unigene Clusters for CCDC83 Gene

Coiled-coil domain containing 83:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC83 Gene

No ASD Table

Relevant External Links for CCDC83 Gene

GeneLoc Exon Structure for
CCDC83
ECgene alternative splicing isoforms for
CCDC83

Expression for CCDC83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC83 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC83 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for CCDC83 Gene

This gene is overexpressed in Gallbladder (43.0), Breast (16.5), and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC83 Gene



Protein tissue co-expression partners for CCDC83 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC83 Gene:

CCDC83

SOURCE GeneReport for Unigene cluster for CCDC83 Gene:

Hs.567774
genes like me logo Genes that share expression patterns with CCDC83: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC83 Gene

Orthologs for CCDC83 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC83 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC83 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia CCDC83 34 35
  • 86.37 (n)
dog
(Canis familiaris)
Mammalia CCDC83 34 35
  • 85.89 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc83 34
  • 76.69 (n)
mouse
(Mus musculus)
Mammalia Ccdc83 34 16 35
  • 75.59 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC83 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC83 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC83 34 35
  • 56.67 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC83 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc83 34
  • 50.76 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc83 34 35
  • 43.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10447 35
  • 29 (a)
OneToOne
Species where no ortholog for CCDC83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC83 Gene

ENSEMBL:
Gene Tree for CCDC83 (if available)
TreeFam:
Gene Tree for CCDC83 (if available)

Paralogs for CCDC83 Gene

No data available for Paralogs for CCDC83 Gene

Variants for CCDC83 Gene

Sequence variations from dbSNP and Humsavar for CCDC83 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000044917 -- 85,882,097(+) GACCA(A/G)CATAG intron-variant
rs1000059529 -- 85,899,085(+) TAATT(A/G)TGAAC intron-variant
rs1000091733 -- 85,899,444(+) AGGTA(C/T)TGTAC intron-variant
rs1000126186 -- 85,863,736(+) GAAGG(C/T)TGACA intron-variant
rs1000205648 -- 85,855,093(+) TCGGT(G/T)GCCTT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC83 Gene

Variant ID Type Subtype PubMed ID
esv2678670 CNV deletion 23128226
esv2744853 CNV deletion 23290073
esv2759845 CNV gain+loss 17122850
esv3548087 CNV deletion 23714750
esv3627077 CNV loss 21293372
esv3627078 CNV loss 21293372
esv3627079 CNV loss 21293372
nsv1035489 CNV gain 25217958
nsv1053808 CNV gain 25217958
nsv418 CNV insertion 18451855
nsv832222 CNV gain 17160897
nsv975957 CNV duplication 23825009

Variation tolerance for CCDC83 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC83 Gene

Disorders for CCDC83 Gene

Relevant External Links for CCDC83

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC83

No disorders were found for CCDC83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC83 Gene

Publications for CCDC83 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. KP-CoT-23 (CCDC83) is a novel immunogenic cancer/testis antigen in colon cancer. (PMID: 22923163) Song M.H. … Lee S.Y. (Int. J. Oncol. 2012) 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. [Characteristics of a novel human testis-specific gene, HSD-9, and its encoding protein]. (PMID: 17633455) Wang Y. … Wang L.F. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007) 3 64

Products for CCDC83 Gene

Sources for CCDC83 Gene

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