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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC82 Gene

protein-coding   GIFtS: 42
GCID: GC11M096085

Coiled-Coil Domain Containing 82

  Search for CCDC82
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 821 2
HSPC0482
Coiled-Coil Domain-Containing Protein 822

External Ids:    HGNC: 262821   Entrez Gene: 797802   Ensembl: ENSG000001492317   UniProtKB: Q8N4S03   

Export aliases for CCDC82 gene to outside databases

Previous GC identifers: GC11M095726 GC11M092152


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC82 Gene: 
CCDC82 (coiled-coil domain containing 82) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC82 gene promoter:
         POU2F2 (Oct-2.1)   oct-B2   oct-B3   AML1a   POU2F2   RORalpha1   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC82 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

CCDC82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC82 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M096085:  view genomic region     (about GC identifiers)

Start:
96,085,929 bp from pter      End:
96,123,087 bp from pter
Size:
37,159 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCD82_HUMAN, Q8N4S0 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 82  
Size: 544 amino acids; 64002 Da
Sequence caution: Sequence=BAB15683.1; Type=Frameshift; Positions=527;
Secondary accessions: B3KPU7 Q8WV71 Q9H2Q5 Q9H5E3
Alternative splicing: 2 isoforms:  Q8N4S0-1   Q8N4S0-2   

Explore the universe of human proteins at neXtProt for CCDC82: NX_Q8N4S0

Explore proteomics data for CCDC82 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4S0

  • CCDC82 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC82 Protein Expression
    REFSEQ proteins: NP_079001.2  
    ENSEMBL proteins: 
     ENSP00000278520   ENSP00000397156   ENSP00000442723   ENSP00000431148   ENSP00000444010  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR025244 DUF4196
     IPR025451 DUF4211

    Graphical View of Domain Structure for InterPro Entry Q8N4S0

    ProtoNet protein and cluster: Q8N4S0


    CCDC82 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC82:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC82 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC82

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC82 
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    SwitchGear 3'UTR luciferase reporter plasmidCCDC82 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC82

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CCDC82 (Q8N4S03 ENSP000002785204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VHLP403373, ENSP000002564744I2D: score=2 STRING: ENSP00000256474
    EWSR1Q018443I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC82 (CCD82)

    Search CenterWatch for drugs/clinical trials and news about CCDC82 / CCD82

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC82 gene (2 alternative transcripts): 
    NM_014148.1  NM_024725.3  

    Unigene Cluster for CCDC82:

    Coiled-coil domain containing 82
    Hs.525088  [show with all ESTs]
    Unigene Representative Sequence: AK074306
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278520(uc009ywp.3) ENST00000545264 ENST00000423339 ENST00000530106(uc009yws.3)
    ENST00000538597 ENST00000530203 ENST00000524836 ENST00000525786 ENST00000542662(uc001pfx.4 uc009ywr.3)

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC82 (see all 13):
    hsa-miR-577 hsa-miR-433 hsa-miR-429 hsa-miR-130a* hsa-miR-23c hsa-miR-181a-2* hsa-miR-374c hsa-miR-942
    SwitchGear 3'UTR luciferase reporter plasmidCCDC82 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCDC82
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC82
    Clone
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    OriGene clones in human, mouse for CCDC82 (see all 8)
    OriGene ORF clones in mouse, rat for CCDC82
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC82 (NM_024725)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC82
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC82
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC82 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC82 
    Primer
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    OriGene qPCR primer pairs and template standards for CCDC82
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC82
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC82
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC82

    Additional mRNA sequence: 

    AF161533.1 AF245436.1 AK027171.1 AK056790.1 AK074306.1 AK313893.1 AK314669.1 BC018663.2 
    BC033726.2 

    13 DOTS entries:

    DT.100754158  DT.315182  DT.75193408  DT.92429695  DT.97779437  DT.95315835  DT.100022743  DT.100713860 
    DT.92429697  DT.95226909  DT.100722065  DT.40216416  DT.40118964 

    24/144 AceView cDNA sequences (see all 144):

    AI476316 BX509709 BM725932 AI685337 AW303806 BM678039 BG779438 AA768873 
    BX283136 CA334825 AA714205 AA749501 BG034082 BC033726 AA287382 H01529 
    AA720647 AA451627 AI784410 AA496142 BE219222 AJ708733 AA478080 BG617599 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTATAATG
    CCDC82 Expression
    About this image


    See CCDC82 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC82

    SOURCE GeneReport for Unigene cluster: Hs.525088
        SABiosciences Custom PCR Arrays for CCDC82
    Primer
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    OriGene qPCR primer pairs and template standards for CCDC82
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC82
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC82

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC82 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc821 , 5 coiled-coil domain containing 821, 5 80.94(n)1
    73.45(a)1
      95
    663961  NM_025534.21  NP_079810.21 
     132469825 
    chicken
    (Gallus gallus)
    Aves CCDC821 coiled-coil domain containing 82 59.2(n)
    49.51(a)
      426136  XM_423807.3  XP_423807.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC826
    Uncharacterized protein
    36(a)
    1 ↔ 1
    3(195047280-195059201)
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc821 coiled-coil domain containing 82 49.8(n)
    39.12(a)
      327538  NM_199822.1  NP_956116.1 


    ENSEMBL Gene Tree for CCDC82 (if available)
    TreeFam Gene Tree for CCDC82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/731 SNPs in CCDC82 are shown (see all 731)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446600161,2
    --96085509(+) AGTGAA/GTAGAG 1 -- int10--------
    rs780886811,2
    C,F--96085670(+) CCACAA/GTTGTG 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1125458031,2
    F--96085711(+) TAATAC/TGGATA 1 -- int12Minor allele frequency- T:0.07CSA WA 120
    rs1485037511,2
    --96085732(+) ATGAAC/TTGTAG 1 -- int10--------
    rs1126073301,2
    C--96085777(+) GTAGCT/-TTTTA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1428223741,2
    --96085789(+) GGATAC/TGTACA 1 -- int10--------
    rs1841793271,2
    --96085790(+) GATACA/GTACAC 1 -- int10--------
    rs1885838781,2
    --96085799(+) ACTACA/GGTCCA 1 -- int10--------
    rs47531971,2
    C,F--96085865(+) AAAATT/AATCTA 1 -- int110Minor allele frequency- A:0.31NA WA CSA EA 371
    rs1811632241,2
    --96085985(+) TAGATA/GTGCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC82 (96085929 - 96123087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCDC82:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898191CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC82

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC82 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CCDC82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    9. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79780 HGNC: 26282 AceView: FLJ23518 Ensembl:ENSG00000149231 euGenes: HUgn79780
    ECgene: CCDC82 H-InvDB: CCDC82

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC82 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC82 gene:
    Search GeneIP for patents involving CCDC82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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