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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC81 Gene

protein-coding GIFtS: 39
GCID: GC11P086085

coiled-coil domain containing 81

Search for CCDC81
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 81¹ ²
FLJ16339¹
FLJ23514¹
Coiled-Coil Domain-Containing Protein 81²

External Ids:	HGNC: 26281¹	Entrez Gene: 60494²	Ensembl: ENSG00000149201⁷	UniProtKB: Q6ZN84³

Export aliases for CCDC81 gene to outside databases

Previous GC identifers: GC11P085764 GC11P082374

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC81 gene promoter:
AP-1 POU6F1 (c2) NF-E2 p45 HEN1 E2F-1 E2F Cart-1 NF-E2 RSRFC4 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC81 promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC81

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC81

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2 Ensembl cytogenetic band: 11q14.2 HGNC cytogenetic band: 11q14.2

CCDC81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC81 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P086085: view genomic region (about GC identifiers)

Start:	86,085,778 bp from pter	End:	86,134,151 bp from pter
Size:	48,374 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCD81_HUMAN, Q6ZN84 (See protein sequence)

Recommended Name: Coiled-coil domain-containing protein 81

Size: 652 amino acids; 76084 Da

Sequence caution: Sequence=BAD96888.1; Type=Erroneous initiation;

Secondary accessions: A0AVL7 Q53FW3 Q9H5E5

Alternative splicing: 3 isoforms: Q6ZN84-1 Q6ZN84-2 Q6ZN84-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC81: NX_Q6ZN84

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZN84

CCDC81 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001149946.1 NP_068599.3

ENSEMBL proteins:

ENSP00000346800 ENSP00000434959 ENSP00000415528 ENSP00000437165 ENSP00000278487

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CCDC81 for domains About GeneDecksing

1 InterPro domain/family:

IPR026295 Coiled-coil_dom_cont_p_81

Graphical View of Domain Structure for InterPro Entry Q6ZN84

ProtoNet protein and cluster: Q6ZN84

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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2 GenomeRNAi human phenotypes for CCDC81:

Increased S DNA content

Increased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCDC81

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about CCDC81 / CCD81

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CCDC81 gene (2 alternative transcripts):

NM_001156474.1 NM_021827.4

Unigene Cluster for CCDC81:

Coiled-coil domain containing 81

Hs.144913 [show with all ESTs]

Unigene Representative Sequence: NM_001156474

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000354755(uc001pbw.2) ENST00000531271 ENST00000445632 ENST00000530845

ENST00000532466 ENST00000532215 ENST00000529603 ENST00000528728(uc010rtq.2 uc001pby.2)

ENST00000531587 ENST00000525247 ENST00000278487(uc001pbx.2)

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Additional cDNA sequence:

AK027167.1 AK131331.1 AK223168.1 AK298875.1 BC126412.1

5 DOTS entries:

DT.101974518 DT.120714541 DT.70104034 DT.40126850 DT.101956977

24/26 AceView cDNA sequences (see all 26):

BE352846 BX098950 BX645417 BF222927 AI655157 BP372183 BE352845 AA939053

AK131331 BI826845 AK027167 NM_021827 CA393848 BP373802 BG392622 BM988671

BP373456 CA448567 AI218035 BM978866 AI916807 AI073989 CD684893 BP430940

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC81 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15a	·	15b
SP1:							-								-		-		-
SP2:																															-		-
SP3:																							-		-				-		-		-
SP4:																							-		-
SP5:																							-		-						-		-

ECgene alternative splicing isoforms for CCDC81

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC81 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTTGTGTA

About this image

CCDC81 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC81 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC81

SOURCE GeneReport for Unigene cluster: Hs.144913

SABiosciences Custom PCR Arrays for CCDC81

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCDC81 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccdc81^{1 , 5}	coiled-coil domain containing 81^{1, 5}	83.26(n)¹ 79.11(a)¹		7 (50.38 cM)⁵ 70884¹ NM_001162979.1¹ NP_001156451.1¹ 89866148⁵
chicken (Gallus gallus)	Aves	-- -- (see all 6)	--	28(a) 28(a) (see all 6)	many → 1 many → 1 (see all 6)	Un(33588925-33590270) Un(819-2164)
lizard (Anolis carolinensis)	Reptilia	CCDC81⁶	--	55(a)	1 ↔ 1	3(200358321-200388283)

ENSEMBL Gene Tree for CCDC81 (if available)
TreeFam Gene Tree for CCDC81 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182371757^1,2		--	86083942(+)	`TGTACC/TTCTCT`	2	--	us2k¹		0	--	--	--	--
rs292105^1,2	C,F,A,H,	--	86083998(+)	`CATGCT/CCTTGT`	2	--	us2k¹ tfbs³		11		NS EA NA WA CSA	786
rs292106^1,2	C,F,A,H,	--	86084069(+)	`ACAAAA/GTTTTG`	2	--	us2k¹		23		NS EA NA WA	2762
rs149114431^1,2		--	86084161(+)	`AATACC/GTATGC`	2	--	us2k¹		0	--	--	--	--
rs292107^1,2	C,F,A,H,	--	86084177(-)	`ATAAGT/AATATA`	2	--	us2k¹ tfbs³		10		NS EA NA WA	766
rs185124774^1,2		--	86084274(+)	`AGCACA/GTAAAT`	2	--	us2k¹		0	--	--	--	--
rs191074577^1,2		--	86084322(+)	`CCAATA/GTATGT`	2	--	us2k¹		0	--	--	--	--
rs614301^1,2	C,F,A,H,	--	86084388(-)	`TTTATA/CATGTT`	2	--	us2k¹ tfbs³		10		NS EA NA WA	738
rs183540629^1,2		--	86084404(+)	`TTGCAA/TATACA`	2	--	us2k¹		0	--	--	--	--
rs188766662^1,2		--	86084793(+)	`ATGTAC/TTGTAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCDC81 (86085778 - 86134151 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC81: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC81 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC81)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 60494	HGNC: 26281	AceView: FLJ23514	Ensembl:ENSG00000149201	euGenes: HUgn60494
ECgene: CCDC81	H-InvDB: CCDC81

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC81	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC81 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC81 gene:
Search GeneIP for patents involving CCDC81

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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CCDC81 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CCDC81

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC81

	SwitchGear 3'UTR luciferase reporter plasmids for CCDC81
	SwitchGear Promoter luciferase reporter plasmids for CCDC81

Search ThermoFisher Antibodies for CCDC81

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC81

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCDC81 gene at Home site.

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CCDC81 Gene

coiled-coil domain containing 81

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for CCDC81 gene

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for CCDC81 gene

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for CCDC81 gene

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Families
for CCDC81 gene

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for CCDC81 gene

Pathways & Interactions
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Expression
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for CCDC81 gene

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for CCDC81 gene

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Export list of displayed genes

CCDC81 Gene

coiled-coil domain containing 81

Aliasesfor CCDC81 gene

Summariesfor CCDC81 gene

Genomic Viewsfor CCDC81 gene

Proteinsfor CCDC81 gene

Protein Domains /Familiesfor CCDC81 gene

Functionfor CCDC81 gene

Pathways & Interactionsfor CCDC81 gene

Drugs & Compoundsfor CCDC81 gene

Transcriptsfor CCDC81 gene

Expression for CCDC81 gene

Orthologsfor CCDC81 gene

Paralogsfor CCDC81 gene

Genomic Variantsfor CCDC81 gene

Disorders / Diseasesfor CCDC81 gene

Publicationsfor CCDC81 gene

External Searches for CCDC81 gene

Genome Databases showing CCDC81 gene

Other Databases showing CCDC81 gene

Specialized Databases showing CCDC81 gene

Intellectual Propertyfor CCDC81 gene

Productsfor CCDC81 gene

View Random Gene

Aliases
for CCDC81 gene

Summaries
for CCDC81 gene

Genomic Views
for CCDC81 gene

Proteins
for CCDC81 gene

Protein Domains /
Families
for CCDC81 gene

Function
for CCDC81 gene

Pathways & Interactions
for CCDC81 gene

Drugs & Compounds
for CCDC81 gene

Transcripts
for CCDC81 gene

Expression
for CCDC81 gene

Orthologs
for CCDC81 gene

Paralogs
for CCDC81 gene

Genomic Variants
for CCDC81 gene

Disorders / Diseases
for CCDC81 gene

Publications
for CCDC81 gene

Intellectual Property
for CCDC81 gene

Products
for CCDC81 gene