Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC80 Gene

Aliases for CCDC80 Gene

  • Coiled-Coil Domain Containing 80 2 3
  • URB 3 4 6
  • Up-Regulated In BRS-3 Deficient Mouse Homolog 3 4
  • Down-Regulated By Oncogenes Protein 1 3 4
  • Steroid Sensitive Gene 1 2 3
  • SSG1 3 6
  • DRO1 3 4
  • Coiled-Coil Domain-Containing Protein 80 3
  • Nuclear Envelope Protein Okuribin 3
  • Okuribin 3

External Ids for CCDC80 Gene

Previous GeneCards Identifiers for CCDC80 Gene

  • GC03M113807
  • GC03M112323
  • GC03M109706

Summaries for CCDC80 Gene

GeneCards Summary for CCDC80 Gene

CCDC80 (Coiled-Coil Domain Containing 80) is a Protein Coding gene. GO annotations related to this gene include heparin binding and fibronectin binding. An important paralog of this gene is SRPX2.

UniProtKB/Swiss-Prot for CCDC80 Gene

  • Promotes cell adhesion and matrix assembly.

Gene Wiki entry for CCDC80 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC80 Gene

Genomics for CCDC80 Gene

Regulatory Elements for CCDC80 Gene

Genomic Location for CCDC80 Gene

Start:
112,604,386 bp from pter
End:
112,649,530 bp from pter
Size:
45,145 bases
Orientation:
Minus strand

Genomic View for CCDC80 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC80 Gene

Proteins for CCDC80 Gene

  • Protein details for CCDC80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76M96-CCD80_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 80
    Protein Accession:
    Q76M96
    Secondary Accessions:
    • D3DN67
    • Q5PR20
    • Q6GPG9
    • Q8IVT6
    • Q8NBV1
    • Q8NHY8

    Protein attributes for CCDC80 Gene

    Size:
    950 amino acids
    Molecular mass:
    108174 Da
    Quaternary structure:
    • Binds to various extracellular matrix proteins.

    Alternative splice isoforms for CCDC80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC80 Gene

Proteomics data for CCDC80 Gene at MOPED

Post-translational modifications for CCDC80 Gene

  • Phosphorylated.
  • Glycosylation at Ser64, Thr65, Thr89, Thr323, Ser409, Ser411, Ser418, Ser513, and Thr516
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC80 Gene

No data available for DME Specific Peptides for CCDC80 Gene

Domains for CCDC80 Gene

Protein Domains for CCDC80 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q76M96

UniProtKB/Swiss-Prot:

CCD80_HUMAN :
  • Q76M96
Family:
  • Belongs to the CCDC80 family.
genes like me logo Genes that share domains with CCDC80: view

No data available for Gene Families for CCDC80 Gene

Function for CCDC80 Gene

Molecular function for CCDC80 Gene

UniProtKB/Swiss-Prot Function: Promotes cell adhesion and matrix assembly.
UniProtKB/Swiss-Prot Induction: Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone (DHT).

Gene Ontology (GO) - Molecular Function for CCDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0005539 glycosaminoglycan binding --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with CCDC80: view
genes like me logo Genes that share phenotypes with CCDC80: view

Animal Models for CCDC80 Gene

MGI Knock Outs for CCDC80:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC80

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC80 Gene

Localization for CCDC80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC80 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC80 Gene COMPARTMENTS Subcellular localization image for CCDC80 gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CCDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005614 interstitial matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with CCDC80: view

Pathways for CCDC80 Gene

SuperPathways for CCDC80 Gene

No Data Available

Interacting Proteins for CCDC80 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000206423%0d%0a9606.ENSP00000365920%0d%0a9606.ENSP00000201031%0d%0a9606.ENSP00000368924%0d%0a
Selected Interacting proteins: ENSP00000206423 Q76M96-CCD80_HUMAN for CCDC80 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CCDC80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with CCDC80: view

No data available for Pathways by source for CCDC80 Gene

Transcripts for CCDC80 Gene

Unigene Clusters for CCDC80 Gene

Coiled-coil domain containing 80:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC80

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCDC80

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC80 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:
SP3: -

Relevant External Links for CCDC80 Gene

GeneLoc Exon Structure for
CCDC80
ECgene alternative splicing isoforms for
CCDC80

Expression for CCDC80 Gene

mRNA expression in normal human tissues for CCDC80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC80 Gene

SOURCE GeneReport for Unigene cluster for CCDC80 Gene Hs.477128

mRNA Expression by UniProt/SwissProt for CCDC80 Gene

Q76M96-CCD80_HUMAN
Tissue specificity: Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart, thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts.
genes like me logo Genes that share expressions with CCDC80: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCDC80 Gene

Orthologs for CCDC80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC80 35
  • 99.19 (n)
  • 99.16 (a)
CCDC80 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC80 35
  • 87.68 (n)
  • 87.86 (a)
CCDC80 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC80 35
  • 80.61 (n)
  • 79.09 (a)
CCDC80 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc80 35
  • 84.78 (n)
  • 84.43 (a)
Ccdc80 16
Ccdc80 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC80 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC80 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc80 35
  • 84.46 (n)
  • 84.85 (a)
chicken
(Gallus gallus)
Aves CCDC80 35
  • 69.72 (n)
  • 70.83 (a)
CCDC80 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC80 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11954 35
zebrafish
(Danio rerio)
Actinopterygii ccdc80 35
  • 62.75 (n)
  • 60.79 (a)
ccdc80 36
  • 55 (a)
OneToMany
CCDC80 (3 of 3) 36
  • 35 (a)
OneToMany
ccdc80l1 36
  • 47 (a)
OneToMany
Species with no ortholog for CCDC80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC80 Gene

ENSEMBL:
Gene Tree for CCDC80 (if available)
TreeFam:
Gene Tree for CCDC80 (if available)

Paralogs for CCDC80 Gene

Paralogs for CCDC80 Gene

Selected SIMAP similar genes for CCDC80 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CCDC80: view

Variants for CCDC80 Gene

Sequence variations from dbSNP and Humsavar for CCDC80 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs981180 -- 112,634,252(+) TGTCC(C/T)AATAC intron-variant
rs981181 -- 112,634,391(+) AGTGA(A/C)TAGAT intron-variant
rs981182 -- 112,634,508(+) GCAGA(C/T)TGAAG intron-variant
rs1352832 -- 112,634,722(+) CATGT(G/T)TATTA intron-variant
rs1388443 -- 112,634,484(+) TCGTC(A/C)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC80 Gene

Variant ID Type Subtype PubMed ID
nsv877342 CNV Gain 21882294

Relevant External Links for CCDC80 Gene

HapMap Linkage Disequilibrium report
CCDC80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC80 Gene

Disorders for CCDC80 Gene

Relevant External Links for CCDC80

Genetic Association Database (GAD)
CCDC80
genes like me logo Genes that share disorders with CCDC80: view

No data available for UniProtKB/Swiss-Prot for CCDC80 Gene

Publications for CCDC80 Gene

  1. URB expression in human bone marrow stromal cells and during mouse development. (PMID: 15325258) Liu Y. … Castagnola P. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. URB is abundantly expressed in adipose tissue and dysregulated in obesity. (PMID: 18178152) Okada T. … Funahashi T. (Biochem. Biophys. Res. Commun. 2008) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. (PMID: 15563452) Bommer G.T. … Kolligs F.T. (J. Biol. Chem. 2005) 3 4

Products for CCDC80 Gene

Sources for CCDC80 Gene

Back to Top

Content