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CCDC80 Gene

protein-coding   GIFtS: 50
GCID: GC03M112323

Coiled-Coil Domain Containing 80

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 801 2     DRO12 3
URB2 3 5     SSG12 5
Steroid Sensitive Gene 11 2     Coiled-Coil Domain-Containing Protein 802
Down-Regulated By Oncogenes Protein 12 3     Nuclear Envelope Protein Okuribin2
Up-Regulated In BRS-3 Deficient Mouse Homolog2 3     okuribin2

External Ids:    HGNC: 306491   Entrez Gene: 1518872   Ensembl: ENSG000000919867   OMIM: 6082985   UniProtKB: Q76M963   

Export aliases for CCDC80 gene to outside databases

Previous GC identifers: GC03M113807 GC03M109706


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC80 Gene:
CCDC80 (coiled-coil domain containing 80) is a protein-coding gene. Diseases associated with CCDC80 include atopic dermatitis, and dermatitis. GO annotations related to this gene include heparin binding and fibronectin binding. An important paralog of this gene is SRPX2.

UniProtKB/Swiss-Prot: CCD80_HUMAN, Q76M96
Function: Promotes cell adhesion and matrix assembly (By similarity)

Gene Wiki entry for CCDC80 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC80 gene promoter:
         Bach1   RFX1   LUN-1   NF-kappaB   c-Rel   IRF-2   NF-kappaB2   ZID   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC80 promoter sequence
   Search Chromatin IP Primers for CCDC80

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

CCDC80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC80 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M112323:  view genomic region     (about GC identifiers)

Start:
112,323,407 bp from pter      End:
112,368,377 bp from pter
Size:
44,971 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CCD80_HUMAN, Q76M96 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 80 precursor  
Size: 950 amino acids; 108174 Da
Subunit: Binds to various extracellular matrix proteins (By similarity)
Secondary accessions: D3DN67 Q5PR20 Q6GPG9 Q8IVT6 Q8NBV1 Q8NHY8
Alternative splicing: 3 isoforms:  Q76M96-1   Q76M96-2   Q76M96-3   

Explore the universe of human proteins at neXtProt for CCDC80: NX_Q76M96

Explore proteomics data for CCDC80 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Glycosylation2 at Ser64, Thr65, Thr89, Thr323, Ser409, Ser411, Ser418, Ser513, Thr516
  • Modification sites at PhosphoSitePlus

  • See CCDC80 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_955805.1  NP_955806.1  

    ENSEMBL proteins: 
     ENSP00000206423   ENSP00000411814   ENSP00000418188   ENSP00000420123  

    CCDC80 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CCDC80
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCDC80
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    Novus Biologicals CCDC80 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC80

    CCDC80 Antibody Products:

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    Abcam antibodies for CCDC80
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    LSBio Antibodies in human, mouse, rat for CCDC80

    CCDC80 Assay Products:

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    Cloud-Clone Corp. ELISAs for CCDC80
    Cloud-Clone Corp. CLIAs for CCDC80


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024856 Equarin
     IPR025232 DUF4174

    Graphical View of Domain Structure for InterPro Entry Q76M96

    ProtoNet protein and cluster: Q76M96

    UniProtKB/Swiss-Prot: CCD80_HUMAN, Q76M96
    Similarity: Belongs to the CCDC80 family


    CCDC80 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCD80_HUMAN, Q76M96
    Function: Promotes cell adhesion and matrix assembly (By similarity)
    Induction: Down-regulated in cancer and after osteoblastic differentiation. Up-regulated by dihydrotestosterone
    (DHT)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005539glycosaminoglycan binding ----
    GO:0008201heparin binding IEA--
         
    CCDC80 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ccdc80):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 

    CCDC80 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ccdc80tm1Ftrm for CCDC80

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC80
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC80

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC80
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC80

    miRNA
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    Block miRNA regulation of human, mouse, rat CCDC80 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CCDC80:
    hsa-miR-141 hsa-miR-561 hsa-miR-200a hsa-miR-3190 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCCDC80 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCDC80
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC80

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCDC80 (NM_199511)
    Sino Biological Human cDNA Clone for CCDC80
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC80

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC80 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC80


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCD80_HUMAN, Q76M96: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005614interstitial matrix IEA--
    GO:0031012extracellular matrix ----

    CCDC80 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC80
    Interactions:

        Search GeneGlobe Interaction Network for CCDC80

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for CCDC80 (Q76M963 ENSP000002064234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PXNP490233I2D: score=1 
    KNCNENSP000003796074STRING: ENSP00000379607
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0030198extracellular matrix organization IEA--

    CCDC80 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC80 (CCD80)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC80 gene (2 alternative transcripts): 
    NM_199511.2  NM_199512.2  

    Unigene Cluster for CCDC80:

    Coiled-coil domain containing 80
    Hs.477128  [show with all ESTs]
    Unigene Representative Sequence: NM_199511
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000206423(uc011bhv.2 uc003dzf.3 uc003dzg.3 uc003dzh.1)
    ENST00000439685 ENST00000479368 ENST00000461431 ENST00000475181 ENST00000469554
    ENST00000473959 ENST00000480275
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCDC80 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CCDC80:
    hsa-miR-141 hsa-miR-561 hsa-miR-200a hsa-miR-3190 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCCDC80 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCDC80
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC80
    Clone
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    OriGene clones in human, mouse for CCDC80 (see all 11)
    OriGene ORF clones in mouse, rat for CCDC80
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CCDC80 (NM_199511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC80
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC80
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC80
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC80
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC80
      QuantiFast Probe-based Assays in human, mouse, rat CCDC80

    Additional mRNA sequence: 

    AB052098.1 AB266387.1 AF506819.1 AK075210.1 AK292881.1 AK304561.1 AL833034.1 AY333429.1 
    AY526612.1 AY548106.1 AY548107.1 AY726593.1 BC023639.2 BC042105.1 BC042128.1 BC073164.1 
    BC086876.1 BC110842.1 BC116178.1 BC116179.1 BX647117.1 BX647817.1 

    21 DOTS entries:

    DT.97846006  DT.100683241  DT.100059305  DT.100059308  DT.105121  DT.99954569  DT.452492  DT.100054627 
    DT.100667184  DT.120865218  DT.100046508  DT.100056273  DT.100667185  DT.100874285  DT.120865182  DT.120865193 
    DT.120865228  DT.432161  DT.92004052  DT.100667183  DT.101985076 

    Selected AceView cDNA sequences (see all 345):

    BI493796 CA438284 CB851484 AI754332 CA418332 BM670418 BU731673 AW957682 
    AY548106 AA036654 NM_199512 BM990159 AA319726 CA421799 BM990446 AI751257 
    AA456579 BC023639 AI652363 BU623240 AI446798 BQ926784 AA382380 AI090486 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC80    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                        
    SP2:                                                                        
    SP3:              -                                                         


    ECgene alternative splicing isoforms for CCDC80

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC80 expression in normal human tissues (normalized intensities)      CCDC80 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCAGCTC
    CCDC80 Expression
    About this image


    CCDC80 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipose
             White adipocyte-like cells
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
             Detroit 551
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
    CCDC80 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC80 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477128

    UniProtKB/Swiss-Prot: CCD80_HUMAN, Q76M96
    Tissue specificity: Expressed in dermal papilla and dermal fibroblasts (at protein level). Expressed in heart,
    thymus, placenta, pancreas, colon, epithelium, spleen and osteoblasts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC80

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC80 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc801 , 5 coiled-coil domain containing 801, 5 84.78(n)1
    84.43(a)1
      16 (29.39 cM)5
    678961  NM_026439.21  NP_080715.21 
     450934025 
    chicken
    (Gallus gallus)
    Aves CCDC801 coiled-coil domain containing 80 69.72(n)
    70.83(a)
      395074  NM_204431.1  NP_989762.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC806
    coiled-coil domain containing 80
    69(a)
    1 ↔ 1
    3(175805757-175833569)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB180355.12   -- 71.73(n)    CB180355.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc801 coiled-coil domain containing 80 62.75(n)
    60.79(a)
      368419  NM_001007198.1  NP_001007199.1 


    ENSEMBL Gene Tree for CCDC80 (if available)
    TreeFam Gene Tree for CCDC80 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC80 gene
    SRPX22  SRPX2  
    1 SIMAP similar gene for CCDC80 using alignment to 3 protein entries:     CCD80_HUMAN (see all proteins):
    okuribin

    CCDC80 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC80 (see all 877)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105395531,2
    C--112294031(+) TGTTG-/AAAGG 
            
    GAATC
    2 -- int11Minor allele frequency- AAAGG:0.00NA 2
    rs592422721,2
    C,F--112323014(+) TACAAC/TATTAC 2 -- ds50014Minor allele frequency- T:0.21WA CSA 124
    rs1826416051,2
    --112323047(+) CAACAA/GGGTTT 2 -- ds50010--------
    rs1409832121,2
    --112323084(+) AAGTTA/GTACTA 2 -- ds50010--------
    rs1449703691,2
    --112323113(+) ACAGCA/TTCACA 2 -- ds50010--------
    rs1478737341,2
    --112323133(+) GAAATA/CTTTCA 2 -- ds50010--------
    rs1392704621,2
    --112323141(+) TCATGA/GAGAAA 2 -- ds50010--------
    rs758021341,2
    C,F--112323155(+) TCAATC/GGAAGT 2 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1500032631,2
    --112323180(+) CTGTCC/TTATTT 2 -- ds50010--------
    rs1452324171,2
    --112323260(+) CAATGC/TAAAAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for CCDC80 (112323407 - 112368377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCDC80:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877342CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC80
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC80

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608298    OMIM disorders: --

    7 diseases for CCDC80:    About MalaCards
    atopic dermatitis    dermatitis    obesity    pancreatic cancer
    pancreatitis    prostate cancer    prostatitis


    CCDC80 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC80

    Export disorders for CCDC80 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC80 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CCDC80)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. URB expression in human bone marrow stromal cells and during mouse development. (PubMed id 15325258)1, 2, 3 Liu Y.... Castagnola P. (Biochem. Biophys. Res. Commun. 2004)
    2. URB is abundantly expressed in adipose tissue and dysregulated in obesity. (PubMed id 18178152)1, 3, 9 Okada T....Funahashi T. (Biochem. Biophys. Res. Commun. 2008)
    3. DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. (PubMed id 15563452)1, 2 Bommer G.T.... Kolligs F.T. (J. Biol. Chem. 2005)
    4. URB expression in human dermal papilla cells. (PubMed id 15998583)1, 2 Cha S.-Y.... Kim J.C. (J. Dermatol. Sci. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells. (PubMed id 23831687)1 Wang G.R....Blanton R.M. (J. Biol. Chem. 2013)
    8. Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis. (PubMed id 23666966)1 Ferraro A....Fusco A. (J. Clin. Endocrinol. Metab. 2013)
    9. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)4 Tao S....Sun J. (Carcinogenesis 2012)
    10. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (PubMed id 23042114)1 Hirota T....Tamari M. (Nat. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 151887 HGNC: 30649 AceView: URB Ensembl:ENSG00000091986 euGenes: HUgn151887
    ECgene: CCDC80 H-InvDB: CCDC80

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCDC80 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC80 gene:
    Search GeneIP for patents involving CCDC80

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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