Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCDC8 Gene

protein-coding   GIFtS: 50
GCID: GC19M046914

Coiled-Coil Domain Containing 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Coiled-Coil Domain Containing 81 2     PPP1R202
3M32 5     Coiled-Coil Domain-Containing Protein 82
Protein Phosphatase 11     p902
Regulatory Subunit 201     Protein Phosphatase 1, Regulatory Subunit 202

External Ids:    HGNC: 253671   Entrez Gene: 839872   Ensembl: ENSG000001695157   OMIM: 6141455   UniProtKB: Q9H0W53   

Export aliases for CCDC8 gene to outside databases

Previous GC identifers: GC00U914333 GC19M051606 GC19M051607 GC19M043345


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCDC8 Gene:
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required
for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the
cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3).
(provided by RefSeq, Dec 2011)

GeneCards Summary for CCDC8 Gene:
CCDC8 (coiled-coil domain containing 8) is a protein-coding gene. Diseases associated with CCDC8 include three m syndrome 3, and 3-m syndrome, ccdc8-related.

Gene Wiki entry for CCDC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC8 gene promoter:
         NRSF form 1   Nkx2-5   NRSF form 2   AP-2gamma   Ik-2   HSF2   AP-2beta   AP-2alpha   Hlf   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC8 promoter sequence
   Search Chromatin IP Primers for CCDC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.33

CCDC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046914:  view genomic region     (about GC identifiers)

Start:
46,913,586 bp from pter      End:
46,916,919 bp from pter
Size:
3,334 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCDC8_HUMAN, Q9H0W5 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 8  
Size: 538 amino acids; 59374 Da
Subunit: Interacts with OBSL1
1 PDB 3D structure from and Proteopedia for CCDC8:
4LG6 (3D)    
Secondary accessions: Q8TB26

Explore the universe of human proteins at neXtProt for CCDC8: NX_Q9H0W5

Explore proteomics data for CCDC8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114429.2  
    ENSEMBL proteins: 
     ENSP00000303158  

    CCDC8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CCDC8
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCDC8
    GenScript Custom Purified and Recombinant Proteins Services for CCDC8
    Novus Biologicals CCDC8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC8

    CCDC8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCDC8
    Novus Biologicals CCDC8 Antibodies
    Abcam antibodies for CCDC8
    Cloud-Clone Corp. Antibodies for CCDC8
    ThermoFisher Antibodies for CCDC8
    LSBio Antibodies in human, mouse, rat for CCDC8

    CCDC8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCDC8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCDC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCDC8
    Cloud-Clone Corp. CLIAs for CCDC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    2 InterPro protein domains:
     IPR026523 PNMA
     IPR026526 Coiled-coil_p8

    Graphical View of Domain Structure for InterPro Entry Q9H0W5

    ProtoNet protein and cluster: Q9H0W5


    CCDC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC8:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC8

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCDC8:
    hsa-mir-193a-3p (MIRT044884)

    Block miRNA regulation of human, mouse, rat CCDC8 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CCDC8:
    hsa-miR-3173-3p hsa-miR-204 hsa-miR-1291 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidCCDC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCDC8
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCDC8

    Clone
    Products:
         
    OriGene clones in human, mouse for CCDC8 (see all 6)
    OriGene ORF clones in mouse, rat for CCDC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC8 (NM_006848)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCDC8
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--

    CCDC8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC8
    Interactions:

        Search GeneGlobe Interaction Network for CCDC8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for CCDC8 (Q9H0W52 ENSP000003031584) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW8Q8N3Y12, ENSP000003106864MINT-8415355 STRING: ENSP00000310686
    TP53P046372, ENSP000002693054MINT-8415355 STRING: ENSP00000269305
    BAG2O958162MINT-8415355
    BAG6P463792MINT-8415355
    CCT2P783712MINT-8415355
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010923negative regulation of phosphatase activity IDA19389623

    CCDC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCDC8 gene: 
    NM_032040.4  

    Unigene Cluster for CCDC8:

    Coiled-coil domain containing 8
    Hs.97876  [show with all ESTs]
    Unigene Representative Sequence: NM_032040
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000307522(uc002pep.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCDC8 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CCDC8:
    hsa-miR-3173-3p hsa-miR-204 hsa-miR-1291 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidCCDC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCDC8
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC8
    Clone
    Products:
         
    OriGene clones in human, mouse for CCDC8 (see all 6)
    OriGene ORF clones in mouse, rat for CCDC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC8 (NM_006848)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCDC8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC8
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC8
      QuantiFast Probe-based Assays in human, mouse, rat CCDC8

    Additional mRNA sequence: 

    AK297668.1 AL136609.1 BC015648.2 BC025243.1 JN703457.1 

    3 DOTS entries:

    DT.103092  DT.92420913  DT.100674192 

    Selected AceView cDNA sequences (see all 73):

    AI910716 BX096201 AA402930 AI888642 AA639998 BC015648 AA446559 BC025243 
    AI678256 AI867969 AI682276 BU844431 BX380957 BF437168 AA459285 AW572293 
    BF477713 AI301367 BG717344 NM_032040 AI970823 AW273847 AW589945 AA459514 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCDC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGGGCTC
    CCDC8 Expression
    About this image

    CCDC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97876

    UniProtKB/Swiss-Prot: CCDC8_HUMAN, Q9H0W5
    Tissue specificity: Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver

        Custom PCR Arrays for CCDC8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCDC8
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC8
    QuantiTect SYBR Green Assays in human, mouse, rat CCDC8
    QuantiFast Probe-based Assays in human, mouse, rat CCDC8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CCDC8 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc81 , 5 coiled-coil domain containing 81, 5 73.29(n)1
    62.88(a)1
      7 (9.15 cM)5
    4341301  NM_001101535.11  NP_001095005.11 
     169927085 


    ENSEMBL Gene Tree for CCDC8 (if available)
    TreeFam Gene Tree for CCDC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CCDC8 (see all 201)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs794600101,2
    C--46913109(+) AAAAG-/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2008338061,2
    C--46913154(+) AGCCTC/TTTTTT 1 -- ds50010--------
    rs129830671,2
    C--46913200(+) TCACTC/GTGTCA 1 -- ds50016Minor allele frequency- G:0.08NA WA CSA 12
    rs1871667911,2
    --46913366(+) CACCAC/TGTTGG 1 -- ds50010--------
    rs1928204211,2
    --46913370(+) ACGTTA/GGCCAG 1 -- ds50010--------
    rs1852504461,2
    --46913395(+) CTTGAC/TCTCGT 1 -- ds50010--------
    rs739424211,2
    C,F--46913532(+) GTTGCG/CCAGAT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1901015651,2
    --46913584(+) GCACCA/GCTAGC 1 -- ds50010--------
    rs104125511,2
    C,F,A,H--46913749(+) CAAGCG/AAAGTG 1 -- ut3120Minor allele frequency- A:0.20NS EA NA WA CSA 2343
    rs1381059421,2
    C--46913811(+) GCAAGA/GGCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC8 (46913586 - 46916919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCDC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912185CNV Loss21882294
    nsv912184CNV Gain21882294

    Human Gene Mutation Database (HGMD): CCDC8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC8
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614145   
    OMIM disorders: 614205  
    UniProtKB/Swiss-Prot: CCDC8_HUMAN, Q9H0W5
  • 3M syndrome 3 (3M3) [MIM:614205]: A disorder characterized by poor postnatal growth and distinctive
    facial features, including triangular facies, frontal bossing, fleshy tipped nose, and fleshy lips. Other
    features may include skeletal anomalies and prominent heels. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 6 diseases for CCDC8:    
    About MalaCards
    three m syndrome 3    3-m syndrome, ccdc8-related    3-m syndrome    multiple myeloma
    thyroiditis    myeloma


    CCDC8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC8

    Export disorders for CCDC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCDC8 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CCDC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Exome sequencing identifies CCDC8 mutations in 3-M syndrome, Suggesting that CCDC8 Contributes in a Pathway with CUL7 and OBSL1 to Control Human Growth. (PubMed id 21737058)1, 2 Hanson D.... Black G.C. (Am. J. Hum. Genet. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling. (PubMed id 23018678)1 Hanson D....Clayton P.E. (J. Mol. Endocrinol. 2012)
    7. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. (PubMed id 21572988)1 Litterman N.... Bonni A. (PLoS Biol. 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. (PubMed id 22084066)1 Dai C.... Gu W. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    10. The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway. (PubMed id 22156540)1 Hanson D....Clayton P.E. (Horm Res Paediatr 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83987 HGNC: 25367 AceView: CCDC8 Ensembl:ENSG00000169515 euGenes: HUgn83987
    ECgene: CCDC8 H-InvDB: CCDC8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCDC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCDC8 gene:
    Search GeneIP for patents involving CCDC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCDC8  
     OriGene qPCR primer pairs and template standards for CCDC8   OriGene Protein Over-expression Lysate for CCDC8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCDC8  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCDC8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCDC8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCDC8   OriGene Custom Protein Services for CCDC8  

     
     
     Block miRNA regulation of human, mouse, rat CCDC8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCDC8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC8 Predesigned siRNA for gene silencing in human, mouse, rat CCDC8
     QuantiFast Probe-based Assays in human, mouse, rat CCDC8 QuantiTect SYBR Green Assays in human, mouse, rat CCDC8
     Custom PCR Arrays for CCDC8 Search Chromatin IP Primers for CCDC8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC8  Search GeneGlobe Interaction Network for CCDC8
     Regulatory tfbs in CCDC8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CCDC8 GenScript cDNA clones with any tag delivered in your preferred vector for CCDC8
     GenScript Custom Assay Services for CCDC8 GenScript Custom overexpressing Cell Line Services for CCDC8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CCDC8
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCDC8 antibodies
     CCDC8 lysates
     Antibodies for CCDC8
     See all of Abcam's Antibodies, Kits and Proteins for CCDC8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CCDC8
     Antibodies for CCDC8
     ELISAs for CCDC8
     CLIAs for CCDC8



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC8
     SwitchGear 3'UTR luciferase reporter plasmids for CCDC8
     SwitchGear Promoter luciferase reporter plasmids for CCDC8
     ThermoFisher Antibodies for CCDC8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC8
     LSBio Antibodies in human, mouse, rat for CCDC8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCDC8 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4