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Aliases for CCDC79 Gene

Aliases for CCDC79 Gene

  • Coiled-Coil Domain Containing 79 2 3
  • Coiled-Coil Domain-Containing Protein 79 4
  • TERB1 4

External Ids for CCDC79 Gene

Previous GeneCards Identifiers for CCDC79 Gene

  • GC16M065346
  • GC16M052664

Summaries for CCDC79 Gene

GeneCards Summary for CCDC79 Gene

CCDC79 (Coiled-Coil Domain Containing 79) is a Protein Coding gene. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for CCDC79 Gene

  • Meiosis-specific telomere-associated protein involved in meiotic telomere clustering, also named bouquet formation, the telomere-mediated chromosomal movement along the nuclear envelope which is crucial for homologous pairing and synapsis. Probably acts as a hub for the assembly of a conserved meiotic telomere complex required for chromosome movements via interaction with TERF1. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC79 Gene

Genomics for CCDC79 Gene

Regulatory Elements for CCDC79 Gene

Genomic Location for CCDC79 Gene

Start:
66,754,596 bp from pter
End:
66,801,620 bp from pter
Size:
47,025 bases
Orientation:
Minus strand

Genomic View for CCDC79 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC79 Gene

Proteins for CCDC79 Gene

  • Protein details for CCDC79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA31-TERB1_HUMAN
    Recommended name:
    Telomere repeats-binding bouquet formation protein 1
    Protein Accession:
    Q8NA31
    Secondary Accessions:
    • A0AUW1

    Protein attributes for CCDC79 Gene

    Size:
    727 amino acids
    Molecular mass:
    83064 Da
    Quaternary structure:
    • Interacts with TERF1, STAG3 and SUN1. Interacts (via Myb-like domain) with the cohesin complex; probably mediated via interaction with STAG3 (By similarity).

    Alternative splice isoforms for CCDC79 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC79 Gene

Proteomics data for CCDC79 Gene at MOPED

Post-translational modifications for CCDC79 Gene

  • Phosphorylation by some CDK protein impairs telomeres localization and interaction with TERF1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC79 Gene

No data available for DME Specific Peptides for CCDC79 Gene

Domains for CCDC79 Gene

Protein Domains for CCDC79 Gene

Suggested Antigen Peptide Sequences for CCDC79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NA31

UniProtKB/Swiss-Prot:

TERB1_HUMAN :
  • Q8NA31
Domain:
  • Contains 1 Myb-like domain.
Family:
  • Belongs to the TERB1 family.
Similarity:
  • Contains 2 ARM repeats.
genes like me logo Genes that share domains with CCDC79: view

No data available for Gene Families for CCDC79 Gene

Function for CCDC79 Gene

Molecular function for CCDC79 Gene

UniProtKB/Swiss-Prot Function: Meiosis-specific telomere-associated protein involved in meiotic telomere clustering, also named bouquet formation, the telomere-mediated chromosomal movement along the nuclear envelope which is crucial for homologous pairing and synapsis. Probably acts as a hub for the assembly of a conserved meiotic telomere complex required for chromosome movements via interaction with TERF1. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity (By similarity).

Gene Ontology (GO) - Molecular Function for CCDC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CCDC79: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC79

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC79 Gene

Localization for CCDC79 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC79 Gene

Chromosome, telomere. Note=Localizes to telomeres during meiotic prophase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC79 Gene COMPARTMENTS Subcellular localization image for CCDC79 gene
Compartment Confidence
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region ISS --
genes like me logo Genes that share ontologies with CCDC79: view

Pathways for CCDC79 Gene

SuperPathways for CCDC79 Gene

No Data Available

Interacting Proteins for CCDC79 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000462883%0d%0a9606.ENSP00000319318%0d%0a9606.ENSP00000323421%0d%0a9606.ENSP00000350036%0d%0a
Selected Interacting proteins: ENSP00000462883 for CCDC79 Gene via STRING

Gene Ontology (GO) - Biological Process for CCDC79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007129 synapsis ISS --
GO:0045141 meiotic telomere clustering ISS --
genes like me logo Genes that share ontologies with CCDC79: view

No data available for Pathways by source for CCDC79 Gene

Transcripts for CCDC79 Gene

mRNA/cDNA for CCDC79 Gene

(19) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(0) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC79 Gene

Coiled-coil domain containing 79:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC79

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CCDC79
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC79 Gene

No ASD Table

Relevant External Links for CCDC79 Gene

GeneLoc Exon Structure for
CCDC79
ECgene alternative splicing isoforms for
CCDC79

Expression for CCDC79 Gene

mRNA expression in normal human tissues for CCDC79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC79 Gene

This gene is overexpressed in Testis (44.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC79 Gene

SOURCE GeneReport for Unigene cluster for CCDC79 Gene Hs.376505

genes like me logo Genes that share expressions with CCDC79: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC79 Gene

Orthologs for CCDC79 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC79 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC79 35
  • 99.4 (n)
  • 99.31 (a)
CCDC79 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC79 35
  • 90.71 (n)
  • 85.02 (a)
CCDC79 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC79 35
  • 90.66 (n)
  • 86.55 (a)
CCDC79 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc79 35
  • 82.8 (n)
  • 71.84 (a)
Ccdc79 16
Ccdc79 36
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC79 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc79 35
  • 81.9 (n)
  • 71.33 (a)
chicken
(Gallus gallus)
Aves CCDC79 35
  • 65.44 (n)
  • 53.38 (a)
CCDC79 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC79 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc79 35
  • 57.74 (n)
  • 47.45 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc79 35
  • 51.48 (n)
  • 44.24 (a)
ccdc79 36
  • 32 (a)
OneToOne
Species with no ortholog for CCDC79:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC79 Gene

ENSEMBL:
Gene Tree for CCDC79 (if available)
TreeFam:
Gene Tree for CCDC79 (if available)

Paralogs for CCDC79 Gene

No data available for Paralogs for CCDC79 Gene

Variants for CCDC79 Gene

Sequence variations from dbSNP and Humsavar for CCDC79 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs171203 -- 66,789,501(+) atggc(A/G)tgaac intron-variant
rs171204 -- 66,789,533(+) gagcc(A/G)agatc intron-variant
rs171205 -- 66,789,555(+) ctcca(A/G)cctgg intron-variant
rs171206 -- 66,789,573(+) agcga(A/G)actcc intron-variant
rs181757 -- 66,789,450(+) gtggt(A/G)gcggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC79 Gene

Variant ID Type Subtype PubMed ID
nsv906786 CNV Loss 21882294
dgv2885n71 CNV Loss 21882294
esv1727322 CNV Deletion 17803354
esv2579855 CNV Deletion 19546169
esv1974003 CNV Deletion 18987734
esv2714645 CNV Deletion 23290073
nsv103310 CNV Loss 16902084
esv8216 CNV Loss 19470904
esv1025546 CNV Deletion 17803354

Relevant External Links for CCDC79 Gene

HapMap Linkage Disequilibrium report
CCDC79

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC79 Gene

Disorders for CCDC79 Gene

No disorders were found for CCDC79 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC79 Gene

Publications for CCDC79 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC79 Gene

Sources for CCDC79 Gene

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