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CCDC78 Gene

protein-coding   GIFtS: 45
GCID: GC16M000772

Coiled-Coil Domain Containing 78


(Previous symbol: C16orf25)
  See CCDC78-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Coiled-Coil Domain Containing 781 2
C16orf251 2 3 5
hsCCDC782 3
CNM42 5
JFP102
Coiled-Coil Domain-Containing Protein 782

External Ids:    HGNC: 141531   Entrez Gene: 1240932   Ensembl: ENSG000001620047   OMIM: 6146665   UniProtKB: A2IDD53   
ORGUL members:         

Export aliases for CCDC78 gene to outside databases

Previous GC identifers: GC16M000713 GC16M000694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCDC78 Gene:
The product of this gene contains two coiled-coil domains. The function of this gene is currently unknown.
(provided by RefSeq, Sep 2012)

GeneCards Summary for CCDC78 Gene:
CCDC78 (coiled-coil domain containing 78) is a protein-coding gene. Diseases associated with CCDC78 include centronuclear myopathy 4.

UniProtKB/Swiss-Prot: CCD78_HUMAN, A2IDD5
Function: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated
cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in
terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification
and is required for CEP152 localization to the deuterosome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC78 gene promoter:
         Max1   USF1   AML1a   XBP-1   c-Ets-1   USF-1   Zic1   ZID   Zic3   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC78 promoter sequence
   Search Chromatin IP Primers for CCDC78

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC78


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CCDC78 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC78 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000772:  view genomic region     (about GC identifiers)

Start:
772,582 bp from pter      End:
776,954 bp from pter
Size:
4,373 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCD78_HUMAN, A2IDD5 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 78  
Size: 438 amino acids; 48521 Da
Sequence caution: Sequence=AAK61249.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DNY4 B4E1U6 Q05BY7 Q05CA0 Q6T2V5 Q6ZR33 Q8IUR3 Q8NAY7 Q96S12
Alternative splicing: 6 isoforms:  A2IDD5-1   A2IDD5-2   A2IDD5-3   A2IDD5-4   A2IDD5-5   A2IDD5-6   (Due to intron retention)

Explore the universe of human proteins at neXtProt for CCDC78: NX_A2IDD5

Explore proteomics data for CCDC78 at MOPED


See CCDC78 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001026907.2  
ENSEMBL proteins: 
 ENSP00000316851   ENSP00000293889   ENSP00000458590  

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antibodies-online proteins for CCDC78 (3 products) 

 
antibodies-online peptides for CCDC78

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: A2IDD5

UniProtKB/Swiss-Prot: CCD78_HUMAN, A2IDD5
Similarity: Belongs to the CCDC78 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CCD78_HUMAN, A2IDD5
Function: Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated
cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in
terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification
and is required for CEP152 localization to the deuterosome

Animal Models:

   genOway: Develop your customized and physiologically relevant rodent model for CCDC78

miRNA
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Block miRNA regulation of human, mouse, rat CCDC78 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate CCDC78:
hsa-miR-516a-3p hsa-miR-516b*
SwitchGear 3'UTR luciferase reporter plasmidCCDC78 3' UTR sequence
Inhib. RNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CCD78_HUMAN, A2IDD5: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
perinuclear region. Cell membrane, sarcolemma. Sarcoplasmic reticulum. Note=Localizes to centrioles and
deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular
pattern within the sarcoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane5
cytosol4
nucleus3

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005814centriole IDA--
GO:0016529sarcoplasmic reticulum IDA--
GO:0042383sarcolemma IDA--
GO:0048471perinuclear region of cytoplasm IDA--

Find genes that share ontologies with CCDC78           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC78
Interactions:

    Search GeneGlobe Interaction Network for CCDC78

1 Interacting protein for CCDC78 (A2IDD53) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MEF2DQ148143I2D: score=2 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003009skeletal muscle contraction IMP--
GO:0030030cell projection organization IEA--
GO:0098535de novo centriole assembly IDA--

Find genes that share ontologies with CCDC78           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CCDC78 (CCD78)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCDC78 gene (2 alternative transcripts): 
NM_173476.2  NM_001031737.2  

Unigene Cluster for CCDC78:

Coiled-coil domain containing 78
Hs.381943  [show with all ESTs]
Unigene Representative Sequence: BC042110
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000345165 ENST00000485091 ENST00000463539 ENST00000482878(uc002cji.3 uc002cjj.3)
ENST00000293889(uc002cjg.3) ENST00000478979 ENST00000481804 ENST00000466708(uc002cjh.3)
ENST00000482152 ENST00000538176 ENST00000439619 ENST00000460023 ENST00000423653
ENST00000544996 ENST00000471861 ENST00000474647
miRNA
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2 qRT-PCR Assays for microRNAs that regulate CCDC78:
hsa-miR-516a-3p hsa-miR-516b*
SwitchGear 3'UTR luciferase reporter plasmidCCDC78 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector: CCDC78 (NM_001031737)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC78
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC78
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat CCDC78

Additional mRNA sequence: 

AK298111.1 AK303991.1 BC042110.1 

8 DOTS entries:

DT.100748569  DT.97839003  DT.120675921  DT.101982722  DT.91814836  DT.101982724  DT.40316695  DT.95371160 

Selected AceView cDNA sequences (see all 40):

BX110503 BM783343 BM700306 AX747208 BM976018 AK091831 AK128575 BM670493 
BI772239 BC027941 CR617330 AW264810 BC042110 AI811221 BE261598 BM753602 
BX354163 BI919228 AI683704 BC031561 AK127495 CB110352 BI769503 BM747436 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CCDC78 (see all 13)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a ·
SP1:                                                                                                                                                  -         
SP2:                                                                                      -     -                                                     -         
SP3:                          -     -     -     -     -     -                             -     -                                                     -         
SP4:                          -     -     -     -     -     -                             -     -                                                               
SP5:                                                                                      -     -                                                               

ExUns: 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:                                                            
SP2:                                                            
SP3:                                                            
SP4:                                                            
SP5:                                                            


ECgene alternative splicing isoforms for CCDC78

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCDC78 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTCAGGATA
CCDC78 Expression
About this image

CCDC78 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCDC78 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.381943

UniProtKB/Swiss-Prot: CCD78_HUMAN, A2IDD5
Tissue specificity: Expressed primarily in skeletal muscle

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC78

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCDC78 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccdc781 , 5 coiled-coil domain containing 781, 5 70.46(n)1
60.28(a)1
  17 (12.89 cM)5
3810771  NM_001165929.11  NP_001159401.11 
 257865805 
chicken
(Gallus gallus)
Aves --
--
Uncharacterized protein
25(a)
20(a)
many → 1
many → 1
14(13176209-13187353)
14(13187748-13193170)
lizard
(Anolis carolinensis)
Reptilia CCDC786
coiled-coil domain containing 78
35(a)
1 ↔ 1
GL343518.1(525477-543048)
zebrafish
(Danio rerio)
Actinopterygii ccdc786
coiled-coil domain containing 78
19(a)
1 ↔ 1
24(39405701-39424954) ENSDARG00000030095


ENSEMBL Gene Tree for CCDC78 (if available)
TreeFam Gene Tree for CCDC78 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCDC78 (see all 301)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2016794371,2
C--700185(+) GCCCCA/CCGAGA 1 -- us2k10--------
rs2002483671,2
C--700230(+) GTGGGC/TACAGC 1 -- us2k10--------
rs609822071,2
C,F--700361(+) GCGCTC/TACCGA 1 -- us2k11Minor allele frequency- T:0.14WA 118
rs2020494521,2
--700365(+) TCACCA/GAGCGC 1 -- us2k10--------
rs3704674861,2
C--700372(+) GCGCTC/TTCCTC 1 -- us2k10--------
rs1468784541,2
C,F--709512(+) TGGCCC/TCTAGC 1 -- ds50011Minor allele frequency- T:0.00NA 3510
rs118670091,2
C,F,A,H--709527(+) TAGGTC/GCGGGG 1 -- ds500112Minor allele frequency- G:0.40NA EA WA EU 1018
rs1113102561,2
C,F--709627(+) CTAGGG/AGGGTG 1 -- ds50012Minor allele frequency- A:0.05CSA WA 119
rs1910391171,2
C--709649(+) TTTCTA/GCCGGC 1 -- ds50010--------
rs1148942081,2
F--709693(+) CCCTCA/CGCTCC 1 -- ds50011Minor allele frequency- C:0.01WA 118

HapMap Linkage Disequilibrium report for CCDC78 (772582 - 776954 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CCDC78 (see all 23):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
dgv2475n71CNV Loss21882294
nsv904707CNV Loss21882294
nsv904796CNV Loss21882294
dgv2492n71CNV Loss21882294
dgv2497n71CNV Loss21882294
nsv904797CNV Loss21882294
dgv2495n71CNV Loss21882294
nsv904812CNV Loss21882294
nsv904759CNV Loss21882294

Human Gene Mutation Database (HGMD): CCDC78
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CCDC78
DNA2.0 Custom Variant and Variant Library Synthesis for CCDC78

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614666   
OMIM disorders: 614807  
UniProtKB/Swiss-Prot: CCD78_HUMAN, A2IDD5
  • Myopathy, centronuclear, 4 (CNM4) [MIM:614807]: A congenital muscle disorder characterized by progressive
    muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal
    muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade
    of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high
    frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of
    sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for CCDC78:    
    About MalaCards
    centronuclear myopathy 4


    Find genes that share disorders with CCDC78           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: CCDC78 (1 document)

    Export disorders for CCDC78 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC78 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC78)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deuterosome-mediated centriole biogenesis. (PubMed id 24075808)1, 2, 3 Klos Dehring D.A....Mitchell B.J. (Dev. Cell 2013)
    2. Dominant mutation of ccdc78 in a unique congenital myopathy with prominent internal nuclei and atypical cores. (PubMed id 22818856)1, 2 Majczenko K.... Dowling J.J. (Am. J. Hum. Genet. 2012)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    5. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124093 HGNC: 14153 AceView: FLJ34512 Ensembl:ENSG00000162004 euGenes: HUgn124093
    ECgene: CCDC78 H-InvDB: CCDC78

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CCDC78 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC78 gene:
    Search GeneIP for patents involving CCDC78

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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