Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC77 Gene

Aliases for CCDC77 Gene

  • Coiled-Coil Domain Containing 77 2 3 5

External Ids for CCDC77 Gene

Previous GeneCards Identifiers for CCDC77 Gene

  • GC12P000498

Summaries for CCDC77 Gene

GeneCards Summary for CCDC77 Gene

CCDC77 (Coiled-Coil Domain Containing 77) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC77 Gene

Genomics for CCDC77 Gene

Regulatory Elements for CCDC77 Gene

Enhancers for CCDC77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F000386 0.2 ENCODE 27.1 -0.8 -780 4.0 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CCDC77 ENSG00000250132 ENSG00000255825 DDX11L8 KDM5A ENSG00000261799 PIR47780
GH12F000406 1.1 VISTA Ensembl ENCODE 18.5 +18.6 18556 3.3 ATF1 ARNT GLI4 BRCA1 ZNF2 GATA2 FOS NCOA1 SMARCB1 MAFF CCDC77 B4GALNT3 SLC6A13 LOC102723544 LOC105369594 PIR37877
GH12F000264 0.5 Ensembl 9.5 -125.4 -125373 0.2 MGA KDM5A CCDC77 SLC6A13 LOC102723544
GH12F000464 1.2 FANTOM5 ENCODE 5.9 +76.2 76207 1.8 SOX13 SAP130 RARA ZFHX2 NR2F6 ZNF600 CREM ZBTB20 EGR2 GATAD2A B4GALNT3 CCDC77 PIR35231 GC12P000495
GH12F000684 1.5 FANTOM5 Ensembl ENCODE 4.5 +296.2 296212 3.0 HDGF HDAC1 PKNOX1 MXI1 ASH2L CEBPG BMI1 ZNF2 POLR2A CREM CCDC77 KDM5A GC12M000680 GC12M000677 PIR42004
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC77 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC77 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000086289 -773 3801 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for CCDC77 Gene

389,273 bp from pter
442,645 bp from pter
53,373 bases
Plus strand

Genomic View for CCDC77 Gene

Genes around CCDC77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC77 Gene

Proteins for CCDC77 Gene

  • Protein details for CCDC77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 77
    Protein Accession:
    Secondary Accessions:
    • B4DDE8

    Protein attributes for CCDC77 Gene

    488 amino acids
    Molecular mass:
    57486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC77 Gene


neXtProt entry for CCDC77 Gene

Post-translational modifications for CCDC77 Gene

  • Ubiquitination at Lys 193, Lys 440, and Lys 477
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC77 Gene

Domains & Families for CCDC77 Gene

Protein Domains for CCDC77 Gene


Suggested Antigen Peptide Sequences for CCDC77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC77: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC77 Gene

Function for CCDC77 Gene

genes like me logo Genes that share phenotypes with CCDC77: view

Animal Models for CCDC77 Gene

MGI Knock Outs for CCDC77:

Animal Model Products

miRNA for CCDC77 Gene

miRTarBase miRNAs that target CCDC77

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC77 Gene

Localization for CCDC77 Gene

Subcellular locations from

Jensen Localization Image for CCDC77 Gene COMPARTMENTS Subcellular localization image for CCDC77 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC77 Gene

Pathways & Interactions for CCDC77 Gene

SuperPathways for CCDC77 Gene

No Data Available

Interacting Proteins for CCDC77 Gene

Gene Ontology (GO) - Biological Process for CCDC77 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC77 Gene

Transcripts for CCDC77 Gene

Unigene Clusters for CCDC77 Gene

Coiled-coil domain containing 77:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC77 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CCDC77 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC77 Gene

This gene is overexpressed in Blymphocyte (37.6) and Testis (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC77 Gene

Protein tissue co-expression partners for CCDC77 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC77 Gene:


SOURCE GeneReport for Unigene cluster for CCDC77 Gene:

genes like me logo Genes that share expression patterns with CCDC77: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC77 Gene

Orthologs for CCDC77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC77 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC77 34 35
  • 93.88 (n)
(Canis familiaris)
Mammalia CCDC77 34 35
  • 88.46 (n)
(Mus musculus)
Mammalia Ccdc77 34 16 35
  • 82.41 (n)
(Rattus norvegicus)
Mammalia Ccdc77 34
  • 82.37 (n)
(Bos Taurus)
Mammalia CCDC77 34 35
  • 81.01 (n)
(Monodelphis domestica)
Mammalia CCDC77 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC77 35
  • 55 (a)
(Gallus gallus)
Aves CCDC77 34 35
  • 64.75 (n)
(Anolis carolinensis)
Reptilia CCDC77 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc77 34
  • 61.61 (n)
Str.11464 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7566 34
(Danio rerio)
Actinopterygii ccdc77 34 35
  • 60.89 (n)
Dr.10395 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.479 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11775 34
Species where no ortholog for CCDC77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC77 Gene

Gene Tree for CCDC77 (if available)
Gene Tree for CCDC77 (if available)

Paralogs for CCDC77 Gene

No data available for Paralogs for CCDC77 Gene

Variants for CCDC77 Gene

Sequence variations from dbSNP and Humsavar for CCDC77 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10047594 -- 397,061(+) GCCAC(A/G)TGTAA intron-variant
rs10082788 -- 410,627(+) acttg(A/G)acctg intron-variant
rs10160995 -- 416,030(+) tgaac(A/G)cctga intron-variant
rs10161265 -- 416,190(+) cccac(C/T)ttaac intron-variant
rs1048462 -- 442,123(+) TCCTT(C/T)TAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC77 Gene

Variant ID Type Subtype PubMed ID
dgv2243n54 CNV loss 21841781
dgv2244n54 CNV loss 21841781
dgv2245n54 CNV loss 21841781
dgv2246n54 CNV loss 21841781
dgv738e59 CNV duplication 20981092
dgv746n106 CNV duplication 24896259
esv1001309 CNV insertion 20482838
esv1005158 CNV gain 20482838
esv1225237 CNV deletion 17803354
esv1463722 CNV deletion 17803354
esv1479845 CNV deletion 17803354
esv1623775 CNV deletion 17803354
esv2009381 CNV deletion 18987734
esv2160803 CNV deletion 18987734
esv2313112 CNV deletion 18987734
esv2403049 CNV deletion 18987734
esv2665030 CNV deletion 23128226
esv2676807 CNV deletion 23128226
esv2745349 CNV deletion 23290073
esv2745350 CNV deletion 23290073
esv2745351 CNV deletion 23290073
esv2745353 CNV deletion 23290073
esv2759875 CNV gain+loss 17122850
esv29798 CNV loss 19812545
esv3628232 CNV gain 21293372
esv3628233 CNV loss 21293372
esv3628234 CNV gain 21293372
esv3628235 CNV loss 21293372
esv3628236 CNV gain 21293372
esv3892121 CNV gain 25118596
esv988269 CNV deletion 20482838
nsv1050781 CNV loss 25217958
nsv1069630 CNV deletion 25765185
nsv442250 CNV gain 18776908
nsv509448 CNV insertion 20534489
nsv514668 CNV gain 21397061
nsv571 CNV insertion 18451855
nsv8884 CNV gain+loss 18304495
nsv975433 CNV duplication 23825009

Variation tolerance for CCDC77 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC77 Gene

Disorders for CCDC77 Gene

Relevant External Links for CCDC77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC77 Gene

Publications for CCDC77 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CCDC77 Gene

Sources for CCDC77 Gene

Loading form....