CCDC77 Gene
protein-coding GIFtS : 39
GCID: GC12 P000498
coiled-coil domain containing 77
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Aliasesfor CCDC77 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coiled-Coil Domain Containing 77 1 2 MGC131831 Coiled-Coil Domain-Containing Protein 772
Export aliases for CCDC77 gene to outside databases Previous GC identifer: GC12P000382
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Summariesfor CCDC77 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CCDC77 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009759.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCDC77 gene promoter: Pax-2b HNF-1 Pax-2 Pax-2a STAT5A HNF-1A Other transcription factors Search SABiosciences Chromatin IP Primers for CCDC77 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CCDC77
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33 CCDC77 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P000498: view genomic region
(about GC identifiers )
Start:
498,439 bp from pter
End:
551,811 bp from pter
Size:
53,373 bases
Orientation:
plus strand
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Proteinsfor CCDC77 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CCD77_HUMAN, Q9BR77 (See
protein sequence )Recommended Name: Coiled-coil domain-containing protein 77 Size : 488 amino acids; 57486 Da
Secondary accessions : B4DDE8Alternative splicing : 2 isoforms : Q9BR77-1 Q9BR77-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC77: NX_Q9BR77 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BR77 CCDC77 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (4 alternative transcripts):
NP_001123618.1 NP_001123619.1 NP_001123620.1 NP_115734.1 ENSEMBL proteins: ENSP00000440554 ENSP00000443209 ENSP00000445873 ENSP00000239830 ENSP00000412925 ENSP00000391870 Human Recombinant Protein Products for CCDC77: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005813 centrosome
IDA --
CCDC77 for ontologies About GeneDecksing CCDC77 Antibody Products: Assay Products for CCDC77:
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Protein
Domains / Familiesfor CCDC77 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9BR77
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Functionfor CCDC77 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): CCDC77 (NM_001130148 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC77 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC77
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC77
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Pathways & Interactionsfor CCDC77 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC77
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Drugs & Compoundsfor CCDC77 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCDC77 Search CenterWatch for drugs/clinical trials and news about CCDC77 / CCD77
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Transcriptsfor CCDC77 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCDC77 gene (4 alternative transcripts): NM_001130146.1 NM_001130147.1 NM_001130148.1 NM_032358.3 Unigene Cluster for CCDC77:
Coiled-coil domain containing 77 Hs.631656 [show with all ESTs ] Unigene Representative Sequence: NM_032358 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000537453 ENST00000540180 ENST00000535052 ENST00000543504 ENST00000540344 ENST00000239830 (uc001qig.3 uc010sdq.2 ) ENST00000412006 ENST00000535959 ENST00000538160 ENST00000540118 ENST00000537286 ENST00000422000 (uc009zdk.3 uc010sdp.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 (see all 4 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): CCDC77 (NM_001130148 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC77 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC77
Additional cDNA sequence: AK027638.1 AK293165.1 AK308216.1 AK316029.1 BC006444.2
11 DOTS entries : DT.101966026 DT.107833
DT.100780845 DT.40126887 DT.91642367 DT.121126389 DT.91865883 DT.95109351 DT.95367737 DT.95367738 DT.92044835 24/67 AceView cDNA sequences (see all 67 ):
BE409041 AW016181 BQ219143 BQ926887 AA935552 AI217359 BX099522 NM_032358 AA314683 BU508172 CR618406 AA296601 BC006444 AI761948 BI913313 CK002982 BQ071469 BQ691297 AI183999 CF127793 BE385672 BU624919 AA427453 AL559532 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC77 (see all 9 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 SP1 :                 -   -                           SP2 :                 -   -                           SP3 :       -           -   -                           SP4 :                 -   -         -   -                 SP5 :       -           -                            
ECgene alternative splicing isoforms for CCDC77
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Expression for CCDC77 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCDC77 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTTTTGAAAAbout this image CCDC77 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
See CCDC77 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCDC77 SOURCE GeneReport for Unigene cluster: Hs.631656 SABiosciences Custom PCR Arrays for CCDC77 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC77Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCDC77 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC77 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC77 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC77
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Orthologsfor CCDC77 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CCDC77 gene from 5/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Ccdc771 , 5
coiled-coil domain containing 771, 5
82.13(n) 1 82.68(a) 1
 
6 (56.95 cM) 5 67200 1 NM_026028.5 1 NP_080304.1 1 120324323 5
chicken (Gallus gallus)
Aves
CCDC771
coiled-coil domain containing 77
64.38(n) 61.2(a)
 
418149 XM_416380.3 XP_416380.1
lizard (Anolis carolinensis)
Reptilia
CCDC776
--
56(a)
1 ↔ 1
5(11937991-11950984)
African clawed frog (Xenopus laevis)
Amphibia
Xl.75662
Xenopus laevis transcribed sequence with weak similarity more
72.6(n)
 
BX852307.1
zebrafish (Danio rerio)
Actinopterygii
Dr.103952
Transcribed sequence with weak similarity to protein more
75.64(n)
 
BM037155.1
ENSEMBL Gene Tree for CCDC77 (if available)TreeFam Gene Tree for CCDC77 (if available)
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Paralogsfor CCDC77 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor CCDC77 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCDC77 (498439 - 551811 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 26 variations for CCDC77 15/20 CNVs (see all 20 ): 23442 86125 30572 31851 71421 86124 86126 75889 37675 75885 75886 75888 86128 35082 2965 6 Indels : 45049 45050 45047 25012 25011 25010
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC77
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Disorders
/ Diseasesfor CCDC77 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor CCDC77 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCDC77 gene integrated from 9 sources : (articles sorted by number of sources associating them with CCDC77) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 2 Scherer S.E.... Gibbs R.A. (2006)
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External Searches for CCDC77 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCDC77 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCDC77 gene
(According to HUGE )
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Specialized Databases showing CCDC77 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCDC77 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CCDC77 gene: Search GeneIP for patents involving CCDC77 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCDC77 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCDC77 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCDC77 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC77 OriGene Protein Over-expression Lysate for CCDC77 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCDC77 OriGene 3'-UTR Clone for CCDC77 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC77 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCDC77 OriGene Custom Protein Services for CCDC77 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC77 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC77 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CCDC77 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCDC77 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC77 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC77
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CCDC77 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC77
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC77
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