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Aliases for CCDC77 Gene

Aliases for CCDC77 Gene

  • Coiled-Coil Domain Containing 77 2 3 5

External Ids for CCDC77 Gene

Previous GeneCards Identifiers for CCDC77 Gene

  • GC12P000498

Summaries for CCDC77 Gene

GeneCards Summary for CCDC77 Gene

CCDC77 (Coiled-Coil Domain Containing 77) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC77 Gene

Genomics for CCDC77 Gene

Regulatory Elements for CCDC77 Gene

Enhancers for CCDC77 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC77 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC77 Gene

389,273 bp from pter
442,645 bp from pter
53,373 bases
Plus strand

Genomic View for CCDC77 Gene

Genes around CCDC77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC77 Gene

Proteins for CCDC77 Gene

  • Protein details for CCDC77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 77
    Protein Accession:
    Secondary Accessions:
    • B4DDE8

    Protein attributes for CCDC77 Gene

    488 amino acids
    Molecular mass:
    57486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC77 Gene


neXtProt entry for CCDC77 Gene

Proteomics data for CCDC77 Gene at MOPED

Post-translational modifications for CCDC77 Gene

  • Ubiquitination at Lys 193, Lys 440, and Lys 477
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC77 Gene

Domains & Families for CCDC77 Gene

Protein Domains for CCDC77 Gene


Suggested Antigen Peptide Sequences for CCDC77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC77: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC77 Gene

Function for CCDC77 Gene

genes like me logo Genes that share phenotypes with CCDC77: view

Animal Models for CCDC77 Gene

MGI Knock Outs for CCDC77:

Animal Model Products

miRNA for CCDC77 Gene

miRTarBase miRNAs that target CCDC77

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC77 Gene

Localization for CCDC77 Gene

Subcellular locations from

Jensen Localization Image for CCDC77 Gene COMPARTMENTS Subcellular localization image for CCDC77 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC77 Gene

Pathways & Interactions for CCDC77 Gene

SuperPathways for CCDC77 Gene

No Data Available

Interacting Proteins for CCDC77 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000239830 for CCDC77 Gene via STRING

Gene Ontology (GO) - Biological Process for CCDC77 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC77 Gene

Drugs & Compounds for CCDC77 Gene

No Compound Related Data Available

Transcripts for CCDC77 Gene

Unigene Clusters for CCDC77 Gene

Coiled-coil domain containing 77:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC77 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CCDC77 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC77 Gene

mRNA expression in normal human tissues for CCDC77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC77 Gene

This gene is overexpressed in Blymphocyte (37.6) and Testis (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC77 Gene

SOURCE GeneReport for Unigene cluster for CCDC77 Gene Hs.631656

genes like me logo Genes that share expression patterns with CCDC77: view

Protein tissue co-expression partners for CCDC77 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC77 Gene

Orthologs for CCDC77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC77 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC77 35
  • 81.01 (n)
  • 77.32 (a)
CCDC77 36
  • 74 (a)
(Canis familiaris)
Mammalia CCDC77 35
  • 88.46 (n)
  • 86.27 (a)
CCDC77 36
  • 85 (a)
(Mus musculus)
Mammalia Ccdc77 35
  • 82.41 (n)
  • 82.68 (a)
Ccdc77 16
Ccdc77 36
  • 81 (a)
(Pan troglodytes)
Mammalia CCDC77 35
  • 93.88 (n)
  • 92.31 (a)
CCDC77 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc77 35
  • 82.37 (n)
  • 82.02 (a)
(Monodelphis domestica)
Mammalia CCDC77 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC77 36
  • 55 (a)
(Gallus gallus)
Aves CCDC77 35
  • 64.75 (n)
  • 61.42 (a)
CCDC77 36
  • 58 (a)
(Anolis carolinensis)
Reptilia CCDC77 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc77 35
  • 61.61 (n)
  • 57.26 (a)
Str.11464 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7566 35
(Danio rerio)
Actinopterygii ccdc77 35
  • 60.89 (n)
  • 57.01 (a)
Dr.10395 35
ccdc77 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.479 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11775 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for CCDC77:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC77 Gene

Gene Tree for CCDC77 (if available)
Gene Tree for CCDC77 (if available)

Paralogs for CCDC77 Gene

No data available for Paralogs for CCDC77 Gene

Variants for CCDC77 Gene

Sequence variations from dbSNP and Humsavar for CCDC77 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4980895 - 411,781(+) CCGTC(A/C)GTGGT reference, missense, utr-variant-5-prime
rs735295 - 438,517(+) CGTTA(C/T)GCATG reference, missense
rs2041298 -- 429,872(+) ccact(C/G)tagcc intron-variant
rs7136116 -- 413,809(+) tttta(G/T)tagag intron-variant
rs10848935 -- 409,925(+) CCCAG(G/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC77 Gene

Variant ID Type Subtype PubMed ID
dgv452e1 CNV Complex 17122850
nsv898565 CNV Gain 21882294
nsv442250 CNV CNV 18776908
essv9499 CNV CNV 17122850
nsv898566 CNV Loss 21882294
nsv514668 CNV Complex 21397061
nsv571 CNV Insertion 18451855
nsv509448 CNV Insertion 20534489
esv2665030 CNV Deletion 23128226
esv2676807 CNV Deletion 23128226
nsv8884 CNV Gain+Loss 18304495
esv2403049 CNV Deletion 18987734
esv1001309 CNV Insertion 20482838
esv2745349 CNV Deletion 23290073
esv2009381 CNV Deletion 18987734
esv2160803 CNV Deletion 18987734
esv2313112 CNV Deletion 18987734
esv1005158 CNV Gain 20482838
esv29798 CNV Loss 19812545
esv2745350 CNV Deletion 23290073
esv1225237 CNV Deletion 17803354
esv1479845 CNV Deletion 17803354
esv1463722 CNV Deletion 17803354
esv1623775 CNV Deletion 17803354
esv2745351 CNV Deletion 23290073
esv2745353 CNV Deletion 23290073
dgv1337n71 CNV Gain 21882294
esv988269 CNV Deletion 20482838

Variation tolerance for CCDC77 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC77 Gene

Disorders for CCDC77 Gene

Relevant External Links for CCDC77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC77 Gene

Publications for CCDC77 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CCDC77 Gene

Sources for CCDC77 Gene