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Aliases for CCDC77 Gene

Aliases for CCDC77 Gene

  • Coiled-Coil Domain Containing 77 2 3 5

External Ids for CCDC77 Gene

Previous GeneCards Identifiers for CCDC77 Gene

  • GC12P000498

Summaries for CCDC77 Gene

GeneCards Summary for CCDC77 Gene

CCDC77 (Coiled-Coil Domain Containing 77) is a Protein Coding gene.

Additional gene information for CCDC77 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC77 Gene

Genomics for CCDC77 Gene

Regulatory Elements for CCDC77 Gene

Enhancers for CCDC77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H000749 1.8 FANTOM5 ENCODE dbSUPER 26 +363.4 363370 7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 RAD52 CCDC77 KDM5A ENSG00000255825 DDX11L8 NINJ2 WNK1 GC12M000753
GH12H000406 1.8 VISTA Ensembl ENCODE 18.6 +18.6 18556 3.3 ATF1 ARNT GLI4 BRCA1 ZNF2 TCF12 ZNF766 GATA2 ATF7 FOS CCDC77 RAD52 B4GALNT3 SLC6A13 LOC102723544 LOC105369594 PIR37877
GH12H001202 1.2 Ensembl ENCODE 25 +815.3 815264 3.4 PKNOX1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 RUNX3 JUNB TSHZ1 CCDC77 RAD52 DCP1B ENSG00000255825 KDM5A ENSG00000249028 GC12P001195 GC12M001280
GH12H000386 1.1 ENCODE 27.1 -0.8 -780 4 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 CCDC77 KDM5A RAD52 ENSG00000255825 DDX11L8 ENSG00000261799 IQSEC3 ENSG00000250132 PIR47780
GH12H000989 1.1 ENCODE 15.9 +601.6 601589 4.4 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3 ENSG00000261799 RAD52 ERC1 KDM5A CCDC77 ENSG00000255825 DDX11L8 LINC00942 WNT5B ENSG00000250132
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC77 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC77 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047526 -773 3401 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207

Genomic Locations for CCDC77 Gene

Genomic Locations for CCDC77 Gene
53,373 bases
Plus strand

Genomic View for CCDC77 Gene

Genes around CCDC77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC77 Gene

Proteins for CCDC77 Gene

  • Protein details for CCDC77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 77
    Protein Accession:
    Secondary Accessions:
    • B4DDE8

    Protein attributes for CCDC77 Gene

    488 amino acids
    Molecular mass:
    57486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC77 Gene


neXtProt entry for CCDC77 Gene

Post-translational modifications for CCDC77 Gene

  • Ubiquitination at posLast=193193, posLast=440440, and posLast=477477
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CCDC77 Gene

Domains & Families for CCDC77 Gene

Gene Families for CCDC77 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC77 Gene


Suggested Antigen Peptide Sequences for CCDC77 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC77: view

No data available for UniProtKB/Swiss-Prot for CCDC77 Gene

Function for CCDC77 Gene

Phenotypes From GWAS Catalog for CCDC77 Gene

genes like me logo Genes that share phenotypes with CCDC77: view

Animal Models for CCDC77 Gene

MGI Knock Outs for CCDC77:

Animal Model Products

miRNA for CCDC77 Gene

miRTarBase miRNAs that target CCDC77

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC77 Gene

Localization for CCDC77 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC77 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CCDC77: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC77 Gene

Pathways & Interactions for CCDC77 Gene

SuperPathways for CCDC77 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC77 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC77 Gene

Drugs & Compounds for CCDC77 Gene

No Compound Related Data Available

Transcripts for CCDC77 Gene

Unigene Clusters for CCDC77 Gene

Coiled-coil domain containing 77:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC77 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CCDC77 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC77 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC77 Gene

This gene is overexpressed in Blymphocyte (37.6) and Testis (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC77 Gene

Protein tissue co-expression partners for CCDC77 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC77 Gene:


SOURCE GeneReport for Unigene cluster for CCDC77 Gene:


Evidence on tissue expression from TISSUES for CCDC77 Gene

  • Nervous system(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with CCDC77: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC77 Gene

Orthologs for CCDC77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC77 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC77 33 34
  • 93.88 (n)
(Canis familiaris)
Mammalia CCDC77 33 34
  • 88.46 (n)
(Mus musculus)
Mammalia Ccdc77 33 16 34
  • 82.41 (n)
(Rattus norvegicus)
Mammalia Ccdc77 33
  • 82.37 (n)
(Bos Taurus)
Mammalia CCDC77 33 34
  • 81.01 (n)
(Monodelphis domestica)
Mammalia CCDC77 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC77 34
  • 55 (a)
(Gallus gallus)
Aves CCDC77 33 34
  • 64.75 (n)
(Anolis carolinensis)
Reptilia CCDC77 34
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc77 33
  • 61.61 (n)
Str.11464 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7566 33
(Danio rerio)
Actinopterygii ccdc77 33 34
  • 60.89 (n)
Dr.10395 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.479 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11775 33
Species where no ortholog for CCDC77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC77 Gene

Gene Tree for CCDC77 (if available)
Gene Tree for CCDC77 (if available)

Paralogs for CCDC77 Gene

No data available for Paralogs for CCDC77 Gene

Variants for CCDC77 Gene

Sequence variations from dbSNP and Humsavar for CCDC77 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000011942 -- 427,821(+) CTAAG(C/G)TATCT intron-variant
rs1000067097 -- 388,903(+) TCCCC(A/C)TCTCT intron-variant, upstream-variant-2KB
rs1000132435 -- 389,696(+) ATCAG(C/T)GCACT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000137550 -- 408,503(+) GTACT(C/G)TGCCT intron-variant
rs1000250492 -- 394,545(+) CTTAG(C/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC77 Gene

Variant ID Type Subtype PubMed ID
nsv975433 CNV duplication 23825009
nsv8884 CNV gain+loss 18304495
nsv571 CNV insertion 18451855
nsv514668 CNV gain 21397061
nsv509448 CNV insertion 20534489
nsv442250 CNV gain 18776908
nsv1069630 CNV deletion 25765185
nsv1050781 CNV loss 25217958
esv988269 CNV deletion 20482838
esv3892121 CNV gain 25118596
esv3628236 CNV gain 21293372
esv3628235 CNV loss 21293372
esv3628234 CNV gain 21293372
esv3628233 CNV loss 21293372
esv3628232 CNV gain 21293372
esv29798 CNV loss 19812545
esv2759875 CNV gain+loss 17122850
esv2745353 CNV deletion 23290073
esv2745351 CNV deletion 23290073
esv2745350 CNV deletion 23290073
esv2745349 CNV deletion 23290073
esv2676807 CNV deletion 23128226
esv2665030 CNV deletion 23128226
esv2403049 CNV deletion 18987734
esv2313112 CNV deletion 18987734
esv2160803 CNV deletion 18987734
esv2009381 CNV deletion 18987734
esv1623775 CNV deletion 17803354
esv1479845 CNV deletion 17803354
esv1463722 CNV deletion 17803354
esv1225237 CNV deletion 17803354
esv1005158 CNV gain 20482838
esv1001309 CNV insertion 20482838
dgv746n106 CNV duplication 24896259
dgv738e59 CNV duplication 20981092
dgv2246n54 CNV loss 21841781
dgv2245n54 CNV loss 21841781
dgv2244n54 CNV loss 21841781
dgv2243n54 CNV loss 21841781

Variation tolerance for CCDC77 Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC77 Gene

Disorders for CCDC77 Gene

Relevant External Links for CCDC77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC77 Gene

Publications for CCDC77 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for CCDC77 Gene

Sources for CCDC77 Gene

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