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Aliases for CCDC74B Gene

Aliases for CCDC74B Gene

  • Coiled-Coil Domain Containing 74B 2 3

External Ids for CCDC74B Gene

Summaries for CCDC74B Gene

GeneCards Summary for CCDC74B Gene

CCDC74B (Coiled-Coil Domain Containing 74B) is a Protein Coding gene. An important paralog of this gene is CCDC74A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC74B Gene

Genomics for CCDC74B Gene

Genomic Location for CCDC74B Gene

Start:
130,139,283 bp from pter
End:
130,145,134 bp from pter
Size:
5,852 bases
Orientation:
Minus strand

Genomic View for CCDC74B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74B Gene

Regulatory Elements for CCDC74B Gene

Proteins for CCDC74B Gene

  • Protein details for CCDC74B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LY2-CC74B_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 74B
    Protein Accession:
    Q96LY2
    Secondary Accessions:
    • Q6NW18

    Protein attributes for CCDC74B Gene

    Size:
    380 amino acids
    Molecular mass:
    41826 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC74B Gene

Proteomics data for CCDC74B Gene at MOPED

Post-translational modifications for CCDC74B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC74B Gene

Domains for CCDC74B Gene

Protein Domains for CCDC74B Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CCDC74B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC74B Gene

Function for CCDC74B Gene

Phenotypes for CCDC74B Gene

GenomeRNAi human phenotypes for CCDC74B:
genes like me logo Genes that share phenotypes with CCDC74B: view

miRNA for CCDC74B Gene

miRTarBase miRNAs that target CCDC74B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC74B Gene

Localization for CCDC74B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC74B Gene COMPARTMENTS Subcellular localization image for CCDC74B gene
Compartment Confidence
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CCDC74B Gene

Pathways for CCDC74B Gene

SuperPathways for CCDC74B Gene

No Data Available

Interacting Proteins for CCDC74B Gene

Gene Ontology (GO) - Biological Process for CCDC74B Gene

None

No data available for Pathways by source for CCDC74B Gene

Transcripts for CCDC74B Gene

Unigene Clusters for CCDC74B Gene

Coiled-coil domain containing 74B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74B Gene

No ASD Table

Relevant External Links for CCDC74B Gene

GeneLoc Exon Structure for
CCDC74B
ECgene alternative splicing isoforms for
CCDC74B

Expression for CCDC74B Gene

mRNA expression in normal human tissues for CCDC74B Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74B Gene

This gene is overexpressed in Testis (10.5) and Pituitary (6.2).

SOURCE GeneReport for Unigene cluster for CCDC74B Gene Hs.29383

genes like me logo Genes that share expressions with CCDC74B: view

Orthologs for CCDC74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc74a 37
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CCDC74B 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for CCDC74B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC74B Gene

ENSEMBL:
Gene Tree for CCDC74B (if available)
TreeFam:
Gene Tree for CCDC74B (if available)

Paralogs for CCDC74B Gene

Paralogs for CCDC74B Gene

Selected SIMAP similar genes for CCDC74B Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for CCDC74B Gene

genes like me logo Genes that share paralogs with CCDC74B: view

Variants for CCDC74B Gene

Sequence variations from dbSNP and Humsavar for CCDC74B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2258632 -- 130,139,986(+) ATAGG(A/C)CCCCA intron-variant
rs2259332 -- 130,140,047(+) CCGGG(A/G)CTGCC missense, reference
rs2259366 -- 130,140,894(-) GTAGC(A/G)GCCCC intron-variant
rs2599963 -- 130,141,622(+) CCGTC(C/T)AGCAC intron-variant
rs2599964 -- 130,141,651(+) TGGTG(A/G)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC74B Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
essv1878 CNV CNV 17122850
nsv875061 CNV Gain 21882294
nsv834375 CNV Loss 17160897
nsv7327 OTHER Inversion 18451855
nsv875074 CNV Gain 21882294
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680

Relevant External Links for CCDC74B Gene

HapMap Linkage Disequilibrium report
CCDC74B

Disorders for CCDC74B Gene

No disorders were found for CCDC74B Gene.

No data available for UniProtKB/Swiss-Prot for CCDC74B Gene

Publications for CCDC74B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC74B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCDC74B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC74B
    • Block miRNA regulation of CCDC74B using miScript Target Protectors

    Sources for CCDC74B Gene

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