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CCDC74B Gene

protein-coding   GIFtS: 42
GCID: GC02M130896

Coiled-Coil Domain Containing 74B

  Search for CCDC74B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Coiled-Coil Domain Containing 74B1 2
Coiled-Coil Domain-Containing Protein 74B2

External Ids:    HGNC: 252671   Entrez Gene: 914092   Ensembl: ENSG000001520767   UniProtKB: Q96LY23   
ORGUL members:         

Export aliases for CCDC74B gene to outside databases

Previous GC identifers: GC02M130614 GC02M123192


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC74B Gene:
CCDC74B (coiled-coil domain containing 74B) is a protein-coding gene. An important paralog of this gene is CCDC74A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC74B gene promoter:
         NF-YB   CBF-B   CBF-A   Tal-1   NF-YA   HSF1 (long)   CP1A   NF-Y   E47   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC74B promoter sequence
   Search Chromatin IP Primers for CCDC74B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC74B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

CCDC74B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC74B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130896:  view genomic region     (about GC identifiers)

Start:
130,896,860 bp from pter      End:
130,902,707 bp from pter
Size:
5,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC74B_HUMAN, Q96LY2 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 74B  
Size: 380 amino acids; 41826 Da
Secondary accessions: Q6NW18
Alternative splicing: 2 isoforms:  Q96LY2-1   Q96LY2-2   

Explore the universe of human proteins at neXtProt for CCDC74B: NX_Q96LY2

Explore proteomics data for CCDC74B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC74B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245236.1  NP_997193.1  

    ENSEMBL proteins: 
     ENSP00000386294   ENSP00000308873   ENSP00000410864   ENSP00000386644   ENSP00000404494  
     ENSP00000399683   ENSP00000386303   ENSP00000396549   ENSP00000376710  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96LY2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC74B:
     Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC74B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC74B
    Interactions:

        Search GeneGlobe Interaction Network for CCDC74B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC74B (CC74B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC74B gene (2 alternative transcripts): 
    NM_001258307.1  NM_207310.2  

    Unigene Cluster for CCDC74B:

    Coiled-coil domain containing 74B
    Hs.29383  [show with all ESTs]
    Unigene Representative Sequence: NM_207310
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496704 ENST00000409943(uc002tqn.1) ENST00000310463(uc002tqm.1)
    ENST00000498526 ENST00000423263 ENST00000409128 ENST00000434929 ENST00000457413
    ENST00000409234 ENST00000441670 ENST00000392984(uc010yzw.1 uc010yzx.1)

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    Additional mRNA sequence: 

    AK057609.1 AK302804.1 BC067771.1 

    15 DOTS entries:

    DT.95308589  DT.40110901  DT.120980712  DT.120981130  DT.314433  DT.99932158  DT.100036180  DT.100819834 
    DT.102830006  DT.92426176  DT.95308579  DT.100700277  DT.100819833  DT.120980812  DT.120981473 

    Selected AceView cDNA sequences (see all 73):

    AI673758 BM462021 BM696622 AA730154 AL133619 BU735145 CD675670 NM_207310 
    AK057609 CD359923 CD674543 BQ218684 BX282411 BC067771 BG724386 AA905453 
    BM554395 BG121334 BF062306 BI767331 BI832351 BI756847 AI982575 AI685732 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC74B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATCGA
    CCDC74B Expression
    About this image

    CCDC74B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC74B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29383
        Custom PCR Arrays for CCDC74B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC74B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC74B6
    coiled-coil domain containing 74B
    31(a)
    1 → many
    21(17740430-17744520) ENSDARG00000093026
            Species with no ortholog for CCDC74B

    ENSEMBL Gene Tree for CCDC74B (if available)
    TreeFam Gene Tree for CCDC74B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC74B gene
    CCDC74A2  
    4 SIMAP similar genes for CCDC74B using alignment to 8 protein entries:     CC74B_HUMAN (see all proteins):
    CCDC74A    CCDC74AV2    CCDC74AV3    DKFZp434E2321

    CCDC74B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC74B
    PGOHUM00000246242


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC74B (see all 253)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3721081451,2
    C--130897506(+) AATGCA/GTGGCT 4 T M mis10--------
    rs22586321,2
    C--130897559(+) ATAGGC/ACCCCA 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1506319261,2
    F--130897616(+) TCCTCC/TGGGAC 4 P syn11Minor allele frequency- T:0.00NA 4050
    rs1437525111,2
    C--130897617(+) CCTCCG/AGGACT 4 /P /L mis11Minor allele frequency- A:0.00NA 4038
    rs764856761,2
    C,F--130897620(+) CCGGGA/GCTGCC 4 A V mis11Minor allele frequency- G:0.12EU 614
    rs1820905971,2
    C--130897638(+) TCTGGC/TTCCCT 4 N S mis10--------
    rs1397255291,2
    C,F--130897660(+) CTTGAG/AGTGCT 4 /L /F mis12Minor allele frequency- A:0.01NA EU 5377
    rs2022180491,2
    C--130897665(+) GGTGCT/CGCAGC 4 /Q /R mis11Minor allele frequency- C:0.00EU 1133
    rs101849211,2
    C,H--130897696(+) GTGGTG/AGGGCC 2 -- int14Minor allele frequency- A:0.00NS EA 420
    rs1454211811,2
    C,F--130897755(+) ACCTCT/CTGGGT 4 /Q syn12Minor allele frequency- C:0.00NA EU 5173

    HapMap Linkage Disequilibrium report for CCDC74B (130896860 - 130902707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCDC74B (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834375CNV Loss17160897
    nsv459274CNV Loss19166990
    nsv821629CNV Loss15273396
    nsv428403CNV Loss18775914
    dgv4305n71CNV Gain21882294
    dgv4306n71CNV Gain21882294
    nsv875074CNV Gain21882294
    nsv875061CNV Gain21882294
    esv2751826CNV Gain17911159
    dgv4307n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC74B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC74B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91409 HGNC: 25267 AceView: DKFZp434E2321 Ensembl:ENSG00000152076 euGenes: HUgn91409
    ECgene: CCDC74B H-InvDB: CCDC74B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC74B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC74B gene:
    Search GeneIP for patents involving CCDC74B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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