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Aliases for CCDC74B Gene

Aliases for CCDC74B Gene

  • Coiled-Coil Domain Containing 74B 2 3

External Ids for CCDC74B Gene

Previous GeneCards Identifiers for CCDC74B Gene

  • GC02M130614
  • GC02M130896
  • GC02M123192

Summaries for CCDC74B Gene

GeneCards Summary for CCDC74B Gene

CCDC74B (Coiled-Coil Domain Containing 74B) is a Protein Coding gene. An important paralog of this gene is CCDC74A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC74B Gene

Genomics for CCDC74B Gene

Regulatory Elements for CCDC74B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC74B Gene

130,139,283 bp from pter
130,145,134 bp from pter
5,852 bases
Minus strand

Genomic View for CCDC74B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74B Gene

Proteins for CCDC74B Gene

  • Protein details for CCDC74B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 74B
    Protein Accession:
    Secondary Accessions:
    • Q6NW18

    Protein attributes for CCDC74B Gene

    380 amino acids
    Molecular mass:
    41826 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74B Gene


neXtProt entry for CCDC74B Gene

Proteomics data for CCDC74B Gene at MOPED

Post-translational modifications for CCDC74B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC74B Gene

Domains & Families for CCDC74B Gene

Protein Domains for CCDC74B Gene


Suggested Antigen Peptide Sequences for CCDC74B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC74B: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC74B Gene

Function for CCDC74B Gene

Phenotypes for CCDC74B Gene

GenomeRNAi human phenotypes for CCDC74B:
genes like me logo Genes that share phenotypes with CCDC74B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC74B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC74B Gene

Localization for CCDC74B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC74B Gene

Pathways & Interactions for CCDC74B Gene

SuperPathways for CCDC74B Gene

No Data Available

Interacting Proteins for CCDC74B Gene

Gene Ontology (GO) - Biological Process for CCDC74B Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC74B Gene

Drugs & Compounds for CCDC74B Gene

No Compound Related Data Available

Transcripts for CCDC74B Gene

Unigene Clusters for CCDC74B Gene

Coiled-coil domain containing 74B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC74B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74B Gene

No ASD Table

Relevant External Links for CCDC74B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC74B Gene

mRNA expression in normal human tissues for CCDC74B Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74B Gene

This gene is overexpressed in Testis (x10.5) and Pituitary (x6.2).

SOURCE GeneReport for Unigene cluster for CCDC74B Gene Hs.29383

genes like me logo Genes that share expression patterns with CCDC74B: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC74B Gene

Orthologs for CCDC74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
(Mus musculus)
Mammalia Ccdc74a 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
(Danio rerio)
Actinopterygii CCDC74B 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for CCDC74B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC74B Gene

Gene Tree for CCDC74B (if available)
Gene Tree for CCDC74B (if available)

Paralogs for CCDC74B Gene

Paralogs for CCDC74B Gene Pseudogenes for CCDC74B Gene

genes like me logo Genes that share paralogs with CCDC74B: view

Variants for CCDC74B Gene

Sequence variations from dbSNP and Humsavar for CCDC74B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2258632 -- 130,139,986(+) ATAGG(A/C)CCCCA intron-variant, downstream-variant-500B
rs2259332 -- 130,140,047(+) CCGGG(A/G)CTGCC missense, reference, downstream-variant-500B
rs2259366 -- 130,140,894(-) GTAGC(A/G)GCCCC intron-variant, downstream-variant-500B
rs2599955 -- 130,140,118(+) GGGGC(A/G)TGGTG intron-variant, downstream-variant-500B
rs2599960 -- 130,140,671(+) GGTCT(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC74B Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
essv1878 CNV CNV 17122850
nsv875061 CNV Gain 21882294
nsv834375 CNV Loss 17160897
nsv7327 OTHER Inversion 18451855
nsv875074 CNV Gain 21882294
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680

Variation tolerance for CCDC74B Gene

Residual Variation Intolerance Score: 94.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.58; 86.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC74B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC74B Gene

Disorders for CCDC74B Gene

Relevant External Links for CCDC74B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC74B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC74B Gene

Publications for CCDC74B Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for CCDC74B Gene

Sources for CCDC74B Gene

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