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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC74B Gene

protein-coding   GIFtS: 41
GCID: GC02M130896

Coiled-Coil Domain Containing 74B

  Search for CCDC74B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 74B1 2
Coiled-Coil Domain-Containing Protein 74B2

External Ids:    HGNC: 252671   Entrez Gene: 914092   Ensembl: ENSG000001520767   UniProtKB: Q96LY23   

Export aliases for CCDC74B gene to outside databases

Previous GC identifers: GC02M130614 GC02M123192


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC74B Gene: 
CCDC74B (coiled-coil domain containing 74B) is a protein-coding gene. An important paralog of this gene is CCDC74A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC74B gene promoter:
         NF-YB   CBF-B   CBF-A   Tal-1   NF-YA   HSF1 (long)   CP1A   NF-Y   E47   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC74B promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC74B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC74B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

CCDC74B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC74B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130896:  view genomic region     (about GC identifiers)

Start:
130,896,860 bp from pter      End:
130,902,707 bp from pter
Size:
5,848 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC74B_HUMAN, Q96LY2 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 74B  
Size: 380 amino acids; 41826 Da
Secondary accessions: Q6NW18
Alternative splicing: 2 isoforms:  Q96LY2-1   Q96LY2-2   

Explore the universe of human proteins at neXtProt for CCDC74B: NX_Q96LY2

Explore proteomics data for CCDC74B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LY2

  • CCDC74B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC74B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001245236.1  NP_997193.1  

    ENSEMBL proteins: 
     ENSP00000386294   ENSP00000308873   ENSP00000410864   ENSP00000386644   ENSP00000404494  
     ENSP00000399683   ENSP00000386303   ENSP00000396549   ENSP00000376710  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LY2


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC74B:
     Decreased influenza A virus in 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC74B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC74B (CC74B)

    Search CenterWatch for drugs/clinical trials and news about CCDC74B / CC74B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC74B gene (2 alternative transcripts): 
    NM_001258307.1  NM_207310.2  

    Unigene Cluster for CCDC74B:

    Coiled-coil domain containing 74B
    Hs.29383  [show with all ESTs]
    Unigene Representative Sequence: NM_207310
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496704 ENST00000409943(uc002tqn.1) ENST00000310463(uc002tqm.1)
    ENST00000498526 ENST00000423263 ENST00000409128 ENST00000434929 ENST00000457413
    ENST00000409234 ENST00000441670 ENST00000392984(uc010yzw.1 uc010yzx.1)

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC74B
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    Additional mRNA sequence: 

    AK057609.1 AK302804.1 BC067771.1 

    15 DOTS entries:

    DT.95308589  DT.40110901  DT.120980712  DT.120981130  DT.314433  DT.99932158  DT.100036180  DT.100819834 
    DT.102830006  DT.92426176  DT.95308579  DT.100700277  DT.100819833  DT.120980812  DT.120981473 

    24/73 AceView cDNA sequences (see all 73):

    AL133619 BX282411 AA730154 BQ218684 CD359923 BM696622 BM462021 AI673758 
    CD674543 CD675670 BU735145 NM_207310 AK057609 BI756847 BG121334 BG773402 
    BI826782 BG721390 AL043924 CF456093 BI767331 CF454580 AL043925 BI488520 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC74B expression in normal human tissues (normalized intensities)      CCDC74B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGATCGA
    CCDC74B Expression
    About this image


    CCDC74B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Uncategorized (Uncategorized)
             PureStem Progenitor EN13
     
     Testis (Reproductive System)

    See CCDC74B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC74B

    SOURCE GeneReport for Unigene cluster: Hs.29383
        SABiosciences Custom PCR Arrays for CCDC74B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC74B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC74B gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC74A6
    coiled-coil domain containing 74A
    29(a)
    1 → many
    21(17740430-17744520)
            Species with no ortholog for CCDC74B

    ENSEMBL Gene Tree for CCDC74B (if available)
    TreeFam Gene Tree for CCDC74B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC74B gene
    CCDC74A2  
    4 SIMAP similar genes for CCDC74B using alignment to 8 protein entries:     CC74B_HUMAN (see all proteins):
    CCDC74A    CCDC74AV2    CCDC74AV3    DKFZp434E2321

    CCDC74B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC74B
    PGOHUM00000246242


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/253 SNPs in CCDC74B are shown (see all 253)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0302704
    ----see VAR_0302702 R H mis40--------
    VAR_0302694
    ----see VAR_0302692 T M mis40--------
    rs3721081451,2
    C--130897506(+) AATGCA/GTGGCT 4 T M mis10--------
    rs22586321,2
    C--130897559(+) ATAGGC/ACCCCA 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1506319261,2
    F--130897616(+) TCCTCC/TGGGAC 4 P syn11Minor allele frequency- T:0.00NA 4050
    rs1437525111,2
    C--130897617(+) CCTCCG/AGGACT 4 /P /L mis11Minor allele frequency- A:0.00NA 4038
    rs764856761,2
    C,F--130897620(+) CCGGGA/GCTGCC 4 A V mis11Minor allele frequency- G:0.12EU 614
    rs1820905971,2
    C--130897638(+) TCTGGC/TTCCCT 4 N S mis10--------
    rs1397255291,2
    C,F--130897660(+) CTTGAG/AGTGCT 4 /L /F mis12Minor allele frequency- A:0.01NA EU 5377
    rs2022180491,2
    C--130897665(+) GGTGCT/CGCAGC 4 /Q /R mis11Minor allele frequency- C:0.00EU 1133

    HapMap Linkage Disequilibrium report for CCDC74B (130896860 - 130902707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for CCDC74B (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834375CNV Loss17160897
    nsv459274CNV Loss19166990
    nsv821629CNV Loss15273396
    nsv428403CNV Loss18775914
    dgv4305n71CNV Gain21882294
    dgv4306n71CNV Gain21882294
    nsv875074CNV Gain21882294
    nsv875061CNV Gain21882294
    esv2751826CNV Gain17911159
    dgv4307n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC74B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC74B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91409 HGNC: 25267 AceView: DKFZp434E2321 Ensembl:ENSG00000152076 euGenes: HUgn91409
    ECgene: CCDC74B H-InvDB: CCDC74B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC74B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC74B gene:
    Search GeneIP for patents involving CCDC74B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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