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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC74B Gene

protein-coding   GIFtS: 40
GCID: GC02M130896

coiled-coil domain containing 74B
  Search for CCDC74B
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCDC74B    

Aliases
for CCDC74B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coiled-Coil Domain Containing 74B1 2
DKFZp434E23211
Coiled-Coil Domain-Containing Protein 74B2

External Ids:    HGNC: 252671   Entrez Gene: 914092   Ensembl: ENSG000001520767   UniProtKB: Q96LY23   

Export aliases for CCDC74B gene to outside databases

Previous GC identifers: GC02M130614 GC02M123192


Summaries
for CCDC74B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CCDC74B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC74B gene promoter:
         NF-YB   CBF-B   CBF-A   Tal-1   NF-YA   HSF1 (long)   CP1A   NF-Y   E47   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC74B promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC74B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC74B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

CCDC74B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC74B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130896:  view genomic region     (about GC identifiers)

Start:
 130,896,860 bp from pter      End:
 130,902,707 bp from pter
Size:
 5,848 bases      Orientation:
 minus strand

Proteins
for CCDC74B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CC74B_HUMAN, Q96LY2 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 74B  
Size: 380 amino acids; 41826 Da
Secondary accessions: Q6NW18
Alternative splicing: 2 isoforms:  Q96LY2-1   Q96LY2-2   

Explore the universe of human proteins at neXtProt for CCDC74B: NX_Q96LY2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96LY2

    • CCDC74B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001245236.1  NP_997193.1  

    ENSEMBL proteins: 
     ENSP00000386294   ENSP00000308873   ENSP00000386250   ENSP00000410864   ENSP00000386644  
     ENSP00000404494   ENSP00000413516   ENSP00000399683   ENSP00000386303   ENSP00000396549  
     ENSP00000376710  

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    Protein Domains /
    Families
    for CCDC74B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LY2


    Function
    for CCDC74B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 GenomeRNAi human phenotype for CCDC74B:
     Decreased influenza A virus in 


    Pathways & Interactions
    for CCDC74B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC74B

    Drugs & Compounds
    for CCDC74B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CCDC74B
    Search CenterWatch for drugs/clinical trials and news about CCDC74B / CC74B 

    Transcripts
    for CCDC74B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for CCDC74B gene (2 alternative transcripts): 
    NM_001258307.1  NM_207310.2  

    Unigene Cluster for CCDC74B:

    Coiled-coil domain containing 74B
    Hs.29383  [show with all ESTs]
    Unigene Representative Sequence: NM_207310
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496704 ENST00000409943(uc002tqn.1) ENST00000310463(uc002tqm.1)
    ENST00000498526 ENST00000409488 ENST00000423263 ENST00000409128 ENST00000434929
    ENST00000418636 ENST00000457413 ENST00000409234 ENST00000441670 ENST00000392984(uc010yzw.1 uc010yzx.1)


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    Additional cDNA sequence: 

    AK057609.1 AK302804.1 BC067771.1 

    15 DOTS entries:

    DT.95308589  DT.40110901  DT.120980712  DT.120981130  DT.314433  DT.99932158  DT.100036180  DT.100819834 
    DT.102830006  DT.92426176  DT.95308579  DT.100700277  DT.100819833  DT.120980812  DT.120981473 

    24/73 AceView cDNA sequences (see all 73):

    BU735145 NM_207310 BM462021 AK057609 BM696622 BQ218684 AA730154 AL133619 
    CD359923 CD675670 BX282411 AI673758 CD674543 AI685732 AA933714 BI830274 
    AI982575 BV197238 CD672356 AL043925 CF456093 AI825782 BC067771 BI756847 

    GeneLoc Exon Structure


    Expression
    for CCDC74B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC74B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGAGATCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCDC74B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCDC74B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC74B

    SOURCE GeneReport for Unigene cluster: Hs.29383
        SABiosciences Custom PCR Arrays for CCDC74B
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    In Situ
    Assay Products:     
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    Orthologs
    for CCDC74B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC74B gene from 1/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-222n4.26
    		 si:ch211-222n4.2
    		 31(a)
    		 1 → many
    		 21(17740430-17744520)


    ENSEMBL Gene Tree for CCDC74B (if available)
    TreeFam Gene Tree for CCDC74B (if available) 

    Paralogs
    for CCDC74B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC74B gene
    CCDC74A2  
    4 SIMAP similar genes for CCDC74B using alignment to 10 protein entries:     CC74B_HUMAN (see all proteins):
    CCDC74A    CCDC74AV2    CCDC74AV3    DKFZp434E2321

    CCDC74B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC74B
    PGOHUM00000246242


    Genomic Variants
    for CCDC74B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/225 NCBI SNPs in CCDC74B are shown (see all 225)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1890941191,2
    		--130896495(+) CACTCA/GAGACA 3 -- ds5001 nc-transcript-variant0--------
    rs1930831881,2
    		--130896528(+) CCTGGC/TTGGAC 3 -- ds5001 nc-transcript-variant0--------
    rs76001501,2
    		C,F,--130896537(+) ACCCCC/TTGTCT 3 -- ds5001 nc-transcript-variant2Minor allele frequency- T:0.50NA 4
    rs1854862611,2
    		--130896558(+) GTCAGG/TGCAGC 3 -- ds5001 nc-transcript-variant0--------
    rs75756401,2
    		C,F,--130896565(+) CAGCAG/AAGGAC 3 -- nc-transcript-variantds50015Minor allele frequency- A:0.30NA WA EA 362
    rs1385975931,2
    		--130896722(+) GGGCCA/GCTGGC 3 -- ds5001 nc-transcript-variant0--------
    rs1899111281,2
    		--130896762(+) CCAGGC/TAGGTC 3 -- ds5001 nc-transcript-variant0--------
    rs126228231,2
    		H--130897038(+) CAGGCA/CTAAAA 3 -- ut31 ds50010--------
    rs287519291,2
    		C,--130897055(+) GAAGTG/ATCAGG 3 -- ut31 ds5001 ese36Minor allele frequency- A:0.47NA 134
    rs1815547541,2
    		--130897063(+) AGGAAA/GTGCTA 3 -- ut31 ds50010--------

    HapMap Linkage Disequilibrium report for CCDC74B (130896860 - 130902707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CCDC74B
         4 CNVs: 0269 3393 2408 8387

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    Disorders / Diseases
    for CCDC74B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CCDC74B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC74B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC74B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CCDC74B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCDC74B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91409 HGNC: 25267 AceView: DKFZp434E2321 Ensembl:ENSG00000152076 euGenes: HUgn91409
    ECgene: CCDC74B H-InvDB: CCDC74B

    Other Databases showing CCDC74B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CCDC74B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC74B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCDC74B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCDC74B gene:
    Search GeneIP for patents involving CCDC74B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCDC74B gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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