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CCDC74A Gene

protein-coding   GIFtS: 37
GCID: GC02P132285

Coiled-Coil Domain Containing 74A

  Search for CCDC74A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 74A1 2
Coiled-Coil Domain-Containing Protein 74A2

External Ids:    HGNC: 251971   Entrez Gene: 905572   Ensembl: ENSG000001630407   UniProtKB: Q96AQ13   

Export aliases for CCDC74A gene to outside databases

Previous GC identifers: GC02P132001 GC02P124278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC74A Gene:
CCDC74A (coiled-coil domain containing 74A) is a protein-coding gene. An important paralog of this gene is CCDC74B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC74A gene promoter:
         HEN1   AML1a   Tal-1   NRSF form 1   HSF1 (long)   HSF1short   CUTL1   MRF-2   GATA-2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC74A promoter sequence
   Search Chromatin IP Primers for CCDC74A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC74A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

CCDC74A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC74A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P132285:  view genomic region     (about GC identifiers)

Start:
132,285,248 bp from pter      End:
132,291,239 bp from pter
Size:
5,992 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CC74A_HUMAN, Q96AQ1 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 74A  
Size: 378 amino acids; 41605 Da
Secondary accessions: Q6P4I5
Alternative splicing: 2 isoforms:  Q96AQ1-1   Q96AQ1-2   

Explore the universe of human proteins at neXtProt for CCDC74A: NX_Q96AQ1

Explore proteomics data for CCDC74A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC74A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245233.1  NP_001245234.1  NP_001245235.1  NP_620125.1  

    ENSEMBL proteins: 
     ENSP00000295171   ENSP00000388252   ENSP00000387009   ENSP00000406839   ENSP00000444610  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96AQ1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC74A:
     Decreased influenza A virus in 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC74A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC74A
    Interactions:

        Search GeneGlobe Interaction Network for CCDC74A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC74A (CC74A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC74A gene (4 alternative transcripts): 
    NM_001258304.1  NM_001258305.1  NM_001258306.1  NM_138770.2  

    Unigene Cluster for CCDC74A:

    Coiled-coil domain containing 74A
    Hs.351461  [show with all ESTs]
    Unigene Representative Sequence: NM_138770
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465939(uc010fnb.1) ENST00000295171(uc002tta.3 uc021vpq.1 uc021vpr.1)
    ENST00000454549 ENST00000409856(uc002ttb.3) ENST00000468650 ENST00000478665
    ENST00000434330 ENST00000467992
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CCDC74A
      QuantiFast Probe-based Assays in human, mouse, rat CCDC74A

    Additional mRNA sequence: 

    AB299086.1 AB299087.1 AK309113.1 BC016861.1 BC063387.1 

    20 DOTS entries:

    DT.95308589  DT.100036181  DT.314433  DT.40110901  DT.120981473  DT.120980712  DT.100036180  DT.120980812 
    DT.100708420  DT.120981130  DT.99932158  DT.102830006  DT.95308579  DT.100819833  DT.92426174  DT.97844984 
    DT.100700277  DT.100819834  DT.92426176  DT.95308593 

    Selected AceView cDNA sequences (see all 110):

    BC063387 AA425820 AA614641 BF111446 AA730140 AA505909 BM757361 BM784650 
    BC016861 AI732734 NM_138770 AI026826 AA730154 CD106309 CR608628 AA868351 
    AI734130 AI734138 BM450441 AI125754 BM982421 CD300329 BE264994 AA437369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC74A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAGCTTCC
    CCDC74A Expression
    About this image

    CCDC74A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC74A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351461
        Custom PCR Arrays for CCDC74A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC74A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC74A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC74B6
    coiled-coil domain containing 74B
    31(a)
    1 → many
    21(17740430-17744520) ENSDARG00000093026
            Species with no ortholog for CCDC74A

    ENSEMBL Gene Tree for CCDC74A (if available)
    TreeFam Gene Tree for CCDC74A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC74A gene
    CCDC74B2  
    4 SIMAP similar genes for CCDC74A using alignment to 5 protein entries:     CC74A_HUMAN (see all proteins):
    CCDC74B    CCDC74AV2    CCDC74AV3    DKFZp434E2321

    CCDC74A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC74A
    PGOHUM00000240295


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC74A (see all 245)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401731381,2
    C--132283416(+) CTTCCC/TGAGTA 4 -- us2k10--------
    rs130065361,2
    F--132283423(+) agtagG/Ctggga 4 -- us2k11Minor allele frequency- C:0.50NA 4
    rs1846805281,2
    --132283467(+) TTTGTA/GTTTTT 4 -- us2k10--------
    rs1895109271,2
    --132283533(+) TGATCC/TGCCCG 4 -- us2k10--------
    rs1808093341,2
    --132283537(+) CCGCCC/TGCCTC 4 -- us2k10--------
    rs130167731,2
    C,A--132283550(+) cctccC/Aaataa 4 -- us2k12Minor allele frequency- A:0.00NA 4
    rs126152841,2
    H--132283586(+) ttttcA/Cccatg 4 -- us2k10--------
    rs1860959221,2
    --132283591(+) ACCATA/GTTGCC 4 -- us2k10--------
    rs1897111341,2
    --132283690(+) GGCCAA/GCTTCT 4 -- us2k10--------
    rs344876311,2
    C--132283720(+) TTTTTT/-CTGAG 4 -- us2k11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for CCDC74A (132285248 - 132291239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CCDC74A (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670824CNV Deletion23128226
    nsv2926CNV Insertion18451855
    nsv428404CNV Loss18775914
    dgv4312n71CNV Loss21882294
    dgv476n27CNV Loss19166990
    nsv470486CNV Loss18288195
    nsv524021CNV Loss19592680
    nsv459396CNV Gain19166990
    dgv4313n71CNV Gain21882294
    nsv834376CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC74A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC74A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Human ORFeome version 1.1: a platform for reverse proteomics. (PubMed id 15489335)1 Rual J.F....Vidal M. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90557 HGNC: 25197 AceView: LOC90557 Ensembl:ENSG00000163040 euGenes: HUgn90557
    ECgene: CCDC74A H-InvDB: CCDC74A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC74A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC74A gene:
    Search GeneIP for patents involving CCDC74A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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