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Aliases for CCDC74A Gene

Aliases for CCDC74A Gene

  • Coiled-Coil Domain Containing 74A 2 3

External Ids for CCDC74A Gene

Previous GeneCards Identifiers for CCDC74A Gene

  • GC02P132001
  • GC02P132285
  • GC02P124278

Summaries for CCDC74A Gene

GeneCards Summary for CCDC74A Gene

CCDC74A (Coiled-Coil Domain Containing 74A) is a Protein Coding gene. An important paralog of this gene is CCDC74B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC74A Gene

Genomics for CCDC74A Gene

Regulatory Elements for CCDC74A Gene

Genomic Location for CCDC74A Gene

Start:
131,527,675 bp from pter
End:
131,533,666 bp from pter
Size:
5,992 bases
Orientation:
Plus strand

Genomic View for CCDC74A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC74A Gene

Proteins for CCDC74A Gene

  • Protein details for CCDC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AQ1-CC74A_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 74A
    Protein Accession:
    Q96AQ1
    Secondary Accessions:
    • Q6P4I5

    Protein attributes for CCDC74A Gene

    Size:
    378 amino acids
    Molecular mass:
    41605 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC74A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC74A Gene

Proteomics data for CCDC74A Gene at MOPED

Post-translational modifications for CCDC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC74A Gene

No data available for DME Specific Peptides for CCDC74A Gene

Domains for CCDC74A Gene

Protein Domains for CCDC74A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC74A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC74A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC74A Gene

Function for CCDC74A Gene

Phenotypes for CCDC74A Gene

GenomeRNAi human phenotypes for CCDC74A:
genes like me logo Genes that share phenotypes with CCDC74A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC74A Gene

Localization for CCDC74A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC74A Gene COMPARTMENTS Subcellular localization image for CCDC74A gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC74A Gene

Pathways for CCDC74A Gene

SuperPathways for CCDC74A Gene

No Data Available

Interacting Proteins for CCDC74A Gene

Gene Ontology (GO) - Biological Process for CCDC74A Gene

None

No data available for Pathways by source for CCDC74A Gene

Transcripts for CCDC74A Gene

Unigene Clusters for CCDC74A Gene

Coiled-coil domain containing 74A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC74A Gene

No ASD Table

Relevant External Links for CCDC74A Gene

GeneLoc Exon Structure for
CCDC74A
ECgene alternative splicing isoforms for
CCDC74A

Expression for CCDC74A Gene

mRNA expression in normal human tissues for CCDC74A Gene

mRNA differential expression in normal tissues according to GTEx for CCDC74A Gene

This gene is overexpressed in Testis (6.8) and Pituitary (5.2).

SOURCE GeneReport for Unigene cluster for CCDC74A Gene Hs.351461

genes like me logo Genes that share expressions with CCDC74A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for CCDC74A Gene

Orthologs for CCDC74A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC74A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc74a 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CCDC74B 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for CCDC74A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC74A Gene

ENSEMBL:
Gene Tree for CCDC74A (if available)
TreeFam:
Gene Tree for CCDC74A (if available)

Paralogs for CCDC74A Gene

Paralogs for CCDC74A Gene

Selected SIMAP similar genes for CCDC74A Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CCDC74A Gene

genes like me logo Genes that share paralogs with CCDC74A: view

Variants for CCDC74A Gene

Sequence variations from dbSNP and Humsavar for CCDC74A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9162 -- 131,533,597(+) TTTAC(A/G)TAAAA utr-variant-3-prime, nc-transcript-variant
rs13660 - 131,532,891(-) GCTCC(C/T)TTCCA missense, reference, synonymous-codon, nc-transcript-variant
rs701651 -- 131,533,471(+) CCTGA(C/T)ACTTC utr-variant-3-prime, nc-transcript-variant
rs1046682 -- 131,533,389(+) CGCTC(A/G)GTGCT reference, synonymous-codon, utr-variant-3-prime, nc-transcript-variant
rs1046685 -- 131,533,401(+) TGAGC(C/T)ACCCC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC74A Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
nsv7327 OTHER Inversion 18451855
esv2670824 CNV Deletion 23128226
nsv524021 CNV Loss 19592680
dgv1252e1 CNV Complex 17122850
dgv1254e1 CNV Complex 17122850
nsv428404 CNV Loss 18775914
dgv1256e1 CNV Complex 17122850
dgv4312n71 CNV Loss 21882294
dgv4313n71 CNV Gain 21882294
dgv476n27 CNV Loss 19166990
nsv459396 CNV Gain 19166990
nsv470486 CNV Loss 18288195
nsv875115 CNV Gain 21882294
esv34704 CNV Gain 17911159
essv2396 CNV CNV 17122850
dgv1257e1 CNV Complex 17122850
essv1836 CNV CNV 17122850
dgv4314n71 CNV Gain 21882294
dgv1258e1 CNV Complex 17122850
nsv834376 CNV Gain 17160897
nsv10185 CNV Gain+Loss 18304495
nsv2926 CNV Insertion 18451855
dgv1259e1 CNV Complex 17122850
dgv1260e1 CNV Complex 17122850
nsv483103 CNV Complex 15286789

Relevant External Links for CCDC74A Gene

HapMap Linkage Disequilibrium report
CCDC74A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC74A Gene

Disorders for CCDC74A Gene

No disorders were found for CCDC74A Gene.

No data available for UniProtKB/Swiss-Prot for CCDC74A Gene

Publications for CCDC74A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CCDC74A Gene

Sources for CCDC74A Gene

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