Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC73 Gene

Aliases for CCDC73 Gene

  • Coiled-Coil Domain Containing 73 2 3 5
  • Sarcoma Antigen NY-SAR-79 3 4
  • Coiled-Coil Domain-Containing Protein 73 3
  • NY-SAR-79 3

External Ids for CCDC73 Gene

Previous GeneCards Identifiers for CCDC73 Gene

  • GC11M032582
  • GC11M032318

Summaries for CCDC73 Gene

GeneCards Summary for CCDC73 Gene

CCDC73 (Coiled-Coil Domain Containing 73) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC73 Gene

Genomics for CCDC73 Gene

Regulatory Elements for CCDC73 Gene

Enhancers for CCDC73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F032706 1.1 FANTOM5 Ensembl ENCODE 11.6 +87.3 87316 1.3 ZNF366 SCRT2 RCOR1 FOS CREM ZNF362 CEBPB JUNB ZNF264 MEF2D EIF3M CCDC73 HNRNPA3P9 ENSG00000244535
GH11F032847 0.2 Ensembl 10.3 -53.0 -52982 0.5 PKNOX1 ZNF280D ZNF146 ZMYM3 KDM1A SPI1 TCP11L1 CCDC73 PRRG4 QSER1
GH11F032851 0.6 Ensembl ENCODE 10.3 -57.7 -57720 1.0 GATAD2A SOX5 SOX13 NFIA FOXA3 BHLHE40 CEBPB ZMYM3 KDM1A TCF7L2 PRRG4 QSER1 TCP11L1 CCDC73
GH11F032849 0.5 Ensembl 10.3 -55.5 -55543 0.8 TCP11L1 CCDC73 PRRG4 QSER1
GH11F032333 0.5 Ensembl ENCODE 10 +461.0 461023 1.3 CTCF POLR2A NR3C1 ZNF24 RAD21 WT1 WT1-AS CCDC73 THEM7P PIR50067
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC73 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC73 Gene

Chromosome:
11
Start:
32,602,080 bp from pter
End:
32,794,658 bp from pter
Size:
192,579 bases
Orientation:
Minus strand

Genomic View for CCDC73 Gene

Genes around CCDC73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC73 Gene

Proteins for CCDC73 Gene

  • Protein details for CCDC73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRK6-CCD73_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 73
    Protein Accession:
    Q6ZRK6
    Secondary Accessions:
    • Q6P5Q7
    • Q6ZMW0
    • Q86WE7

    Protein attributes for CCDC73 Gene

    Size:
    1079 amino acids
    Molecular mass:
    124154 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH62749.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO65175.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAC87304.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18615.1; Type=Frameshift; Positions=448; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC73 Gene

Post-translational modifications for CCDC73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC73 Gene

No data available for DME Specific Peptides for CCDC73 Gene

Domains & Families for CCDC73 Gene

Protein Domains for CCDC73 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC73: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC73 Gene

Function for CCDC73 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC73 Gene

Localization for CCDC73 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC73 Gene COMPARTMENTS Subcellular localization image for CCDC73 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC73 Gene

Pathways & Interactions for CCDC73 Gene

SuperPathways for CCDC73 Gene

No Data Available

Interacting Proteins for CCDC73 Gene

Gene Ontology (GO) - Biological Process for CCDC73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC73 Gene

Transcripts for CCDC73 Gene

mRNA/cDNA for CCDC73 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC73 Gene

Coiled-coil domain containing 73:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC73 Gene

No ASD Table

Relevant External Links for CCDC73 Gene

GeneLoc Exon Structure for
CCDC73
ECgene alternative splicing isoforms for
CCDC73

Expression for CCDC73 Gene

mRNA expression in normal human tissues for CCDC73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC73 Gene

This gene is overexpressed in Testis (x22.5).

Protein differential expression in normal tissues from HIPED for CCDC73 Gene

This gene is overexpressed in Liver (38.3), Bone (11.7), and Fetal ovary (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC73 Gene



Protein tissue co-expression partners for CCDC73 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC73 Gene:

CCDC73

SOURCE GeneReport for Unigene cluster for CCDC73 Gene:

Hs.706808
genes like me logo Genes that share expression patterns with CCDC73: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC73 Gene

Orthologs for CCDC73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC73 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia CCDC73 34 35
  • 87.1 (n)
cow
(Bos Taurus)
Mammalia CCDC73 34 35
  • 86.64 (n)
mouse
(Mus musculus)
Mammalia Ccdc73 34 16 35
  • 77.41 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc73 34
  • 76.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC73 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC73 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC73 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC73 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccdc73 35
  • 31 (a)
OneToOne
Species where no ortholog for CCDC73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC73 Gene

ENSEMBL:
Gene Tree for CCDC73 (if available)
TreeFam:
Gene Tree for CCDC73 (if available)

Paralogs for CCDC73 Gene

No data available for Paralogs for CCDC73 Gene

Variants for CCDC73 Gene

Sequence variations from dbSNP and Humsavar for CCDC73 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128630 -- 32,681,946(+) ataCC(A/C)ACATA intron-variant
rs1038554 -- 32,672,020(-) GGATG(G/T)AGATG intron-variant
rs10458903 -- 32,787,720(+) GAATC(G/T)TTGTG intron-variant
rs1049240 -- 32,602,355(+) AAAAT(C/T)TGAAC reference, synonymous-codon, utr-variant-3-prime
rs10591021 -- 32,606,807(+) TTTTT(-/TTT)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC73 Gene

Variant ID Type Subtype PubMed ID
esv1483356 CNV deletion 17803354
esv2646311 CNV deletion 19546169
esv2744317 CNV deletion 23290073
esv2744318 CNV deletion 23290073
esv2759815 CNV gain 17122850
esv3305860 CNV mobile element insertion 20981092
esv3351163 CNV duplication 20981092
esv3414559 CNV insertion 20981092
esv34742 CNV gain 17911159
nsv1043616 CNV loss 25217958
nsv1159852 CNV deletion 26073780
nsv477740 CNV novel sequence insertion 20440878
nsv832109 CNV gain 17160897
nsv957216 CNV deletion 24416366
nsv971998 CNV duplication 23825009

Variation tolerance for CCDC73 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC73 Gene

Disorders for CCDC73 Gene

Relevant External Links for CCDC73

Genetic Association Database (GAD)
CCDC73
Human Genome Epidemiology (HuGE) Navigator
CCDC73
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC73

No disorders were found for CCDC73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC73 Gene

Publications for CCDC73 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 46 64
  3. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for CCDC73 Gene

Sources for CCDC73 Gene

Content
Loading form....