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Aliases for CCDC71L Gene

Aliases for CCDC71L Gene

  • Coiled-Coil Domain Containing 71 Like 2 3
  • C7orf74 3 4
  • Coiled-Coil Domain-Containing Protein 71L 3
  • Coiled-Coil Domain Containing 71-Like 5
  • Chromosome 7 Open Reading Frame 74 2

External Ids for CCDC71L Gene

Previous HGNC Symbols for CCDC71L Gene

  • C7orf74

Previous GeneCards Identifiers for CCDC71L Gene

  • GC07M106298

Summaries for CCDC71L Gene

GeneCards Summary for CCDC71L Gene

CCDC71L (Coiled-Coil Domain Containing 71 Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC71L Gene

Genomics for CCDC71L Gene

Regulatory Elements for CCDC71L Gene

Enhancers for CCDC71L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G106716 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14 -56.9 -56859 3.5 PKNOX1 ATF1 ARNT SIN3A E2F7 TCF12 ELK1 GATA2 CBX5 FOS CCDC71L HBP1 NAMPT PIK3CG ENSG00000243797
GH07G106772 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -113.4 -113363 4.6 HDGF PKNOX1 CREB3L1 ARNT YY1 ZNF766 FOS KLF13 JUNB ZNF592 ENSG00000228742 CCDC71L ENSG00000267052 PIK3CG CBLL1 ENSG00000243797
GH07G106567 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +92.1 92126 2.7 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 YY1 ZNF766 CBX5 FOS CCDC71L NAMPT ENSG00000267052 LARP1BP2
GH07G106552 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +108.5 108488 1.3 PKNOX1 WRNIP1 SIN3A YBX1 YY1 ZNF766 CBX5 ZNF143 ZNF207 CAVIN1 CCDC71L NAMPT PIK3CG ENSG00000267052 LARP1BP2
GH07G106765 1.5 FANTOM5 Ensembl ENCODE 11.1 -107.5 -107464 5.7 PKNOX1 ATF1 BRCA1 ZNF766 ELK1 GATA2 FOS KLF13 CAVIN1 ZNF592 ENSG00000228742 PIK3CG CCDC71L ENSG00000267052 HBP1 NAMPT ENSG00000243797
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC71L on UCSC Golden Path with GeneCards custom track

Promoters for CCDC71L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216494 888 2601 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 ZBTB7B YY1 ZNF766 CBX5

Genomic Location for CCDC71L Gene

Chromosome:
7
Start:
106,656,765 bp from pter
End:
106,661,188 bp from pter
Size:
4,424 bases
Orientation:
Minus strand

Genomic View for CCDC71L Gene

Genes around CCDC71L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC71L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC71L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC71L Gene

Proteins for CCDC71L Gene

  • Protein details for CCDC71L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9Z2-CC71L_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 71L
    Protein Accession:
    Q8N9Z2
    Secondary Accessions:
    • Q7Z756

    Protein attributes for CCDC71L Gene

    Size:
    235 amino acids
    Molecular mass:
    26261 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13906.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24398.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC71L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC71L Gene

Post-translational modifications for CCDC71L Gene

  • Ubiquitination at Lys54, Lys61, and Lys96
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC71L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC71L Gene

Domains & Families for CCDC71L Gene

Protein Domains for CCDC71L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC71L: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC71L Gene

Function for CCDC71L Gene

Phenotypes for CCDC71L Gene

genes like me logo Genes that share phenotypes with CCDC71L: view

Animal Model Products

CRISPR Products

miRNA for CCDC71L Gene

miRTarBase miRNAs that target CCDC71L

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC71L Gene

Localization for CCDC71L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC71L Gene

Pathways & Interactions for CCDC71L Gene

SuperPathways for CCDC71L Gene

No Data Available

Interacting Proteins for CCDC71L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000430897%0d%0a9606.ENSP00000336687%0d%0a
Selected Interacting proteins: Q8N9Z2-CC71L_HUMAN ENSP00000430897 for CCDC71L Gene via IID STRING

Gene Ontology (GO) - Biological Process for CCDC71L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC71L Gene

Drugs & Compounds for CCDC71L Gene

No Compound Related Data Available

Transcripts for CCDC71L Gene

mRNA/cDNA for CCDC71L Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(169) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC71L Gene

Coiled-coil domain containing 71-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC71L Gene

No ASD Table

Relevant External Links for CCDC71L Gene

GeneLoc Exon Structure for
CCDC71L
ECgene alternative splicing isoforms for
CCDC71L

Expression for CCDC71L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC71L Gene

Protein differential expression in normal tissues from HIPED for CCDC71L Gene

This gene is overexpressed in Rectum (22.6), Spleen (13.3), Oral epithelium (10.8), and Stomach (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC71L Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC71L Gene:

CCDC71L

SOURCE GeneReport for Unigene cluster for CCDC71L Gene:

Hs.29692
genes like me logo Genes that share expression patterns with CCDC71L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC71L Gene

Orthologs for CCDC71L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC71L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC71L 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia CCDC71L 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc71l 34
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Ccdc71l 34 16 35
  • 80.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC71L 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC71L 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC71L 35
  • 48 (a)
OneToOne
Species where no ortholog for CCDC71L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC71L Gene

ENSEMBL:
Gene Tree for CCDC71L (if available)
TreeFam:
Gene Tree for CCDC71L (if available)

Paralogs for CCDC71L Gene

No data available for Paralogs for CCDC71L Gene

Variants for CCDC71L Gene

Sequence variations from dbSNP and Humsavar for CCDC71L Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs869025233 Uncertain significance 106,660,419(-) AGGAG(A/C)GCTGC intron-variant, reference, missense
rs1000667404 -- 106,657,230(+) TGCCC(C/T)CAACA intron-variant, utr-variant-3-prime
rs1000674102 -- 106,656,898(+) TTCTA(A/C)TGCGC intron-variant, utr-variant-3-prime
rs1000879162 -- 106,660,411(+) TTGGC(C/T)GGGCA intron-variant, reference, synonymous-codon
rs1001514776 -- 106,656,506(+) TTTTT(A/T)GTAGG intron-variant, utr-variant-3-prime

Variation tolerance for CCDC71L Gene

Gene Damage Index Score: 0.12; 2.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC71L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC71L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC71L Gene

Disorders for CCDC71L Gene

Relevant External Links for CCDC71L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC71L

No disorders were found for CCDC71L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC71L Gene

Publications for CCDC71L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for CCDC71L Gene

Sources for CCDC71L Gene

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