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Aliases for CCDC70 Gene

Aliases for CCDC70 Gene

  • Coiled-Coil Domain Containing 70 2 3 5

External Ids for CCDC70 Gene

Previous GeneCards Identifiers for CCDC70 Gene

  • GC13P051335
  • GC13P052436
  • GC13P033224

Summaries for CCDC70 Gene

GeneCards Summary for CCDC70 Gene

CCDC70 (Coiled-Coil Domain Containing 70) is a Protein Coding gene.

Gene Wiki entry for CCDC70 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC70 Gene

Genomics for CCDC70 Gene

Regulatory Elements for CCDC70 Gene

Genomic Location for CCDC70 Gene

Chromosome:
13
Start:
51,861,981 bp from pter
End:
51,866,236 bp from pter
Size:
4,256 bases
Orientation:
Plus strand

Genomic View for CCDC70 Gene

Genes around CCDC70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC70 Gene

Proteins for CCDC70 Gene

  • Protein details for CCDC70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSX1-CCD70_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 70
    Protein Accession:
    Q6NSX1
    Secondary Accessions:
    • Q8N7A8
    • Q9H097

    Protein attributes for CCDC70 Gene

    Size:
    233 amino acids
    Molecular mass:
    28767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC70 Gene

Proteomics data for CCDC70 Gene at MOPED

Post-translational modifications for CCDC70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC70 Gene

Domains & Families for CCDC70 Gene

Protein Domains for CCDC70 Gene

Suggested Antigen Peptide Sequences for CCDC70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC70: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC70 Gene

Function for CCDC70 Gene

Phenotypes for CCDC70 Gene

genes like me logo Genes that share phenotypes with CCDC70: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC70 Gene

Localization for CCDC70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC70 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC70 Gene COMPARTMENTS Subcellular localization image for CCDC70 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for CCDC70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CCDC70: view

Pathways & Interactions for CCDC70 Gene

SuperPathways for CCDC70 Gene

No Data Available

Interacting Proteins for CCDC70 Gene

Gene Ontology (GO) - Biological Process for CCDC70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC70 Gene

Drugs & Compounds for CCDC70 Gene

No Compound Related Data Available

Transcripts for CCDC70 Gene

mRNA/cDNA for CCDC70 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC70 Gene

Coiled-coil domain containing 70:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC70 Gene

No ASD Table

Relevant External Links for CCDC70 Gene

GeneLoc Exon Structure for
CCDC70
ECgene alternative splicing isoforms for
CCDC70

Expression for CCDC70 Gene

mRNA expression in normal human tissues for CCDC70 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC70 Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for CCDC70 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC70 Gene



SOURCE GeneReport for Unigene cluster for CCDC70 Gene Hs.120573

genes like me logo Genes that share expression patterns with CCDC70: view

Protein tissue co-expression partners for CCDC70 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC70 Gene

Orthologs for CCDC70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC70 35
  • 82.88 (n)
  • 78.83 (a)
CCDC70 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC70 35
  • 83.78 (n)
  • 80.63 (a)
CCDC70 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc70 35
  • 83.33 (n)
  • 83.33 (a)
Ccdc70 16
Ccdc70 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC70 35
  • 99.43 (n)
  • 99.14 (a)
CCDC70 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC70 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC70 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC70 36
  • 33 (a)
OneToOne
Species with no ortholog for CCDC70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC70 Gene

ENSEMBL:
Gene Tree for CCDC70 (if available)
TreeFam:
Gene Tree for CCDC70 (if available)

Paralogs for CCDC70 Gene

No data available for Paralogs for CCDC70 Gene

Variants for CCDC70 Gene

Sequence variations from dbSNP and Humsavar for CCDC70 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1054515 - 51,865,994(+) GCCAC(A/G)TTGCC reference, missense
rs17076052 - 51,865,754(+) AGTAC(C/T)GCACT reference, missense
rs549831 -- 51,863,977(-) AAGGG(A/C)TGAGA intron-variant
rs575555 -- 51,863,485(-) GAAAC(C/T)ATGCC intron-variant
rs577331 -- 51,863,285(-) CTGAA(A/C)GCCCT intron-variant

Variation tolerance for CCDC70 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC70 Gene

HapMap Linkage Disequilibrium report
CCDC70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC70 Gene

Disorders for CCDC70 Gene

Relevant External Links for CCDC70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC70

No disorders were found for CCDC70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC70 Gene

Publications for CCDC70 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CCDC70 Gene

Sources for CCDC70 Gene

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