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Aliases for CCDC7 Gene

Aliases for CCDC7 Gene

  • Coiled-Coil Domain Containing 7 2 3 5
  • BIOT2 3 4
  • Chromosome 10 Open Reading Frame 68 2
  • Protein BIOT2 4
  • C10orf68 3
  • BioT2-A 3
  • BioT2-B 3
  • BioT2-C 3

External Ids for CCDC7 Gene

Previous HGNC Symbols for CCDC7 Gene

  • C10orf68

Previous GeneCards Identifiers for CCDC7 Gene

  • GC10P032739
  • GC10P032776
  • GC10P032735

Summaries for CCDC7 Gene

GeneCards Summary for CCDC7 Gene

CCDC7 (Coiled-Coil Domain Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC7 Gene

  • May play a role in tumorigenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC7 Gene

Genomics for CCDC7 Gene

Regulatory Elements for CCDC7 Gene

Promoters for CCDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC7 Gene

Chromosome:
10
Start:
32,446,082 bp from pter
End:
32,882,874 bp from pter
Size:
436,793 bases
Orientation:
Plus strand

Genomic View for CCDC7 Gene

Genes around CCDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC7 Gene

Proteins for CCDC7 Gene

  • Protein details for CCDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M83-CCDC7_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 7
    Protein Accession:
    Q96M83
    Secondary Accessions:
    • Q5VW55
    • Q8IVQ0
    • Q8NEQ0

    Protein attributes for CCDC7 Gene

    Size:
    486 amino acids
    Molecular mass:
    55780 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC7 Gene

Proteomics data for CCDC7 Gene at MOPED

Post-translational modifications for CCDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC7 Gene

No data available for DME Specific Peptides for CCDC7 Gene

Domains & Families for CCDC7 Gene

Protein Domains for CCDC7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC7: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC7 Gene

Function for CCDC7 Gene

Molecular function for CCDC7 Gene

UniProtKB/Swiss-Prot Function:
May play a role in tumorigenesis.
genes like me logo Genes that share phenotypes with CCDC7: view

miRNA for CCDC7 Gene

miRTarBase miRNAs that target CCDC7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC7 Gene

Localization for CCDC7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC7 Gene COMPARTMENTS Subcellular localization image for CCDC7 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC7 Gene

Pathways & Interactions for CCDC7 Gene

SuperPathways for CCDC7 Gene

No Data Available

Interacting Proteins for CCDC7 Gene

Selected Interacting proteins: Q96M83-CCDC7_HUMAN for CCDC7 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for CCDC7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC7 Gene

Drugs & Compounds for CCDC7 Gene

No Compound Related Data Available

Transcripts for CCDC7 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC7 Gene

No ASD Table

Relevant External Links for CCDC7 Gene

GeneLoc Exon Structure for
CCDC7
ECgene alternative splicing isoforms for
CCDC7

Expression for CCDC7 Gene

mRNA expression in normal human tissues for CCDC7 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC7 Gene

This gene is overexpressed in Testis (x10.5).

Protein differential expression in normal tissues from HIPED for CCDC7 Gene

This gene is overexpressed in Esophagus (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC7 Gene



mRNA Expression by UniProt/SwissProt for CCDC7 Gene

Q96M83-CCDC7_HUMAN
Tissue specificity: Expressed in epithelium of normal cervix and cervical cancer. Overexpressed in early and interim cervical cancer.
genes like me logo Genes that share expression patterns with CCDC7: view

Protein tissue co-expression partners for CCDC7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCDC7 Gene

Orthologs for CCDC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC7 35
  • 83.05 (n)
  • 69.49 (a)
dog
(Canis familiaris)
Mammalia CCDC7 35
  • 83.02 (n)
  • 69.13 (a)
-- 36
  • 34 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc7b 16
1700008F21Rik 35
  • 64.34 (n)
  • 43.7 (a)
rat
(Rattus norvegicus)
Mammalia Ccdc7 35
  • 68.46 (n)
  • 53.74 (a)
Species with no ortholog for CCDC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC7 Gene

ENSEMBL:
Gene Tree for CCDC7 (if available)
TreeFam:
Gene Tree for CCDC7 (if available)

Paralogs for CCDC7 Gene

(1) SIMAP similar genes for CCDC7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCDC7: view

No data available for Paralogs for CCDC7 Gene

Variants for CCDC7 Gene

Sequence variations from dbSNP and Humsavar for CCDC7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12268559 - 32,567,818(+) GGAGA(A/C)AGAAA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs56391924 - 32,456,320(+) CACTT(A/C)AAGAA nc-transcript-variant, reference, missense
rs881034 -- 32,865,982(+) CAAAC(A/G)CACAC intron-variant
rs885116 -- 32,472,847(+) CACCT(C/G/T)GGGCT intron-variant, upstream-variant-2KB
rs947703 -- 32,866,251(-) TATCA(A/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC7 Gene

Variant ID Type Subtype PubMed ID
esv275237 CNV Gain+Loss 21479260
dgv631n71 CNV Gain 21882294
nsv895005 CNV Loss 21882294
esv24286 CNV Gain 19812545

Variation tolerance for CCDC7 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC7 Gene

HapMap Linkage Disequilibrium report
CCDC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC7 Gene

Disorders for CCDC7 Gene

Relevant External Links for CCDC7

Genetic Association Database (GAD)
CCDC7
Human Genome Epidemiology (HuGE) Navigator
CCDC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC7

No disorders were found for CCDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC7 Gene

Publications for CCDC7 Gene

  1. Overexpression of the hBiot2 gene is associated with development of human cervical cancer. (PMID: 21109960) Shen Y.M. … Zhao X. (Oncol. Rep. 2011) 2 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. A cohesin-RAD21 interactome. (PMID: 22145905) Panigrahi A.K. … Pati D. (Biochem. J. 2012) 3
  4. Novel gene hBiot2 is an independent prognostic factor in colorectal cancer patients. (PMID: 22024937) Shen Y.M. … Sun X.F. (Oncol. Rep. 2012) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for CCDC7 Gene

Sources for CCDC7 Gene

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