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Aliases for CCDC7 Gene

Aliases for CCDC7 Gene

  • Coiled-Coil Domain Containing 7 2 3 5
  • C10orf68 3 4
  • BIOT2 3 4
  • Coiled-Coil Domain-Containing Protein 7 3
  • Chromosome 10 Open Reading Frame 68 2
  • Uncharacterized Protein C10orf68 3
  • Protein BIOT2 4
  • BioT2-A 3
  • BioT2-B 3
  • BioT2-C 3

External Ids for CCDC7 Gene

Previous HGNC Symbols for CCDC7 Gene

  • C10orf68

Previous GeneCards Identifiers for CCDC7 Gene

  • GC10P032739
  • GC10P032776
  • GC10P032735

Summaries for CCDC7 Gene

GeneCards Summary for CCDC7 Gene

CCDC7 (Coiled-Coil Domain Containing 7) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC7 Gene

  • May play a role in tumorigenesis.

Additional gene information for CCDC7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC7 Gene

Genomics for CCDC7 Gene

Regulatory Elements for CCDC7 Gene

Enhancers for CCDC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H032937 1.4 Ensembl ENCODE dbSUPER 14.9 +493.7 493722 5.2 HDAC1 ELF3 ARID4B SIN3A ZSCAN5C SCRT2 NFYC REST ELF1 NR2F2 LOC105376486 CCDC7 AK3P5
GH10H032947 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +509.5 509475 17.1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 SP3 ZC3H11A ZNF610 GLIS1 RCOR2 LOC105376486 ITGB1 EPC1 CCDC7 ITGB1-DT AK3P5
GH10H031602 1.4 FANTOM5 ENCODE 13.4 -842.4 -842353 3.1 HDGF SIN3A DMAP1 ZBTB7B GLIS2 ELK1 ZNF143 KLF7 SP3 SP5 ZEB1-AS1 CCDC7 EPC1 ENSG00000223834 PIR43423
GH10H032978 1.8 FANTOM5 ENCODE dbSUPER 10.2 +536.9 536918 8 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 EPC1 CCDC7 LOC105376486 ITGB1 ITGB1-DT
GH10H032331 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.6 -113.1 -113060 2.4 HDGF PKNOX1 ATF1 SIN3A BATF ZNF2 GATA2 ZNF350 ZNF143 ATF7 EPC1 CCDC7 ARHGAP12 ENSG00000233825 ENSG00000226842
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC7 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000026557 318 2401 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Locations for CCDC7 Gene

Genomic Locations for CCDC7 Gene
436,793 bases
Plus strand

Genomic View for CCDC7 Gene

Genes around CCDC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC7 Gene

Proteins for CCDC7 Gene

  • Protein details for CCDC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • B0QZ71
    • Q08AN7
    • Q5VW55
    • Q8IVQ0
    • Q8N7T7
    • Q8NEQ0
    • Q9H943

    Protein attributes for CCDC7 Gene

    1385 amino acids
    Molecular mass:
    157448 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI25092.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB14400.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAC05140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC7 Gene


neXtProt entry for CCDC7 Gene

Post-translational modifications for CCDC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC7 Gene

Domains & Families for CCDC7 Gene

Gene Families for CCDC7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC7 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC7: view

No data available for UniProtKB/Swiss-Prot for CCDC7 Gene

Function for CCDC7 Gene

Molecular function for CCDC7 Gene

UniProtKB/Swiss-Prot Function:
May play a role in tumorigenesis.

Phenotypes From GWAS Catalog for CCDC7 Gene

genes like me logo Genes that share phenotypes with CCDC7: view

Animal Model Products

miRNA for CCDC7 Gene

miRTarBase miRNAs that target CCDC7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC7 Gene

Localization for CCDC7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC7 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC7 Gene

Pathways & Interactions for CCDC7 Gene

SuperPathways for CCDC7 Gene

No Data Available

Interacting Proteins for CCDC7 Gene

Gene Ontology (GO) - Biological Process for CCDC7 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC7 Gene

Drugs & Compounds for CCDC7 Gene

No Compound Related Data Available

Transcripts for CCDC7 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC7 Gene

No ASD Table

Relevant External Links for CCDC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC7 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC7 Gene

This gene is overexpressed in Testis (x10.5).

Protein differential expression in normal tissues from HIPED for CCDC7 Gene

This gene is overexpressed in Esophagus (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC7 Gene

Protein tissue co-expression partners for CCDC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC7 Gene:


mRNA Expression by UniProt/SwissProt for CCDC7 Gene:

Tissue specificity: Expressed in epithelium of normal cervix and cervical cancer. Overexpressed in early and interim cervical cancer.
genes like me logo Genes that share expression patterns with CCDC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC7 Gene

Orthologs for CCDC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC7 34
  • 98 (a)
(Bos Taurus)
Mammalia CCDC7 33 34
  • 83.05 (n)
(Canis familiaris)
Mammalia CCDC7 33 34
  • 83.02 (n)
(Rattus norvegicus)
Mammalia Ccdc7 33
  • 68.46 (n)
(Mus musculus)
Mammalia 1700008F21Rik 33 34
  • 64.34 (n)
Ccdc7 34
  • 49 (a)
Ccdc7b 16
(Monodelphis domestica)
Mammalia CCDC7 34
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC7 34
  • 15 (a)
Species where no ortholog for CCDC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC7 Gene

Gene Tree for CCDC7 (if available)
Gene Tree for CCDC7 (if available)

Paralogs for CCDC7 Gene

(1) SIMAP similar genes for CCDC7 Gene using alignment to 5 proteins: Pseudogenes for CCDC7 Gene

genes like me logo Genes that share paralogs with CCDC7: view

No data available for Paralogs for CCDC7 Gene

Variants for CCDC7 Gene

Sequence variations from dbSNP and Humsavar for CCDC7 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000013295 -- 32,657,887(+) CAGAT(A/G)CCATA intron-variant
rs1000024535 -- 32,644,514(+) GTTGC(A/T)AATGA intron-variant
rs1000027578 -- 32,473,057(+) AACAT(A/G)CAAAA intron-variant
rs1000028812 -- 32,603,695(+) ATTTC(A/G)TTATG intron-variant
rs1000029192 -- 32,564,441(+) TGTTG(C/T)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC7 Gene

Variant ID Type Subtype PubMed ID
nsv831827 CNV loss 17160897
nsv6287 CNV insertion 18451855
nsv1149421 CNV duplication 26484159
nsv1133984 CNV deletion 24896259
esv3891783 CNV gain 25118596
esv3622841 CNV loss 21293372
esv3622839 CNV loss 21293372
esv3622838 CNV gain 21293372
esv3622837 CNV loss 21293372
esv3622836 CNV loss 21293372
esv3622834 CNV loss 21293372
esv3622833 CNV gain 21293372
esv3622830 CNV loss 21293372
esv3578755 CNV loss 25503493
esv3546131 CNV deletion 23714750
esv3546129 CNV deletion 23714750
esv3395516 CNV insertion 20981092
esv3135489 CNV deletion 24192839
esv2761591 CNV loss 21179565
esv2759741 CNV loss 17122850
esv275237 CNV gain+loss 21479260
esv2735195 CNV deletion 23290073
esv2735184 CNV deletion 23290073
esv2676134 CNV deletion 23128226
esv2660827 CNV deletion 23128226
esv2461269 CNV deletion 19546169
esv24286 CNV gain 19812545
esv1722312 CNV insertion 17803354
dgv40n21 CNV loss 19592680

Variation tolerance for CCDC7 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.52; 88.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC7 Gene

Disorders for CCDC7 Gene

Relevant External Links for CCDC7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC7 Gene

Publications for CCDC7 Gene

  1. Overexpression of the hBiot2 gene is associated with development of human cervical cancer. (PMID: 21109960) Shen YM … Zhao X (Oncology reports 2011) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CCDC7 Gene

Sources for CCDC7 Gene

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