CCDC7 Gene
protein-coding GIFtS: 41
GCID: GC10P032776
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coiled-coil domain containing 7
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Aliases
for CCDC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 71 2 | | RP11-479G22.12 | | FLJ327621 | | Coiled-Coil Domain-Containing Protein 72 | | BioT2-A2 | | BIOT23 | | BioT2-B2 | | Protein BIOT23 | | BioT2-C2 | | |
Export aliases for CCDC7 gene to outside databasesPrevious GC identifers: GC10P032739 GC10P032454 |
Summaries
for CCDC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CCDC7_HUMAN, Q96M83Function: May play a role in tumorigenesis (By similarity)
|
Genomic Views
for CCDC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC7 gene promoter:
LyF-1 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p11.22 Ensembl cytogenetic band: 10p11.22 HGNC cytogenetic band: 10p11.23CCDC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P032776: view genomic region
(about GC identifiers)
Start:
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32,735,041 bp from pter |
End:
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32,863,501 bp from pter |
Size:
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128,461 bases |
Orientation:
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plus strand |
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Proteins
for CCDC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCDC7_HUMAN, Q96M83 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 7 Size: 486 amino acids; 55780 Da
Secondary accessions: Q5VW55 Q8IVQ0 Q8NEQ0Alternative splicing: 2 isoforms: Q96M83-1 Q96M83-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC7: NX_Q96M83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M83
CCDC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001021554.1 NP_659460.3
ENSEMBL proteins: ENSP00000436435 ENSP00000277657 ENSP00000355078 ENSP00000433128 ENSP00000401923 ENSP00000441041 ENSP00000440632 ENSP00000439930 ENSP00000442531
Human Recombinant Protein Products for CCDC7:
CCDC7 Antibody Products:
Assay Products for CCDC7: |
Protein
Domains /
Families
for CCDC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96M83 |
Function
for CCDC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CCDC7_HUMAN, Q96M83Function: May play a role in tumorigenesis (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC7 (NM_015933) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC7 |
|
Pathways & Interactions
for CCDC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC7
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for CCDC7 (Q96M832, 3 ENSP000002776574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC7
Search CenterWatch for drugs/clinical trials and news about CCDC7
|
Transcripts
for CCDC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC7 gene (2 alternative transcripts): NM_001026383.1 NM_145023.4 Unigene Cluster for CCDC7: Coiled-coil domain containing 7 Hs.585464 [show with all ESTs]Unigene Representative Sequence: BX64777112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476558(uc009xly.1 uc009xlx.1) ENST00000277657(uc001iwk.3 uc009xlv.3)
ENST00000362006(uc001iwj.3) ENST00000496320(uc009xlw.1) ENST00000489718
ENST00000493685 ENST00000435402 ENST00000471905 ENST00000539197 ENST00000537047
ENST00000545067(uc009xlu.2) ENST00000535327
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC7 (NM_015933) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC7 |
Additional cDNA sequence: AK023093.1 AK057324.1 AK058148.1 AK097668.1 AK301824.1 BC022020.2 BC042672.1 BC125090.1 BC125091.1 BX647771.1 EF656618.1 EF656619.1 EF656620.1 16 DOTS entries: DT.452941 DT.121253086 DT.95164795 DT.100797251 DT.97764095 DT.409722 DT.100737698 DT.100748333 DT.101967067 DT.100748334 DT.75115732 DT.40127360 DT.40129985 DT.99946159 DT.121253051 DT.91770516 24/48 AceView cDNA sequences (see all 48): AA400069 BM554024 NM_145023 BC022020 BX952720 AI018457 AI243111 BC042672 AA421130 BI825699 AK057324 AA416799 AA861428 BG724355 AK058148 BX098451 BU567456 AU130596 AA401505 AK023093 AA973049 BX647771 BQ441383 BI520023
GeneLoc Exon Structure
|
Expression
for CCDC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAATTCAG
About this image
See CCDC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC7
SOURCE GeneReport for Unigene cluster: Hs.585464
UniProtKB/Swiss-Prot: CCDC7_HUMAN, Q96M83Tissue specificity: Expressed in epithelium of normal cervix and cervical cancer. Overexpressed in early and interimcervical cancer
SABiosciences Custom PCR Arrays for CCDC7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC7 |
Orthologs
for CCDC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CCDC7 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for CCDC7 (if available)
TreeFam Gene Tree for CCDC7 (if available) |
Paralogs
for CCDC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC7 gene
1 SIMAP similar gene for CCDC7 using alignment to 6 protein entries: CCDC7_HUMAN (see all proteins):DKFZp686N0559
CCDC7 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CCDC7
PGOHUM00000259090
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Genomic Variants
for CCDC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC7 (32735041 - 32863501 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC7
1 CNV: 65637 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC7 |
|
Disorders
/ Diseases
for CCDC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC7 for disorders About GeneDecksing
3  diseases for CCDC7: About MalaCardscervical cancer alzheimer's disease cervicitis
Human Genome Epidemiology (HuGE) Navigator: CCDC7 (2 documents)
Export disorders for CCDC7 gene to outside databases
|
Publications
for CCDC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CCDC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Overexpression of the hBiot2 gene is associated with development of human cervical cancer. (PubMed id 21109960)1, 2 Shen Y.M....Zhao X. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Novel gene hBiot2 is an independent prognostic factor in colorectal cancer patients. (PubMed id 22024937)1 Shen Y.M....Sun X.F. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- RNA interference against Biot2, a novel mouse testis - specific gene, inhibits the growth of tumor cells. (PubMed id 19277478)1 Wang C.T....Wei Y.Q. (2009)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for CCDC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC7 gene:
Search GeneIP for patents involving CCDC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC7 | | | OriGene Protein Over-expression Lysate for CCDC7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC7 |
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 | | | CCDC7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC7 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCDC7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC7 |
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