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Aliases for CCDC69 Gene

Aliases for CCDC69 Gene

  • Coiled-Coil Domain Containing 69 2 3 5

External Ids for CCDC69 Gene

Previous GeneCards Identifiers for CCDC69 Gene

  • GC05M150541
  • GC05M145706
  • GC05M150560

Summaries for CCDC69 Gene

GeneCards Summary for CCDC69 Gene

CCDC69 (Coiled-Coil Domain Containing 69) is a Protein Coding gene. An important paralog of this gene is MTUS2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC69 Gene

Genomics for CCDC69 Gene

Regulatory Elements for CCDC69 Gene

Promoters for CCDC69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC69 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC69 Gene

Chromosome:
5
Start:
151,181,052 bp from pter
End:
151,224,145 bp from pter
Size:
43,094 bases
Orientation:
Minus strand

Genomic View for CCDC69 Gene

Genes around CCDC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC69 Gene

Proteins for CCDC69 Gene

  • Protein details for CCDC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI79-CCD69_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 69
    Protein Accession:
    A6NI79
    Secondary Accessions:
    • A8K9X6

    Protein attributes for CCDC69 Gene

    Size:
    296 amino acids
    Molecular mass:
    34796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC69 Gene

Proteomics data for CCDC69 Gene at MOPED

Post-translational modifications for CCDC69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC69 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CCDC69

No data available for DME Specific Peptides for CCDC69 Gene

Domains & Families for CCDC69 Gene

Protein Domains for CCDC69 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC69: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC69 Gene

Function for CCDC69 Gene

genes like me logo Genes that share phenotypes with CCDC69: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC69 Gene

Localization for CCDC69 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC69 Gene COMPARTMENTS Subcellular localization image for CCDC69 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
golgi apparatus 2
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC69 Gene

Pathways & Interactions for CCDC69 Gene

SuperPathways for CCDC69 Gene

No Data Available

Interacting Proteins for CCDC69 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000347586%0d%0a9606.ENSP00000216455%0d%0a9606.ENSP00000364361%0d%0a9606.ENSP00000309477%0d%0a
Selected Interacting proteins: A6NI79-CCD69_HUMAN ENSP00000347586 for CCDC69 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for CCDC69 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC69 Gene

Drugs & Compounds for CCDC69 Gene

No Compound Related Data Available

Transcripts for CCDC69 Gene

Unigene Clusters for CCDC69 Gene

Coiled-coil domain containing 69:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC69 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11
SP1: - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CCDC69 Gene

GeneLoc Exon Structure for
CCDC69
ECgene alternative splicing isoforms for
CCDC69

Expression for CCDC69 Gene

mRNA expression in normal human tissues for CCDC69 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC69 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC69 Gene

This gene is overexpressed in Plasma (28.9), Serum (17.0), and Monocytes (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC69 Gene



SOURCE GeneReport for Unigene cluster for CCDC69 Gene Hs.655336

genes like me logo Genes that share expression patterns with CCDC69: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC69 Gene

Orthologs for CCDC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC69 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC69 35
  • 85.49 (n)
  • 82.99 (a)
CCDC69 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC69 35
  • 86.51 (n)
  • 83.67 (a)
CCDC69 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC69 35
  • 99.43 (n)
  • 99.29 (a)
CCDC69 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC69 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc69 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC69 36
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC69 35
  • 66.53 (n)
  • 56.54 (a)
CCDC69 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC69 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc69 35
  • 55.76 (n)
  • 43.88 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc69 35
  • 54.48 (n)
  • 37.82 (a)
CABZ01005777.1 36
  • 27 (a)
OneToOne
Species with no ortholog for CCDC69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC69 Gene

ENSEMBL:
Gene Tree for CCDC69 (if available)
TreeFam:
Gene Tree for CCDC69 (if available)

Paralogs for CCDC69 Gene

Paralogs for CCDC69 Gene

(1) SIMAP similar genes for CCDC69 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC69: view

Variants for CCDC69 Gene

Sequence variations from dbSNP and Humsavar for CCDC69 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs248427 - 151,185,447(+) GCCGC(A/C/G/T)TGTCC reference, missense
rs153462 -- 151,225,509(+) ATGAG(A/G)CCTCA upstream-variant-2KB
rs153463 -- 151,225,139(+) AATAA(A/T)ACTAA upstream-variant-2KB
rs168699 -- 151,185,715(+) CATGT(A/G)CTAGC intron-variant
rs193728 -- 151,186,209(+) AGAAC(A/G)GTTTT intron-variant

Variation tolerance for CCDC69 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.19; 92.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC69 Gene

HapMap Linkage Disequilibrium report
CCDC69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC69 Gene

Disorders for CCDC69 Gene

Relevant External Links for CCDC69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC69

No disorders were found for CCDC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC69 Gene

Publications for CCDC69 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3

Products for CCDC69 Gene

Sources for CCDC69 Gene

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