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Aliases for CCDC69 Gene

Aliases for CCDC69 Gene

  • Coiled-Coil Domain Containing 69 2 3 5

External Ids for CCDC69 Gene

Previous GeneCards Identifiers for CCDC69 Gene

  • GC05M150541
  • GC05M145706
  • GC05M150560

Summaries for CCDC69 Gene

GeneCards Summary for CCDC69 Gene

CCDC69 (Coiled-Coil Domain Containing 69) is a Protein Coding gene. An important paralog of this gene is MTUS1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC69 Gene

Genomics for CCDC69 Gene

Regulatory Elements for CCDC69 Gene

Enhancers for CCDC69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G151195 1.4 Ensembl ENCODE dbSUPER 12.1 +27.5 27543 1.7 PKNOX1 TBL1XR1 BMI1 RAD21 EGR1 SCRT2 RELB ETV6 IKZF2 CREM CCDC69 ANXA6 GM2A LOC105378230 GC05P151163
GH05G151233 1.5 Ensembl ENCODE dbSUPER 9.2 -10.5 -10500 2.4 FOXA2 ARID4B DMAP1 ZNF48 YY1 ZNF143 ZNF207 ZNF263 SP5 KAT8 GM2A CCDC69 SLC36A3
GH05G150756 1.4 ENCODE dbSUPER 9.8 +465.8 465766 3.3 CREB3L1 MLX DMAP1 YY1 ZNF143 SP3 NFYC MEF2D ZNF610 RCOR2 SMIM3 ZNF300P1 CCDC69 RPL7P1 RPS14 DCTN4 PIR34076
GH05G151769 1.4 ENCODE dbSUPER 9.8 -548.3 -548342 5.2 HDGF FOXA2 PKNOX1 MLX ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A RPLP1P6 SMIM3 SPARC CCDC69 LOC105378231 ATOX1 LOC100652758
GH05G151074 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +142.9 142874 13.6 CREB3L1 AGO1 DMAP1 YY1 ZNF263 SP3 MCM3 NFYC TBX21 MEF2D TNIP1 ZNF300P1 ANXA6 RBM22 CCDC69 IRGM CD74 DCTN4 SLC36A1 SMIM3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC69 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189098 345 1201 HDGF ATF1 AGO1 ZNF48 YY1 ZNF143 TBX21 KAT8 ZNF579 GLIS1

Genomic Location for CCDC69 Gene

Chromosome:
5
Start:
151,181,052 bp from pter
End:
151,224,145 bp from pter
Size:
43,094 bases
Orientation:
Minus strand

Genomic View for CCDC69 Gene

Genes around CCDC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC69 Gene

Proteins for CCDC69 Gene

  • Protein details for CCDC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI79-CCD69_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 69
    Protein Accession:
    A6NI79
    Secondary Accessions:
    • A8K9X6

    Protein attributes for CCDC69 Gene

    Size:
    296 amino acids
    Molecular mass:
    34796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC69 Gene

Post-translational modifications for CCDC69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC69 Gene

No data available for DME Specific Peptides for CCDC69 Gene

Domains & Families for CCDC69 Gene

Protein Domains for CCDC69 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC69: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC69 Gene

Function for CCDC69 Gene

genes like me logo Genes that share phenotypes with CCDC69: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC69 Gene

Localization for CCDC69 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC69 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytoskeleton 2
golgi apparatus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC69 Gene

Pathways & Interactions for CCDC69 Gene

SuperPathways for CCDC69 Gene

No Data Available

Interacting Proteins for CCDC69 Gene

Gene Ontology (GO) - Biological Process for CCDC69 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC69 Gene

Drugs & Compounds for CCDC69 Gene

No Compound Related Data Available

Transcripts for CCDC69 Gene

mRNA/cDNA for CCDC69 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC69 Gene

Coiled-coil domain containing 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC69 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11
SP1: - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for CCDC69 Gene

GeneLoc Exon Structure for
CCDC69
ECgene alternative splicing isoforms for
CCDC69

Expression for CCDC69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC69 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC69 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC69 Gene

This gene is overexpressed in Plasma (28.9), Serum (17.0), and Monocytes (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC69 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC69 Gene:

CCDC69

SOURCE GeneReport for Unigene cluster for CCDC69 Gene:

Hs.655336

Evidence on tissue expression from TISSUES for CCDC69 Gene

  • Muscle(2)
genes like me logo Genes that share expression patterns with CCDC69: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC69 Gene

Orthologs for CCDC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC69 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia CCDC69 34 35
  • 86.51 (n)
cow
(Bos Taurus)
Mammalia CCDC69 34 35
  • 85.49 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC69 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC69 35
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc69 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC69 34 35
  • 66.53 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC69 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc69 34
  • 55.76 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc69 34
  • 54.48 (n)
CABZ01005777.1 35
  • 27 (a)
OneToOne
Species where no ortholog for CCDC69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC69 Gene

ENSEMBL:
Gene Tree for CCDC69 (if available)
TreeFam:
Gene Tree for CCDC69 (if available)

Paralogs for CCDC69 Gene

Paralogs for CCDC69 Gene

(1) SIMAP similar genes for CCDC69 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC69: view

Variants for CCDC69 Gene

Sequence variations from dbSNP and Humsavar for CCDC69 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000017543 -- 151,219,326(+) CCGCC(A/C)CCCTT intron-variant
rs1000051295 -- 151,200,062(+) ACTGG(A/G)TGAAT intron-variant
rs1000083459 -- 151,199,859(+) ACAGT(C/T)AACTT intron-variant
rs1000171992 -- 151,212,645(+) AAACC(A/G)ACAGG intron-variant
rs1000198793 -- 151,193,733(+) CAAAG(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC69 Gene

Variant ID Type Subtype PubMed ID
nsv1133364 CNV tandem duplication 24896259

Variation tolerance for CCDC69 Gene

Residual Variation Intolerance Score: 84.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.19; 92.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC69 Gene

Disorders for CCDC69 Gene

Relevant External Links for CCDC69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC69

No disorders were found for CCDC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC69 Gene

Publications for CCDC69 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for CCDC69 Gene

Sources for CCDC69 Gene

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