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Aliases for CCDC68 Gene

Aliases for CCDC68 Gene

  • Coiled-Coil Domain Containing 68 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen Se57-1 3 4
  • Cutaneous T-Cell Lymphoma Associated Antigen 2 3
  • CTCL-Associated Antigen Se57-1 3 4
  • CTCL Tumor Antigen Se57-1 3
  • SE57-1 3

External Ids for CCDC68 Gene

Previous GeneCards Identifiers for CCDC68 Gene

  • GC18M050720
  • GC18M052568
  • GC18M049277

Summaries for CCDC68 Gene

GeneCards Summary for CCDC68 Gene

CCDC68 (Coiled-Coil Domain Containing 68) is a Protein Coding gene. Diseases associated with CCDC68 include Cutaneous T Cell Lymphoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC68 Gene

Genomics for CCDC68 Gene

Regulatory Elements for CCDC68 Gene

Enhancers for CCDC68 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC68 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC68 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC68 Gene

54,901,509 bp from pter
54,959,508 bp from pter
58,000 bases
Minus strand

Genomic View for CCDC68 Gene

Genes around CCDC68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC68 Gene

Proteins for CCDC68 Gene

  • Protein details for CCDC68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 68
    Protein Accession:
    Secondary Accessions:
    • B2R9I3

    Protein attributes for CCDC68 Gene

    335 amino acids
    Molecular mass:
    38869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC68 Gene

Proteomics data for CCDC68 Gene at MOPED

Post-translational modifications for CCDC68 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC68 Gene

No data available for DME Specific Peptides for CCDC68 Gene

Domains & Families for CCDC68 Gene

Protein Domains for CCDC68 Gene


Suggested Antigen Peptide Sequences for CCDC68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC68 Gene

Function for CCDC68 Gene

genes like me logo Genes that share phenotypes with CCDC68: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC68 Gene

Localization for CCDC68 Gene

Subcellular locations from

Jensen Localization Image for CCDC68 Gene COMPARTMENTS Subcellular localization image for CCDC68 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC68 Gene

Pathways & Interactions for CCDC68 Gene

SuperPathways for CCDC68 Gene

No Data Available

Interacting Proteins for CCDC68 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000337209 Q9H2F9-CCD68_HUMAN for CCDC68 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for CCDC68 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC68 Gene

Drugs & Compounds for CCDC68 Gene

No Compound Related Data Available

Transcripts for CCDC68 Gene

Unigene Clusters for CCDC68 Gene

Coiled-coil domain containing 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC68 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -

Relevant External Links for CCDC68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC68 Gene

mRNA expression in normal human tissues for CCDC68 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC68 Gene

This gene is overexpressed in Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for CCDC68 Gene

This gene is overexpressed in Adipocyte (45.0) and Platelet (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC68 Gene

SOURCE GeneReport for Unigene cluster for CCDC68 Gene Hs.120790

mRNA Expression by UniProt/SwissProt for CCDC68 Gene

Tissue specificity: Expressed in bone marrow, colon, small intestine, spleen, testis, trachea and cutaneous T-cell lymphoma (CTCL).
genes like me logo Genes that share expression patterns with CCDC68: view

Protein tissue co-expression partners for CCDC68 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CCDC68 Gene

Orthologs for CCDC68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC68 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC68 35
  • 86.17 (n)
  • 81.49 (a)
CCDC68 36
  • 81 (a)
(Canis familiaris)
Mammalia CCDC68 35
  • 87.36 (n)
  • 82.99 (a)
CCDC68 36
  • 83 (a)
(Mus musculus)
Mammalia Ccdc68 35
  • 78.58 (n)
  • 72.67 (a)
Ccdc68 16
Ccdc68 36
  • 72 (a)
(Pan troglodytes)
Mammalia CCDC68 35
  • 99.8 (n)
  • 99.4 (a)
CCDC68 36
  • 99 (a)
(Monodelphis domestica)
Mammalia CCDC68 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 69 (a)
-- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia CCDC68 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc68 35
  • 57.17 (n)
  • 48.48 (a)
Species with no ortholog for CCDC68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC68 Gene

Gene Tree for CCDC68 (if available)
Gene Tree for CCDC68 (if available)

Paralogs for CCDC68 Gene

(1) SIMAP similar genes for CCDC68 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC68: view

No data available for Paralogs for CCDC68 Gene

Variants for CCDC68 Gene

Sequence variations from dbSNP and Humsavar for CCDC68 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs34751112 - 54,919,314(+) GAATC(A/G)CAAAC reference, missense
rs7232786 -- 54,906,885(+) TACAT(A/G)CATCA intron-variant
rs4801109 -- 54,904,203(+) TTGAT(C/T)TTCTG utr-variant-3-prime
rs4801110 -- 54,904,510(+) ATTCA(C/T)ATCAA intron-variant
rs4801111 -- 54,910,348(+) tagag(A/C/T)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC68 Gene

Variant ID Type Subtype PubMed ID
esv268797 CNV Insertion 20981092

Variation tolerance for CCDC68 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC68 Gene

Disorders for CCDC68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCDC68

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC68 Gene

Publications for CCDC68 Gene

  1. Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer. (PMID: 15142679) Gerhardt A. … Eichmueller S. (Cancer Lett. 2004) 2 3 4 67
  2. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Coiled-coil domain containing 68 (CCDC68) demonstrates a tumor-suppressive role in pancreatic ductal adenocarcinoma. (PMID: 25381825) Radulovich N. … Tsao M.S. (Oncogene 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CCDC68 Gene

Sources for CCDC68 Gene