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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC67 Gene

protein-coding GIFtS: 41
GCID: GC11P093063

coiled-coil domain containing 67

Search for CCDC67
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 67¹ ²
FLJ25393¹
Coiled-Coil Domain-Containing Protein 67²

External Ids:	HGNC: 26344¹	Entrez Gene: 159989²	Ensembl: ENSG00000165325⁷	UniProtKB: Q05D60³

Export aliases for CCDC67 gene to outside databases

Previous GC identifers: GC11P092704 GC11P089147

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC67 gene promoter:
HOXA9B HOXA9 HFH-3 CUTL1 Nkx5-1 FOXL1 Meis-1b FOXI1 RORalpha1 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC67 promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC67

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC67

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21

CCDC67 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC67 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P093063: view genomic region (about GC identifiers)

Start:	93,063,137 bp from pter	End:	93,171,653 bp from pter
Size:	108,517 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCD67_HUMAN, Q05D60 (See protein sequence)

Recommended Name: Coiled-coil domain-containing protein 67

Size: 604 amino acids; 70977 Da

Caution: It is uncertain whether Met-1 or Met-9 is the initiator

Secondary accessions: Q8NEF1 Q96LL7

Alternative splicing: 2 isoforms: Q05D60-1 Q05D60-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC67: NX_Q05D60

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q05D60

CCDC67 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_857596.2

ENSEMBL proteins:

ENSP00000432111 ENSP00000431946 ENSP00000433537 ENSP00000435527 ENSP00000433254

ENSP00000434635 ENSP00000433002 ENSP00000435079 ENSP00000433859 ENSP00000298050

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q05D60

UniProtKB/Swiss-Prot: CCD67_HUMAN, Q05D60

Similarity: Belongs to the CEP63 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCDC67

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CCDC67 (Q05D60^{2, 3} ENSP00000298050⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-67314 I2D: score=4 STRING: ENSP00000311695
IFIT3	O14879²^,³, ENSP00000360876⁴	MINT-67722 I2D: score=4 STRING: ENSP00000360876

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCDC67
Search CenterWatch for drugs/clinical trials and news about CCDC67 / CCD67

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CCDC67 gene:

NM_181645.3

Unigene Cluster for CCDC67:

Coiled-coil domain containing 67

Hs.436625 [show with all ESTs]

Unigene Representative Sequence: NM_181645

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534747 ENST00000530862(uc001pdo.1) ENST00000531792(uc001pdp.3)

ENST00000530053 ENST00000531448 ENST00000530273 ENST00000532819 ENST00000527307

ENST00000525646 ENST00000529909 ENST00000298050(uc001pdq.3)

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		hsa-miR-569 hsa-miR-22 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-561 hsa-miR-589* hsa-miR-618 hsa-miR-888

		SwitchGear 3'UTR luciferase reporter plasmid: CCDC67 3' UTR sequence

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Additional cDNA sequence:

AK058122.1 AK127973.1 BC017929.1 BC031247.1 BC050325.1

6 DOTS entries:

DT.100747167 DT.95262149 DT.100747402 DT.101957995 DT.40128617 DT.75197290

16 AceView cDNA sequences:

BC031247 BF433973 AI299894 AI217872 BC050325 BI463928 BX118528 AI701113

AI016815 BG217110 BG721858 BG722163 AA813464 CA314836 BX103744 BE503843

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC67 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGAATT

About this image

CCDC67 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Fourth Ventricle

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC67 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC67

SOURCE GeneReport for Unigene cluster: Hs.436625

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCDC67 gene from 2/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CCDC67¹	coiled-coil domain containing 67	65.91(n) 50.44(a)		419006 XM_417199.3 XP_417199.3
lizard (Anolis carolinensis)	Reptilia	CCDC67⁶	--	47(a)	1 ↔ 1	3(196310681-196372508)

ENSEMBL Gene Tree for CCDC67 (if available)
TreeFam Gene Tree for CCDC67 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CCDC67 gene

CEP63²

1 SIMAP similar gene for CCDC67 using alignment to 9 protein entries: CCD67_HUMAN (see all proteins):

CEP63

CCDC67 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3019207^1,2	C,	--	93061931(-)	`GCGCCC/GGGCCA`	1	--	us2k¹		3		WA NA	240
rs11820178^1,2	C,F,H,	--	93062194(+)	`cagagC/Tgagac`	1	--	us2k¹		1		NA	4
rs71064741^1,2	C	--	93062208(-)	`TTTTTTTTT TTT/-TTTTT`	1	--	us2k¹		1		NA	2
rs189441048^1,2		--	93062248(+)	`AGTTTA/GCTAAG`	1	--	us2k¹		0	--	--	--	--
rs147934889^1,2		--	93062308(+)	`CACTGC/GATTTG`	1	--	us2k¹		0	--	--	--	--
rs141724337^1,2		--	93062335(+)	`GTTTAA/CATCTT`	1	--	us2k¹		0	--	--	--	--
rs35846321^1,2	C,	--	93062649(+)	`ACGCG-/TTTTCA`	1	--	us2k¹		1		NA	2
rs181951692^1,2		--	93062845(+)	`GGGTGC/TGCATT`	1	--	us2k¹		0	--	--	--	--
rs3020061^1,2	C,F,O,A,H,	--	93063200(-)	`CGGACG/AGTGTT`	1	--	us2k¹ ese³		26		NA NS EA WA CSA	2292
rs3020060^1,2	C,F,H,	--	93063334(-)	`CCTAGT/CGTCTT`	1	--	us2k¹		17		NS EA NA WA CSA	900

HapMap Linkage Disequilibrium report for CCDC67 (93063137 - 93171653 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for CCDC67
5 CNVs: 23117 22784 4991 23428 101299
7 Indels: 39850 61174 24832 44951 75759 75760 42530

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC67 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC67)

Utopia: connect your pdf to the dynamic
world of online information

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)¹ Imboden M....Probst-Hensch N.M. (2012)
Epigenetic alteration of CCDC67 and its tumor suppress or function in gastric cancer. (PubMed id 22610074)¹ Park S.J....Kim Y.S. (2012)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 159989	HGNC: 26344	AceView: FLJ25393	Ensembl:ENSG00000165325	euGenes: HUgn159989
ECgene: CCDC67	H-InvDB: CCDC67

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC67	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC67 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC67 gene:
Search GeneIP for patents involving CCDC67

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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CCDC67 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC67

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC67

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCDC67 gene at Home site.

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CCDC67 Gene

coiled-coil domain containing 67

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Export list of displayed genes

CCDC67 Gene

coiled-coil domain containing 67

Aliasesfor CCDC67 gene

Summariesfor CCDC67 gene

Genomic Viewsfor CCDC67 gene

Proteinsfor CCDC67 gene

Protein Domains /Familiesfor CCDC67 gene

Functionfor CCDC67 gene

Pathways & Interactionsfor CCDC67 gene

Drugs & Compoundsfor CCDC67 gene

Transcriptsfor CCDC67 gene

Expression for CCDC67 gene

Orthologsfor CCDC67 gene

Paralogsfor CCDC67 gene

Genomic Variantsfor CCDC67 gene

Disorders / Diseasesfor CCDC67 gene

Publicationsfor CCDC67 gene

External Searches for CCDC67 gene

Genome Databases showing CCDC67 gene

Other Databases showing CCDC67 gene

Specialized Databases showing CCDC67 gene

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Productsfor CCDC67 gene

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Aliases
for CCDC67 gene

Summaries
for CCDC67 gene

Genomic Views
for CCDC67 gene

Proteins
for CCDC67 gene

Protein Domains /
Families
for CCDC67 gene

Function
for CCDC67 gene

Pathways & Interactions
for CCDC67 gene

Drugs & Compounds
for CCDC67 gene

Transcripts
for CCDC67 gene

Expression
for CCDC67 gene

Orthologs
for CCDC67 gene

Paralogs
for CCDC67 gene

Genomic Variants
for CCDC67 gene

Disorders / Diseases
for CCDC67 gene

Publications
for CCDC67 gene

Intellectual Property
for CCDC67 gene

Products
for CCDC67 gene