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Aliases for CCDC67 Gene

Aliases for CCDC67 Gene

  • Coiled-Coil Domain Containing 67 2 3
  • Coiled-Coil Domain-Containing Protein 67 4
  • DEUP1 4

External Ids for CCDC67 Gene

Previous GeneCards Identifiers for CCDC67 Gene

  • GC11P092704
  • GC11P093063
  • GC11P089147

Summaries for CCDC67 Gene

GeneCards Summary for CCDC67 Gene

CCDC67 (Coiled-Coil Domain Containing 67) is a Protein Coding gene. GO annotations related to this gene include MHC class II protein binding. An important paralog of this gene is CEP63.

UniProtKB/Swiss-Prot for CCDC67 Gene

  • Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC67 Gene

Genomics for CCDC67 Gene

Regulatory Elements for CCDC67 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC67 Gene

Chromosome:
11
Start:
93,329,952 bp from pter
End:
93,438,487 bp from pter
Size:
108,536 bases
Orientation:
Plus strand

Genomic View for CCDC67 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC67 Gene

Proteins for CCDC67 Gene

  • Protein details for CCDC67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05D60-DEUP1_HUMAN
    Recommended name:
    Deuterosome protein 1
    Protein Accession:
    Q05D60
    Secondary Accessions:
    • Q8NEF1
    • Q96LL7

    Protein attributes for CCDC67 Gene

    Size:
    604 amino acids
    Molecular mass:
    70977 Da
    Quaternary structure:
    • Interacts with CEP152; the interaction is mutually exclusive with CEP63.
    Miscellaneous:
    • CEP63 and CCDC67/DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, CCDC67/DEUP1 mediates de novo centriole amplification in multiciliated cells

    Alternative splice isoforms for CCDC67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC67 Gene

Proteomics data for CCDC67 Gene at MOPED

Post-translational modifications for CCDC67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC67 Gene

Domains & Families for CCDC67 Gene

Protein Domains for CCDC67 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC67 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05D60

UniProtKB/Swiss-Prot:

DEUP1_HUMAN :
  • Belongs to the CEP63 family.
Family:
  • Belongs to the CEP63 family.
genes like me logo Genes that share domains with CCDC67: view

No data available for Gene Families for CCDC67 Gene

Function for CCDC67 Gene

Molecular function for CCDC67 Gene

UniProtKB/Swiss-Prot Function:
Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for CCDC67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC67: view

Phenotypes for CCDC67 Gene

GenomeRNAi human phenotypes for CCDC67:
genes like me logo Genes that share phenotypes with CCDC67: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC67 Gene

Localization for CCDC67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC67 Gene

Cytoplasm. Note=Localizes to the deuterosome. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CCDC67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IBA --
GO:0098536 deuterosome ISS --
genes like me logo Genes that share ontologies with CCDC67: view

No data available for Subcellular locations from COMPARTMENTS for CCDC67 Gene

Pathways & Interactions for CCDC67 Gene

SuperPathways for CCDC67 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007099 centriole replication IBA --
GO:0030030 cell projection organization IEA --
GO:0098535 de novo centriole assembly ISS --
GO:1903251 multi-ciliated epithelial cell differentiation ISS --
genes like me logo Genes that share ontologies with CCDC67: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC67 Gene

Drugs & Compounds for CCDC67 Gene

No Compound Related Data Available

Transcripts for CCDC67 Gene

Unigene Clusters for CCDC67 Gene

Coiled-coil domain containing 67:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC67 Gene

No ASD Table

Relevant External Links for CCDC67 Gene

GeneLoc Exon Structure for
CCDC67
ECgene alternative splicing isoforms for
CCDC67

Expression for CCDC67 Gene

mRNA expression in normal human tissues for CCDC67 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC67 Gene

This gene is overexpressed in Testis (x36.8).

Protein differential expression in normal tissues from HIPED for CCDC67 Gene

This gene is overexpressed in Testis (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC67 Gene



SOURCE GeneReport for Unigene cluster for CCDC67 Gene Hs.436625

genes like me logo Genes that share expression patterns with CCDC67: view

Protein tissue co-expression partners for CCDC67 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC67 Gene

Orthologs for CCDC67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC67 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC67 35
  • 89.25 (n)
  • 86.25 (a)
CCDC67 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC67 35
  • 90.84 (n)
  • 88.74 (a)
CCDC67 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc67 35
  • 77.11 (n)
  • 79.62 (a)
Ccdc67 16
Ccdc67 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC67 35
  • 99.45 (n)
  • 98.68 (a)
CCDC67 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc67 35
  • 79.53 (n)
  • 82.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC67 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC67 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC67 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC67 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc67 35
  • 53.76 (n)
  • 42.83 (a)
zebrafish
(Danio rerio)
Actinopterygii cep63 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5362 36
  • 42 (a)
OneToMany
Species with no ortholog for CCDC67:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC67 Gene

ENSEMBL:
Gene Tree for CCDC67 (if available)
TreeFam:
Gene Tree for CCDC67 (if available)

Paralogs for CCDC67 Gene

Paralogs for CCDC67 Gene

(1) SIMAP similar genes for CCDC67 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCDC67: view

Variants for CCDC67 Gene

Sequence variations from dbSNP and Humsavar for CCDC67 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1004417 -- 93,397,402(+) TGTCA(C/T)CTATG intron-variant
rs1456236 -- 93,389,637(-) TATTA(A/G)GACCT intron-variant
rs1456244 -- 93,437,941(+) TACTA(C/T)AAAAT utr-variant-3-prime, downstream-variant-500B
rs1805280 -- 93,436,013(-) AAAAA(A/T)ttttt intron-variant
rs2019814 -- 93,435,719(+) TCACC(A/G)GGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC67 Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
nsv438 CNV Loss 18451855
nsv898180 CNV Gain 21882294
nsv468793 CNV Loss 19166990
nsv898181 CNV Gain 21882294
nsv507609 CNV Insertion 20534489
esv2478418 CNV Deletion 19546169
esv2316215 CNV Deletion 18987734
esv3167 CNV Deletion 18987735
esv2744921 CNV Deletion 23290073
esv1004124 CNV Deletion 20482838
esv1760867 CNV Deletion 17803354
esv5775 CNV Loss 19470904
nsv439 CNV Loss 18451855
nsv508649 CNV Loss 20534489
dgv38n16 CNV Deletion 17901297
esv1003032 CNV Deletion 20482838
nsv498766 CNV Loss 21111241
esv1079371 CNV Deletion 17803354

Variation tolerance for CCDC67 Gene

Residual Variation Intolerance Score: 77.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC67 Gene

HapMap Linkage Disequilibrium report
CCDC67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC67 Gene

Disorders for CCDC67 Gene

Relevant External Links for CCDC67

Genetic Association Database (GAD)
CCDC67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC67
genes like me logo Genes that share disorders with CCDC67: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC67 Gene

Publications for CCDC67 Gene

  1. The Cep63 paralogue Deup1 enables massive deA novo centriole biogenesis for vertebrate multiciliogenesis. (PMID: 24240477) Zhao H. … Zhu X. (Nat. Cell Biol. 2013) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67
  5. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 67

Products for CCDC67 Gene

Sources for CCDC67 Gene

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