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Aliases for CCDC66 Gene

Aliases for CCDC66 Gene

  • Coiled-Coil Domain Containing 66 2 3

External Ids for CCDC66 Gene

Summaries for CCDC66 Gene

GeneCards Summary for CCDC66 Gene

CCDC66 (Coiled-Coil Domain Containing 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC66 Gene

Genomics for CCDC66 Gene

Genomic Location for CCDC66 Gene

Start:
56,557,156 bp from pter
End:
56,621,836 bp from pter
Size:
64,681 bases
Orientation:
Plus strand

Genomic View for CCDC66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC66 Gene

Regulatory Elements for CCDC66 Gene

Proteins for CCDC66 Gene

  • Protein details for CCDC66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUB6-CCD66_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 66
    Protein Accession:
    A2RUB6
    Secondary Accessions:
    • B3KWL8
    • Q4VC34
    • Q8N949

    Protein attributes for CCDC66 Gene

    Size:
    948 amino acids
    Molecular mass:
    109411 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47509.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI32828.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04607.1; Type=Frameshift; Positions=214; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC66 Gene

Proteomics data for CCDC66 Gene at MOPED

Post-translational modifications for CCDC66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC66 Gene

Domains for CCDC66 Gene

Protein Domains for CCDC66 Gene

ProtoNet:
genes like me logo Genes that share domains with CCDC66: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC66 Gene

Function for CCDC66 Gene

Phenotypes for CCDC66 Gene

genes like me logo Genes that share phenotypes with CCDC66: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC66 Gene

Localization for CCDC66 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC66 Gene COMPARTMENTS Subcellular localization image for CCDC66 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for CCDC66 Gene

Pathways for CCDC66 Gene

SuperPathways for CCDC66 Gene

No Data Available

Interacting Proteins for CCDC66 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378167%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: A2RUB6-CCD66_HUMAN ENSP00000378167 for CCDC66 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for CCDC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046548 retinal rod cell development IEA --
GO:0060060 post-embryonic retina morphogenesis in camera-type eye IEA --
genes like me logo Genes that share ontologies with CCDC66: view

No data available for Pathways by source for CCDC66 Gene

Transcripts for CCDC66 Gene

Unigene Clusters for CCDC66 Gene

Coiled-coil domain containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC66 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for CCDC66 Gene

GeneLoc Exon Structure for
CCDC66
ECgene alternative splicing isoforms for
CCDC66

Expression for CCDC66 Gene

mRNA expression in normal human tissues for CCDC66 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC66 Gene

SOURCE GeneReport for Unigene cluster for CCDC66 Gene Hs.476399

genes like me logo Genes that share expressions with CCDC66: view

Orthologs for CCDC66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC66 36
  • 99.44 (n)
  • 98.95 (a)
CCDC66 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC66 36
  • 86.6 (n)
  • 79.1 (a)
CCDC66 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC66 36
  • 87.68 (n)
  • 81 (a)
CCDC66 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc66 36
  • 79.48 (n)
  • 70.14 (a)
Ccdc66 16
Ccdc66 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC66 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC66 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc66 36
  • 77.19 (n)
  • 68.89 (a)
chicken
(Gallus gallus)
Aves CCDC66 36
  • 64.91 (n)
  • 54.13 (a)
CCDC66 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC66 37
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc66 36
  • 52.62 (n)
  • 47.46 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC66 (1 of 2) 37
  • 33 (a)
OneToMany
CCDC66 (2 of 2) 37
  • 30 (a)
OneToMany
LOC796628 36
  • 51.93 (n)
  • 40.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2586 37
  • 35 (a)
OneToOne
Species with no ortholog for CCDC66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC66 Gene

ENSEMBL:
Gene Tree for CCDC66 (if available)
TreeFam:
Gene Tree for CCDC66 (if available)

Paralogs for CCDC66 Gene

No data available for Paralogs for CCDC66 Gene

Variants for CCDC66 Gene

Sequence variations from dbSNP and Humsavar for CCDC66 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs282522 -- 56,595,650(+) catca(A/G)tggac intron-variant
rs282523 -- 56,596,138(+) ggttt(C/T)gagct intron-variant
rs282524 -- 56,596,441(+) tctta(G/T)gcatt intron-variant
rs282525 -- 56,596,625(+) ttcgt(A/C)tgttt intron-variant
rs282526 -- 56,597,245(+) tctgt(C/T)ccatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC66 Gene

Variant ID Type Subtype PubMed ID
nsv876817 CNV Gain 21882294
esv2725303 CNV Deletion 23290073
nsv460557 CNV Loss 19166990
esv2555353 CNV Deletion 19546169
esv2725304 CNV Deletion 23290073
esv1966969 CNV Deletion 18987734
esv2725305 CNV Deletion 23290073
esv3123 CNV Deletion 18987735
esv2671315 CNV Deletion 23128226
esv2621307 CNV Deletion 19546169
esv1141708 CNV Deletion 17803354
dgv808n67 CNV Loss 20364138
nsv435762 CNV Deletion 17901297
esv2725306 CNV Deletion 23290073
esv21892 CNV Loss 19812545
esv2678954 CNV Deletion 23128226
nsv528087 CNV Loss 19592680
esv2659644 CNV Deletion 23128226
nsv820061 CNV Loss 19587683

Relevant External Links for CCDC66 Gene

HapMap Linkage Disequilibrium report
CCDC66

Disorders for CCDC66 Gene

(1) University of Copenhagen DISEASES for CCDC66 Gene

Relevant External Links for CCDC66

Genetic Association Database (GAD)
CCDC66
Human Genome Epidemiology (HuGE) Navigator
CCDC66
genes like me logo Genes that share disorders with CCDC66: view

No data available for UniProtKB/Swiss-Prot for CCDC66 Gene

Publications for CCDC66 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3

Products for CCDC66 Gene

Sources for CCDC66 Gene

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