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Aliases for CCDC66 Gene

Aliases for CCDC66 Gene

  • Coiled-Coil Domain Containing 66 2 3 5

External Ids for CCDC66 Gene

Summaries for CCDC66 Gene

GeneCards Summary for CCDC66 Gene

CCDC66 (Coiled-Coil Domain Containing 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC66 Gene

Genomics for CCDC66 Gene

Regulatory Elements for CCDC66 Gene

Promoters for CCDC66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC66 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC66 Gene

Chromosome:
3
Start:
56,557,111 bp from pter
End:
56,621,836 bp from pter
Size:
64,726 bases
Orientation:
Plus strand

Genomic View for CCDC66 Gene

Genes around CCDC66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC66 Gene

Proteins for CCDC66 Gene

  • Protein details for CCDC66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RUB6-CCD66_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 66
    Protein Accession:
    A2RUB6
    Secondary Accessions:
    • B3KWL8
    • Q4VC34
    • Q8N949

    Protein attributes for CCDC66 Gene

    Size:
    948 amino acids
    Molecular mass:
    109411 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47509.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI32828.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04607.1; Type=Frameshift; Positions=214; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC66 Gene

Proteomics data for CCDC66 Gene at MOPED

Post-translational modifications for CCDC66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for CCDC66 Gene

Domains & Families for CCDC66 Gene

Protein Domains for CCDC66 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC66: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC66 Gene

Function for CCDC66 Gene

Phenotypes for CCDC66 Gene

genes like me logo Genes that share phenotypes with CCDC66: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC66 Gene

Localization for CCDC66 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC66 Gene COMPARTMENTS Subcellular localization image for CCDC66 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC66 Gene

Pathways & Interactions for CCDC66 Gene

SuperPathways for CCDC66 Gene

No Data Available

Interacting Proteins for CCDC66 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378167%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: A2RUB6-CCD66_HUMAN ENSP00000378167 for CCDC66 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for CCDC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046548 retinal rod cell development IEA --
GO:0050908 detection of light stimulus involved in visual perception IEA --
genes like me logo Genes that share ontologies with CCDC66: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC66 Gene

Drugs & Compounds for CCDC66 Gene

No Compound Related Data Available

Transcripts for CCDC66 Gene

Unigene Clusters for CCDC66 Gene

Coiled-coil domain containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC66 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - -
SP8:
SP9:

Relevant External Links for CCDC66 Gene

GeneLoc Exon Structure for
CCDC66
ECgene alternative splicing isoforms for
CCDC66

Expression for CCDC66 Gene

mRNA expression in normal human tissues for CCDC66 Gene

Protein differential expression in normal tissues from HIPED for CCDC66 Gene

This gene is overexpressed in Esophagus (27.4), Neutrophil (18.9), and Plasma (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC66 Gene



SOURCE GeneReport for Unigene cluster for CCDC66 Gene Hs.476399

genes like me logo Genes that share expression patterns with CCDC66: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC66 Gene

Orthologs for CCDC66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC66 35
  • 99.44 (n)
  • 98.95 (a)
CCDC66 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC66 36
  • 78 (a)
OneToOne
CCDC66 35
  • 86.6 (n)
  • 79.1 (a)
dog
(Canis familiaris)
Mammalia CCDC66 35
  • 87.68 (n)
  • 81 (a)
CCDC66 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc66 16
Ccdc66 35
  • 79.48 (n)
  • 70.14 (a)
Ccdc66 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC66 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC66 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc66 35
  • 77.19 (n)
  • 68.89 (a)
chicken
(Gallus gallus)
Aves CCDC66 35
  • 64.91 (n)
  • 54.13 (a)
CCDC66 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC66 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc66 35
  • 52.62 (n)
  • 47.46 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC66 (1 of 2) 36
  • 33 (a)
OneToMany
CCDC66 (2 of 2) 36
  • 30 (a)
OneToMany
LOC796628 35
  • 51.93 (n)
  • 40.22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2586 36
  • 35 (a)
OneToOne
Species with no ortholog for CCDC66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC66 Gene

ENSEMBL:
Gene Tree for CCDC66 (if available)
TreeFam:
Gene Tree for CCDC66 (if available)

Paralogs for CCDC66 Gene

No data available for Paralogs for CCDC66 Gene

Variants for CCDC66 Gene

Sequence variations from dbSNP and Humsavar for CCDC66 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1491170 - 56,593,570(-) TTGAC(C/T)GAGAG intron-variant, nc-transcript-variant, reference, missense
rs7637449 - 56,594,003(+) CAGAC(A/G)ACGAC nc-transcript-variant, reference, missense
rs4681904 - 56,615,984(+) CTGAT(A/C/G)AAATC nc-transcript-variant, reference, missense
rs282524 -- 56,596,441(+) tctta(G/T)gcatt intron-variant
rs282543 -- 56,601,164(-) gactc(C/T)ttcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC66 Gene

Variant ID Type Subtype PubMed ID
nsv876817 CNV Gain 21882294
esv2725303 CNV Deletion 23290073
nsv460557 CNV Loss 19166990
esv2555353 CNV Deletion 19546169
esv2725304 CNV Deletion 23290073
esv1966969 CNV Deletion 18987734
esv2725305 CNV Deletion 23290073
esv3123 CNV Deletion 18987735
esv2671315 CNV Deletion 23128226
esv2621307 CNV Deletion 19546169
esv1141708 CNV Deletion 17803354
dgv808n67 CNV Loss 20364138
nsv435762 CNV Deletion 17901297
esv2725306 CNV Deletion 23290073
esv21892 CNV Loss 19812545
esv2678954 CNV Deletion 23128226
nsv528087 CNV Loss 19592680
esv2659644 CNV Deletion 23128226
nsv820061 CNV Loss 19587683

Variation tolerance for CCDC66 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.11; 93.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC66 Gene

HapMap Linkage Disequilibrium report
CCDC66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC66 Gene

Disorders for CCDC66 Gene

Relevant External Links for CCDC66

Genetic Association Database (GAD)
CCDC66
Human Genome Epidemiology (HuGE) Navigator
CCDC66
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC66

No disorders were found for CCDC66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC66 Gene

Publications for CCDC66 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PMID: 21948523) Al-Balool H.H. … Jackson M.S. (Genome Res. 2011) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CCDC66 Gene

Sources for CCDC66 Gene

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