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Aliases for CCDC64 Gene

Aliases for CCDC64 Gene

  • Coiled-Coil Domain Containing 64 2 3
  • Coiled-Coil Domain-Containing Protein 64A 3 4
  • BICD-Related Protein 1 3 4
  • BICDR-1 3 4
  • Bicaudal D-Related Protein 1 3
  • WUGSC:H_267D11.1 3
  • H_267D11.1 3
  • BICDR1 4

External Ids for CCDC64 Gene

Previous GeneCards Identifiers for CCDC64 Gene

  • GC12P118891
  • GC12P120427
  • GC12P117436

Summaries for CCDC64 Gene

GeneCards Summary for CCDC64 Gene

CCDC64 (Coiled-Coil Domain Containing 64) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding and dynactin binding. An important paralog of this gene is CCDC64B.

UniProtKB/Swiss-Prot for CCDC64 Gene

  • Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC64 Gene

Genomics for CCDC64 Gene

Regulatory Elements for CCDC64 Gene

Genomic Location for CCDC64 Gene

Start:
119,989,844 bp from pter
End:
120,094,495 bp from pter
Size:
104,652 bases
Orientation:
Plus strand

Genomic View for CCDC64 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC64 Gene

Proteins for CCDC64 Gene

  • Protein details for CCDC64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP65-BICR1_HUMAN
    Recommended name:
    Bicaudal D-related protein 1
    Protein Accession:
    Q6ZP65
    Secondary Accessions:
    • A8MUC8
    • B4DWL0
    • B5MDJ0
    • O95000

    Protein attributes for CCDC64 Gene

    Size:
    573 amino acids
    Molecular mass:
    64841 Da
    Quaternary structure:
    • Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6 (By similarity).
    SequenceCaution:
    • Sequence=AAC83181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC85259.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC64 Gene

Proteomics data for CCDC64 Gene at MOPED

Post-translational modifications for CCDC64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC64 Gene

No data available for DME Specific Peptides for CCDC64 Gene

Domains for CCDC64 Gene

Protein Domains for CCDC64 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC64 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZP65

UniProtKB/Swiss-Prot:

BICR1_HUMAN :
  • Q6ZP65
Family:
  • Belongs to the BICDR family.
genes like me logo Genes that share domains with CCDC64: view

No data available for Gene Families for CCDC64 Gene

Function for CCDC64 Gene

Molecular function for CCDC64 Gene

UniProtKB/Swiss-Prot Function: Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for CCDC64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017137 Rab GTPase binding ISS --
GO:0034452 dynactin binding ISS --
genes like me logo Genes that share ontologies with CCDC64: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC64 Gene

Localization for CCDC64 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC64 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes around the centrosome. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC64 Gene COMPARTMENTS Subcellular localization image for CCDC64 gene
Compartment Confidence
cytoskeleton 4
extracellular 2
nucleus 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCDC64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome ISS --
genes like me logo Genes that share ontologies with CCDC64: view

Pathways for CCDC64 Gene

SuperPathways for CCDC64 Gene

No Data Available

Interacting Proteins for CCDC64 Gene

Gene Ontology (GO) - Biological Process for CCDC64 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development ISS --
GO:0055107 Golgi to secretory granule transport ISS --
genes like me logo Genes that share ontologies with CCDC64: view

No data available for Pathways by source for CCDC64 Gene

Transcripts for CCDC64 Gene

Unigene Clusters for CCDC64 Gene

Coiled-coil domain containing 64:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC64 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - -
SP2: - - -
SP3:
SP4: - - -
SP5: -
SP6:
SP7:

Relevant External Links for CCDC64 Gene

GeneLoc Exon Structure for
CCDC64
ECgene alternative splicing isoforms for
CCDC64

Expression for CCDC64 Gene

mRNA expression in normal human tissues for CCDC64 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC64 Gene

This gene is overexpressed in Pituitary (6.7), Kidney - Cortex (6.4), and Skin - Not Sun Exposed (Suprapubic) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC64 Gene

SOURCE GeneReport for Unigene cluster for CCDC64 Gene Hs.369763

genes like me logo Genes that share expressions with CCDC64: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC64 Gene

Orthologs for CCDC64 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC64 35
  • 99.7 (n)
  • 99.78 (a)
CCDC64 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC64 35
  • 90.24 (n)
  • 94.91 (a)
CCDC64 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC64 35
  • 91.26 (n)
  • 95.74 (a)
CCDC64 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc64 35
  • 90.05 (n)
  • 94.59 (a)
Ccdc64 16
Ccdc64 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC64 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC64 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc64 35
  • 90.15 (n)
  • 95.28 (a)
chicken
(Gallus gallus)
Aves CCDC64 35
  • 81.39 (n)
  • 86.5 (a)
CCDC64 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC64 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc64 35
  • 72.05 (n)
  • 75.05 (a)
Str.19901 35
zebrafish
(Danio rerio)
Actinopterygii LOC100537719 35
  • 64.27 (n)
  • 62.08 (a)
si:ch211-235m3.5 36
  • 32 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001308 35
  • 49.56 (n)
  • 33.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32137 35
  • 50.71 (n)
  • 36.69 (a)
CG32137 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
CSA.2341 36
  • 26 (a)
ManyToMany
Species with no ortholog for CCDC64:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC64 Gene

ENSEMBL:
Gene Tree for CCDC64 (if available)
TreeFam:
Gene Tree for CCDC64 (if available)

Paralogs for CCDC64 Gene

Paralogs for CCDC64 Gene

Selected SIMAP similar genes for CCDC64 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC64: view

Variants for CCDC64 Gene

Sequence variations from dbSNP and Humsavar for CCDC64 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs378041 -- 120,029,518(+) TCTCA(A/G)AATTA intron-variant
rs379816 -- 120,053,433(+) TTTTC(C/T)CCGTT intron-variant
rs380123 -- 120,041,330(-) TCAGG(C/T)TTCAG intron-variant
rs394646 -- 119,995,200(+) TAGAG(C/T)TTTCT intron-variant
rs402682 -- 120,038,682(-) GGGTC(A/G)CTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC64 Gene

Variant ID Type Subtype PubMed ID
nsv510575 CNV Loss 20534489
nsv899554 CNV Gain 21882294
esv26018 CNV Loss 19812545
nsv510323 CNV Loss 20534489
nsv903 CNV Insertion 18451855
nsv7237 OTHER Inversion 18451855
nsv899555 CNV Loss 21882294

Relevant External Links for CCDC64 Gene

HapMap Linkage Disequilibrium report
CCDC64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC64 Gene

Disorders for CCDC64 Gene

Relevant External Links for CCDC64

Genetic Association Database (GAD)
CCDC64
Human Genome Epidemiology (HuGE) Navigator
CCDC64
genes like me logo Genes that share disorders with CCDC64: view

No data available for UniProtKB/Swiss-Prot for CCDC64 Gene

Publications for CCDC64 Gene

  1. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz H.J. … Yaspo M.L. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for CCDC64 Gene

Sources for CCDC64 Gene

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