CCDC64 Gene
protein-coding GIFtS: 43
GCID: GC12P120427
|
|
coiled-coil domain containing 64
| |
Aliases
for CCDC64 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 641 2 | | H_267D11.12 | | Coiled-Coil Domain-Containing Protein 64A2 3 | | WUGSC:H_267D11.12 | | BICDR-12 3 | | Bicaudal D-Related Protein 12 | | BICD-Related Protein 12 3 | | BICDR13 | | FLJ264501 | | |
Export aliases for CCDC64 gene to outside databasesPrevious GC identifers: GC12P118891 GC12P117436 |
Summaries
for CCDC64 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BICR1_HUMAN, Q6ZP65Function: Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth.Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in thepericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation,thereby inhibiting neuritogenesis (By similarity)
|
Genomic Views
for CCDC64 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC64 gene promoter:
STAT1 NRSF form 1 MyoD STAT1beta NRSF form 2 HNF-1A STAT1alpha HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC64
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC64 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.23 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.23CCDC64 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P120427: view genomic region
(about GC identifiers)
Start:
|
120,427,648 bp from pter |
End:
|
120,532,299 bp from pter |
Size:
|
104,652 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC64 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BICR1_HUMAN, Q6ZP65 (See
protein sequence)Recommended Name: Bicaudal D-related protein 1 Size: 573 amino acids; 64841 Da
Subunit: Interacts with KIF1C. Interacts with RAB6A and RAB6B; interaction is specific to Rab6 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, centrosome (By similarity). Note=Localizes around the centrosome (Bysimilarity)
Sequence caution: Sequence=AAC83181.1; Type=Erroneous gene model prediction; Sequence=BAC85259.1; Type=Miscellaneousdiscrepancy; Note=Aberrant splicing;
Secondary accessions: A8MUC8 O95000Explore the universe of human proteins at neXtProt for CCDC64: NX_Q6ZP65
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZP65
CCDC64 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997194.2
ENSEMBL proteins: ENSP00000380690 ENSP00000449064 ENSP00000447477 ENSP00000447939 ENSP00000399658 ENSP00000257583
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CCDC64 for ontologies About GeneDecksing
CCDC64 Antibody Products:
Assay Products for CCDC64: |
Protein
Domains /
Families
for CCDC64 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6ZP65 UniProtKB/Swiss-Prot: BICR1_HUMAN, Q6ZP65Similarity: Belongs to the BICDR family |
Function
for CCDC64 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BICR1_HUMAN, Q6ZP65Function: Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth.Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in thepericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation,thereby inhibiting neuritogenesis (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC64 (NM_207311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC64 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC64 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC64 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0017137 | Rab GTPase binding |
ISS | -- | | GO:0034452 | dynactin binding |
ISS | -- |
CCDC64 for ontologies About GeneDecksing
|
Pathways & Interactions
for CCDC64 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC64
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/6 Interacting proteins for CCDC64 (Q6ZP653 ENSP000003806904) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031175 | neuron projection development |
ISS | -- | | GO:0055107 | Golgi to secretory granule transport |
ISS | -- |
CCDC64 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC64 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC64
Search CenterWatch for drugs/clinical trials and news about CCDC64 / BICR1
|
Transcripts
for CCDC64 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC64 gene: NM_207311.2 Unigene Cluster for CCDC64: Coiled-coil domain containing 64 Hs.369763 [show with all ESTs]Unigene Representative Sequence: NM_20731113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397558(uc001txk.2 uc001txl.1 uc009zwv.1 uc010sze.1 uc010szf.1)
ENST00000546420 ENST00000546861 ENST00000550245 ENST00000546790 ENST00000548673
ENST00000550197 ENST00000546460 ENST00000547841 ENST00000546502 ENST00000546857
ENST00000446727 ENST00000257583
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC64 (NM_207311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC64 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC64 |
Additional cDNA sequence: AK129960.1 AK297888.1 AK301580.1 U88834.1 10 DOTS entries: DT.310685 DT.97838857 DT.91654657 DT.91852319 DT.121172536 DT.121172643 DT.92016854 DT.97783689 DT.97796495 DT.99979023 24/84 AceView cDNA sequences (see all 84): BQ690977 AI207000 BU683970 BX089201 BI907338 AI878856 BQ637480 BI761571 BX951980 NM_207311 BM458771 BU163592 BQ882210 AI627924 BE891474 BX102169 BQ882213 AK129960 CK299198 AA410903 BM759392 AW152325 BX110064 AI567681
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC64 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC64
|
Expression
for CCDC64 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC64 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGGATTTT
About this image
See CCDC64 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC64
SOURCE GeneReport for Unigene cluster: Hs.369763
SABiosciences Custom PCR Arrays for CCDC64
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC64
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC64 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC64 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC64 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC64 |
Orthologs
for CCDC64 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC64 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for CCDC64 (if available)
TreeFam Gene Tree for CCDC64 (if available) |
Paralogs
for CCDC64 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC64 gene
- CCDC64B2
1 SIMAP similar gene for CCDC64 using alignment to 6 protein entries: BICR1_HUMAN (see all proteins):CCDC64B
CCDC64 for paralogs About GeneDecksing
|
Genomic Variants
for CCDC64 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC64 (120427648 - 120532299 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CCDC64
2 CNVs: 35050 71597
1 Inversion: 37131 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC64 |
|
Disorders
/ Diseases
for CCDC64 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC64 for disorders About GeneDecksing
1  disease for CCDC64: About MalaCardsneuronitis
Human Genome Epidemiology (HuGE) Navigator: CCDC64 (1 document)
Export disorders for CCDC64 gene to outside databases
|
Publications
for CCDC64 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC64 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC64) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1 Need A.C....Goldstein D.B. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for CCDC64 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC64 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC64 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC64 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC64 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC64 gene:
Search GeneIP for patents involving CCDC64
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC64 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC64 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC64 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC64 | | | OriGene Protein Over-expression Lysate for CCDC64 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC64 | | OriGene 3'-UTR Clone for CCDC64 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC64 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC64 | | OriGene Custom Protein Services for CCDC64 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC64 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC64 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC64 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC64 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC64 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC64 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC64 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC64 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC64 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC64 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC64 |
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