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Aliases for CCDC63 Gene

Aliases for CCDC63 Gene

  • Coiled-Coil Domain Containing 63 2 3 5
  • Outer Row Dynein Assembly 5 Homolog (Chlamydomonas) 2
  • Coiled-Coil Domain-Containing Protein 63 3
  • Outer Row Dynein Assembly 5 Homolog 3
  • ODA5 3

External Ids for CCDC63 Gene

Previous GeneCards Identifiers for CCDC63 Gene

  • GC12P109748
  • GC12P111284
  • GC12P108301

Summaries for CCDC63 Gene

GeneCards Summary for CCDC63 Gene

CCDC63 (Coiled-Coil Domain Containing 63) is a Protein Coding gene. An important paralog of this gene is CCDC114.

UniProtKB/Swiss-Prot for CCDC63 Gene

  • Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC63 Gene

Genomics for CCDC63 Gene

Regulatory Elements for CCDC63 Gene

Enhancers for CCDC63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CCDC63 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC63 Gene

110,844,486 bp from pter
110,907,535 bp from pter
63,050 bases
Plus strand

Genomic View for CCDC63 Gene

Genes around CCDC63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC63 Gene

Proteins for CCDC63 Gene

  • Protein details for CCDC63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 63
    Protein Accession:
    Secondary Accessions:
    • B4DY03
    • Q0P603
    • Q6P2E1

    Protein attributes for CCDC63 Gene

    563 amino acids
    Molecular mass:
    66250 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH44815.1; Type=Frameshift; Positions=241; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC63 Gene


neXtProt entry for CCDC63 Gene

Post-translational modifications for CCDC63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC63 Gene

No data available for DME Specific Peptides for CCDC63 Gene

Domains & Families for CCDC63 Gene

Protein Domains for CCDC63 Gene


Suggested Antigen Peptide Sequences for CCDC63 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC63: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC63 Gene

Function for CCDC63 Gene

Molecular function for CCDC63 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.

Phenotypes for CCDC63 Gene

GenomeRNAi human phenotypes for CCDC63:
genes like me logo Genes that share phenotypes with CCDC63: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC63 Gene

Localization for CCDC63 Gene

Subcellular locations from

Jensen Localization Image for CCDC63 Gene COMPARTMENTS Subcellular localization image for CCDC63 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC63 Gene

Pathways & Interactions for CCDC63 Gene

SuperPathways for CCDC63 Gene

No Data Available

Interacting Proteins for CCDC63 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000312399 for CCDC63 Gene via STRING

Gene Ontology (GO) - Biological Process for CCDC63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development ISS --
genes like me logo Genes that share ontologies with CCDC63: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC63 Gene

Drugs & Compounds for CCDC63 Gene

No Compound Related Data Available

Transcripts for CCDC63 Gene

Unigene Clusters for CCDC63 Gene

Coiled-coil domain containing 63:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC63 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: - -

Relevant External Links for CCDC63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC63 Gene

mRNA expression in normal human tissues for CCDC63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC63 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for CCDC63 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC63 Gene

Protein tissue co-expression partners for CCDC63 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC63 Gene:


SOURCE GeneReport for Unigene cluster for CCDC63 Gene:

genes like me logo Genes that share expression patterns with CCDC63: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC63 Gene

Orthologs for CCDC63 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC63 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC63 34
  • 84.44 (n)
  • 79.82 (a)
CCDC63 35
  • 79 (a)
(Canis familiaris)
Mammalia CCDC63 34
  • 83.24 (n)
  • 77.96 (a)
CCDC63 35
  • 77 (a)
(Mus musculus)
Mammalia Ccdc63 34
  • 76.33 (n)
  • 72.45 (a)
Ccdc63 16
Ccdc63 35
  • 69 (a)
(Pan troglodytes)
Mammalia CCDC63 34
  • 98.93 (n)
  • 99.11 (a)
CCDC63 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc63 34
  • 79.08 (n)
  • 76.41 (a)
(Monodelphis domestica)
Mammalia CCDC63 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC63 35
  • 58 (a)
(Gallus gallus)
Aves CCDC63 34
  • 59.96 (n)
  • 45.79 (a)
CCDC63 35
  • 43 (a)
(Anolis carolinensis)
Reptilia CCDC63 35
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14905 35
  • 23 (a)
CG17083 35
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
Species where no ortholog for CCDC63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC63 Gene

Gene Tree for CCDC63 (if available)
Gene Tree for CCDC63 (if available)

Paralogs for CCDC63 Gene

Paralogs for CCDC63 Gene

genes like me logo Genes that share paralogs with CCDC63: view

Variants for CCDC63 Gene

Sequence variations from dbSNP and Humsavar for CCDC63 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12371434 - 110,880,051(+) GAACT(C/T)GGCCA reference, missense
rs7303049 -- 110,862,170(+) GAAGA(A/G)GAGCT intron-variant
rs7303257 -- 110,887,119(+) TTTTT(A/T)AATTT intron-variant
rs7304923 -- 110,844,416(+) atcgt(G/T)tgtta upstream-variant-2KB
rs7305904 -- 110,900,087(+) tgtac(A/G)ctgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC63 Gene

Variant ID Type Subtype PubMed ID
esv1606344 CNV deletion 17803354
esv1606463 CNV insertion 17803354
esv2171541 CNV deletion 18987734
esv3446331 CNV duplication 20981092
esv3630744 CNV gain 21293372
esv3630745 CNV loss 21293372
nsv1120267 CNV tandem duplication 24896259
nsv509476 CNV insertion 20534489
nsv513365 CNV insertion 21212237
nsv7236 OTHER inversion 18451855
nsv952477 CNV deletion 24416366

Variation tolerance for CCDC63 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC63 Gene

Disorders for CCDC63 Gene

Relevant External Links for CCDC63

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC63 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC63 Gene

Publications for CCDC63 Gene

  1. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PMID: 21270382) Baik I. … Shin C. (Am. J. Clin. Nutr. 2011) 3 46 65
  2. Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. (PMID: 21372407) Takeuchi F. … Kato N. (Circ. J. 2011) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Common variants at 12q24 are associated with drinking behavior in Han Chinese. (PMID: 23364009) Yang X. … Gu D. (Am. J. Clin. Nutr. 2013) 3 65
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65

Products for CCDC63 Gene

Sources for CCDC63 Gene

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