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Aliases for CCDC62 Gene

Aliases for CCDC62 Gene

  • Coiled-Coil Domain Containing 62 2 3 5
  • Cancer/Testis Antigen 109 2 3
  • Coiled-Coil Domain-Containing Protein 60 3
  • Coiled-Coil Domain-Containing Protein 62 3
  • Testis-Specific Protein TSP-NY 3
  • Protein TSP-NY 4
  • Aaa-Protein 3
  • Protein Aaa 4
  • ERAP75 3
  • TSP-NY 3
  • CT109 3

External Ids for CCDC62 Gene

Previous GeneCards Identifiers for CCDC62 Gene

  • GC12P121784
  • GC12P121825
  • GC12P123259
  • GC12P120219

Summaries for CCDC62 Gene

GeneCards Summary for CCDC62 Gene

CCDC62 (Coiled-Coil Domain Containing 62) is a Protein Coding gene. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity and estrogen receptor binding.

UniProtKB/Swiss-Prot for CCDC62 Gene

  • Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC62 Gene

Genomics for CCDC62 Gene

Regulatory Elements for CCDC62 Gene

Enhancers for CCDC62 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G122866 1.4 FANTOM5 ENCODE dbSUPER 11.5 +93.4 93443 2.7 RB1 ARID4B DMAP1 ZBTB40 RAD21 RARA YY1 SCRT2 ZNF143 CREM VPS37B HIP1R CCDC62 PITPNM2 B3GNT4 PIR41686 PIR39782 GC12M122867
GH12G122870 1.2 ENCODE dbSUPER 11.5 +97.9 97921 4.3 HDGF SIN3A YY1 ETS1 SCRT2 RELB ETV6 IKZF2 CREM ZNF263 VPS37B HIP1R CCDC62 B3GNT4 PIR39782 ENSG00000280138
GH12G122865 1.1 ENCODE dbSUPER 11.5 +91.6 91636 0.4 SOX13 CTCF PKNOX1 SAP130 ARID4B MAX ZNF48 RAD21 YY1 POLR2A VPS37B HIP1R CCDC62 ENSG00000256152 PIR41686 GC12M122867
GH12G122637 1 Ensembl ENCODE 10.5 -136.3 -136327 0.4 CTCF PKNOX1 SAP130 WRNIP1 ARID4B MAX RAD21 RFX5 ZNF143 SMC3 ENSG00000256044 DENR HCAR1 CCDC62 ENSG00000274191 ENSG00000256249
GH12G122868 0.8 ENCODE dbSUPER 11.5 +90.1 90062 0.2 SCRT1 POLR2A ZNF740 SCRT2 HNF4A VPS37B HIP1R CCDC62 ENSG00000256152 GC12M122863
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC62 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058636 373 1001 INSM2 SIN3A ZNF76 KLF17 FEZF1 GLIS2 EGR1 ZNF366 ZSCAN5C KLF7

Genomic Location for CCDC62 Gene

Chromosome:
12
Start:
122,774,327 bp from pter
End:
122,827,528 bp from pter
Size:
53,202 bases
Orientation:
Plus strand

Genomic View for CCDC62 Gene

Genes around CCDC62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC62 Gene

Proteins for CCDC62 Gene

  • Protein details for CCDC62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9F0-CCD62_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 62
    Protein Accession:
    Q6P9F0
    Secondary Accessions:
    • A8K8V1
    • B3KUP3
    • Q6ZVF2
    • Q86VJ0
    • Q9BYZ5

    Protein attributes for CCDC62 Gene

    Size:
    684 amino acids
    Molecular mass:
    77748 Da
    Quaternary structure:
    • Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.
    SequenceCaution:
    • Sequence=AAG49396.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC62 Gene

Post-translational modifications for CCDC62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC62 Gene

Domains & Families for CCDC62 Gene

Protein Domains for CCDC62 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC62 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P9F0

UniProtKB/Swiss-Prot:

CCD62_HUMAN :
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2.
Domain:
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2.
genes like me logo Genes that share domains with CCDC62: view

No data available for Gene Families for CCDC62 Gene

Function for CCDC62 Gene

Molecular function for CCDC62 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

Gene Ontology (GO) - Molecular Function for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030331 estrogen receptor binding IPI 18563714
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IPI 18563714
genes like me logo Genes that share ontologies with CCDC62: view

Phenotypes for CCDC62 Gene

GenomeRNAi human phenotypes for CCDC62:
genes like me logo Genes that share phenotypes with CCDC62: view

Animal Model Products

CRISPR Products

miRNA for CCDC62 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC62 Gene

Localization for CCDC62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC62 Gene

Cytoplasm. Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC62 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19126643
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CCDC62: view

Pathways & Interactions for CCDC62 Gene

SuperPathways for CCDC62 Gene

No Data Available

Interacting Proteins for CCDC62 Gene

Selected Interacting proteins: Q6P9F0-CCD62_HUMAN for CCDC62 Gene via IID

Symbol External ID(s) Details
SPAST

Gene Ontology (GO) - Biological Process for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IPI 18563714
GO:0071392 cellular response to estradiol stimulus IDA 18563714
genes like me logo Genes that share ontologies with CCDC62: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC62 Gene

Drugs & Compounds for CCDC62 Gene

No Compound Related Data Available

Transcripts for CCDC62 Gene

mRNA/cDNA for CCDC62 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC62 Gene

Coiled-coil domain containing 62:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC62 Gene

No ASD Table

Relevant External Links for CCDC62 Gene

GeneLoc Exon Structure for
CCDC62
ECgene alternative splicing isoforms for
CCDC62

Expression for CCDC62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC62 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC62 Gene

This gene is overexpressed in Testis (x34.2).

Protein differential expression in normal tissues from HIPED for CCDC62 Gene

This gene is overexpressed in Monocytes (31.1), Rectum (29.3), and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC62 Gene



Protein tissue co-expression partners for CCDC62 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC62 Gene:

CCDC62

SOURCE GeneReport for Unigene cluster for CCDC62 Gene:

Hs.592008

mRNA Expression by UniProt/SwissProt for CCDC62 Gene:

Q6P9F0-CCD62_HUMAN
Tissue specificity: Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.

Evidence on tissue expression from TISSUES for CCDC62 Gene

  • Lung(5)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CCDC62: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC62 Gene

Orthologs for CCDC62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC62 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia CCDC62 34 35
  • 86.23 (n)
dog
(Canis familiaris)
Mammalia CCDC62 34 35
  • 86.22 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc62 34
  • 81.63 (n)
mouse
(Mus musculus)
Mammalia Ccdc62 34 16 35
  • 80.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CCDC62 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc62 34
  • 63.19 (n)
zebrafish
(Danio rerio)
Actinopterygii hip1ra 34 35
  • 52.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for CCDC62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC62 Gene

ENSEMBL:
Gene Tree for CCDC62 (if available)
TreeFam:
Gene Tree for CCDC62 (if available)

Paralogs for CCDC62 Gene

No data available for Paralogs for CCDC62 Gene

Variants for CCDC62 Gene

Sequence variations from dbSNP and Humsavar for CCDC62 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035498 A colorectal cancer sample
rs1000017450 -- 122,793,303(+) TGTTC(A/G)TATGA intron-variant
rs1000035780 -- 122,790,401(+) CTCAC(A/C)TCTGT intron-variant
rs1000111074 -- 122,800,565(+) TGGGA(A/T)TACAG intron-variant
rs1000194091 -- 122,787,089(+) CTATA(A/G)GTATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC62 Gene

Variant ID Type Subtype PubMed ID
nsv1145636 CNV deletion 24896259

Variation tolerance for CCDC62 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC62 Gene

Disorders for CCDC62 Gene

Relevant External Links for CCDC62

Genetic Association Database (GAD)
CCDC62
Human Genome Epidemiology (HuGE) Navigator
CCDC62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC62

No disorders were found for CCDC62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC62 Gene

Publications for CCDC62 Gene

  1. CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. (PMID: 19126643) Chen M. … Yeh S. (Carcinogenesis 2009) 2 3 4 64
  2. ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. (PMID: 18563714) Chen M. … Yeh S. (Prostate 2008) 2 3 4 64
  3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 46 64
  4. Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. (PMID: 19165854) Domae S. … Ono T. (Int. J. Cancer 2009) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CCDC62 Gene

Sources for CCDC62 Gene

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