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Aliases for CCDC62 Gene

Aliases for CCDC62 Gene

  • Coiled-Coil Domain Containing 62 2 3
  • Cancer/Testis Antigen 109 2 3
  • ERAP75 3 6
  • Coiled-Coil Domain-Containing Protein 60 3
  • Coiled-Coil Domain-Containing Protein 62 3
  • Testis-Specific Protein TSP-NY 3
  • Protein TSP-NY 4
  • Aaa-Protein 3
  • Protein Aaa 4
  • TSP-NY 3
  • CT109 3

External Ids for CCDC62 Gene

Summaries for CCDC62 Gene

GeneCards Summary for CCDC62 Gene

CCDC62 (Coiled-Coil Domain Containing 62) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC62 Gene

  • Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC62 Gene

Genomics for CCDC62 Gene

Genomic Location for CCDC62 Gene

Start:
122,774,327 bp from pter
End:
122,827,528 bp from pter
Size:
53,202 bases
Orientation:
Plus strand

Genomic View for CCDC62 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC62 Gene

Regulatory Elements for CCDC62 Gene

Proteins for CCDC62 Gene

  • Protein details for CCDC62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9F0-CCD62_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 62
    Protein Accession:
    Q6P9F0
    Secondary Accessions:
    • A8K8V1
    • B3KUP3
    • Q6ZVF2
    • Q86VJ0
    • Q9BYZ5

    Protein attributes for CCDC62 Gene

    Size:
    684 amino acids
    Molecular mass:
    77748 Da
    Quaternary structure:
    • Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.
    SequenceCaution:
    • Sequence=AAG49396.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC62 Gene

Proteomics data for CCDC62 Gene at MOPED

Post-translational modifications for CCDC62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC62 Gene

No data available for DME Specific Peptides for CCDC62 Gene

Domains for CCDC62 Gene

Protein Domains for CCDC62 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

CCD62_HUMAN
Domain:
  • Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2:
    • Q6P9F0
genes like me logo Genes that share domains with CCDC62: view

No data available for Gene Families for CCDC62 Gene

Function for CCDC62 Gene

Molecular function for CCDC62 Gene

UniProtKB/Swiss-Prot Function: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.

Gene Ontology (GO) - Molecular Function for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030331 estrogen receptor binding IPI 19126643
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IPI 19126643
genes like me logo Genes that share ontologies with CCDC62: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CCDC62 Gene

Localization for CCDC62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC62 Gene

Cytoplasm. Nucleus. Note=Mainly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC62 Gene COMPARTMENTS Subcellular localization image for CCDC62 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19126643
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CCDC62: view

Pathways for CCDC62 Gene

SuperPathways for CCDC62 Gene

No Data Available

Interacting Proteins for CCDC62 Gene

Gene Ontology (GO) - Biological Process for CCDC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 19126643
GO:0071392 cellular response to estradiol stimulus IDA 19126643
genes like me logo Genes that share ontologies with CCDC62: view

No data available for Pathways by source for CCDC62 Gene

Transcripts for CCDC62 Gene

mRNA/cDNA for CCDC62 Gene

(8) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC62 Gene

Coiled-coil domain containing 62:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC62 Gene

No ASD Table

Relevant External Links for CCDC62 Gene

GeneLoc Exon Structure for
CCDC62
ECgene alternative splicing isoforms for
CCDC62

Expression for CCDC62 Gene

mRNA expression in normal human tissues for CCDC62 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC62 Gene

This gene is overexpressed in Testis (34.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC62 Gene

SOURCE GeneReport for Unigene cluster for CCDC62 Gene Hs.592008

mRNA Expression by UniProt/SwissProt for CCDC62 Gene

Q6P9F0-CCD62_HUMAN
Tissue specificity: Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.
genes like me logo Genes that share expressions with CCDC62: view

Orthologs for CCDC62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC62 36
  • 99.35 (n)
  • 98.95 (a)
CCDC62 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC62 36
  • 86.23 (n)
  • 83.04 (a)
CCDC62 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC62 36
  • 86.22 (n)
  • 83.43 (a)
CCDC62 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc62 36
  • 80.11 (n)
  • 77.47 (a)
Ccdc62 16
Ccdc62 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC62 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 27 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc62 36
  • 81.63 (n)
  • 79.15 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc62 36
  • 63.19 (n)
  • 59.72 (a)
zebrafish
(Danio rerio)
Actinopterygii hip1ra 36
  • 52.32 (n)
  • 45.57 (a)
hip1ra 37
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToOne
Species with no ortholog for CCDC62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC62 Gene

ENSEMBL:
Gene Tree for CCDC62 (if available)
TreeFam:
Gene Tree for CCDC62 (if available)

Paralogs for CCDC62 Gene

No data available for Paralogs for CCDC62 Gene

Variants for CCDC62 Gene

Sequence variations from dbSNP and Humsavar for CCDC62 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs701484 -- 122,778,782(-) cctgc(C/T)tcagc intron-variant
rs839352 -- 122,781,836(-) ggtcg(C/T)gaatt intron-variant
rs839353 -- 122,781,541(-) cgccc(A/G)gctaa intron-variant
rs839354 -- 122,780,863(-) TGACC(A/G)CATGC intron-variant
rs839355 -- 122,775,738(-) ctatt(C/T)gggag intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC62 Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294
dgv1497n71 CNV Loss 21882294

Relevant External Links for CCDC62 Gene

HapMap Linkage Disequilibrium report
CCDC62

Disorders for CCDC62 Gene

(2) University of Copenhagen DISEASES for CCDC62 Gene

Relevant External Links for CCDC62

Genetic Association Database (GAD)
CCDC62
Human Genome Epidemiology (HuGE) Navigator
CCDC62
genes like me logo Genes that share disorders with CCDC62: view

No data available for UniProtKB/Swiss-Prot for CCDC62 Gene

Publications for CCDC62 Gene

  1. ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. (PMID: 18563714) Chen M. … Yeh S. (Prostate 2008) 2 3 4
  2. CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. (PMID: 19126643) Chen M. … Yeh S. (Carcinogenesis 2009) 2 3 4
  3. Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. (PMID: 19165854) Domae S. … Ono T. (Int. J. Cancer 2009) 3 4
  4. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CCDC62 Gene

Sources for CCDC62 Gene

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