CCDC62 Gene
protein-coding GIFtS: 41
GCID: GC12P123259
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|
coiled-coil domain containing 62
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Aliases
for CCDC62 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 621 2 | | Cancer/Testis Antigen 1092 | | ERAP751 2 5 | | Coiled-Coil Domain-Containing Protein 602 | | CT1091 2 | | Coiled-Coil Domain-Containing Protein 622 | | TSP-NY1 2 | | Testis-Specific Protein TSP-NY2 | | FLJ403441 | | Protein Aaa3 | | Aaa-Protein1 | | Protein TSP-NY3 |
Export aliases for CCDC62 gene to outside databasesPrevious GC identifers: GC12P121784 GC12P121825 GC12P120219 |
Summaries
for CCDC62 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CCD62_HUMAN, Q6P9F0Function: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation,although at lower level; little effect on vitamin D receptor/VDR
|
Genomic Views
for CCDC62 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC62 gene promoter:
AML1a Pax-6 HSF1 (long) Pax-2 Pax-2a C/EBPalpha POU2F1 POU2F1a HSF2 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC62
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC62 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31CCDC62 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P123259: view genomic region
(about GC identifiers)
Start:
|
123,258,874 bp from pter |
End:
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123,312,075 bp from pter |
Size:
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53,202 bases |
Orientation:
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plus strand |
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Proteins
for CCDC62 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD62_HUMAN, Q6P9F0 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 62 Size: 684 amino acids; 77748 Da
Subunit: Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ERtarget genes, including cyclin-D1/CCND1 AP-1 promoter
Subcellular location: Cytoplasm. Nucleus. Note=Mainly nuclear
Sequence caution: Sequence=AAG49396.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K8V1 B3KUP3 Q6ZVF2 Q86VJ0 Q9BYZ5Alternative splicing: 3 isoforms: Q6P9F0-1 Q6P9F0-2 Q6P9F0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC62: NX_Q6P9F0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P9F0
CCDC62 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_958843.2
ENSEMBL proteins: ENSP00000253079 ENSP00000376236 ENSP00000341471 ENSP00000439893 ENSP00000445045 ENSP00000376235
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CCDC62 for ontologies About GeneDecksing
CCDC62 Antibody Products:
Assay Products for CCDC62: |
Protein
Domains /
Families
for CCDC62 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6P9F0 UniProtKB/Swiss-Prot: CCD62_HUMAN, Q6P9F0Domain: Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 andESR2 |
Function
for CCDC62 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CCD62_HUMAN, Q6P9F0Function: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation,although at lower level; little effect on vitamin D receptor/VDR
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC62 (NM_201435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC62 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC62 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC62 |
|
Pathways & Interactions
for CCDC62 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC62
|
Drugs & Compounds
for CCDC62 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC62
Search CenterWatch for drugs/clinical trials and news about CCDC62 / CCD62
|
Transcripts
for CCDC62 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC62 gene (2 alternative transcripts): NM_032573.5 NM_201435.4 Unigene Cluster for CCDC62: Coiled-coil domain containing 62 Hs.592008 [show with all ESTs]Unigene Representative Sequence: NM_2014356 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000253079(uc010tah.2 uc001udc.3 uc021rfn.1) ENST00000392441
ENST00000341952 ENST00000539171 ENST00000537566(uc001ude.3) ENST00000392440
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC62 (NM_201435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC62 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC62 |
Additional cDNA sequence: AK292466.1 AY009105.1 BC060796.1 NR_027918.2 6 DOTS entries: DT.100724678 DT.92011292 DT.91751378 DT.440801 DT.100754651 DT.91658497 2 AceView cDNA sequences: NM_032573 NM_201435
GeneLoc Exon Structure
|
Expression
for CCDC62 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC62 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTTAGCTT
About this image
See CCDC62 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC62
SOURCE GeneReport for Unigene cluster: Hs.592008
UniProtKB/Swiss-Prot: CCD62_HUMAN, Q6P9F0Tissue specificity: Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, withpredominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR(PubMed:19165854). Overexpressed in various cancers
SABiosciences Custom PCR Arrays for CCDC62
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC62
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC62 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC62 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC62 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC62 |
Orthologs
for CCDC62 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC62 gene from 2/12 species (see all 12) About this table
ENSEMBL Gene Tree for CCDC62 (if available)
TreeFam Gene Tree for CCDC62 (if available) |
Paralogs
for CCDC62 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC62 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC62 (123258874 - 123312075 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC62: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC62 |
|
Disorders
/ Diseases
for CCDC62 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC62 for disorders About GeneDecksing
OMIM gene information: 613481
OMIM disorders: --
10  diseases for CCDC62: About MalaCardsrhizomelic chondrodysplasia punctata chondrodysplasia punctata spastic paraplegia paraplegia
zellweger syndrome spasticity chondrodysplasia parkinson's disease
prostate cancer prostatitis
2 diseases from the University of Copenhagen DISEASES database for CCDC62:Paraplegia Zellweger syndrome Human Genome Epidemiology (HuGE) Navigator: CCDC62 (1 document)
Export disorders for CCDC62 gene to outside databases
|
Publications
for CCDC62 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC62 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC62) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. (PubMed id 19126643)1, 2, 3 Chen M....Yeh S. (2009)
- ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. (PubMed id 18563714)1, 2, 3 Chen M....Yeh S. (2008)
- Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. (PubMed id 19165854)1, 2 Domae S....Ono T. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1 ....Wood N.W. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for CCDC62 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC62 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC62 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC62 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC62 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC62 gene:
Search GeneIP for patents involving CCDC62
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC62 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC62 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC62 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC62 | | | OriGene Protein Over-expression Lysate for CCDC62 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC62 | | OriGene 3'-UTR Clone for CCDC62 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC62 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC62 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC62 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC62 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC62 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC62 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC62 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC62 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC62 |
| |  |  |  |  | | | | |
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 |
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 | | | CCDC62 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC62 |
|  |  |  | | | | ThermoFisher Antibodies for CCDC62 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC62 |
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