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Aliases for CCDC60 Gene

Aliases for CCDC60 Gene

  • Coiled-Coil Domain Containing 60 2 3 5

External Ids for CCDC60 Gene

Previous GeneCards Identifiers for CCDC60 Gene

  • GC12P118238
  • GC12P119772
  • GC12P116780

Summaries for CCDC60 Gene

GeneCards Summary for CCDC60 Gene

CCDC60 (Coiled-Coil Domain Containing 60) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC60 Gene

Genomics for CCDC60 Gene

Regulatory Elements for CCDC60 Gene

Enhancers for CCDC60 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC60 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC60 Gene

Chromosome:
12
Start:
119,334,712 bp from pter
End:
119,541,047 bp from pter
Size:
206,336 bases
Orientation:
Plus strand

Genomic View for CCDC60 Gene

Genes around CCDC60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC60 Gene

Proteins for CCDC60 Gene

  • Protein details for CCDC60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWA6-CCD60_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 60
    Protein Accession:
    Q8IWA6

    Protein attributes for CCDC60 Gene

    Size:
    550 amino acids
    Molecular mass:
    63091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC60 Gene

Proteomics data for CCDC60 Gene at MOPED

Post-translational modifications for CCDC60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC60 Gene

Domains & Families for CCDC60 Gene

Protein Domains for CCDC60 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC60: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC60 Gene

Function for CCDC60 Gene

genes like me logo Genes that share phenotypes with CCDC60: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC60 Gene

Localization for CCDC60 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC60 Gene COMPARTMENTS Subcellular localization image for CCDC60 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC60 Gene

Pathways & Interactions for CCDC60 Gene

SuperPathways for CCDC60 Gene

No Data Available

Interacting Proteins for CCDC60 Gene

Selected Interacting proteins: Q8IWA6-CCD60_HUMAN for CCDC60 Gene via UniProtKB

Symbol External ID(s) Details
MTUS2

Gene Ontology (GO) - Biological Process for CCDC60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC60 Gene

Drugs & Compounds for CCDC60 Gene

No Compound Related Data Available

Transcripts for CCDC60 Gene

Unigene Clusters for CCDC60 Gene

Coiled-coil domain containing 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC60 Gene

No ASD Table

Relevant External Links for CCDC60 Gene

GeneLoc Exon Structure for
CCDC60
ECgene alternative splicing isoforms for
CCDC60

Expression for CCDC60 Gene

mRNA expression in normal human tissues for CCDC60 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC60 Gene

This gene is overexpressed in Testis (x17.6) and Bladder (x5.7).

Protein differential expression in normal tissues from HIPED for CCDC60 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC60 Gene



SOURCE GeneReport for Unigene cluster for CCDC60 Gene Hs.98188

genes like me logo Genes that share expression patterns with CCDC60: view

Protein tissue co-expression partners for CCDC60 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC60 Gene

Orthologs for CCDC60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC60 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC60 35
  • 84.65 (n)
  • 82.75 (a)
CCDC60 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC60 35
  • 83.9 (n)
  • 79.4 (a)
CCDC60 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc60 35
  • 77.76 (n)
  • 78.13 (a)
Ccdc60 16
Ccdc60 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC60 35
  • 99.52 (n)
  • 98.91 (a)
CCDC60 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc60 35
  • 78.34 (n)
  • 78.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC60 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC60 35
  • 50.17 (n)
  • 36.85 (a)
CCDC60 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC60 36
  • 37 (a)
OneToOne
Species with no ortholog for CCDC60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC60 Gene

ENSEMBL:
Gene Tree for CCDC60 (if available)
TreeFam:
Gene Tree for CCDC60 (if available)

Paralogs for CCDC60 Gene

No data available for Paralogs for CCDC60 Gene

Variants for CCDC60 Gene

Sequence variations from dbSNP and Humsavar for CCDC60 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_033667 -
VAR_033668 -
VAR_033669 -
rs7136758 -- 119,382,345(+) CCAGC(A/G)CACTG intron-variant
rs7295944 -- 119,361,001(+) cgtgg(C/T)ggcgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC60 Gene

Variant ID Type Subtype PubMed ID
nsv832528 CNV Gain 17160897
nsv899552 CNV Loss 21882294
nsv899553 CNV Gain 21882294
nsv832529 CNV Loss 17160897
esv2127888 CNV Deletion 18987734
esv2674874 CNV Deletion 23128226
esv3817 CNV Deletion 18987735
dgv318e199 CNV Deletion 23128226
esv2746459 CNV Deletion 23290073
esv7481 CNV Loss 19470904

Variation tolerance for CCDC60 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.15; 84.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC60 Gene

Disorders for CCDC60 Gene

Relevant External Links for CCDC60

Genetic Association Database (GAD)
CCDC60
Human Genome Epidemiology (HuGE) Navigator
CCDC60
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC60

No disorders were found for CCDC60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC60 Gene

Publications for CCDC60 Gene

  1. A genome-wide association study in 574 schizophrenia trios using DNA pooling. (PMID: 18332876) Kirov G. … O'Donovan M.C. (Mol. Psychiatry 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CCDC60 Gene

Sources for CCDC60 Gene

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