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Aliases for CCDC6 Gene

Aliases for CCDC6 Gene

  • Coiled-Coil Domain Containing 6 2 3 5
  • Papillary Thyroid Carcinoma-Encoded Protein 3 4
  • D10S170 3 4
  • TST1 3 4
  • DNA Segment On Chromosome 10 (Unique) 170 2
  • Probe PH4 (Transforming Sequence 2
  • DNA Segment 2
  • Single Copy 2
  • Protein H4 4
  • Thyroid-1 2
  • PTC 3
  • TPC 3
  • H4 3

External Ids for CCDC6 Gene

Previous HGNC Symbols for CCDC6 Gene

  • TST1
  • D10S170

Previous GeneCards Identifiers for CCDC6 Gene

  • GC10M060895
  • GC10M061218
  • GC10M061548
  • GC10M055536

Summaries for CCDC6 Gene

Entrez Gene Summary for CCDC6 Gene

  • This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

GeneCards Summary for CCDC6 Gene

CCDC6 (Coiled-Coil Domain Containing 6) is a Protein Coding gene. Diseases associated with CCDC6 include differentiated thyroid carcinoma and thyroid cancer. Among its related pathways are RB in Cancer and Pathways in cancer. GO annotations related to this gene include SH3 domain binding and structural constituent of cytoskeleton.

Gene Wiki entry for CCDC6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC6 Gene

Genomics for CCDC6 Gene

Regulatory Elements for CCDC6 Gene

Promoters for CCDC6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC6 Gene

Chromosome:
10
Start:
59,788,747 bp from pter
End:
59,906,656 bp from pter
Size:
117,910 bases
Orientation:
Minus strand

Genomic View for CCDC6 Gene

Genes around CCDC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC6 Gene

Proteins for CCDC6 Gene

  • Protein details for CCDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16204-CCDC6_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 6
    Protein Accession:
    Q16204
    Secondary Accessions:
    • Q15250
    • Q6GSG7

    Protein attributes for CCDC6 Gene

    Size:
    474 amino acids
    Molecular mass:
    53291 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC60637.1; Type=Frameshift; Positions=456; Evidence={ECO:0000305};

neXtProt entry for CCDC6 Gene

Proteomics data for CCDC6 Gene at MOPED

Post-translational modifications for CCDC6 Gene

  • Ubiquitination at Lys 188
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC6 Gene

Domains & Families for CCDC6 Gene

Protein Domains for CCDC6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16204

UniProtKB/Swiss-Prot:

CCDC6_HUMAN :
  • The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
Domain:
  • The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.
genes like me logo Genes that share domains with CCDC6: view

No data available for Gene Families for CCDC6 Gene

Function for CCDC6 Gene

Gene Ontology (GO) - Molecular Function for CCDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23108047
genes like me logo Genes that share ontologies with CCDC6: view
genes like me logo Genes that share phenotypes with CCDC6: view

Human Phenotype Ontology for CCDC6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for CCDC6

miRNA for CCDC6 Gene

miRTarBase miRNAs that target CCDC6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC6 Gene

Localization for CCDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC6 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=May be a cytoskeletal protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC6 Gene COMPARTMENTS Subcellular localization image for CCDC6 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 4
cytoskeleton 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for CCDC6 Gene

Pathways & Interactions for CCDC6 Gene

genes like me logo Genes that share pathways with CCDC6: view

Pathways by source for CCDC6 Gene

1 BioSystems pathway for CCDC6 Gene
2 KEGG pathways for CCDC6 Gene

SIGNOR curated interactions for CCDC6 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCDC6 Gene

None

Drugs & Compounds for CCDC6 Gene

(1) Drugs for CCDC6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CCDC6: view

Transcripts for CCDC6 Gene

mRNA/cDNA for CCDC6 Gene

Unigene Clusters for CCDC6 Gene

Coiled-coil domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC6 Gene

No ASD Table

Relevant External Links for CCDC6 Gene

GeneLoc Exon Structure for
CCDC6
ECgene alternative splicing isoforms for
CCDC6

Expression for CCDC6 Gene

mRNA expression in normal human tissues for CCDC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC6 Gene



SOURCE GeneReport for Unigene cluster for CCDC6 Gene Hs.591360

mRNA Expression by UniProt/SwissProt for CCDC6 Gene

Q16204-CCDC6_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with CCDC6: view

Protein tissue co-expression partners for CCDC6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CCDC6 Gene

Orthologs for CCDC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC6 35
  • 93.48 (n)
  • 98.93 (a)
CCDC6 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC6 35
  • 92.87 (n)
  • 98.87 (a)
CCDC6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc6 35
  • 85.01 (n)
  • 94.43 (a)
Ccdc6 16
Ccdc6 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC6 35
  • 99.86 (n)
  • 100 (a)
CCDC6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc6 35
  • 84.87 (n)
  • 94.65 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC6 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC6 35
  • 83.65 (n)
  • 93.45 (a)
CCDC6 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC6 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc6 35
  • 78.41 (n)
  • 93.17 (a)
Str.2001 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53501 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccdc6b 35
  • 76.63 (n)
  • 92.89 (a)
ccdc6a 36
  • 84 (a)
OneToMany
ccdc6b 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6664 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T09B9.4 36
  • 21 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13926 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3546 36
  • 57 (a)
OneToOne
Species with no ortholog for CCDC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC6 Gene

ENSEMBL:
Gene Tree for CCDC6 (if available)
TreeFam:
Gene Tree for CCDC6 (if available)

Paralogs for CCDC6 Gene

(2) SIMAP similar genes for CCDC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC6: view

No data available for Paralogs for CCDC6 Gene

Variants for CCDC6 Gene

Sequence variations from dbSNP and Humsavar for CCDC6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1053266 - 59,792,934(-) CGCAC(A/C/G)CCTCC reference, missense
rs15055 -- 59,788,817(+) TCAAA(A/G)ACTAA utr-variant-3-prime
rs895243 -- 59,877,145(+) ATTAC(G/T)CAGTG intron-variant
rs714340 -- 59,846,217(+) TTCTC(C/T)AGAAT intron-variant
rs1149659 -- 59,859,189(+) AAATA(C/T)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC6 Gene

Variant ID Type Subtype PubMed ID
esv29571 CNV Gain+Loss 19812545
nsv820824 CNV Deletion 20802225
esv1123063 CNV Deletion 17803354
esv2737474 CNV Deletion 23290073
nsv25344 CNV Insertion 16902084

Variation tolerance for CCDC6 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.76; 95.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC6 Gene

HapMap Linkage Disequilibrium report
CCDC6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC6 Gene

Disorders for CCDC6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CCDC6 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
thyroid cancer
  • malignant neoplasm of thyroid gland
thyroid cancer, monmedullary, 1
  • papillary thyroid carcinoma
papillary carcinoma
  • papillary carcinoma nos
astroblastoma
  • cerebral astroblastoma
- elite association - COSMIC cancer census association via MalaCards
Search CCDC6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CCDC6_HUMAN
  • Note=A chromosomal aberration involving CCDC6 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene. {ECO:0000269 PubMed:2406025}.

Relevant External Links for CCDC6

Genetic Association Database (GAD)
CCDC6
Human Genome Epidemiology (HuGE) Navigator
CCDC6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC6
genes like me logo Genes that share disorders with CCDC6: view

No data available for Genatlas for CCDC6 Gene

Publications for CCDC6 Gene

  1. Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo. (PMID: 8058316) Grieco M. … Vecchio G. (Oncogene 1994) 2 3 4 67
  2. Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins. (PMID: 19487296) Richardson D.S. … Mulligan L.M. (Cancer Res. 2009) 3 23
  3. Characterization of the promoter region and oligomerization domain of H4 (D10S170), a gene frequently rearranged with the ret proto-oncogene. (PMID: 7753554) Tong Q. … Jhiang S.M. (Oncogene 1995) 3 23
  4. Estimating the recombination frequency for the PTC-Kell linkage. (PMID: 6745938) Anne-Spence M. … Sparkes R.S. (Hum. Genet. 1984) 2 3
  5. New therapeutic perspectives in CCDC6 deficient lung cancer cells. (PMID: 25302833) Morra F. … Celetti A. (Int. J. Cancer 2015) 3

Products for CCDC6 Gene

Sources for CCDC6 Gene

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