Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CCDC6 Gene

protein-coding   GIFtS: 58
GCID: GC10M061548

Coiled-Coil Domain Containing 6

(Previous name: DNA segment on chromosome 10 (unique) 170)
(Previous symbols: TST1, D10S170)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Coiled-Coil Domain Containing 61 2     DNA Segment1
D10S1701 2 3 5     DNA Segment On Chromosome 10 (Unique) 1701
TST11 2 3 5     Probe PH4 (Transforming Sequence1
Papillary Thyroid Carcinoma-Encoded Protein2 3     Single Copy1
H42 5     thyroid-11
PTC2 5     Coiled-Coil Domain-Containing Protein 62
TPC2 5     Protein H43

External Ids:    HGNC: 187821   Entrez Gene: 80302   Ensembl: ENSG000001080917   OMIM: 6019855   UniProtKB: Q162043   

Export aliases for CCDC6 gene to outside databases

Previous GC identifers: GC10M060895 GC10M061218 GC10M055536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CCDC6 Gene:
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may
function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene
containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the
cause of thyroid papillary carcinoma.(provided by RefSeq, Sep 2010)

GeneCards Summary for CCDC6 Gene:
CCDC6 (coiled-coil domain containing 6) is a protein-coding gene. Diseases associated with CCDC6 include papillary thyroid carcinoma, and papillary carcinoma. GO annotations related to this gene include SH3 domain binding and structural constituent of cytoskeleton.

Gene Wiki entry for CCDC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC6 gene promoter:
         NRSF form 1   Nkx2-2   POU3F2 (N-Oct-5b)   LUN-1   CUTL1   NRSF form 2   AREB6   POU2F1   POU2F1a   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC6 promoter sequence
   Search Chromatin IP Primers for CCDC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q21.2

CCDC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M061548:  view genomic region     (about GC identifiers)

Start:
61,548,505 bp from pter      End:
61,666,414 bp from pter
Size:
117,910 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CCDC6_HUMAN, Q16204 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 6  
Size: 474 amino acids; 53291 Da
Sequence caution: Sequence=AAC60637.1; Type=Frameshift; Positions=456;
Secondary accessions: Q15250 Q6GSG7

Explore the universe of human proteins at neXtProt for CCDC6: NX_Q16204

Explore proteomics data for CCDC6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys188
  • Modification sites at PhosphoSitePlus

  • See CCDC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005427.2  
    ENSEMBL proteins: 
     ENSP00000263102  

    CCDC6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CCDC6
    GenScript Custom Purified and Recombinant Proteins Services for CCDC6
    Novus Biologicals CCDC6 Proteins
    Novus Biologicals CCDC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC6

    CCDC6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CCDC6
    Novus Biologicals CCDC6 Antibodies
    Abcam antibodies for CCDC6
    Cloud-Clone Corp. Antibodies for CCDC6
    ThermoFisher Antibodies for CCDC6
    LSBio Antibodies in human, mouse, rat for CCDC6

    CCDC6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CCDC6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CCDC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CCDC6
    Cloud-Clone Corp. CLIAs for CCDC6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019152 DUF2046

    Graphical View of Domain Structure for InterPro Entry Q16204

    ProtoNet protein and cluster: Q16204

    UniProtKB/Swiss-Prot: CCDC6_HUMAN, Q16204
    Domain: The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a
    coiled-coil conformation


    CCDC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton TAS8058316
    GO:0005515protein binding IPI--
    GO:0017124SH3 domain binding IEA--
         
    CCDC6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCDC6:
    hsa-mir-331-5p (MIRT038182), hsa-mir-342-3p (MIRT043723), hsa-mir-181a-5p (MIRT025091), hsa-mir-99a-5p (MIRT048602), hsa-mir-128-3p (MIRT021879), hsa-mir-92a-3p (MIRT048991)

    Block miRNA regulation of human, mouse, rat CCDC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCDC6 (see all 158):
    hsa-miR-520f hsa-miR-146a hsa-miR-128 hsa-miR-409-5p hsa-miR-149 hsa-miR-92b hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CCDC6
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CCDC6

    Clone
    Products:
         
    OriGene clones in human, mouse for CCDC6 (see all 6)
    OriGene ORF clones in mouse, rat for CCDC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC6 (NM_005436)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CCDC6
    Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CCDC6_HUMAN, Q16204: Cytoplasm. Cytoplasm, cytoskeleton (Probable). Note=May be a cytoskeletal protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytoskeleton4
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--

    CCDC6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CCDC6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Thyroid cancer
    Thyroid cancer
    2RB in Cancer
    RB in Cancer
    3Pathways in cancer
    Pathways in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CCDC6
        RB in Cancer


    2 Kegg Pathways  (Kegg details for CCDC6):
        Pathways in cancer
    Thyroid cancer


    CCDC6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC6
    Interactions:

        Search GeneGlobe Interaction Network for CCDC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CCDC6 (Q162041, 2, 3 ENSP000002631024) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXW7Q969H01, 2EBI-1045350,EBI-359574 MINT-8399620 MINT-8399547 MINT-8399589 MINT-8399538 MINT-8399653 MINT-8399514 MINT-8399571 MINT-8399642 MINT-8399603
    CUL1Q136162MINT-8399620 MINT-8399460 MINT-8399514
    PPP1CAP621363, ENSP000003260314I2D: score=1 STRING: ENSP00000326031
    PPP4CP605103, ENSP000002793874I2D: score=3 STRING: ENSP00000279387
    USP7Q930093, ENSP000003435354I2D: score=2 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CCDC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC6

    1 Novoseek inferred chemical compound relationship for CCDC6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 41.7 4 9703361 (1), 7753554 (1), 15680400 (1)



    CCDC6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CCDC6 gene: 
    NM_005436.4  

    Unigene Cluster for CCDC6:

    Coiled-coil domain containing 6
    Hs.591360  [show with all ESTs]
    Unigene Representative Sequence: NM_005436
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263102(uc001jks.4) ENST00000491922 ENST00000518638

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CCDC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CCDC6 (see all 158):
    hsa-miR-520f hsa-miR-146a hsa-miR-128 hsa-miR-409-5p hsa-miR-149 hsa-miR-92b hsa-miR-130b hsa-miR-374b*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCDC6
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC6
    Clone
    Products:
         
    OriGene clones in human, mouse for CCDC6 (see all 6)
    OriGene ORF clones in mouse, rat for CCDC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CCDC6 (NM_005436)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CCDC6
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC6
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC6
      QuantiFast Probe-based Assays in human, mouse, rat CCDC6

    Additional mRNA sequence: 

    AK024913.1 AK055515.1 AK056848.1 AK292593.1 BC022284.1 BC036757.2 BC064391.1 S72869.1 

    10 DOTS entries:

    DT.320353  DT.91704074  DT.100822334  DT.100822337  DT.121297447  DT.121436635  DT.40106340  DT.86839263 
    DT.100036557  DT.100708533 

    Selected AceView cDNA sequences (see all 96):

    AK055515 AL704784 AA112388 BX477234 AK056848 N44799 NM_005436 BQ233348 
    BU500248 AL543347 CA866111 AA112389 CR607870 BI333089 AA053054 BF700425 
    BE908904 AI657158 CB269185 BX481419 AA356502 CA941083 AA773636 BE786971 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CCDC6 expression in normal human tissues (normalized intensities)      CCDC6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGAATCA
    CCDC6 Expression
    About this image


    CCDC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Lateral Ventricle
    CCDC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591360

    UniProtKB/Swiss-Prot: CCDC6_HUMAN, Q16204
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for CCDC6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CCDC6
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC6
    QuantiTect SYBR Green Assays in human, mouse, rat CCDC6
    QuantiFast Probe-based Assays in human, mouse, rat CCDC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc61 , 5 coiled-coil domain containing 61, 5 85.01(n)1
    94.43(a)1
      10 (36.68 cM)5
    765511  NM_001111121.11  NP_001104591.11 
     700971215 
    chicken
    (Gallus gallus)
    Aves CCDC61 coiled-coil domain containing 6 83.65(n)
    93.45(a)
      423666  NM_001031221.1  NP_001026392.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC66
    coiled-coil domain containing 6
    96(a)
    1 ↔ 1
    GL343251.1(313809-335357)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC535012 hypothetical protein MGC53501 81.51(n)    BC045133.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049328.12   -- 76.84(n)   335905  BC049328.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG66646
    --
    43(a)
    1 ↔ 1
    3L(17005986-17009280)
    worm
    (Caenorhabditis elegans)
    Secernentea T09B9.46
    Protein T09B9.4 (T09B9.4) mRNA, complete cds
    21(a)
    1 ↔ 1
    X(9771714-9774352) WBGene00011645


    ENSEMBL Gene Tree for CCDC6 (if available)
    TreeFam Gene Tree for CCDC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CCDC6 gene
    2 SIMAP similar genes for CCDC6 using alignment to 2 protein entries:     CCDC6_HUMAN (see all proteins):
    CCDC6-RETa    CCDC6-RETc

    CCDC6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CCDC6 (see all 2703)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423088361,2
    C--55621476(+) AGCAA-/ACACAC/A
    CACACACACAC
    ACACA
    2 -- cds10--------
    rs1114777391,2
    C--55629372(+) AAAGCC/TGGGGA 1 -- int10--------
    rs1995948341,2
    C--55629372(+) AAGCT-/GGGGGGA 1 -- int10--------
    rs1485497451,2
    C--55629417(+) AAGCC-/AGGGGGA 1 -- int10--------
    rs1399474891,2
    C--55629484(+) AAGCC-/GGGGGGA 1 -- int10--------
    rs1453667361,2
    --55629690(+) AGCCG-/GCGGGAG 1 -- int10--------
    rs1117194461,2
    C,F--55629691(+) GCCGGG/CGGGAG 1 -- int12Minor allele frequency- C:0.50NA WA 4
    rs720529271,2
    C--55629740(+) GCCGG-/CG/GGGAG
    AAGGAAAGCCG
    GGAGA
    1 -- int10--------
    rs342817021,2
    C--55632186(+) TCCGT-/AACAACAA 1 -- cds10--------
    rs790041721,2
    C--55633044(+) ACCCCA/GCCCCC 1 -- int12Minor allele frequency- G:0.25NA 4

    HapMap Linkage Disequilibrium report for CCDC6 (61548505 - 61666414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCDC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737474CNV Deletion23290073
    nsv820824CNV Deletion20802225
    esv1123063CNV Deletion17803354
    nsv25344CNV Insertion16902084
    esv29571CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC6
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601985   
    OMIM disorders: 188550  
    UniProtKB/Swiss-Prot: CCDC6_HUMAN, Q16204
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas.
    Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene

  • 15 diseases for CCDC6:    About MalaCards
    papillary thyroid carcinoma    papillary carcinoma    follicular thyroid carcinoma    thyroiditis
    progressive multifocal leukoencephalopathy    thyroid cancer    toxic shock syndrome    burkitt's lymphoma
    lung adenocarcinoma    alzheimer's disease    lung cancer    adenocarcinoma
    multiple myeloma    myeloma    malaria

    1 disease from the University of Copenhagen DISEASES database for CCDC6:
    Thyroid cancer

    CCDC6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for CCDC6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 88.1 4 10931090 (1), 7753554 (1), 15680400 (1)
    papillary thyroid cancer 76.3 3 7491517 (2), 15680400 (1)
    thyroid cancer 61.7 2 8545102 (1), 16331264 (1)
    thyroid carcinoma 42.6 1 9474864 (1)
    tumors 25.9 4 7491517 (1), 8634704 (1), 9474864 (1)

    Genetic Association Database (GAD): CCDC6
    Human Genome Epidemiology (HuGE) Navigator: CCDC6 (4 documents)

    Export disorders for CCDC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CCDC6 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with CCDC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo. (PubMed id 8058316)1, 2, 3 Grieco M.... Vecchio G. (Oncogene 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    4. Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. (PubMed id 18474871)1, 4 Jazdzewski K....de la Chapelle A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    10. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. (PubMed id 2406025)1, 2 Grieco M.... Vecchio G. (Cell 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8030 HGNC: 18782 AceView: CCDC6 Ensembl:ENSG00000108091 euGenes: HUgn8030
    ECgene: CCDC6 Kegg: 8030 H-InvDB: CCDC6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CCDC6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CCDC6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CCDC6 gene:
    Search GeneIP for patents involving CCDC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CCDC6  
     OriGene qPCR primer pairs and template standards for CCDC6   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CCDC6  
     OriGene qSTAR qPCR primer pairs in human, mouse for CCDC6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CCDC6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CCDC6   OriGene Custom Protein Services for CCDC6  

     
     
     Block miRNA regulation of human, mouse, rat CCDC6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCDC6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC6 Predesigned siRNA for gene silencing in human, mouse, rat CCDC6
     QuantiFast Probe-based Assays in human, mouse, rat CCDC6 QuantiTect SYBR Green Assays in human, mouse, rat CCDC6
     Custom PCR Arrays for CCDC6 Search Chromatin IP Primers for CCDC6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC6  Search GeneGlobe Interaction Network for CCDC6
     Regulatory tfbs in CCDC6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CCDC6 GenScript cDNA clones with any tag delivered in your preferred vector for CCDC6
     GenScript Custom Assay Services for CCDC6 GenScript Custom overexpressing Cell Line Services for CCDC6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CCDC6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CCDC6 antibodies
     CCDC6 proteins
     CCDC6 lysates
     Antibodies for CCDC6
     See all of Abcam's Antibodies, Kits and Proteins for CCDC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CCDC6
     Antibodies for CCDC6
     ELISAs for CCDC6
     CLIAs for CCDC6



     Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CCDC6
     SwitchGear Promoter luciferase reporter plasmids for CCDC6
     ThermoFisher Antibodies for CCDC6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC6
     LSBio Antibodies in human, mouse, rat for CCDC6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CCDC6 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4