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Aliases for CCDC6 Gene

Aliases for CCDC6 Gene

  • Coiled-Coil Domain Containing 6 2 3
  • D10S170 3 4 6
  • TST1 3 4 6
  • Papillary Thyroid Carcinoma-Encoded Protein 3 4
  • TPC 3 6
  • PTC 3 6
  • H4 3 6
  • DNA Segment On Chromosome 10 (Unique) 170 2
  • Coiled-Coil Domain-Containing Protein 6 3
  • Probe PH4 (Transforming Sequence 2
  • DNA Segment 2
  • Single Copy 2
  • Protein H4 4
  • Thyroid-1 2

External Ids for CCDC6 Gene

Previous Symbols for CCDC6 Gene

  • TST1
  • D10S170

Summaries for CCDC6 Gene

Entrez Gene Summary for CCDC6 Gene

  • This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

GeneCards Summary for CCDC6 Gene

CCDC6 (Coiled-Coil Domain Containing 6) is a Protein Coding gene. Diseases associated with CCDC6 include thyroid carcinoma, papillary and thyroid cancer. Among its related pathways are Pathways in cancer and RB in Cancer. GO annotations related to this gene include SH3 domain binding and structural constituent of cytoskeleton.

Gene Wiki entry for CCDC6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC6 Gene

Genomics for CCDC6 Gene

Genomic Location for CCDC6 Gene

Start:
59,788,747 bp from pter
End:
59,906,656 bp from pter
Size:
117,910 bases
Orientation:
Minus strand

Genomic View for CCDC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC6 Gene

Regulatory Elements for CCDC6 Gene

Proteins for CCDC6 Gene

  • Protein details for CCDC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16204-CCDC6_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 6
    Protein Accession:
    Q16204
    Secondary Accessions:
    • Q15250
    • Q6GSG7

    Protein attributes for CCDC6 Gene

    Size:
    474 amino acids
    Molecular mass:
    53291 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC60637.1; Type=Frameshift; Positions=456; Evidence={ECO:0000305};

neXtProt entry for CCDC6 Gene

Proteomics data for CCDC6 Gene at MOPED

Post-translational modifications for CCDC6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys188

Other Protein References for CCDC6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC6 Gene

Domains for CCDC6 Gene

Protein Domains for CCDC6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CCDC6_HUMAN
Domain:
  • The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation:
    • Q16204
genes like me logo Genes that share domains with CCDC6: view

No data available for Gene Families for CCDC6 Gene

Function for CCDC6 Gene

Gene Ontology (GO) - Molecular Function for CCDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 8058316
GO:0005515 protein binding IPI 23108047
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with CCDC6: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC6 Gene

Localization for CCDC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC6 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=May be a cytoskeletal protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC6 Gene COMPARTMENTS Subcellular localization image for CCDC6 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CCDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC6: view

Pathways for CCDC6 Gene

genes like me logo Genes that share pathways with CCDC6: view

Pathways by source for CCDC6 Gene

1 BioSystems pathway for CCDC6 Gene
2 KEGG pathways for CCDC6 Gene

Gene Ontology (GO) - Biological Process for CCDC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CCDC6: view

Compounds for CCDC6 Gene

(1) Novoseek inferred chemical compound relationships for CCDC6 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 41.7 3
genes like me logo Genes that share compounds with CCDC6: view

Transcripts for CCDC6 Gene

mRNA/cDNA for CCDC6 Gene

Unigene Clusters for CCDC6 Gene

Coiled-coil domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC6 Gene

No ASD Table

Relevant External Links for CCDC6 Gene

GeneLoc Exon Structure for
CCDC6
ECgene alternative splicing isoforms for
CCDC6

Expression for CCDC6 Gene

mRNA expression in normal human tissues for CCDC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC6 Gene

SOURCE GeneReport for Unigene cluster for CCDC6 Gene Hs.591360

mRNA Expression by UniProt/SwissProt for CCDC6 Gene

Q16204-CCDC6_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with CCDC6: view

Orthologs for CCDC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC6 36
  • 99.86 (n)
  • 100 (a)
CCDC6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC6 36
  • 93.48 (n)
  • 98.93 (a)
CCDC6 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC6 36
  • 92.87 (n)
  • 98.87 (a)
CCDC6 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc6 36
  • 85.01 (n)
  • 94.43 (a)
Ccdc6 16
Ccdc6 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC6 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC6 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc6 36
  • 84.87 (n)
  • 94.65 (a)
chicken
(Gallus gallus)
Aves CCDC6 36
  • 83.65 (n)
  • 93.45 (a)
CCDC6 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC6 37
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53501 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc6 36
  • 78.41 (n)
  • 93.17 (a)
Str.2001 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ccdc6a 37
  • 84 (a)
OneToMany
ccdc6b 36
  • 76.63 (n)
  • 92.89 (a)
ccdc6b 37
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6664 37
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T09B9.4 37
  • 21 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13926 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3546 37
  • 57 (a)
OneToOne
Species with no ortholog for CCDC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC6 Gene

ENSEMBL:
Gene Tree for CCDC6 (if available)
TreeFam:
Gene Tree for CCDC6 (if available)

Paralogs for CCDC6 Gene

Selected SIMAP similar genes for CCDC6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC6: view

No data available for Paralogs for CCDC6 Gene

Variants for CCDC6 Gene

Sequence variations from dbSNP and Humsavar for CCDC6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15055 -- 59,788,817(+) TCAAA(A/G)ACTAA utr-variant-3-prime
rs714340 -- 59,846,217(+) TTCTC(C/T)AGAAT intron-variant
rs895243 -- 59,877,145(+) ATTAC(G/T)CAGTG intron-variant
rs920964 -- 59,821,209(-) ATAGG(C/T)ACAAT intron-variant
rs965898 -- 59,835,226(+) GTAAA(A/C)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC6 Gene

Variant ID Type Subtype PubMed ID
esv29571 CNV Gain+Loss 19812545
nsv820824 CNV Deletion 20802225
esv1123063 CNV Deletion 17803354
esv2737474 CNV Deletion 23290073
nsv25344 CNV Insertion 16902084

Relevant External Links for CCDC6 Gene

HapMap Linkage Disequilibrium report
CCDC6

Disorders for CCDC6 Gene

(1) OMIM Diseases for CCDC6 Gene (601985)

UniProtKB/Swiss-Prot

CCDC6_HUMAN
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

(1) University of Copenhagen DISEASES for CCDC6 Gene

(5) Novoseek inferred disease relationships for CCDC6 Gene

Disease -log(P) Hits PubMed IDs
thyroid papillary carcinoma 88.1 3
papillary thyroid cancer 76.3 3
thyroid cancer 61.7 2
thyroid carcinoma 42.6 1
tumors 25.9 3

Relevant External Links for CCDC6

Genetic Association Database (GAD)
CCDC6
Human Genome Epidemiology (HuGE) Navigator
CCDC6
genes like me logo Genes that share disorders with CCDC6: view

Publications for CCDC6 Gene

  1. Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo. (PMID: 8058316) Grieco M. … Vecchio G. (Oncogene 1994) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for CCDC6 Gene

Sources for CCDC6 Gene

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