CCDC59 Gene
protein-coding GIFtS: 44
GCID: GC12M082617
|
|
coiled-coil domain containing 59
| |
Aliases
for CCDC59 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 591 2 | | TTF-1-Associated Protein 262 3 | | BR221 2 3 | | TTF-1-Associated Protein BR22 3 | | TAP261 2 3 | | HSPC1281 | | Coiled-Coil Domain-Containing Protein 592 3 | | Thyroid Transcription Factor 1-Associated Protein 262 |
Export aliases for CCDC59 gene to outside databasesPrevious GC identifers: GC12M081250 GC12M081270 GC12M082746 GC12M079803 |
Summaries
for CCDC59 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TAP26_HUMAN, Q9P031Function: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C(SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities
|
Genomic Views
for CCDC59 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC59 gene promoter:
STAT5B p53 Tal-1 HTF POU3F1 Lmo2 IRF-1 E47 Egr-2 FOXJ2 (long isoform)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC59
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC59 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q21.31 Ensembl cytogenetic band: 12q21.31 HGNC cytogenetic band: 12q21.31CCDC59 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M082617: view genomic region
(about GC identifiers)
Start:
|
82,617,460 bp from pter |
End:
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82,752,584 bp from pter |
Size:
|
135,125 bases |
Orientation:
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minus strand |
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Proteins
for CCDC59 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAP26_HUMAN, Q9P031 (See
protein sequence)Recommended Name: Thyroid transcription factor 1-associated protein 26 Size: 241 amino acids; 28670 Da
Subunit: Interacts with NKX2-1
Subcellular location: Nucleus (Probable)
Secondary accessions: Q9H2V5 Q9NW62Explore the universe of human proteins at neXtProt for CCDC59: NX_Q9P031
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P031
CCDC59 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054886.2
ENSEMBL proteins: ENSP00000450183 ENSP00000256151
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
CCDC59 for ontologies About GeneDecksing
CCDC59 Antibody Products:
Assay Products for CCDC59: |
Protein
Domains /
Families
for CCDC59 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC59 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P031ProtoNet protein and cluster: Q9P031 UniProtKB/Swiss-Prot: TAP26_HUMAN, Q9P031Similarity: Belongs to the TAP26 family |
Function
for CCDC59 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAP26_HUMAN, Q9P031Function: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C(SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CCDC59 (NM_014167) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC59 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC59 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC59 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CCDC59 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CCDC59:
|
Pathways & Interactions
for CCDC59 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CCDC59
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/15 Interacting proteins for CCDC59 (Q9P0311, 3 ENSP000002561514) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
CCDC59 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC59 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC59
Search CenterWatch for drugs/clinical trials and news about CCDC59 / TAP26
|
Transcripts
for CCDC59 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC59 gene: NM_014167.4 Unigene Cluster for CCDC59: Coiled-coil domain containing 59 Hs.582627 [show with all ESTs]Unigene Representative Sequence: NM_0141677 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000552377 ENST00000256151(uc001szp.4 uc021rbm.1) ENST00000550589
ENST00000548126 ENST00000547758 ENST00000552606 ENST00000552412
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC59 (NM_014167) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC59 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC59 |
Additional cDNA sequence: AF161477.1 AF213377.1 AK001156.1 AK225139.1 BC020647.1 NR_033192.1 11 DOTS entries: DT.413931 DT.100035788 DT.100762519 DT.121163948 DT.91731054 DT.99983686 DT.100654175 DT.121163919 DT.75103203 DT.91731055 DT.100678641 24/131 AceView cDNA sequences (see all 131): BQ013536 BG942302 AI148678 BM846580 BM969955 CB135361 AI142307 CK823591 AA570035 BU736576 BX349662 T48328 CR611206 AA493141 BX358200 BM847229 BM704254 AA262594 AA811212 AI825568 AA133846 BC020647 AI668949 CB160753
GeneLoc Exon Structure
|
Expression
for CCDC59 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC59 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATACTTTT
About this image
See CCDC59 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC59
SOURCE GeneReport for Unigene cluster: Hs.582627
UniProtKB/Swiss-Prot: TAP26_HUMAN, Q9P031Tissue specificity: Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells
SABiosciences Custom PCR Arrays for CCDC59
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC59
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC59 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC59 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC59 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC59 |
Orthologs
for CCDC59 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC59 gene from 7/15 species (see all 15) About this table
ENSEMBL Gene Tree for CCDC59 (if available)
TreeFam Gene Tree for CCDC59 (if available) |
Paralogs
for CCDC59 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC59 gene
CCDC59 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CCDC59
PGOHUM00000261154 PGOHUM00000243415
|
Genomic Variants
for CCDC59 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC59 (82617460 - 82752584 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC59
1 CNV: 4782 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC59 |
|
Disorders
/ Diseases
for CCDC59 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC59 for disorders About GeneDecksing
1  disease for CCDC59: About MalaCardsthyroiditis
Export disorders for CCDC59 gene to outside databases
|
Publications
for CCDC59 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC59 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CCDC59) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells. (PubMed id 16630564)1, 2, 3 Yang M.-C.... Yang Y.-S. (2006)
- BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells. (PubMed id 12882447)1, 2, 3 Yang M.C....Yang Y.S. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter. (PubMed id 11152647)1, 2 Yang Y.-S.... Weissler J.C. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
|
External Searches for CCDC59 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC59 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC59 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC59 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC59 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC59 gene:
Search GeneIP for patents involving CCDC59
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC59 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC59 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC59 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC59 | | | OriGene Protein Over-expression Lysate for CCDC59 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC59 | | OriGene 3'-UTR Clone for CCDC59 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC59 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC59 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC59 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC59 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC59 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC59 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC59 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC59 |
| |  |  |  |  | | | | |
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 |
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 | | | CCDC59 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC59 |
|  |  |  | | | | ThermoFisher Antibodies for CCDC59 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC59 |
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