Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC59 Gene

Aliases for CCDC59 Gene

  • Coiled-Coil Domain Containing 59 2 3
  • Coiled-Coil Domain-Containing Protein 59 3 4
  • TTF-1-Associated Protein BR2 3 4
  • TTF-1-Associated Protein 26 3 4
  • TAP26 3 4
  • BR22 3 4
  • Thyroid Transcription Factor 1-Associated Protein 26 3
  • HSPC128 3

External Ids for CCDC59 Gene

Summaries for CCDC59 Gene

GeneCards Summary for CCDC59 Gene

CCDC59 (Coiled-Coil Domain Containing 59) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC59 Gene

  • Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC59 Gene

Genomics for CCDC59 Gene

Genomic Location for CCDC59 Gene

Start:
82,223,681 bp from pter
End:
82,358,805 bp from pter
Size:
135,125 bases
Orientation:
Minus strand

Genomic View for CCDC59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC59 Gene

Regulatory Elements for CCDC59 Gene

Proteins for CCDC59 Gene

  • Protein details for CCDC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P031-TAP26_HUMAN
    Recommended name:
    Thyroid transcription factor 1-associated protein 26
    Protein Accession:
    Q9P031
    Secondary Accessions:
    • Q9H2V5
    • Q9NW62

    Protein attributes for CCDC59 Gene

    Size:
    241 amino acids
    Molecular mass:
    28670 Da
    Quaternary structure:
    • Interacts with NKX2-1.

neXtProt entry for CCDC59 Gene

Proteomics data for CCDC59 Gene at MOPED

Post-translational modifications for CCDC59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC59 Gene

Domains for CCDC59 Gene

Protein Domains for CCDC59 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TAP26_HUMAN
Family:
  • Belongs to the TAP26 family.:
    • Q9P031
genes like me logo Genes that share domains with CCDC59: view

No data available for Gene Families for CCDC59 Gene

Function for CCDC59 Gene

Molecular function for CCDC59 Gene

UniProtKB/Swiss-Prot Function: Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

Gene Ontology (GO) - Molecular Function for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11152647
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CCDC59: view

Phenotypes for CCDC59 Gene

GenomeRNAi human phenotypes for CCDC59:
genes like me logo Genes that share phenotypes with CCDC59: view

miRNA for CCDC59 Gene

miRTarBase miRNAs that target CCDC59

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC59 Gene

Localization for CCDC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC59 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC59 Gene COMPARTMENTS Subcellular localization image for CCDC59 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CCDC59: view

Pathways for CCDC59 Gene

SuperPathways for CCDC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CCDC59: view

No data available for Pathways by source for CCDC59 Gene

Transcripts for CCDC59 Gene

Unigene Clusters for CCDC59 Gene

Coiled-coil domain containing 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC59 Gene

No ASD Table

Relevant External Links for CCDC59 Gene

GeneLoc Exon Structure for
CCDC59
ECgene alternative splicing isoforms for
CCDC59

Expression for CCDC59 Gene

mRNA expression in normal human tissues for CCDC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC59 Gene

SOURCE GeneReport for Unigene cluster for CCDC59 Gene Hs.582627

mRNA Expression by UniProt/SwissProt for CCDC59 Gene

Q9P031-TAP26_HUMAN
Tissue specificity: Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells.
genes like me logo Genes that share expressions with CCDC59: view

Orthologs for CCDC59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC59 36
  • 98.76 (n)
  • 97.51 (a)
CCDC59 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC59 36
  • 85.17 (n)
  • 79.82 (a)
CCDC59 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC59 36
  • 80.61 (n)
  • 72.38 (a)
CCDC59 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc59 36
  • 77.68 (n)
  • 70.71 (a)
Ccdc59 16
Ccdc59 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 58 (a)
OneToMany
-- 37
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc59 36
  • 78.38 (n)
  • 71.55 (a)
chicken
(Gallus gallus)
Aves CCDC59 36
  • 65.89 (n)
  • 60.23 (a)
CCDC59 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC59 37
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3654 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc59 36
  • 58.17 (n)
  • 55 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc59 36
  • 51.74 (n)
  • 43.48 (a)
ccdc59 37
  • 34 (a)
OneToOne
Species with no ortholog for CCDC59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC59 Gene

ENSEMBL:
Gene Tree for CCDC59 (if available)
TreeFam:
Gene Tree for CCDC59 (if available)

Paralogs for CCDC59 Gene

Pseudogenes.org Pseudogenes for CCDC59 Gene

genes like me logo Genes that share paralogs with CCDC59: view

No data available for Paralogs for CCDC59 Gene

Variants for CCDC59 Gene

Sequence variations from dbSNP and Humsavar for CCDC59 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14568 -- 82,352,991(+) CATAT(G/T)TAGAA utr-variant-3-prime, nc-transcript-variant
rs4242870 -- 82,353,613(+) ATACT(A/G)TTTCC intron-variant
rs4460873 -- 82,352,751(+) TTTGC(C/T)TCCCT utr-variant-3-prime, nc-transcript-variant
rs4517595 -- 82,353,234(+) GTTCA(G/T)TATTT missense, reference, nc-transcript-variant
rs4519155 -- 82,353,409(+) TCTAA(A/G)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC59 Gene

Variant ID Type Subtype PubMed ID
nsv832471 CNV Loss 17160897
nsv899348 CNV Gain 21882294

Relevant External Links for CCDC59 Gene

HapMap Linkage Disequilibrium report
CCDC59

Disorders for CCDC59 Gene

Relevant External Links for CCDC59

Genetic Association Database (GAD)
CCDC59
genes like me logo Genes that share disorders with CCDC59: view

No data available for UniProtKB/Swiss-Prot for CCDC59 Gene

Publications for CCDC59 Gene

  1. The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells. (PMID: 16630564) Yang M.-C. … Yang Y.-S. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells. (PMID: 12882447) Yang M.-C. … Yang Y.-S. (Eur. Respir. J. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter. (PMID: 11152647) Yang Y.-S. … Weissler J.C. (Am. J. Respir. Cell Mol. Biol. 2001) 3 4

Products for CCDC59 Gene

Sources for CCDC59 Gene

Back to Top

Content