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Aliases for CCDC59 Gene

Aliases for CCDC59 Gene

  • Coiled-Coil Domain Containing 59 2 3 5
  • Coiled-Coil Domain-Containing Protein 59 3 4
  • TTF-1-Associated Protein BR2 3 4
  • TTF-1-Associated Protein 26 3 4
  • TAP26 3 4
  • BR22 3 4
  • HSPC128 3

External Ids for CCDC59 Gene

Previous GeneCards Identifiers for CCDC59 Gene

  • GC12M081250
  • GC12M081270
  • GC12M082746
  • GC12M079803
  • GC12M082617

Summaries for CCDC59 Gene

GeneCards Summary for CCDC59 Gene

CCDC59 (Coiled-Coil Domain Containing 59) is a Protein Coding gene. Diseases associated with CCDC59 include Pulmonary Surfactant Metabolism Dysfunction. Among its related pathways are Diseases of metabolism and Infectious disease. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for CCDC59 Gene

  • Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC59 Gene

Genomics for CCDC59 Gene

Regulatory Elements for CCDC59 Gene

Enhancers for CCDC59 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC59 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC59 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC59 Gene

Chromosome:
12
Start:
82,223,681 bp from pter
End:
82,358,805 bp from pter
Size:
135,125 bases
Orientation:
Minus strand

Genomic View for CCDC59 Gene

Genes around CCDC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC59 Gene

Proteins for CCDC59 Gene

  • Protein details for CCDC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P031-TAP26_HUMAN
    Recommended name:
    Thyroid transcription factor 1-associated protein 26
    Protein Accession:
    Q9P031
    Secondary Accessions:
    • Q9H2V5
    • Q9NW62

    Protein attributes for CCDC59 Gene

    Size:
    241 amino acids
    Molecular mass:
    28670 Da
    Quaternary structure:
    • Interacts with NKX2-1.

neXtProt entry for CCDC59 Gene

Proteomics data for CCDC59 Gene at MOPED

Post-translational modifications for CCDC59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC59 Gene

Domains & Families for CCDC59 Gene

Protein Domains for CCDC59 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P031

UniProtKB/Swiss-Prot:

TAP26_HUMAN :
  • Belongs to the TAP26 family.
Family:
  • Belongs to the TAP26 family.
genes like me logo Genes that share domains with CCDC59: view

No data available for Gene Families for CCDC59 Gene

Function for CCDC59 Gene

Molecular function for CCDC59 Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.
genes like me logo Genes that share phenotypes with CCDC59: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC59 Gene

Localization for CCDC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC59 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC59 Gene COMPARTMENTS Subcellular localization image for CCDC59 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for CCDC59 Gene

Pathways & Interactions for CCDC59 Gene

genes like me logo Genes that share pathways with CCDC59: view

Gene Ontology (GO) - Biological Process for CCDC59 Gene

None

No data available for SIGNOR curated interactions for CCDC59 Gene

Drugs & Compounds for CCDC59 Gene

No Compound Related Data Available

Transcripts for CCDC59 Gene

Unigene Clusters for CCDC59 Gene

Coiled-coil domain containing 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC59 Gene

No ASD Table

Relevant External Links for CCDC59 Gene

GeneLoc Exon Structure for
CCDC59
ECgene alternative splicing isoforms for
CCDC59

Expression for CCDC59 Gene

mRNA expression in normal human tissues for CCDC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC59 Gene

This gene is overexpressed in Lung (46.6), Pancreas (10.1), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC59 Gene



SOURCE GeneReport for Unigene cluster for CCDC59 Gene Hs.582627

mRNA Expression by UniProt/SwissProt for CCDC59 Gene

Q9P031-TAP26_HUMAN
Tissue specificity: Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells.
genes like me logo Genes that share expression patterns with CCDC59: view

Protein tissue co-expression partners for CCDC59 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CCDC59 Gene

Orthologs for CCDC59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC59 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC59 35
  • 85.17 (n)
  • 79.82 (a)
CCDC59 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC59 35
  • 80.61 (n)
  • 72.38 (a)
CCDC59 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc59 35
  • 77.68 (n)
  • 70.71 (a)
Ccdc59 16
Ccdc59 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC59 35
  • 98.76 (n)
  • 97.51 (a)
CCDC59 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc59 35
  • 78.38 (n)
  • 71.55 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC59 35
  • 65.89 (n)
  • 60.23 (a)
CCDC59 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC59 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc59 35
  • 58.17 (n)
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3654 35
zebrafish
(Danio rerio)
Actinopterygii ccdc59 35
  • 51.74 (n)
  • 43.48 (a)
ccdc59 36
  • 34 (a)
OneToOne
Species with no ortholog for CCDC59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC59 Gene

ENSEMBL:
Gene Tree for CCDC59 (if available)
TreeFam:
Gene Tree for CCDC59 (if available)

Paralogs for CCDC59 Gene

Pseudogenes.org Pseudogenes for CCDC59 Gene

genes like me logo Genes that share paralogs with CCDC59: view

No data available for Paralogs for CCDC59 Gene

Variants for CCDC59 Gene

Sequence variations from dbSNP and Humsavar for CCDC59 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs14568 -- 82,352,991(+) CATAT(G/T)TAGAA nc-transcript-variant, utr-variant-3-prime
rs17774157 -- 82,353,349(+) GCAAC(A/C)AACAG intron-variant
rs34312454 -- 82,354,021(+) AGTTG(-/T)TTTTT intron-variant
rs79915959 -- 82,352,677(+) GTGAG(G/T)GCAGT nc-transcript-variant, utr-variant-3-prime
rs34902584 -- 82,352,497(+) TGTTC(-/T)TTAAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC59 Gene

Variant ID Type Subtype PubMed ID
nsv832471 CNV Loss 17160897
nsv899348 CNV Gain 21882294

Variation tolerance for CCDC59 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC59 Gene

Disorders for CCDC59 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC59 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pulmonary surfactant metabolism dysfunction
  • pulmonary alveolar proteinosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCDC59

Genetic Association Database (GAD)
CCDC59
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC59
genes like me logo Genes that share disorders with CCDC59: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC59 Gene

Publications for CCDC59 Gene

  1. The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells. (PMID: 16630564) Yang M.-C. … Yang Y.-S. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells. (PMID: 12882447) Yang M.-C. … Yang Y.-S. (Eur. Respir. J. 2003) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CCDC59 Gene

Sources for CCDC59 Gene

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