Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC58 Gene

Aliases for CCDC58 Gene

  • Coiled-Coil Domain Containing 58 2 3 5

External Ids for CCDC58 Gene

Previous GeneCards Identifiers for CCDC58 Gene

  • GC03M123562
  • GC03M122078
  • GC03M119451

Summaries for CCDC58 Gene

GeneCards Summary for CCDC58 Gene

CCDC58 (Coiled-Coil Domain Containing 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC58 Gene

Genomics for CCDC58 Gene

Regulatory Elements for CCDC58 Gene

Enhancers for CCDC58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F122356 0.3 FANTOM5 11.6 +27.1 27134 0.0 HDGF PKNOX1 POLR2A GATA2 EED ZNF143 ETV6 CREM MTA2 CBFB CSTA CCDC58 FAM162A
GH03F122408 0.4 Ensembl 10.7 -26.3 -26320 1.6 PRDM1 WDR5B LOC102723582 CCDC58 FAM162A PARP14
GH03F122314 1.2 FANTOM5 ENCODE 10.7 +68.6 68610 1.5 MTA2 HLF IKZF1 MNT TBX21 CSTA WDR5B CCDC58 FAM162A PARP14 PARP9 DTX3L DIRC2 CD86 KPNA1
GH03F122313 1 FANTOM5 Ensembl 10.7 +70.0 69981 0.6 GATA3 CBX3 CSTA CCDC58 FAM162A PARP14 WDR5B PARP9 DTX3L DIRC2 KPNA1 HNRNPA1P23
GH03F122414 0.2 ENCODE 10.6 -32.9 -32878 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS WDR5B LOC102723582 CCDC58 FAM162A SEC22A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC58 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CCDC58 Gene

122,359,589 bp from pter
122,383,281 bp from pter
23,693 bases
Minus strand

Genomic View for CCDC58 Gene

Genes around CCDC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC58 Gene

Proteins for CCDC58 Gene

  • Protein details for CCDC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 58
    Protein Accession:
    Secondary Accessions:
    • Q32LY6

    Protein attributes for CCDC58 Gene

    144 amino acids
    Molecular mass:
    16620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC58 Gene

Post-translational modifications for CCDC58 Gene

  • Ubiquitination at Lys 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC58 Gene

No data available for DME Specific Peptides for CCDC58 Gene

Domains & Families for CCDC58 Gene

Protein Domains for CCDC58 Gene

Suggested Antigen Peptide Sequences for CCDC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC58 family.
  • Belongs to the CCDC58 family.
genes like me logo Genes that share domains with CCDC58: view

No data available for Gene Families for CCDC58 Gene

Function for CCDC58 Gene

genes like me logo Genes that share phenotypes with CCDC58: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC58 Gene

Localization for CCDC58 Gene

Subcellular locations from

Jensen Localization Image for CCDC58 Gene COMPARTMENTS Subcellular localization image for CCDC58 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytoskeleton 2
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for CCDC58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with CCDC58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC58 Gene

Pathways & Interactions for CCDC58 Gene

SuperPathways for CCDC58 Gene

No Data Available

Interacting Proteins for CCDC58 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000291458 Q4VC31-CCD58_HUMAN for CCDC58 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC58 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC58 Gene

Transcripts for CCDC58 Gene

Unigene Clusters for CCDC58 Gene

Coiled-coil domain containing 58:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC58 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for CCDC58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC58 Gene

mRNA expression in normal human tissues for CCDC58 Gene

Protein differential expression in normal tissues from HIPED for CCDC58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Liver (6.7), and Liver, secretome (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC58 Gene

Protein tissue co-expression partners for CCDC58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC58 Gene:


SOURCE GeneReport for Unigene cluster for CCDC58 Gene:

genes like me logo Genes that share expression patterns with CCDC58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC58 Gene

Orthologs for CCDC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC58 34
  • 99.54 (n)
(Bos Taurus)
Mammalia CCDC58 34 35
  • 96.53 (n)
(Canis familiaris)
Mammalia CCDC58 34 35
  • 96.06 (n)
(Rattus norvegicus)
Mammalia Ccdc58 34
  • 95.6 (n)
(Mus musculus)
Mammalia Ccdc58 34 16 35
  • 94.68 (n)
(Monodelphis domestica)
Mammalia CCDC58 35
  • 88 (a)
(Gallus gallus)
Aves CCDC58 34 35
  • 83.1 (n)
(Anolis carolinensis)
Reptilia CCDC58 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc58 34
  • 72.92 (n)
Str.6520 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7053 34
(Danio rerio)
Actinopterygii ccdc58 34 35
  • 70.56 (n)
zgc73369 34
fruit fly
(Drosophila melanogaster)
Insecta CG15881 34 35
  • 50.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005402 34
  • 50.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5031 35
  • 44 (a)
Species where no ortholog for CCDC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC58 Gene

Gene Tree for CCDC58 (if available)
Gene Tree for CCDC58 (if available)

Paralogs for CCDC58 Gene

No data available for Paralogs for CCDC58 Gene

Variants for CCDC58 Gene

Sequence variations from dbSNP and Humsavar for CCDC58 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10588871 -- 122,359,090(+) TCCAT(-/AC)ACTAG downstream-variant-500B
rs10660235 -- 122,370,457(+) TCTCA(-/AA)AAAAA intron-variant
rs111289055 -- 122,366,069(+) GCTAC(C/T)AGGGA intron-variant
rs111604414 -- 122,359,831(+) TCCTT(A/T)AAAAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111619637 -- 122,381,654(+) TGGAG(G/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC58 Gene

Variant ID Type Subtype PubMed ID
esv2574672 CNV deletion 19546169
esv2677337 CNV deletion 23128226
esv33139 CNV loss 17666407
esv3568993 CNV loss 25503493
esv3597607 CNV loss 21293372
nsv3973 CNV deletion 18451855

Variation tolerance for CCDC58 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC58 Gene

Disorders for CCDC58 Gene

Relevant External Links for CCDC58

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC58 Gene

Publications for CCDC58 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for CCDC58 Gene

Sources for CCDC58 Gene

Loading form....