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Aliases for CCDC58 Gene

Aliases for CCDC58 Gene

  • Coiled-Coil Domain Containing 58 2 3 5

External Ids for CCDC58 Gene

Previous GeneCards Identifiers for CCDC58 Gene

  • GC03M123562
  • GC03M122078
  • GC03M119451

Summaries for CCDC58 Gene

GeneCards Summary for CCDC58 Gene

CCDC58 (Coiled-Coil Domain Containing 58) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC58 Gene

Genomics for CCDC58 Gene

Regulatory Elements for CCDC58 Gene

Enhancers for CCDC58 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC58 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC58 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC58 Gene

122,359,589 bp from pter
122,383,281 bp from pter
23,693 bases
Minus strand

Genomic View for CCDC58 Gene

Genes around CCDC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC58 Gene

Proteins for CCDC58 Gene

  • Protein details for CCDC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 58
    Protein Accession:
    Secondary Accessions:
    • Q32LY6

    Protein attributes for CCDC58 Gene

    144 amino acids
    Molecular mass:
    16620 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC58 Gene

Proteomics data for CCDC58 Gene at MOPED

Post-translational modifications for CCDC58 Gene

  • Ubiquitination at Lys 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC58 Gene

No data available for DME Specific Peptides for CCDC58 Gene

Domains & Families for CCDC58 Gene

Protein Domains for CCDC58 Gene


Suggested Antigen Peptide Sequences for CCDC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC58 family.
  • Belongs to the CCDC58 family.
genes like me logo Genes that share domains with CCDC58: view

No data available for Gene Families for CCDC58 Gene

Function for CCDC58 Gene

Phenotypes for CCDC58 Gene

genes like me logo Genes that share phenotypes with CCDC58: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC58 Gene

Localization for CCDC58 Gene

Subcellular locations from

Jensen Localization Image for CCDC58 Gene COMPARTMENTS Subcellular localization image for CCDC58 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytoskeleton 2
cytosol 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC58 Gene

Pathways & Interactions for CCDC58 Gene

SuperPathways for CCDC58 Gene

No Data Available

Interacting Proteins for CCDC58 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000291458 Q4VC31-CCD58_HUMAN for CCDC58 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CCDC58 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC58 Gene

Drugs & Compounds for CCDC58 Gene

No Compound Related Data Available

Transcripts for CCDC58 Gene

Unigene Clusters for CCDC58 Gene

Coiled-coil domain containing 58:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC58 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -

Relevant External Links for CCDC58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC58 Gene

mRNA expression in normal human tissues for CCDC58 Gene

Protein differential expression in normal tissues from HIPED for CCDC58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Liver (6.7), and Liver, secretome (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC58 Gene

SOURCE GeneReport for Unigene cluster for CCDC58 Gene Hs.220594

genes like me logo Genes that share expression patterns with CCDC58: view

Protein tissue co-expression partners for CCDC58 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC58 Gene

Orthologs for CCDC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC58 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC58 35
  • 96.53 (n)
  • 97.92 (a)
CCDC58 36
  • 98 (a)
(Canis familiaris)
Mammalia CCDC58 35
  • 96.06 (n)
  • 97.22 (a)
CCDC58 36
  • 74 (a)
(Mus musculus)
Mammalia Ccdc58 35
  • 94.68 (n)
  • 96.53 (a)
Ccdc58 16
Ccdc58 36
  • 97 (a)
(Pan troglodytes)
Mammalia CCDC58 35
  • 99.54 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccdc58 35
  • 95.6 (n)
  • 98.61 (a)
(Monodelphis domestica)
Mammalia CCDC58 36
  • 88 (a)
(Gallus gallus)
Aves CCDC58 35
  • 83.1 (n)
  • 84.03 (a)
CCDC58 36
  • 84 (a)
(Anolis carolinensis)
Reptilia CCDC58 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc58 35
  • 72.92 (n)
  • 75 (a)
Str.6520 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7053 35
(Danio rerio)
Actinopterygii ccdc58 35
  • 70.56 (n)
  • 79.17 (a)
zgc73369 35
ccdc58 36
  • 76 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005402 35
  • 50.12 (n)
  • 45.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15881 35
  • 50.26 (n)
  • 46.87 (a)
CG15881 36
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5031 36
  • 44 (a)
Species with no ortholog for CCDC58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC58 Gene

Gene Tree for CCDC58 (if available)
Gene Tree for CCDC58 (if available)

Paralogs for CCDC58 Gene

genes like me logo Genes that share paralogs with CCDC58: view

No data available for Paralogs for CCDC58 Gene

Variants for CCDC58 Gene

Sequence variations from dbSNP and Humsavar for CCDC58 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2332176 -- 122,382,091(+) TAGGC(A/T)CTCGA intron-variant
rs2332177 -- 122,382,092(+) AGGCA(C/G)TCGAT intron-variant
rs2332178 -- 122,360,696(-) GGGGT(A/G)AATTC intron-variant
rs2332179 -- 122,360,583(-) AAAAA(C/T)AGTAA intron-variant
rs4491840 -- 122,361,900(+) GTTTT(A/G)GTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC58 Gene

Variant ID Type Subtype PubMed ID
esv33139 CNV Loss 17666407
esv2574672 CNV Deletion 19546169
esv2677337 CNV Deletion 23128226
nsv3973 CNV Loss 18451855

Variation tolerance for CCDC58 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC58 Gene

Disorders for CCDC58 Gene

Relevant External Links for CCDC58

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC58 Gene

Publications for CCDC58 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Common genetic variants associate with serum phosphorus concentration. (PMID: 20558539) Kestenbaum B. … Fox C.S. (J. Am. Soc. Nephrol. 2010) 3
  5. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha C.M. … KAPttgen A. (Hum. Mol. Genet. 2010) 3

Products for CCDC58 Gene

Sources for CCDC58 Gene