CCDC58 Gene
protein-coding GIFtS: 43
GCID: GC03M122078
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coiled-coil domain containing 58
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Aliases
for CCDC58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 581 2 | | FLJ332731 | | Coiled-Coil Domain-Containing Protein 582 |
Export aliases for CCDC58 gene to outside databasesPrevious GC identifers: GC03M123562 GC03M119451 |
Summaries
for CCDC58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC58 gene promoter:
STAT5A CUTL1 Arnt FOXL1 POU2F1 FOXJ2 (long isoform) POU2F1a USF-1 ARP-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1CCDC58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M122078: view genomic region
(about GC identifiers)
Start:
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122,078,436 bp from pter |
End:
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122,102,078 bp from pter |
Size:
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23,643 bases |
Orientation:
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minus strand |
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Proteins
for CCDC58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD58_HUMAN, Q4VC31 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 58 Size: 144 amino acids; 16620 Da
Secondary accessions: Q32LY6Explore the universe of human proteins at neXtProt for CCDC58: NX_Q4VC31
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4VC31
CCDC58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017928.1
ENSEMBL proteins: ENSP00000291458 ENSP00000420769 ENSP00000420248 ENSP00000418810
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
CCDC58 for ontologies About GeneDecksing
CCDC58 Antibody Products:
Assay Products for CCDC58: |
Protein
Domains /
Families
for CCDC58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC58 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4VC31ProtoNet protein and cluster: Q4VC31 UniProtKB/Swiss-Prot: CCD58_HUMAN, Q4VC31Similarity: Belongs to the CCDC58 family |
Function
for CCDC58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC58 (NM_001017928) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC58 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC58 |
|
Pathways & Interactions
for CCDC58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC58
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for CCDC58 (Q4VC313 ENSP000002914584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC58
Search CenterWatch for drugs/clinical trials and news about CCDC58 / CCD58
|
Transcripts
for CCDC58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC58 gene: NM_001017928.2 Unigene Cluster for CCDC58: Coiled-coil domain containing 58 Hs.220594 [show with all ESTs]Unigene Representative Sequence: BF6699277 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000291458(uc003eey.3) ENST00000497726 ENST00000466854 ENST00000460810
ENST00000479899 ENST00000479414 ENST00000498466
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC58 (NM_001017928) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC58 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC58 |
Additional cDNA sequence: BC054051.1 BC062725.1 BC109378.1 6 DOTS entries: DT.101979552 DT.97838234 DT.410481 DT.120906460 DT.92416183 DT.40132469 24/35 AceView cDNA sequences (see all 35): BG211098 BE503517 BQ421477 BF173217 BU633841 AW290910 BC054051 AW515683 BU601941 AW474887 N95803 N50778 BX486447 BC062725 AA668330 BM785360 BU533446 AA280658 AW615148 BF594490 BM740853 AW118097 BF001285 CD683826
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC58 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC58
|
Expression
for CCDC58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGATATCA
About this image
See CCDC58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC58
SOURCE GeneReport for Unigene cluster: Hs.220594
SABiosciences Custom PCR Arrays for CCDC58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC58 |
Orthologs
for CCDC58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC58 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for CCDC58 (if available)
TreeFam Gene Tree for CCDC58 (if available) |
Paralogs
for CCDC58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC58 gene
CCDC58 for paralogs About GeneDecksing
5/18 Pseudogenes.org Pseudogenes for CCDC58 (see all 18)
PGOHUM00000238492 PGOHUM00000242363 PGOHUM00000234854 PGOHUM00000234999 PGOHUM00000237601
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Genomic Variants
for CCDC58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC58 (122078436 - 122102078 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC58
2 CNVs: 98424 7357 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC58 |
|
Disorders
/ Diseases
for CCDC58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC58 for disorders About MalaCards
CCDC58 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for CCDC58:Ehrlichiosis Human Genome Epidemiology (HuGE) Navigator: CCDC58 (1 document)
Export disorders for CCDC58 gene to outside databases
|
Publications
for CCDC58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC58 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CCDC58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1 O'Seaghdha C.M....KAPttgen A. (2010)
- Common genetic variants associate with serum phosphor us concentration. (PubMed id 20558539)1 Kestenbaum B....Fox C.S. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for CCDC58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC58 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC58 gene:
Search GeneIP for patents involving CCDC58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC58 | | | OriGene Protein Over-expression Lysate for CCDC58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC58 | | OriGene 3'-UTR Clone for CCDC58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC58 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC58 | | OriGene Custom Protein Services for CCDC58 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC58 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC58 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC58 |
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 | | | CCDC58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CCDC58 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC58 |
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