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Aliases for CCDC57 Gene

Aliases for CCDC57 Gene

  • Coiled-Coil Domain Containing 57 2 3

External Ids for CCDC57 Gene

Previous GeneCards Identifiers for CCDC57 Gene

  • GC17M077705
  • GC17M077652
  • GC17M080059
  • GC17M075459

Summaries for CCDC57 Gene

GeneCards Summary for CCDC57 Gene

CCDC57 (Coiled-Coil Domain Containing 57) is a Protein Coding gene.

Gene Wiki entry for CCDC57 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC57 Gene

Genomics for CCDC57 Gene

Regulatory Elements for CCDC57 Gene

Transcription factor binding sites by QIAGEN in the CCDC57 gene promoter:

Genomic Location for CCDC57 Gene

Start:
82,101,460 bp from pter
End:
82,212,830 bp from pter
Size:
111,371 bases
Orientation:
Minus strand

Genomic View for CCDC57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC57 Gene

Proteins for CCDC57 Gene

  • Protein details for CCDC57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAC2-CCD57_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 57
    Protein Accession:
    Q2TAC2
    Secondary Accessions:
    • A6NP51
    • A8MQC7
    • Q8IWG2
    • Q8TER3

    Protein attributes for CCDC57 Gene

    Size:
    916 amino acids
    Molecular mass:
    103167 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAW89746.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC57 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC57 Gene

Proteomics data for CCDC57 Gene at MOPED

Post-translational modifications for CCDC57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC57 Gene

Domains for CCDC57 Gene

Protein Domains for CCDC57 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC57 Gene

Function for CCDC57 Gene

Gene Ontology (GO) - Molecular Function for CCDC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC57: view

Phenotypes for CCDC57 Gene

genes like me logo Genes that share phenotypes with CCDC57: view

Animal Model Products

CRISPR Products

miRNA for CCDC57 Gene

miRTarBase miRNAs that target CCDC57

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC57

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC57 Gene

Localization for CCDC57 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC57 Gene COMPARTMENTS Subcellular localization image for CCDC57 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC57 Gene

Pathways for CCDC57 Gene

SuperPathways for CCDC57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC57 Gene

None

No data available for Pathways by source for CCDC57 Gene

Transcripts for CCDC57 Gene

Unigene Clusters for CCDC57 Gene

Coiled-coil domain containing 57:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC57

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC57 Gene

No ASD Table

Relevant External Links for CCDC57 Gene

GeneLoc Exon Structure for
CCDC57
ECgene alternative splicing isoforms for
CCDC57

Expression for CCDC57 Gene

mRNA expression in normal human tissues for CCDC57 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC57 Gene

SOURCE GeneReport for Unigene cluster for CCDC57 Gene Hs.631724

genes like me logo Genes that share expressions with CCDC57: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC57 Gene

Orthologs for CCDC57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC57 35
  • 91.3 (n)
  • 88.92 (a)
CCDC57 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC57 35
  • 77.7 (n)
  • 70.47 (a)
CCDC57 36
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC57 35
  • 75.85 (n)
  • 66.25 (a)
CCDC57 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc57 35
  • 69.89 (n)
  • 61.36 (a)
Ccdc57 16
Ccdc57 36
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC57 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC57 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC57 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc57 35
  • 55.74 (n)
  • 47.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc57 35
  • 52.87 (n)
  • 43.78 (a)
CCDC57 36
  • 27 (a)
OneToMany
CCDC57 (1 of 2) 36
  • 45 (a)
OneToMany
Species with no ortholog for CCDC57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC57 Gene

ENSEMBL:
Gene Tree for CCDC57 (if available)
TreeFam:
Gene Tree for CCDC57 (if available)

Paralogs for CCDC57 Gene

Selected SIMAP similar genes for CCDC57 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CCDC57: view

No data available for Paralogs for CCDC57 Gene

Variants for CCDC57 Gene

Sequence variations from dbSNP and Humsavar for CCDC57 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13949 -- 82,101,720(+) GGGCC(C/T)CTGGC reference, missense
rs1127664 -- 82,127,710(-) CCTCC(C/T)AGGGT reference, stop-gained
rs1127678 -- 82,101,611(-) CCTAC(A/G)TGTTG utr-variant-3-prime
rs3088177 -- 82,153,848(-) AATTT(C/T)CTTCG intron-variant
rs3922470 -- 82,152,283(-) GAGGA(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC57 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3343n71 CNV Loss 21882294
nsv909167 CNV Gain+Loss 21882294
dgv3344n71 CNV Loss 21882294
dgv3345n71 CNV Loss 21882294
nsv909181 CNV Loss 21882294
nsv457976 CNV Gain 19166990
nsv470621 CNV Gain 18288195
nsv909186 CNV Loss 21882294
dgv3351n71 CNV Loss 21882294
nsv909192 CNV Gain 21882294
dgv3353n71 CNV Loss 21882294
nsv909198 CNV Loss 21882294
nsv909201 CNV Gain+Loss 21882294
nsv112507 CNV Insertion 16902084
esv2716472 CNV Deletion 23290073
nsv819888 CNV Loss 19587683
esv1493148 CNV Deletion 17803354
esv2716475 CNV Deletion 23290073
nsv512510 CNV Loss 21212237
esv7032 CNV Loss 19470904
esv2716476 CNV Deletion 23290073
esv3678 CNV Deletion 18987735
esv1149029 CNV Deletion 17803354
esv2716477 CNV Deletion 23290073
esv2716478 CNV Deletion 23290073
esv2716479 CNV Deletion 23290073
nsv112197 CNV Loss 16902084
esv2716480 CNV Deletion 23290073
esv3254 CNV Deletion 18987735
esv1004361 CNV Deletion 20482838
esv2716481 CNV Deletion 23290073
dgv3354n71 CNV Loss 21882294
nsv112226 CNV Loss 16902084
nsv833572 CNV Loss 17160897
dgv3355n71 CNV Loss 21882294
nsv909208 CNV Loss 21882294
nsv2166 CNV Insertion 18451855

Relevant External Links for CCDC57 Gene

HapMap Linkage Disequilibrium report
CCDC57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC57 Gene

Disorders for CCDC57 Gene

Relevant External Links for CCDC57

Genetic Association Database (GAD)
CCDC57
Human Genome Epidemiology (HuGE) Navigator
CCDC57
genes like me logo Genes that share disorders with CCDC57: view

No data available for UniProtKB/Swiss-Prot for CCDC57 Gene

Publications for CCDC57 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PMID: 15851553) Ozyildirim A.M. … Laurie G.W. (Invest. Ophthalmol. Vis. Sci. 2005) 3

Products for CCDC57 Gene

Sources for CCDC57 Gene

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