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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC53 Gene

protein-coding   GIFtS: 48
GCID: GC12M102406

Coiled-Coil Domain Containing 53

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 531 2
Coiled-Coil Domain-Containing Protein 532 3
CGI-1162
WASH Complex Subunit CCDC532

External Ids:    HGNC: 242561   Entrez Gene: 510192   Ensembl: ENSG000001208607   UniProtKB: Q9Y3C03   

Export aliases for CCDC53 gene to outside databases

Previous GC identifers: GC12M100910 GC12M099466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC53 Gene: 
CCDC53 (coiled-coil domain containing 53) is a protein-coding gene. Diseases associated with CCDC53 include paraplegia, and spasticity. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CCD53_HUMAN, Q9Y3C0
Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
that serve as transport intermediates during endosome sorting

Gene Wiki entry for CCDC53 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC53 gene promoter:
         HOXA9B   HOXA9   Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   CUTL1   Nkx3-1 v2   Nkx3-1 v3   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC53 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC53

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.3

CCDC53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC53 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M102406:  view genomic region     (about GC identifiers)

Start:
102,406,705 bp from pter      End:
102,455,927 bp from pter
Size:
49,223 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCD53_HUMAN, Q9Y3C0 (See protein sequence)
Recommended Name: WASH complex subunit CCDC53  
Size: 194 amino acids; 21173 Da
Subunit: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or
CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P),
FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53
Secondary accessions: B2RC74 Q53FF0 Q6IAI4 Q96QK0

Explore the universe of human proteins at neXtProt for CCDC53: NX_Q9Y3C0

Explore proteomics data for CCDC53 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3C0

  • CCDC53 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC53 Protein Expression
    REFSEQ proteins: NP_057137.1  
    ENSEMBL proteins: 
     ENSP00000438122   ENSP00000240079   ENSP00000440134   ENSP00000443857   ENSP00000441810  
     ENSP00000440139   ENSP00000443922   ENSP00000445501  

    Human Recombinant Protein Products for CCDC53: 
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    Novus Biologicals CCDC53 Protein
    Novus Biologicals CCDC53 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC53 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071203WASH complex IDA19922875

    CCDC53 for ontologies           About GeneDecksing



    CCDC53 Antibody Products: 
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    Assay Products for CCDC53: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CCDC53 
    Cloud-Clone Corp. CLIAs for CCDC53


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019309 WASH_CCDC53

    Graphical View of Domain Structure for InterPro Entry Q9Y3C0

    ProtoNet protein and cluster: Q9Y3C0

    UniProtKB/Swiss-Prot: CCD53_HUMAN, Q9Y3C0
    Similarity: Belongs to the CCDC53 family


    CCDC53 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCD53_HUMAN, Q9Y3C0
    Function: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates
    the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules
    that serve as transport intermediates during endosome sorting

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    CCDC53 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC53:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC53 
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    miRNA
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    Inhib. RNA
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC53


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for CCDC53 (Q9Y3C01, 2, 3 ENSP000002400794) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCRS1Q96EZ81, 2, 3, ENSP000003496404EBI-712969,EBI-348259 MINT-67720 I2D: score=5 STRING: ENSP00000349640
    C7orf55-LUC7L2Q9Y3832, 3MINT-65846 I2D: score=5 
    LUC7L2Q9Y3832, 3MINT-65846 I2D: score=5 
    GDF9O603832, 3MINT-65843 I2D: score=5 
    LAMC1P110472, 3MINT-65844 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CCDC53 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC53 (CCD53)

    Search CenterWatch for drugs/clinical trials and news about CCDC53 / CCD53

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC53 gene: 
    NM_016053.2  

    Unigene Cluster for CCDC53:

    Coiled-coil domain containing 53
    Hs.405692  [show with all ESTs]
    Unigene Representative Sequence: BQ067713
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538761 ENST00000240079(uc010svw.2) ENST00000544341 ENST00000545679
    ENST00000540536 ENST00000535501 ENST00000536197 ENST00000542923 ENST00000539515
    ENST00000541569 ENST00000500685 ENST00000326351 ENST00000536930
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CCDC53
    SwitchGear 3'UTR luciferase reporter plasmidCCDC53 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CCDC53
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC53
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC53
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC53

    Additional mRNA sequence: 

    AF151874.1 AF155655.1 AK223339.1 AK314970.1 BC010889.1 CR457171.1 

    12 DOTS entries:

    DT.217397  DT.40115837  DT.40275478  DT.100787444  DT.95162976  DT.100787443  DT.100024439  DT.100787442 
    DT.121182008  DT.91654945  DT.92431732  DT.95309435 

    24/175 AceView cDNA sequences (see all 175):

    CR609797 CR621235 AV703174 CR623956 AV703111 AV707776 AA131262 AI702842 
    AI306519 CA417919 BM932235 AA716324 AA725258 AA933054 AI348351 AA152196 
    AA743656 AA987345 AA975991 BQ446362 AA384523 AA131350 AW188175 BF309042 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC53 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                -     -                                             
    SP2:                                -     -                             -               
    SP3:                                      -                                             
    SP4:                                -                                                   
    SP5:                                -     -                                             


    ECgene alternative splicing isoforms for CCDC53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACTACCA
    CCDC53 Expression
    About this image


    See CCDC53 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC53

    SOURCE GeneReport for Unigene cluster: Hs.405692
        SABiosciences Custom PCR Arrays for CCDC53
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC53 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc531 , 5 coiled-coil domain containing 531, 5 87.8(n)1
    90.21(a)1
      10 (43.70 cM)5
    672821  NM_026070.31  NP_080346.11 
     882010935 
    chicken
    (Gallus gallus)
    Aves CCDC531 coiled-coil domain containing 53 78.52(n)
    77.84(a)
      418094  XM_416327.3  XP_416327.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC536
    Uncharacterized protein
    73(a)
    1 ↔ 1
    5(17485079-17505260)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.44612 Transcribed sequence with moderate similarity to protein more 80.8(n)    137728057 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc557182 hypothetical protein MGC55718 77.17(n)   393142  BC045438.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74291 CG7429 47.7(n)
    36.78(a)
      34097  NM_135334.4  NP_609178.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ddl-16
    WASH complex subunit CCDC53 homolog
    27(a)
    1 ↔ 1
    II(5647153-5647886)


    ENSEMBL Gene Tree for CCDC53 (if available)
    TreeFam Gene Tree for CCDC53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC53 gene
    1 SIMAP similar gene for CCDC53 using alignment to 8 protein entries:     CCD53_HUMAN (see all proteins):
    FBXL18

    CCDC53 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CCDC53
    PGOHUM00000260416 PGOHUM00000241832


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/879 SNPs in CCDC53 are shown (see all 879)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503377001,2
    --102406222(+) TTGCAC/TTGGGT 1 -- int10--------
    rs1141649771,2
    C,F--102406297(+) TTTAAG/AACAGA 1 -- int11Minor allele frequency- A:0.05WA 118
    rs1867032361,2
    --102406326(+) TGGCTG/TGAGTG 1 -- int10--------
    rs1379884051,2
    C--102406582(+) CAGGCA/GTGAGC 1 -- int10--------
    rs1424216361,2
    --102406651(+) TAGCAC/GTAATT 1 -- int10--------
    rs11284051,2
    C--102406763(-) AGCTTC/TTTCTA 1 -- ut312Minor allele frequency- T:0.00NA 4
    rs2017988931,2
    --102406836(+) ACAGAA/GTGTAA 1 -- ut310--------
    rs18015191,2
    C--102406899(-) ATCTTC/TTTTTA 2 S F mis11Minor allele frequency- T:0.00NA 2
    rs2003253591,2
    C--102406905(+) AAGATG/TCGCTA 2 E A mis10--------
    rs1915613341,2
    --102406911(+) CGCTAC/TCTGAA 2 D G mis10--------

    HapMap Linkage Disequilibrium report for CCDC53 (102406705 - 102455927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CCDC53:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899473CNV Loss21882294
    nsv899472CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC53
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC53

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CCDC53:    About MalaCards
    paraplegia    spasticity

    1 disease from the University of Copenhagen DISEASES database for CCDC53:
    Paraplegia

    CCDC53 for disorders           About GeneDecksing


    Export disorders for CCDC53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC53 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CCDC53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. (PubMed id 19922875)1, 2 Derivery E.... Gautreau A. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51019 HGNC: 24256 AceView: CGI-116 Ensembl:ENSG00000120860 euGenes: HUgn51019
    ECgene: CCDC53 H-InvDB: CCDC53

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC53 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC53 gene:
    Search GeneIP for patents involving CCDC53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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